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Genome-Wide Identification of Haploinsufficiency in Fission Yeast
( Seung Tae Baek ),( Sang Jo Han ),( Mi Young Nam ),( Young Dae Kim ),( Li La Kim ),( Hyun Jee Lee ),( Kyung Sun Heo ),( Hye Mi Lee ),( Min Ho Lee ),( Song Kyu Park ),( Pil Jae Maeng ),( Young Woo Par 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.6
자기부상열차의 부상제어 요구 성능을 고려한 시스템의 설계
조정민(Jo Jeong-Min),이종민(Lee Jong-Min),강병관(Kang Byung-Gwan),박성호(Par,Sung-Ho),김철호(Kim Cheol-Ho),최종묵(Choi Jong-Mook),김국진(Kim Kuk-Jin) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
The performance of magnetic levitation controller is affected from not only levitation control algorithm but also the interaction between compositing system, so it is important to design maglev system considering the character of magnetic levitation controller in order to get the required performance of Maglev. The factors affecting the levitation controller of maglev are the dynamics of levitation magnet, the carrying weight of the overall system, the normal force and lateral force of traction motor and rail condition. In this paper the interaction between magnet and vehicle weight is analysed on side of stability of levitation controller in order to get the required performance of levitation controller.
( Ae Rin Baek ),( Ji Min Lee ),( Hyun Jung Seo ),( Jong Sook Park ),( June Hyuk Lee ),( Sung Woo Park ),( An Soo Jang ),( Do Jin Kim ),( Eun Suk Koh ),( Soo Taek Uh ),( Yong Hoon Kim ),( Choon Sik Par 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.3
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by the accumulation of excessive fibroblasts and myofibroblasts in the extracellular matrix. The transforming growth factor β1 (TGF-β1).induced epithelial-to-mesenchymal transition (EMT) is thought to be a possible source of fibroblasts/ myofibroblasts in IPF lungs. We have previously reported that apolipoprotein A1 (ApoA1) has anti-fibrotic activity in experimental lung fibrosis. In this study, we determine whether ApoA1 modulates TGF-β1.induced EMT in experimental lung fibrosis and clarify its mechanism of action. Methods: The A549 alveolar epithelial cell line was treated with TGF-β1 with or without ApoA1. Morphological changes and expression of EMT-related markers, including E-cadherin, N-cadherin, and α-smooth muscle actin were evaluated. Expressions of Smad and non-Smad mediators and TGF-β1 receptor type 1 (TβRI) and type 2 (TβRII) were measured. The silica-induced lung fibrosis model was established using ApoA1 overexpressing transgenic mice. Results: TGF-β1.treated A549 cells were changed to the mesenchymal morphology with less E-cadherin and more N-cadherin expression. The addition of ApoA1 inhibited the TGF-β1.induced change of the EMT phenotype. ApoA1 inhibited the TGF-β1.induced increase in the phosphorylation of Smad2 and 3 as well as that of ERK and p38 mitogenactivated protein kinase mediators. In addition, ApoA1 reduced the TGF-β1.induced increase in TβRI and TβRII expression. In a mouse model of silica-induced lung fibrosis, ApoA1 overexpression reduced the silica-mediated effects, which were increased N-cadherin and decreased E-cadherin expression in the alveolar epithelium. Conclusion: Our data demonstrate that ApoA1 inhibits TGF-β1.induced EMT in experimental lung fibrosis.
