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        일반논문 : 판소리 수궁가 의학기사(醫學記事)에 내포된 역사성과 조선후기 민중 의학지식의 보급 -김연수 창본 수궁가의 사설을 대상으로-

        인상우 ( Sang Woo Ahn ) 전남대학교 호남학연구원 2010 호남학 Vol.0 No.47

        <수궁가>는 구토설화에서 파생된 판소리 창본으로 내용 중 醫學記事가 자주 등장한다. 醫學記事는 신재효의 창본정리 과정에서 <수궁가> 전반에 삽입된 것으로 보이는데, 지방관청에 소속된 官藥房을 했던 부친의 영향으로 『東醫寶鑑』과 여러 의서들, 藥器를 쉽게 접할 수 있었던 까닭에 <수궁가> 내에 그 내용을 충분히 실어 넣은 것으로 보인다. 본고에서 진행한 <수궁가>의 의학적 분석을 통한 연구는 <수궁가>에서 절반 가까이 차지하는 藥性歌 및 醫學記事의 많은 부분이 한의학 지식과 매우 일치하며, 내용전반에 민간에서 쓸 수 있는 한의학 지식을 바탕에 깔고 있음을 확인할 수 있었다. 특히 『東醫寶鑑』이 점차 보편화되면서 <수궁가> 속의 醫學記事도 전문성을 더해갔다. <수궁가>에서 도가적 양생사상의 신선술과 주술에 의거한 치료형태를 풍자하고 희화시켰던 양상은, 동시기에 『東醫寶鑑』이 여러 의서를 종합하면서 도가적인 주술이나 미신적인 요소를 배제하고, 체계적이고 임상의학적으로 재정비했다는 점과 맥을 같이한다. 18세기중반 이후로 19~20세기 양반지식층의 애호참여로 유교사상을 재정비하면서 醫學記事가 전문지식의 과시수단으로 사용되기도 하였으나, 한편으로는 전문성있는 의학지식을 판소리내에 삽입함으로써 판소리에 사실성을 부여하고, 청자들로 하여금 판소리의 현실감을 극대화하는 역할로 작용하였다. 그로인해 <수궁가>내에서 더욱 전문화된 醫藥記事들은 이후 판소리, 국문한문소설로 변화되어 보급되었고, 19세기부터는 라디오매체와 음반사의 판소리 취입으로 더욱 보편화되면서 서민들의 입과 귀로 널리 전해졌다. 비록 醫學記事가 서민들에게 의학지식의 보급을 목적으로 작성된 것은 아니었다 하더라도, 의료정책이 미비했던 당시 『東醫寶鑑』을 바탕으로 보완되었던 <수궁가>의 보급은 원래의 목적이상으로 민중들에게 민간의학지식을 파급시키는 역할을 수행했다. Sugungga is a Pansori[recite a dramatic song] story derived from a tale about a terrapin and a rabbit, and Yakseongga appears in its first part. Sugungga has been handed down through a lineage of singers: Song Heung-Rok, Song Gwang-Rok, Song Woo-Ryong, Ryu Seong-Jun, and Kim, Yeon-Su. Yakseongga completely settled in Sugungga thanks to adaptation of Shin Jae-Hyo, whose medicinal knowledge was mostly from his father, Shin Gwang-Heup, an official pharmacist in a local government office. Between the 17th century and the mid-18th century, Sugungga was evolved from ancient taoistic idea of health to Confucianistic rational subject. This was similar in nature that Korean medicine was overhauled to a more scientific and clinical practice in the same period by putting together diverse medicinal books such as DongeuiBogam, Huangdi Neijing, Hyang-yak Jipseongbang, Euibang Ryuchwi, and Euibang Chalyo, while eliminating elements of taoistic charms or superstitions. This study confirmed that from the study of oriental medicine, Yakseongga in Sugungga was based on oriental medicinal knowledge, not simple humor. It seems that Yakseongga was heavily influenced by oriental medicinal books such as Huangdi Neijing, Hyang-yak Jipseongbang, Dongeui Bogam, and Jejung Sinpyeon. After the mid-18th century, deconfucianistic Sugungga was modified again. Participation of aristocratic intellectuals from the 19th and 20th Century tarnished lively popularity of Sugungga, while Confucianism was reintroduced and “ostentation of expertise” became more noticeable in Yakseongga. Such trends of pansori became more popular following the introduction of modern novels as well as radios and phonograph records. Although Yakseongga was not made to teach medicinal knowledge, it performed a role of distributing folk remedies to the public far beyond its original intention when it had been compiled based on Dongeui Bogam and Jejung Sinpyeon.

