성인 지역사회 폐렴의 원인 미생물에 대한 전향적 다기관 연구 : Legionella, Leptospira, Hantaan virus and Orientia tsutsugamushi

김민자,정희진,손장욱,심희선,박대원,박승철,우준희,강재명,김유겸,신완식,김양리,이환종,김지희 대한감염학회 2001 감염 Vol.33 No.1

Background : Despite rigorous investigations, the etiology of community-acquired pneumonia remains unknown in about 50% of hospitalized patients. The diagnosis of the etiological agent is becoming more challenging and more critical as number of newer pathogens have been recognized in recent years. In the 3-year period prospective study we investigated adult patients with community-acquired pneumonia for Legionella, Leptospira, Hantaan virus and Orientia tsutsugamushi as potential etiologic agents. Methods : A prospective multicenter study was performed from May 1997 to April 2000. A total of 431 patients with community-acquired pneumonia under the inclusion criteria were examined for specific microbial diagnosis; sputum culture and PCR, and serologic teats including indirect immunofluorescence antibody (IFA) test for Legionella, and hemagglutination tests for Leptosoira, Hantaan virus and O. tsutsugamushi. Etiologic diagnosis was determined on the basis of the review of case record forms and specific laboratory diagnostic criteria. Results : During the study period a total of 385 sputum and 283 serum samples were examined. Legionella pneumonia was diagnosed in 2.3% (10/431) of the cases examined : 1.4% cases with PCR-positive (5/367) and 2.1% with positive IFA test (6/283). Leptospirosis and scrub typhus were diagnosed in 0.4% (1/252) and 2.0% (5/252), respectively. All 5 cases with scrub typhus occurred in late fall, and rash or eschar was not found. None of cases was Hantaan virus infection. Conclusion : The results suggest that Legionella, Leptospira, and O. tsutsugamushi should be considered in the etiologic diagnosis and empirical antibiotic therapy of community-acquired pneumonia. (Korean J Infect Dis 32:24∼31, 2001)

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

실리콘의 TMAH 식각을 사용한 Suspended-type 마이크로 가스센서의 제조

김현호,이상문,임준우,강봉휘,정완영,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

In recent years, different types of microfabricated 'suspended-type' structure have been used as freestanding membranes for a variety of micro gas sensors. We examined the silicon etching characteristics of tetramethyl ammonium hydroxide(TMAH). A suspended type micro gas sensor with platinum heater, sensing electrode and temperature sensor using TMAH etching of silicon was fabricated on silicon nitride(1,500Å)/ silicon dioxide (3,000Å)/ silicon nitride(1,500Å) dielectric membrane. It has low thermal conductivity and balanced stress with silicon substrate for the purpose of improving the thermal isolation between heater and silicon substrate. To avoid any chemical or physical damages to gas sensing material during the photolithography or shadow mask process, the tin dioxide film was deposited onto whole surface of device by using maskless electron beam(e-beam) evaporation technology. The power consumption of the fabricated device was about 40mW at the operating temperature of 250°C. In case of adding Pt(2wt.%) or Pd(2wt.%) catalyst, the sensitivity to CO was higher and the sensitivity to C_(4)H_(10) was higher than those to other gases, respectively.

팩강성이 모래의 강도에 미치는 영향

金昞逸,任俊赫,柳完圭 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

Various researches have been undertaken to develop a new soil improvement method which can replace sand compaction pile(SCP) due to an increase of sand cost. Pack pile is one of the new methods reinforced by pack material such as geotextiles. In this study, a series of triaxial compression tests are carried out to find out shear strength characteristics of sand with and without pack. Total 6 different types of geotextile are selected for pack material. Based on the test results, stiffness of pack increases the strength of sand considerably.

개불(Ureshis unicinctus) 受精卵의 卵割類型과 形態形成에 關한 硏究

김완종,최준섭,신길상 순천향대학교 기초과학연구소 1995 순천향자연과학연구 논문집 Vol.1 No.2

The present study was carried out to examine the early embryogenesis of Urechis unicinctus in terms of its cleavage pattern and morphogenesis. The first sign of fertilization was the appearance of fertilization membrane, which was 20㎛ in maximum thickness. The cleavage pattern was equal holoblastic in early stage and partial unequal cleavage in later stage. There appeared the cavity in blastula, and then cilia which were derived from the peripheral blastomeres, activated the motility of the larva. Ultrastructures of cleaving zygote included microvilli on free cell surface, numerous nuclear pores of nucleus, well developed rough endoplasmic reticulum, Golgi complex and mitochondria in the cytoplasm. In addition, yolk granules and vesicles were also distributed in the cytoplasm. Cytokinesis was followed by the karyokinesis, through the formation of the cleavage furrow. Morphogenesis of Urechis unicinctus is summarized by the serial equal holoblastic cleavages, the cell movements, and the formations of a blastocoel and cilia.

