Beck Depression Inventory를 이용한 내과 환자의 우울성향 조사 보고

반건호,염태호,한홍무 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.3

It has been known that many medically ill patients have psychological problems, such as depression or anxiety. Many have attempted to define these problems objectively and several self-rating devices for depression or anxiety have been developed. This study was designed to investigate the characteristics of depressive trends in medically ill patients. The author performed Beck's Depression Inventory (BDI) on 82 inpatients & 93 outpatients in Kyung-Hee University hospital and 200 normal subjects from August to September, 1986. The results were as follows; 1) In comparison of the three groups, the difference of total score of BDI was significant, especially between inpatients and normal subjects. 2) The total score of BDI of female was significantly higher than that of male in outpatients and normal subjects. 3) The BDI score of low educational group was significantly higher than that of high educational group in outpatients and normal subjects. 4) In normal subjects, BDI score was significantly increased by aging, but not in inpatients and outpatients. 5) Categorized as depression were 39.0% of inpatients, 30.1% of outpatients, and 27.0% of normal subjects, when the tentative cut off score was 21. 6) The significant items among three groups were items, No. 3, 15, 16, 17, 18, 19, 20 and 21, which were manifestations of somatization in the depression. 7) Depending upon above findings, BDI is thought to be a useful device for screening depressive trends in medically ill patients.

노화와 간경변이 인체의 적혈구, 혈장 및 위 점막의 Glutathione 농도와 Glutathione Peroxidase 활성도에 대해 미치는 영향

백광호,김종혁,백일현,한태호,박현주,박상훈,서중산,박충기,유재영 대한노인병학회 2001 대한노인병학회지 Vol.5 No.3

대두(Glycine max L.) phy A cDNA의 선별과 Cloning

이재호,한태룡 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

cDNA for phytochrome A gene was screened with a cDNA library constructed from etiolated soybean seedlings. A genomic subclone (pB41, 1.5 kb) containing chromophore bearing region of phytochrome A was used as a probe. All the positive clones analyzed show identical restriction maps suggesting that phy A gene presents as a single copy. A clone with full coding region (3.6 kb) was subcloned and sequenced. The deduced amino acid sequence analysis of the coding regions suggest that pB44SC is categorized as phy A. The pB44SC is 62~63 % identical with monocot phy A and 74-84% identical with dicot phy A. It is only 49-51% identical with phy B and phy C.

