http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Sunmin Yim ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Jung-in Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (QSND) laser has been used for treatment of pigmented disorders. However, the photobiological mechanism of the low-fluence 1064-nm QSND laser is not yet fully understood. Objectives: To evaluate inhibitory effects of the low-fluence 1064-nm QSND laser on the melanogenesis and assess whether increasing the number of passes of low-fluence the 1064-nm QSND laser has positive correlation with improvements of the pigmentation. Methods: The skins of six Hair Moprpholoy-2 melanin-possessing hairless mice were treated with ultraviolet B radiation followed by 0, 2, 4, 6 passes the low-fluence 1064-nm QSND laser. Pigmentation changes of skins were evaluated with spectrophotometry and pigmentation-related protein expressions. Additionally, biopsy specimens were obtained to figure out the difference of melanin particles. Results: The low-fluence 1064-nm QSND laser improved the lightness of the skin in comparison to the control skin. Biopsy specimens showed decreased amounts of melanin particles. In the western blot of the specimen, expressions of MITF and tyrosinase were reduced. Conclusion: The low-fluence 1064-nm QSND laser has effects on the melanogenesis which change expressions of the pigmentation-related proteins. Moreover, the more passes of the laser toning can bring the more progress on the skin pigmentation.
( Sunmin Yim ),( Hyeon Jeong Park ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Heun Joo Lee ),( Young Jun Choi ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Chronic pruritus without cutaneous manifestation is one of the most common chief complaints in Dermatology. It persists more than 6 weeks and impacts a great amount of patients’ quality of life. Correlation between IgE related immune reaction and presentation of chronic pruritus has been studied. Objectives: To analyze clinical characteristics of chronic pruritus patients without cutaneous manifestation. Methods: This was a retrospective study that enrolled 128 patients suffering from chronic pruritus without cutaneous manifestation. We reviewed electric medical records of these patients who visited Kangbuk Samsung Hospital in 2017. Results: 128 patients of chronic pruritus without cutaneous manifestation were investigated (70 males and 58 females, average age 41.0). Their initial laboratory test revealed following figures; average serum IgE level, 639 IU/ml; average number of Multiple allergosorbent test (MAST) positive allergens, 2.64. The number of patients presenting more than 100 IU/ml IgE level was 91 (71%). The mean history of illness and follow up period were 761 days and 144 days, respectively. Average 2 antihistamine agents have been used for symptoms. 30 patients (23%) have been prescribed additional methylprednisolone or cyclosporine for persisting pruritus. Conclusion: This study demonstrated that chronic pruritus patients without cutaneous manifestation have similar clinical characteristics in allergic skin diseases, including chronic urticaria, atopic dermatitis.
( Sunmin Yim ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Joon Hong Min ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Grid fractional radiofrequency (GFR), fractional radiofrequency microneedle (FRM) and high intensity focused ultrasound (HIFU) have each specific mechanism for skin rejuvenation. Nasolabial fold wrinkles can be treated by applying consecutive sessions of three modalities. Objectives: To evaluate the clinical efficacy of the combined treatment of nasolabial fold wrinkles in Asians. Methods: This was a prospective study that enrolled twenty subjects with moderate nasolabial fold wrinkles. Subjects visited the clinic every four weeks for a total of three treatment sessions. Subjects received a combination therapy of GFR, FRM, and HIFU. Evaluation included medical photographs and satisfaction questionnaires. Two dermatologists evaluated the clinical photographs using the modified Fitzpatrick wrinkle scale (mFWS). Results: A total of eighteen subjects were assessed. The median age was 56.5 (Range 49-64). mFWS showed an improved score of 1.0 (IQR 0.5-1.375) at twenty weeks compared to a baseline score of 1.5 (IQR 1-1.875). (p <0.005) Six subjects (33 %) reported more than moderate improvement at twentieth week. There were no long-term complications associated with the treatment. Conclusion: This study was the first of its kind to use a triple combined therapy for the treatment of skin wrinkles. The results demonstrated the efficacy and safety of the combination therapy on nasolabial fold wrinkles.