정유미,박정민,채기준,이상호,나재훈,Jung Yumi,Par Jung-Min,Chae Kijoon,Lee Sang-Ho,Nah Jaehoon 한국정보처리학회 2004 정보처리학회논문지 C : 정보통신,정보보안 Vol.11 No.6
멀티캐스트는 송신자가 많은 수신자들에게 동시에 데이터를 전송하므로 송신자의 자원을 절약하고 네트워크의 점유율을 낮춤으로 효율성을 제공하는 통신 기술이나 여러 수신자들이 같은 그룹 주소를 사용하므로 공격을 받을 위험이 크다. 따라서 멀티캐스트 스트림에 대한 인증 및 서명은 중요한 문제이다. 본 논문에서는 패킷을 전송한 송신자의 신원을 확인하고 데이터가 변조되지 않았음을 확인하는 소스 인증 방법으로 다중 체인 인증기범을 제안하였다. 제안한 기법은 부인 방지를 제공하고 여러 패킷에 대한 전자서명으로 인증함으로써 오버헤드론 줄이며 지연없이 이루어지므로 실시간 멀티미디어 서비스에 사용할 수 있다. Multicast communication is simultaneous transmission of data to multiple receivers and saves considerably sender resources and network bandwidth. It has high risk to attack using group address and inherent complexity of routing packets to a large group of receivers. It is therefore critical to provide source authentication, allowing a receiver to ensure that received data is authentic. In this paper, we propose the multiple chain authentication scheme for secure and efficient multicast stream. To evaluate the performance of our scheme, we compare our technique with two other previously proposed schemes using simulation results. Our scheme provides non-repudiation of origin, low overhead by amortizing the signature operation over multiple packets, and high packet loss resistance.
A rare cause of painful neck mass: submandibular gland flstula
( Hak-jun Kim ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Sung-min Par 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Salivary gland fistula is a fistula involving a salivary gland or duct. Most salivary gland fistulae are related to the parotid gland. Submandibular fistulas on the other hand are very rare entities with only few cases reported till date. Most of submandibular gland fistulas are known to be congenital in origin, but acquired cases can rarely occur. Herein, we report a rare case regarding submandibular gland fistula in dermatologic literatures. A 53-year-old woman presented with erythematous patch with painful subcutaneous mass on lt. side of neck, which had developed over the course of 3 weeks. Symptom persisted despite treatment with empirical oral antibiotics. The computed tomography neck scan revealed enhancing tubular structure from submandibular gland to anterior aspect of platysma muscle and abscess, which was consistent with submandibular gland fistula. The patient was managed conservatively with antibiotic therapy for 3 months and the symptoms improved markedly. Submandibular gland fistula is rare condition and might be easily misdiagnosed, because it usually presents nonspecific symptoms like painful neck swelling. Accurate diagnosis may be achieved by means of through clinical manifestation, radiographic findings, and sometimes surgical exploration. Dermatologist should be kept in mind the possibility of a submandibular gland fistula when a painful mass arising in the neck does not respond to initial treatment.
麥酒麥의 品質低位性 原因 究明 Ⅰ. 氣象, 土壤 및 麥酒麥의 栽培的 特性 調査에 의한 適應地帶 區分
Chang Hwan Cho(曺章煥),Moon Woong Par(朴文雄),Kyung Soo Min(閔庚洙),Ho Sung Ha(河浩成) 한국육종학회 1990 한국육종학회지 Vol.22 No.4
To suggest the adaptive zones of malting barley, fifteen places were selected by their average temperature during the cropping period. Climatic variables, soil properties of the regions were investigated as well as growth, yield and quality of crops collected from farm fields. Selected areas were classified by daily minimum temperature averaged over January into 3 broad zones as Zone Ⅰ (above -2℃) Zone Ⅱ (between -2 and -3℃) and Zone Ⅲ (between -3 and -4℃). There were clear regional differences in soil properties and crop characteristics investigated. Zone Ⅰ and Ⅱ were considered as the adaptive zones for malting barley cropping. Majority of soils in Zone Ⅰ were local alluvial soil, fluviomarine soil, old alluvium soil and alluvial plain soil, whilest soils of Zone Ⅱ and Ⅲ were local alluvial soil, granite and granite-gneiss residual soil. Chemical analysis of soils showed that Zone Ⅰ has higher contents of NH₄-N, organic matter and soluble Boron, whereas Zone Ⅱ has higher NH₄-N, Ca, Mg, K and Fe. On the other hand, Zone Ⅲ showed lower contents in all investigated soil components except CEC, Ca and P₂O₅. Chemical analysis of plant material sampled at the times of effective tiller termination and yellow ripening stage showed that far southern regions produced crops of lower contents of T-N, P₂O₅, SiO₂, Fe and Mn, indicating a faster translocation of these nutrients to the ears. Crops produced in Zone Ⅰ had a smaller cuim length and a shorter duration of growth for heading and maturity, but they produced bigger numbers of ears and higher grain yields. Grain per ear and 1000 grain weight were smaller compared with other regions. Zone Ⅰ and Zone Ⅱ were again considered as adaptive regions for proper growth and yield of malting barley. Zone Ⅰ and Ⅱ produced better crops of malting quality compared to Zone Ⅲ as germination energy, germination rate, solube N, Kolbach. index, saccharification time and diastatic power were higher in Zone Ⅰ and soluble N, saccharification time and Kolbach index were higher in Zone Ⅱ. The adaptive regions of malting barley were south of a line connecting Muan, Yeongam, Jangheung, Bosung, Seungju and Kwangyang in Jonnam province and Hadong, Southern parts of Sanchung, Eureong, Haman, Milyang, Kimhae in Gyeongnam province. These regions were considered as advantageous in both yield and quality.