거골의 박리성 골연골염

하권익,한성호,양보규,김치홍,김태성 대한스포츠의학회 1995 대한스포츠의학회지 Vol.13 No.1

거골의 박리성 골연골염은 연골과 연골하골이 균열되고 관절 면으로부터 부분적 혹은 전체적으로 분리되는 병변으로 흔치 않은 병변이다. 거골의 박리성 골연골염은 잘 알려져 있음에도 불구하고, 수술적 치료의 결과에 대한 지식은 적은 편이다. 저자들은 1998년 1월부터 1992년 12월까지 만 5년간 16명, 16례의 거골 박리성 골연 골염 환자를 평균 29개월 추시관찰 및 분석하여 다음과 같은 결과를 얻었다. 1) 연령 분포는 최소 15세에서 최장 58세 였으며 평균 30세 였다. 2) 16명의 환자중 남자가 14례 여자가 2례였고 우측 거골이 10례, 좌측 거골이 6례 였다. 3) 외상과 관계있는 환자는 16례중 15례였으며 거골의 내측에 병변이 있는 경우가 10례, 외측이 6례 였으며 양측인 경우는 없었다. 4) 증상 발현후 수술까지의 기간은 최단 3개월에서 최장 7년이 였으며 평균 25.9개월 이었다. 16명 전례에서 동통을 호소하였으며 6명에서 강직 및 불안정성을 각각 호소하였다. 5) Berndt와 Harty에 의한 병변 분류는 stage Ⅰ은 없었으며 stage Ⅱ는 4례, stage Ⅲ가 7례, stage Ⅳ는 5례로 stage Ⅲ이 가장 많았다. 6) 치료는 관절 개방술에 의한 절제술(1례), 절제술과 소파술 및 다발성 천공술(8례), 절제술 및 소파술 (3례), 소파술 및 bone peg(1례), 관절경적 소파술 및 다발성 천공술 (3례) 시행하였으며 치료결과는 O'Farrell 등이 사용한 평가 방법에 의하면 우수 13례 (81%), 양호 2례(12.5%), 불량 1례 (6.5%)였다. Osteochondritis dissecans of the talus is defined as a subchondral bony lesion of small fragment of bone, usually under two centimetres in diameter, with overlying intact articular cartilage. This fragment then becomes separated from its bed and undergoes necrosis. Although the lesion of osteochondritis dissecans of the talus is well known, there is little information in the literature concerning the results of surgical treatment. Sixteen cases of osteochondritis dissecans of the talus, operated on between January 1988 and December 1992, were studied. All were available for follow-up an average 29 months later and clinical analysis were as follows; 1. Age incidence was distributed from 15 years to 58 years (average 28) 2. 16 patients (14 male, 2 female) were examined and followed-up ; in ten the right ankle was involved and six the left ankle. 3. Of the 16 patients, 14 patients were associated with a history of trauma and 10 patients had medial lesions and 6 patients, lateral lesions. 4. The duration of symptom on these cases ranged from 3 months to 7 years, with an average of 25.9 months. All patients complain of pain when using the ankle and 6 patients complain of stiffness of the ankle and sensation of Berndt and Harty, four ankles had a stage Ⅱ lesion, nine had a stage Ⅲ lesion and five had a stage Ⅳ lesion. 6. The methods of treatment were excision (1 case), excision, curettage and drilling (8 cases), excision and curettage (3 cases), curettage with bone pegging (1 case) and arthroscopic curettage and drilling (3 cases). According to O'Farrell grading system which combined subjective with the objective assessment, 13 patients (81%) had good results, 2 patients (12.5%) had fair results, and 1 patient (6.5%) had a poor result.

Insulin에 의하여 유도된 혈장 Homovanillic Acid 농도변화와 정신분열병환자의 임상증상

김병효,윤태호,한규희 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

요 약12명의 정상대조군과 54명의 항정신병약물을 복용중인 정신분열병환자를 연구대상으로 하여 insulin 투여후의 혈장 HVA농도의 변동을 알아 보았다. Insulin투여후의 변동을 알아 보기 위해 오전 8시에 기저 혈액을 채혈하고 insulin(0.1 unit/kg)을 투여한 후 30, 60, 90분 시점에 채혈하였다.정상대조군은 insulin을 투여하지 않은 상태의 오전 8시 기저치는 12.46ng/ml이었으며 이로부터 insulin투여 후 30, 60, 90분 후 HVA의 농도는 11.94, 11.86, 11.21ng/ml로 유의하게 감소하는 경향을 볼 수 있었다. 전체 정신분열병환자의 기저치는 10.81, insulin투여 30분 후 10.73, 60분 후 11.27, 90분 후 10.97ng/ml로 나타났다. 25명의 양성군 환자들의 기저치는 10.38, 30분 후 9.83, 60분 후 10.31, 90분후 9.73ng/ml로 나타났다. 27명의 음성군환자들의 기저치는 11.44, 30분 후 11.64, 60분 후 12.18, 90분 후 11.53ng/ml로 나타났다. 양성-음성지수와 HVA농도의 변동을 살펴 보았던 바 음성지수가 증가함에 따라 HVA농도도 증가하는 양상을 볼 수 있었다. The authors tried to compare the significant changes of plasma homovanillic acid(HVA) concentration after insulin administration in normal controls(n=12) and schizophrenic patients(n=54). Male patients with schizophrenia taking neuroleptics were participated in this study, with multiple samplings at baseline, 30 minutes, 60 minutes and 90 minutes after insulin administration. There was a gradual decrement of plasma HVA concentrations from 8 to 9:30 am in normal controls. Plasma concentration at baseline was 12.46ng/ml in normal controls. It decreased to 11.94, 11.86 and 11.21ng/ml at 30 minutes, 60 minutes and 90 minutes after insulin administration. Plasma concentration at baseline was 10.81ng/ml in schizophrenic patients. It changed to 10.73, 11.27, and 10.97ng/ml at 30 minutes, 60 minutes and 90 minutes after insulin administration. This pattern was not correlated with clinical variables, such as age, onset age, duration of illness and presence of family history. Schizophrenic patients were grouped into five groups by negative syndrome scale. The negative syndrome score correlated positively with plasma HVA concentration. This result suggests that plasma HVA concentration can be a biological marker for the clinical states in patients with schizophrenia. In the near future, the author will try to confirm whether the insulin-HVA method can be used as a biological indicator for the elucidation of complex clinical manifestations of schizophrenia.

