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흰쥐의 대동맥의 수축반응과 열충격단백질에 대한 비소의 영향
박태규,권윤정,김중영 한국환경과학회 2003 한국환경과학회지 Vol.12 No.6
In order to examine if arsenic, one of environmental stresses, contributes to hypertension as one of cardiovas cular pathological factors, this study was performed in vivo and in vitro, using intacted or pithed rats and aorta ring preparation, respectively. And also the relationship between expression of heat shock protein (HSP) 90 and vasoactives-induced contractile response was elucidated. To measure blood pressure, the carotid arterial pressure was recorded on physiograph(Grass Co. 79E) connected to strain gauge. On the other hand, contractile response of vascular ring preparation isolated from rat was determined in organ bath and was recorded on physiograph connected to isometric transducer. And HSP was detacted by Western blotting whole cell lysis. Preganglionic nerve stimulation was increased by 26.0% in arterial pressure of rat treated with arsenic. Vascular contractile response was monitored and HSP were measured by Western blotting of whole lysis prepared from samples exposed with 0, 0.5, 1, 2 and 4 mM of arsenic for 8 hours. The dose-vascular responses of potassium chloride were augmented by increasing dose of arsenic in the strips exposed to arsenic for 8 hours, and were not augmented for 1, 3, 5 hours. And the response of relaxation of rat aorta induced by histamine was not influenced by arsenic stress. The increase of HSP 90 expression in rat aorta was pronounced at 8 hours after 4 mM of arsenic treatment, but HSP 60 expression was not. Arsenic stress not only increased the expression of HSP 90 in the rat aorta, but also augmented contractions to potassium chloride. These results indicated that arsenic stress was sufficient to induce heat shock protein 90, resulting in increased vascular contractility in rat aorta.
부상여재를 이용한 2단 직접여과 시스템의 총인제거에 관한 연구
우달식 ( Dal Sik Woo ),신성훈 ( Sung Hoon Sin ),채수권 ( Su Kwen Chae ),정종태 ( Jong Tae Jung ),조용현 ( Young Hyun Cho ),한상윤 ( Sang Yun Han ),김희영 ( Hee Young Kim ) 한국수처리학회 2013 한국수처리학회지 Vol.21 No.1
Wastewater treatment plants are required to meet the enhanced discharge standards which are differentiated by 0.2, 0.3 and O.5mgT-P/L for the district I, II and III, respectively. Thus, this study was performed whether the two stage direct filtration system combined process of inline mixer process and upflow two stage filter process with floating filter medium was an efficient treatment method for total phosphorus removal from secondary sewage effluent. In the two stage direct filtration experiments, coagulants including aluminum sulphate (alum), polyaluminium chloride (PACI), polyaluminum silicate chloride-2 (PACS-2) ferric chloride (FeCl3) were injected to study the optimum condition for the P04-P removal by jar test. The maximal T-P removal efficiency was achieved for 2.5~3.0 AI (Fe)/P mole ratio and pH 6.0-6.5. Based on the two stage direct filtration experiments, it can be concluded that PACI and FeCl3 were found as an efficient coagulant for the total phosphorus removal and better flocculation. The operation of the two stage direct filtration system at filtration rate of 600m/day could achieve satisfied T-P removal.
고혈압-뜸 임상시험 참여자들의 혈압 관리행동에 대한 질적연구
문아지,김태정,이성근,김남권,이기상,Moon, A-Ji,Kim, Tae-Jung,Lee, Seoung-Geun,Kim, Nam-Kwen,Lee, Key-Sang 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4
Objectives : The purpose of this study which adopted a qualitative method was to evaluate blood pressure management behaviors of pre- and stage 1 hypertension patients and to provide fundamental data for developing a strategy about proper oriental medical treatment through analyzing factors related to a moxibustion clinical trial. Methods : Semi-structured interviews that focused on personal experiences with hypertension and its management were conducted with 10 hypertensive patients. The interviews lasted for approximately 50 minutes. Results : Most participants recognized that the direct cause of high blood pressure was unhealthy behavior rather than inheritance. Thus, the hypertensive patient believed they could recover their blood pressure to a normal level through removing the direct cause of hypertension instead of taking drugs. The reasons for these statements were that the drugs for controlling hypertension are not natural and they may have side effects. On future management plan of patients, most of them will continue to keep moxibustion and healthy behavior in the well-controlled blood pressure group. However in the uncontrolled blood pressure group, there was an increasing tendency to begin medication. Conclusions : For developing a strategy for an individual approach to hypertension management, we need to develop a client-centered attitude and strategy. That is, we need to tailor our approach to individual cases to avoid generalizations and stereotyping when developing an adherence increasing strategy.