해산어와 담수어 신장의 미세구조 비교

김완종,신길상,최준섭 순천향대학교 기초과학연구소 1995 순천향자연과학연구 논문집 Vol.1 No.1

This study was carried out to examine the ultrastructural differences of the kidneys of a marine fish and a freshwater fish by light and electron microscopes. In the case of Carassius carassius, the kidney is characterized by numerous glomeruli. Renal tubule cells are columnar type and their organelles are fully differentiated. In the case of Ditrema temmincki glomeruli and Bowman's capsules are separated each other in the distribution. Renal tubule cells bear short or long microvilli toward the lumen. Invaginations of the cytoplasm at the tubular base are seen and mitochondria are well developed in terms of cristae. There are congested blood cells, particularly nucleated red blood cells, in the kidney of Sebastes inermis, so it is suggested that the organ is related with the hematopoietic function. In conclusion, ultrastructures of the kidneys have been adapted for the marine or freshwater environments.

비유기중의 소유방염에 대한 항균펩타이드(Buforin Ⅱb)의 효능실험

김인송,권성균,임형준,이완규 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.3

Recently, a novel antimicrobial peptide including Buforin II has been emphasized to kill multi-drug resistant bacteria and avoid promoting multi-drug resistance. This study evaluated the efficacy of an antimicrobial peptide (Buforin IIb) on bovine mastitis. Based on the Minimum inhibitory concentration(MIC, 4 g/ml) of Buforin IIb, syringes were made five concentration(MIC×10, ×50, ×100, ×300, and ×500). Thirty three cows(38 quarters) with bovine mastitis were selected using California mastitis test and grouped in dependant on drug concentration and treatment duration. Each group treated by intramammary infusion twice a day for 3 5 days. The milk samples of 5 groups were aseptically collected from quarters at 0, 3, 7 and 14 days, and 2 groups were collected at 0, 5, 9 and 14 days after first treatment. Collected samples were used for bacterial culture and somatic cell count. Bacterial number(log_(10) mean CFU/ml) was decreased in dependant on drug concentration and extending treatment duration. In group D(MIC×300), bacterial number was decreased from 4.59±0.10(day 0) to 2.89±1.37(day 3), 4.04±0.33(day 7), and 4.19 ± 0.10(day 14), respectively(p 0.05). Bacterial number of B2(MIC×50, 5 days treated) is decreased, approximately 10%, than group B1(MIC×50, 3 days treated). Somatic cell count of group D was slightly decreased from 11,100(×10³)(day 0), to 7,386(×10³)(3 day), 6,886(×10³)(day 7), and 9,661(×10³)(day 14). Staphylococcus spp., was the most common isolate, was bacteriologically cured 100% by Buforin IIb treatment. Overall results indicate that Buforin IIb could have possibility to cure bovine mastitis, if higher concentration over experimental concentration were treated with extending treatment duration.

CORBA 클라이언트/서버 구조의 자바 통합 개발 환경의 설계 및 구현

김완수,김흥준,박순규 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

Today, most of the well-known software development tools and methods faced with problems of scalability, modularity, granularity, and maintenance. These problems result in the fact that these tools and methods are standalone. In this paper, we propose a design and implementation of software development environment for Java application based upon CORBA-based Client/Server model. Proposed model has facilities to overcome a problem caused by updates and its distribution and is possible to overcome problems of scalability, modularity and granularity because it based upon Client/Server model.

인트라넷을 기반으로 한 구매 시스템의 설계 및 구현

김창근,김완규,김흥준 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

As the uses of WWW are growing, the uses of internet and intranet are growing too. Many companies put into operation the computerization of job processing using the intranet. However, in the majority of the cases, intranets are limited by bulletins board, information floor and chatting room in the function. In this paper, internet shopping mall typed Procurement system based on intranet is designed and implemented.

汚物收去車輛의 最適 route設定에 관한 硏究

金正子,李相玩 동아대학교 환경문제연구소 1980 硏究報告 Vol.4 No.1

This study is considered for the rationalization of collection transportation system by the technique of O.R. To improve the present environmental public pollution condition, selecting a sample model, investigating and analyzing it's distribution route, we could determine optimum route to garbage collection vehicles. Actually, by the result of application to Young-Do district, we could reduce 5㎞ per day in distance and it's all expenditures concerned with time and transportation. But, for realization of this study, we have to consider traffic system.