소듐-물 반응사고 중/후반기 계통거동특성 연구

정지영,어재혁,김태준,정경체,김병호,한도희,박남국 한국공업화학회 2004 응용화학 Vol.8 No.1

In order to investigate the later phase of a sodium-water reaction (SWR) event in KALIMER (Korea Advanced Liquid MEtal Reactor), the code SELPSTA (Sodium-water reaction Event Later Phase System Transient Analyzer) has been developed and an experimeantal study has been carried out for verification of the simple analysis model applied to the code. The 24 data set obtained in the experiment have been pre-analyzed. Comparison of SELPSTA results with experimental data shows fairly good agreement in the transient.

일 농촌지역에서 발기부전의 유병률 및 상관 요인

홍진표,송해철,이무송,이창화,안준호,한오수,안태영,김성윤 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The purpose of this study was to investigate the prevalence of erectile dysfunction (ED) in a rural area of Korea and to examine the relationship between the prevalence and correlates of subjects. Method : This study was done as a part of the chronic disease survey of rural area by the Asan Foundation. Among 30 years or older population from Jung Eup, a rural area of Korea, 711 male subjects were sampled using a cluster probability sampling method. Trained interviewers visited and interviewed subjects aged 30 years or older with a structured interview. ED was categorized as 'none', 'mild', 'moderate', or 'severe' according to the ability to 'attain and/or maintain an erection satisfactory for sexual intercourse'. Response rate was 54.3% (N=386). Results : The age weighted prevalence of ED was 27.2% (minimal 14.1%, moderate 7.6%, severe 5.5%). Prevalence and severity increased with age. Liver disease and underweight were significantly (p<0.05) associated with ED. Smoking seemed to be correlated with ED, but did not reach statistically significant level. Conclusion : ED was highly prevalent in the rural community of Korea. Medical, sociodemographic, and lifestyle variables associated with ED may alert physicians to patients at risk for ED and offer insight to its etiology.

Lymphovascular space invasion is highly associated with lymph node metastasis and recurrence in endometrial cancer

( Ho Suap Hahn ),( In Ho Lee ),( Tae Jin Kim ),( Ki Heon Lee ),( Jae Uk Shim ),( Jae Wook Kim ),( Kyung Taek Lim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

The purpose of this study was to evaluate whether lymphovascular space invasion (LVSI) is a prognostic factor for lymph node metastasis and relapse of disease in endometrial cancer. We retrospectively analyzed the medical records of 438 patients with endometrial adenocarcinoma treated by surgical staging, including pelvic and paraaortic lymph node dissection, between January 1996 and July 2011. One hundred sixty three patients (37.2%) were LVSI-positive and 275 (62.8%) were negative. LVSI-positive patients were statistically significantly older and showed more advanced stage, poorer differentiation, and a higher frequency of non-endometrioid histology type, myometrial invasion, and positive peritoneal cytology than LVSI-negative patients. Surgeries by laparotomy rather than laparoscopy and more adjuvant therapies were conducted in LVSI-positive patients. The median numbers of pelvic and paraaortic lymph nodes removed were not different, but LVSI-positive patients showed more lymph node metastases. The LVSI-positive group also showed a higher recurrence of disease and lower survival rates than the LVSI-negative group. Negative predictive values of LVSI for lymph node metastasis and recurrence of disease were 96.4 and 97.1%, respectively. In multivariate analysis, LVSI did not influence overall or disease-free survival after adjusting for several confounding factors. The presence of LVSI is highly associated with lymph node metastasis and relapse of disease in endometrial cancer, but dose not influence survival as an independent factor. Therefore, LVSI may be a valuable prognostic factor when used in conjunction with other risk factors.