( Dong Jae Kim ),( Seung Hyeok Seok ),( Min Won Baek ),( Hui Young Lee ),( Yi Rang Na ),( Kyoung Jin Noh ),( Sung Hoon Park ),( Hyun Kyoung Lee ),( Noton Kumar Dutta ),( Byoung Hee Lee ),( Jae Hak Par 한국동물실험대체법학회 2007 한국동물실험대체법학회 학술대회집 Vol.2007 No.1
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor triggered by xenobiotics such as 3-methylcholanthrene (3MC). The hypoxia-inducible factor-1a1pha (HIF-1a1pha) is a conditionally regulated transcription factor activated by low oxygen conditions. Since both transcription factors share their common partner, AhR nuclear translocator (ARNT) to form heterodimeric complex for AhR- and hypoxia-mediated signaling, activation of the HIF-1alpha may lead to interference with 3MC induced AhR signaling by sequestering ARNT. To test this hypothesis, wild type zebrafish embryos and transgenic zebrafish embryos that express GFP in response to AhR ligands were exposed to 3MC (60 µM) at 72 h after fertilization for 3 h and then transferred to hypoxic condition caused by cobalt chloride (10-4 M). Semiquantative RT-PCR PCR analysis showed that hypoxic conditions by cobalt chloride decreased 3MC–induced cyp1a1 mRNA expression in wild type zebrafish embryos. GFP expression of 3MC-induced transgenic zebrafish embryos were decreased in hypoxic conditions. Our results demonstrated that hypoxic conditions inhibited 3MC-induced AhR signaling. But it is not clear whether this is mediated through competition for ARNT or through other mechanism.
Cadmium-Induced transient expression of a reporter gene in zebrafish (Danio rerio)
( Dong Jae Kim ),( Seung Hyeok Seok ),( Min Won Baek ),( Hui Young Lee ),( Yi Rang Na ),( Kyoung Jin Noh ),( Sung Hoon Park ),( Hyun Kyoung Lee ),( Noton Kumar Dutta ),( Byoung Hee Lee ),( Jae Hak Par 한국동물실험대체법학회 2007 한국동물실험대체법학회 학술대회집 Vol.2007 No.1
Cadmium (Cd) is a serious environmental pollutant and can cause a variety of adverse effects in humans and animals. Heat shock proteins (HSPs) play a major role in a self-protective mechanism after exposure to heat shock, toxic chemicals, and other environmental stresses. Recently, our laboratory developed a heat shock responsive transgenic zebrafish that expresses green fluorescence protein (GFP) after exposure to copper sulfate. In this study, we showed Cd toxicity on zebrafish larvae and tested responsiveness of our transient zebrafish system to Cd exposure. Cd treated larvae showed morphologic abnormalities such as spinal lordosis and kyphosis. Cd induced enhanced green fluorescence protein (EGFP) reporter gene expression in pHhsp70-EGFP transfected CHSE 214 cells, with EGFP expressed in a dose-responsive manner. Embryos injected with pHhsp-EGFP were exposed to DMSO (0.01%) or Cd (low dose: 2 µM; high dose: 20 µM) 72 h after fertilization for 3 h. Cd induced EGFP expression in skin epithelium, olfactory epithelium, retina, liver, pronephric ducts, and myotubes. These EGFP expressing tissues are related to absorption and detoxification of Cd. Our transient zebrafish biosensor could be utilized as a biomarker, indicating the presence of environmental toxicants, in an early warning system.