Squamoid eccrine ductal carcinoma of the ear helix
( Sunmin Yim ),( Yeon Gu Choi ),( Gyoo Huh ),( Hyeon Jeong Park ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Heun Joo Lee ),( Young Jun Choi ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Squamoid eccrine ductal carcinoma (SEDC) is a rarely reported malignant skin tumor. It is characterized by showing both atypical squamous and ductal differentiation. SEDC occurs on sun-exposed area and appears as gradually developed nodular or ulcerative lesions. We describe a case of SEDC on the left ear helix of an 80-year-old male patient. After receiving a punch biopsy for diagnosis, the patient underwent a wide excision to remove the tumor. Histopathology results revealed ulcerative, infiltrative lesions extending from the epidermis to the upper dermis with atypical squamous cell proliferation. Tubular and ductal structures with hyperchromatic nuclei were observed in the deeper layer of the dermis. Immunohistochemistry showed positive staining for CK5/6, CK7, Epithelial membrane antigen, P53, and P63. Carcinoembryonic antigen, S-100, gross cystic disease fluid protein 15 and periodic acid-Schiff showed negative staining. The biphasic histopathology features and immunohistochemistry findings help differentiating SEDC from squamous cell carcinoma and other eccrine origin malignant tumors. Clinically, SEDC frequently appears on sun-exposed body areas, especially on the head and neck. It also shows local recurrence despite complete resection. These characteristic features demand cautious attention for diagnosis and treatment of SEDC.
[P014] Clinical efficacy of laser epilation as an early treatment modality of Becker`s nevus
( Sunmin Yim ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Joon Hong Min ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Background: Becker`s nevus is a relatively common harmatoma that, in adult patients, is usually accompanied with hair growth. Objectives: The purpose of this study is to evaluate the efficacy of epilation laser treatments, namely, long-pulsed 1064-nm Nd:YAG and 755-nm Alexandrite laser, in the treatment of Becker`s nevus Methods: Retrospective chart reviews and photographic analyses were performed for patients treated with epilation lasers. Clinical improvement was assessed by two blinded physicians using 5-point global assessment scale. Results: Total 13 patients (8 males, 5 females) with Fitzpatrick skin types IV, a mean age 2 of 5.0±9.4 years, were included. The most common lesions were on the cheeks (4 patients, 30.8 %) and every lesion showed scattered patterns of hair growth. 8 patients were treated with long-pulsed 1064-nm Nd:YAG laser; 4 patients were treated with 755-nm Alexandrite laser and one patient was treated with both lasers. The mean treatment interval was 28.7±6.0 days. The median total treatment session was 2.0 (interquartile range 1.0). After laser epilation therapy, 11 patients (84.6 %) showed an improvement margin of 50 %. The difference of treatment response between two lasers was not clinically significant. (p=0.80) No persistent and serious adverse events were observed during the follow-up period. Conclusion: Laser epilation can be an effective, early therapeutic option for the treatment of Becker`s nevus.
A case of inverted type a (clonal) nevus
( Sunmin Yim ),( Hyeon Jeong Park ),( Junghwa Yang ),( Yunho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Inverted type A (clonal) nevus is a unusual type of melanocytic nevus. It contains pigmented nests of type A nevus cells in the depth of a banal. The nest is occasionally surrounded by type B or C nevus cells. Therefore, type A nevus cells are layered in deeper portion of nevus and Type B and C nevus cells are observed on superficial layers. An unusual presentation of inverted type A nevus have been rarely reported with superficial neurotization. We described a case of a 68 year-old female complained of solitary, 0.4 cm-sized, dome shaped, brownish to skin-colored papule on the occiput. There was no pruritus or pain on the lesion. The excision biopsy was performed. The histology examination revealed clustered, swirling, epithelioid, type A nevus cells proliferation in the deep portion of perifollicular area. The dense, basophilic type B nevus cells were surrounding the nests of type A cells. Moreover, extensive neurotized type C nevus cells appeared in the upper dermis. No atypia and abnormal mitosis were observed. It could be diagnosed with inverted type A nevus based on the clinical and histological findings.