      • 국내 한의학 학술지에 발표된 동의보감 연구 현황 조사

        한창현(Chang-hyun Han),박상영(Sang-young Park),권오민(Oh-min Kwon),안상영(Sang-young Ahn),안상우(Sang-woo Ahn) 한국의사학회 2009 한국의사학회지 Vol.22 No.2

        Background : To understand Korean medicine it is crucial to first understand medical aspect of ‘DongUiBoGam’. It is also meaningful that it became one of the influential book even to posterity. Also based on the apprehension, we can take a view of development of Korean medicine led by ‘DongUiBoGam’. Objectives : This study aims to review the status, study field, specialist of DongUiBoGam. In the process, this review will grasp trends in this field of studies and will direct further researches into the right direction. Method : The computerized Korean databases were searched from their respective inceptions up to December 2008. The search terms used were ‘DongUiBoGam’ and random or Korean language terms related to DongUiBoGam. Several specialized journals were also manually searched for relevant articles. Result : Since the 2000s, DongUiBoGam papers in the Korean Literature is increased. Published 58 papers on The Korean Journal of Oriental Medical Prescription were more than the other journals. 58 papers published in The Korean Journal of Oriental Medical Prescription are the best in many areas related to Korean medicine. Most people have submitted papers related to DongUiBoGam was Woo-yeal Jeong. Conclusions : ‘DongUiBoGam’ research is conducted and current tendency and outlook for ‘DongUiBoGam’ is carried out focusing on several associations.

      • 3′-UTR Polymorphisms of <i>MTHFR</i> and <i>TS</i> Associated with Osteoporotic Vertebral Compression Fracture Susceptibility in Postmenopausal Women

        Ahn, Tae-Keun,Kim, Jung Oh,Kim, Hyun Woo,Park, Han Sung,Shim, Jeong Hyun,Ropper, Alexander E.,Han, In Bo,Kim, Nam Keun MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.3

        <P>Postmenopausal osteoporosis is one of the most prominent diseases in postmenopausal women and it is increasing in prevalence with the aging population. Furthermore, osteoporosis and osteoporotic vertebral compression fractures (OVCFs) are related to mortality and decreased quality of life. Therefore, searching for biomarkers that are able to identify postmenopausal women who are at high risk of developing OVCFs is an effective strategy for improving the quality of life of patients and alleviating social and economic burdens. In this study, we investigated methylenetetrahydrofolate reductase (<I>MTHFR</I>) and thymidylate synthase (<I>TS</I>) gene polymorphisms in postmenopausal women with OVCF. We recruited 301 postmenopausal women and performed genotyping for the presence of <I>MTHFR</I> 2572C>A, 4869C>G and TS 1100C>T, 1170A>G. Genotyping was analyzed using the polymerization chain reaction restriction fragment length polymorphism assay. MTHFR 2572C>A and TS 1100C>T were associated with the prevalence of osteoporosis (MTHFR 2572CC versus CA+AA: odd ratio [OR] adjusted age, hypertention [HTN], and diabetes mellitus [DM] = 0.49, <I>p</I> = 0.012) and the occurrence of OVCFs (MTHFR 2572CC versus CA+AA: OR adjusted age, HTN, and DM = 0.38, <I>p</I> = 0.013; TS 1100CC versus CT+TT: OR adjusted age, HTN, and DM = 0.46, <I>p</I> = 0.02). Our novel finding is the identification of MTHFR and TS genetic variants that decrease susceptibility to OVCFs. Our findings suggest that polymorphisms in the <I>MTHFR</I> and <I>TS</I> genes are associated with susceptibility to osteoporosis and OVCFs in postmenopausal women.</P>

      • KCI등재후보
      • Frontal Assessment Battery to Evaluate Frontal Lobe Dysfunction in ALS Patients

        Ahn, Suk-Won,Kim, Su-Hyun,Kim, Jee-Eun,Kim, Sung-Min,Kim, Seung Hyun,Sung, Jung-Joon,Lee, Kwang-Woo,Hong, Yoon-Ho Cambridge University Press 2011 The Canadian journal of neurological sciences Vol.38 No.2