자궁내막 생검에서 비정형 자궁내막증식증 진단 시 향후 임상적 접근 방법

한호섭 ( Ho Suap Hahn ),윤석근 ( Seok Geun Yoon ),김우철 ( Woo Chul Kim ),최홍준 ( Hong Jun Choi ),이인호 ( In Ho Lee ),권용순 ( Yong Soon Kwon ),김태진 ( Tae Jin Kim ),임경택 ( Kyung Taek Lim ),이기헌 ( Ki Heon Lee ),심재욱 ( Jae 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12

목적: 자궁내막 생검 시 비정형 자궁내막증식증 진단받은 환자군에서 향후 적절한 임상적 접근 방법을 모색하였다. 연구 방법: 2000년 1월부터 2007년 12월까지 자궁내막 생검에서 비정형 자궁내막증식증 진단받고 자궁적출술을 시행받은 108명의 환자들을 대상으로 병리조직학적 소견을 재검토하여 임상병리적 고찰을 시행하였다. 결과: 비정형 자궁내막증식증은 87건에서 자궁내막 소파술로, 17건에서는 Z-sampler를 이용한 자궁내막 생검으로 진단되었고, 나머지 4건에서는 자궁내시경을 이용한 용종제거술 시행 후 진단되었다. 이들 환자에서 자궁적출술 시행 결과, 33.3%에서 단순성 또는 복잡성 자궁내막증식증을 보였고, 52.8%에서 비정형 단순성 또는 비정형 복잡성 자궁내막증식증을 보였다. 3.7%에서는 정상 내막 소견을 보였으나, 나머지 10.2% (11/108)에서는 자궁내막암이 비정형 복잡성 자궁내막증식증과 동반되어 있었다. 자궁내막암이 동반된 11건 모두에서 암조직은 자궁내막에 국한되어 있었고 자궁근층 침범은 없었다. 결론: 자궁내막 조직생검에서 비정형 자궁내막증식증 진단 시 자궁내막암과 동반되어 있을 위험도가 증가한다는 것을 간과해서는 안 되며, 환자의 임상적 접근 방법에 있어서도 자궁내막암의 가능성과, 수술 전 자궁내막 조직생검과 자궁적출술 후 조직학적 소견의 차이가 크다는 것을 염두에 두어야 한다. Objective: To evaluate the proper approach in women diagnosed with atypical endometrial hyperplasia (AEH) by endometrial biopsy. Methods: We retrospectively analyzed the medical records of 108 patients who underwent hysterectomies for AEH diagnosed by endometrial biopsy from 2000 to 2007. The results of the endometrial biopsies were graded on an ordinal scale and were compared with pathologic features obtained at the hysterectomy. Results: AEH was initially diagnosed by dilatation and curettage (87 cases) or endometrial biopsy with a Z-sampler (17 cases). The remaining four cases were diagnosed by hysteroscopic polypectomy. In patients preoperatively diagnosed with AEH by biopsy, hysterectomy specimens revealed a rate of simple or complex endometrial hyperplasia without atypia of 33.3% with AEH and normal endometrium found in 52.8 and 3.7% of specimens, respectively. The incidence of endometrial carcinoma was considerably high (11/108, 10.2%). All cases were confined to the endometrium and two of those were located at the adenomyosis without myometrial invasion. All patients with endometrial carcinoma displayed coexisting atypical complex hyperplasia following hysterectomy. Conclusion: Biopsy specimens showing AEH, particularly atypical complex hyperplasia, are associated with an increased risk of coexisting endometrial carcinoma. When considering management strategies for women with a biopsy diagnosis of AEH, clinicians should take into account the considerable rate of concurrent endometrial cancer and the discrepancy with pathologic diagnosis.