( Sunmin Yim ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Joon ),( Hong Min ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk K 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Background: Onycholysis is the detachment of the nail plate from the nail bed that occurs at distal portion of nail plate. It is commonly associated with psoriasis, lichen planus, onychomycosis, trauma and wet work. Objectives: The purpose of this study is to evaluate the clinical efficacy of 1064-nm picosecond domain Nd:YAG (P-Nd:YAG) and cryotherapy on patients with onycholysis. Methods: Retrospective chart reviews and photographic analyses were performed. Nail plate and matrix lesions were irradiated with P-Nd:YAG laser. Nail bed and hyponychium lesions showing subungual hyperkeratosis were treated with cryotherapy. Clinical improvement was assessed by two blinded physicians using 5-point global assessment scale. Results: Three patients (all females, mean age 47.0±9.5 years) were analyzed. A total of 28 nails, consisting of 22 finger nails and 6 toe nails, were treated with P-Nd:YAG and cryotherapy. Three patients received both modes of treatment simultaneously. The mean treatment interval was 18.1±3.6 days. The mean treatment session was 4.0. After receiving the combined P-Nd:YAG and cryotherapy, all Three patients (100 %) showed more than 50% improvement. There were no serious adverse events associated with the treatment during follow-up period. Conclusion: Concurrent P-Nd:YAG and cryotherapy can be an effective and safe treatment choice for refractory onycholysis.
[P464] A case of methylphenidate induced livedo reticularis on the extremities
( Sunmin Yim ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Joon Hong Min ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Methylphenidate is the drug of choice for patients with Attention deficit hyperactivity disorders (ADHD). It acts as a dopamine and norepinephrine reuptake inhibitor, resulting in a prolongation of dopamine receptor effects. Most common side effects associated with its use include nervousness, insomnia, and dizziness. Although patients on methylphenidate frequently complain of dermatologic symptoms such as hyperhidrosis, hypersensitivity, pruritus, and hair loss, cases of peripheral vasculopathy without systemic involvement have rarely been documented. We describe the case of an 11 year-old male with ADHD who has been on methylphenidate for two years. On his initial visit to this hospital, he complained of regional erythematous reticular patches on both hands, lower legs, and both feet. The patient denied having systemic symptoms such as fever, malaise and arthralgia. Subsequent blood tests and rheumatologic labs were unremarkable. After discontinuing methylphenidate for two weeks, the patient`s symptoms were relieved. This case shows that the latent reaction of methylphenidate can induce symptoms of peripheral vasculopathy, such as livedo reticularis and the Raynaud phenomenon.
( Junghwa Yang ),( Yunho Lee ),( Sunmin Yim ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Rosacea is a chronic inflammatory skin disease with various clinical manifestations. Its cause and pathophysiology are not fully understood, but recently it has been shown to have an association with numerous systemic diseases. Objectives: To investigate (1) the association between rosacea and systemic comorbidities and (2) if the subtypes and the severity of rosacea have an effect on comorbidities. Methods: A matched case-control study was conducted using health care center data for three years (2014-2017). Rosacea group was identified by clinical photo review of two dermatologists. Rosacea-free control group was matched to case by age and sex. By using SPSS version 19.0., the data measured in health check-up program were analyzed. Results: Among 1829 subjects who visited our center, 229 (case) and 458 (control) were identified and selected for analysis. Body mass index(BMI), family history of liver disease and past medical history of thyroid cancer, hypertension, and kidney disease are associated with rosacea. Conclusion: Rosacea is associated with several systemic comorbid diseases.
( Jung Yup Kim ),( Sunmin Yim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Jung-in Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Scars can affect patients, leading to emotional complications. Various laser technologies including fractional laser, Q-Switched Nd:YAG laser, and pulsed dye laser have been tried to revise the scar. Up to now, there has been no reliable study to evaluate an effect of picosecond Nd:YAG laser for reducing scars. Objectives: This retrospective clinical study was performed to investigate the beneficial effect of picosecond Nd:YAG laser in treatment for hypertrophic scars. Methods: A retrospective review was conducted on patients treated with picosecond Nd:YAG laser for the purpose of scar improvement. Twenty-seven patients with hypertrophic scars were included in this study. The vancouver scar scale (VSS), global assessment score (GAS), and participant’s subjective satisfaction were used to determine the effect of scar improvement. All side effects were recorded to assess the safety of the modality. Results: Mean age of patients was 33.4±15.2 years old and male-to-female ratio was 2:3. Mean total treatment session was 3.4±1.3 and mean total duration of treatment was 13±7.3 weeks. Average VSS score was remarkably decreased after treatment. Average GAS and participant’s satisfaction indicated fair cosmetic improvement. No significant side effects were observed during follow-up. Conclusion: Picosecond Nd:YAG laser may be considered as an effective and safe optional modality for the treatment of scar.