        <B>Background:</B><P>Assessment of frontal lobe impairment in amyotrophic lateral sclerosis (ALS) is a matter of great importance, since it often causes ALS patients to decrease medication and nursing compliance, thus shortening their survival time.</P><B>Methods:</B><P>The frontal assessment battery (FAB) is a short and rapid method for assessing frontal executive functions. We investigated the applicability of the FAB as a screening method for assessing cognitive impairments in 61 ALS patients. Depending on the results of the FAB, we classified patients into two subgroups: FAB-normal and FAB-abnormal. We then performed additional evaluations of cognitive function using the Korean version of the mini-mental state examination (K-MMSE), a verbal fluency test (COWAT), and a neuropsychiatric inventory (NPI). Results of these tests were compared between the two groups using Mann-Whitney U-tests, and Spearman correlation analyses were used to investigate the relationships between FAB score and disease duration and severity.</P><B>Results:</B><P>Of the 61 sporadic ALS patients included in this study, 14 were classified as FAB-abnormal and 47 were classified as FAB-normal. The FAB-normal and FAB-abnormal patients performed significantly differently in all domains of the COWAT. There was no difference in behavioral disturbance, as assessed by the NPI, between the two groups. The FAB scores were found to significantly correlate with both disease duration and severity.</P><B>Conclusions:</B><P>The FAB shows promise as a method of screening for frontal lobe dysfunction in ALS, as it is not only quick and easy, but also reliable. Additional studies should examine how FAB performance changes as ALS progresses.</P>

      • KCI등재후보

        Scoring of prognostic factors that influence long-term survival in patients with hepatic metastasis of colorectal cancer

        Sung Woo Ahn,Ahn Soo Na,Jae Do Yang,Hong Pil Hwang,Hee Chul Yu,Baik Hwan Cho 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.3

        Backgrounds/Aims: To find independent predictors that affect the survival in patients with hepatic metastasis of colorectal cancer after surgery and to devise a risk scoring system. Methods: Among 150 patients who underwent hepatic resection after diagnosis of colorectal cancer with hepatic metastasis between March 1994 and February 2009, we analyzed clinical, pathologic and outcome data retrospectively. Results: The 1-year survival rate was 83%, and the 5-year survival rate was 35%. Nine factors were found to be independent predictors of adverse outcome by univariate analysis: stage of primary tumor, CA19-9 >36 U/ml, extrahepatic disease, distribution of the hepatic tumor, number of hepatic tumors >3, largest hepatic tumor >5 cm, total size >10 cm, CEA >10 ng/ml, and metachronous cancer. The last two of these criteria were also significant risk factors on multivariate analysis. When these criteria were used as a risk scoring system, assigning one point for each criterion and dividing the cases into A, B and C groups, the total score was highly predictive of outcomes (p<0.001). No patients in group C (6 to 9 points) were long-term survivors. Conclusions: Long-term outcome can be predicted from nine criteria that are readily available for all patients. Patients meeting up to two criteria (group A) are more likely to have a favorable outcome compared to the three or over (groups B and C). This scoring system may offer an easy, rapid, and reliable prognostic indicator of survival outcome after hepatic resection in patients with hepatic metastasis from colorectal cancer. (Korean J Hepatobiliary Pancreat Surg 2011;15:146-151)

      • SCIESCOPUSKCI등재

        Optimization of Manufacturing Conditions for Improving Storage Stability of Coffee-Supplemented Milk Beverage Using Response Surface Methodology

        Sung-il Ahn,Jun-hong Park,Jae-hoon Kim,Duk-geun Oh,Moojoong Kim,Donghwa Chung,Jin-woo Jhoo,Gur-yoo Kim 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.1

        This study aimed at optimizing the manufacturing conditions of a milk beverage supplemented with coffee, and monitoring its physicochemical and sensory properties during storage. Raw milk, skim milk powder, coffee extract, and emulsifiers were used to manufacture the beverage. Two sucrose fatty acid esters, F110 and F160, were identified as suitable emulsifiers. The optimum conditions for the beverage manufacture, which can satisfy two conditions at the same time, determined by response surface methodology (RSM), were 5,000 rpm primary homogenization speed and 0.207% sucrose fatty acid emulsifier addition. The particle size and zeta-potential of the beverage under the optimum condition were 190.1 nm and - 25.94 ±0.06 mV, respectively. In comparison study between F110 added group (GF110) and F160 added group (GF160) during storage, all samples maintained its pH around 6.6 to 6.7, and there was no significant difference (p

      • SCIEKCI등재

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