골반 및 대동맥 주위 림프절 절제술을 포함한 자궁내막암 병기설정 수술에서 수술적 접근 방법 비교

한호섭 ( Ho Suap Hahn ),윤석근 ( Seok Geun Yoon ),김우철 ( Woo Chul Kim ),최홍준 ( Hong Jun Choi ),이인호 ( In Ho Lee ),권용순 ( Yong Soon Kwon ),김태진 ( Tae Jin Kim ),임경택 ( Kyung Taek Lim ),이기헌 ( Ki Heon Lee ),심재욱 ( Jae 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9

목적: 자궁내막암의 병기설정 수술 시 복강경식 병기설정술 (이하 복강경식)과 복식 병기설정술 (이하 복식)을 비교하였다. 연구 방법: 1996년 1월부터 2007년 12월까지 골반 및 대동맥 주위 림프절 절제술을 포함한 자궁내막암의 병기설정 수술을 시행한 272명 (복강경식: 90명, 복식: 182명)을 대상으로 양군 간의 수술 및 임상 결과를 비교해보았다. 결과: 양군 간에 평균나이, 체질량 지수, 암의 조직학적 유형에 차이가 없었으나 암의 분화도와 수술적 병기는 복식이 더 높았다. 절제된 골반 림프절과 대동맥 주위 림프절수는 복강경식에서 각각 33.1±13.2, 16.1±11.6, 복식에서 각각 32.5±14.5, 19.0±12.7으로 유의한 차이는 없었다. 복강경식이 복식에 비하여 수술시간과 수술 후 입원기간이 짧았으며, 수술 전후 혈색소 변화도 더 적었다. 수술 후 합병증의 유의한 차이는 없었으나 양성 림프절 전이나 수술 후 항암 보조요법 시행은 복식이 더 많았다. 교란요인 교정 후 수술 방법은 생존율에 영향을 미치지 않았다. 결론: 골반 및 대동맥 주위 림프절 절제술을 포함한 자궁내막암의 병기설정 수술 시, 절제된 림프절수는 비슷하나 복강경식이 복식에 비하여 수술시간, 입원기간, 출혈량에서 우수하므로 우선적 수술 방법으로 고려해볼 수 있겠다. Objective: To compare laparoscopic surgery with laparotomy in comprehensive surgical staging of endometrial cancer. Methods: We retrospectively analyzed the medical records of 272 patients with endometrial adenocarcinoma treated by staging operation including pelvic and paraaortic lymphadenectomy between January, 1996 and December, 2007. Results: There was no significant difference between the two groups in terms of age, body mass index, or histologic type, but in the laparotomy group, grade and surgical stage were significantly higher. All the patients, 182 in the laparotomy and 90 in the laparoscopy group, had lymphadenectomy, and the mean number of pelvic and paraaortic lymph nodes (LNs) obtained were 33.1±13.2 and 16.1±11.6 in the laparoscopy group, and 32.5±14.5 and 19.0±12.7 in the laparotomy group, respectively; these differences were not statistically significant. In the laparoscopy group, the operating time and postoperative hospital length of stay were shorter than in the laparotomy group, as were the pre- and post-operative hemoglobin changes. There were no significant differences between the two groups in terms of intra- or post-operative complications, but positive lymph nodal metastasis and conducting of postoperative adjuvant therapy were highter in the laparotomy group. The operative technique did not influence overall or disease-free survival after adjusting for several confounding factors. Conclusion: Laparoscopic-assisted surgical staging for endometrial cancer required a shorter operating time, shorter postoperative hospital stay, and lower blood loss compared to traditional laparotomy staging, and can be a good therapeutic option for staging operation including lymphadenectomy of endometrial cancer.