A Study on the Correlation of Left Atrial Volume Change according to Left Ventricular Contraction in Atrial Fibrillation

Sung Kwan Kim,Hee Chang Chae,Choong Beom Seo,Eun Hee Seo,Chang Min Dae,Tae Eun Kim 대한CT영상기술학회 2022 대한CT영상기술학회지 Vol.24 No.1

The purpose of this study was to increase accuracy and success rate of radiofrequency catheter ablation by analysis of left atrial volume change relative to left ventricular volume change and left atrial diameter change relative to left atrial volume change. 20 patients with normal heart rhythm were set as the control group, and 20 patients with diagnosed atrial fibrillation were set as the experimental group. The cardiac cycle was divided into 10 stages ranging from 0% to 90%, and left ventricular volume, left atrial volume, left atrial diameter, pulmonary vein diameter were measured for each group. the correlation between the left ventricular volume and the left atrial volume was analyzed, and the correlation between the left atrial volume and left atrial diameter was analyzed. The diameter of the pulmonary veins was measured. As a result of analyzing the correlation between left ventricular volume and left atrial volume through Spearman correlation, the control group showed a negative correlation.(P<0.001) The experimental group were not correlated.(P=0.075) As a result of analyzing the correlation between the left atrial volume and the left atrial diameter, both groups showed a positive correlation.(P<0.001) As a result of analyzing the diameter of the pulmonary vein by Wilcoxon signed-rank test, both groups showed a significant difference in the maximum diameter and the minimum diameter.(P<0.001) Because the volume and diameter of the left atrium in patients with atrial fibrillation change irregularly, the radiologist check all cardiac cycle and reconstruct to increase the accuracy and success rate of radiofrequency catheter ablation.

암세포 증식에 대한 YB-1 안티센스 올리고핵산염의 영향

김명성 ( Myung Sung Kim ),이완식 ( Wan Sik Lee ),박창환 ( Chang Hwan Park ),주영은 ( Young Eun Joo ),김현수 ( Hyun Soo Kim ),최성규 ( Sung Kyu Choi ),유종선 ( Jong Sun Rew ),정영도 ( Young Do Jung ),김세종 ( Sei Jong Kim ),안봉환 대한내과학회 2006 대한내과학회지 Vol.71 No.3

목적: YB-1은 PCNA, DNA 중합효소 및 MDR 유전자 등의 전사인자로 작용한다. YB-1 유전자는 정상 어른의 간에서는 발현되지 않지만 태아의 간이나 재생 중인 간에서는 발현이 현저히 증가되어서 세포의 증식과 밀접한 관련이 있음이 보고되었다. 본 연구에서는 YB-1 유전자의 안티센스 올리고핵산염을 이용하여 YB-1의 발현을 억제함으로써 암세포 증식을 차단 할 수 있는지를 실험하고 암치료를 위한 유전자 요법으로서의 가능성을 알아보았다. 방법: 세포주로는 Chang liver, HepG2, CT-26 세포를 사용하였고, 사람의 정상세포로는 섬유아세포와 내피세포가 혼재된 조직을 사용하였다. YB-1 유전자의 안티센스 올리고핵산염으로는 YB-1 cDNA의 변역 시작 부위에 상보적인 21mer 올리고핵산염을 제작하여 사용하였다. 세포의 성장은 MTT assay를 이용하였고, 유전자 발현은 Northern blot으로 분석하였으며, 세포주기 변화는 propidium iodide로 염색하여 유식세포분석기로 분석하였다. 동물실험에서는 CT-26 세포를 1.0×10(5)개씩 Balb/c 생쥐의 피하에 접종하여 종양을 유도하였다. 종양이 유도된 Balb/c 생쥐에 YB-1 안티센스 올리고핵산염을 꼬리정맥이나 종양조직에 주사한 후 종양의 크기를 측정하여 종양억제 효과를 관찰하였다. 결과: YB-1 안티센스 올리고핵산염은 CT-26 세포에서는 50 nM 이상 농도에서 Chang liver와 HepG2 세포에서는 10 nM 이상 농도에서 세포주의 성장을 강하게 억제하였지만 정상 조직세포의 성장에는 아무런 영향을 미치지 않았다. 안티센스 올리고핵산염을 DOTAP에 담지한 경우 세포성장 억제에 미치는 효과가 안티센스 올리고핵산염 단독 처치 보다 강하였다. 이때 YB-1의 발현은 증식이 억제된 세포주(Chang liver 및 CT-26)에서는 감소하였으나 정상조직세포에서는 변화가 없었다. 증식이 억제된 세포주에서 세포주기를 살펴보면 초기에 S phase가 감소함을 관찰 할 수 있었다. 꼬리정맥이나 종양조직에 YB-1 안티센스 올리고핵산염을 주입 시 종양의 크기가 유의하게 감소하였다. 결론: 이상의 실험 결과 YB-1 안티센스 올리고핵산염은 암세포의 성장을 저해하며 종양 동물모델에서 종양의 성장을 억제할 수 있음을 시사하였다. Background: Human YB-1 is a transcription factor that binds to the inverted CCAAT box in the promoter region of a variety of genes such as PCNA, DNA polymerase and MDR. In this study we evaluated the effect of YB-1 antisense oligonucleotides on tumor cell growth. Methods: Chang liver, HepG2 and CT-26 cells were cultured as immortalized cell lines. The MTT (3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyltetrazolium bromide) assay, Northern blot and flow cytometric analyses were used to determine cell growth, gene expression and cell cycle changes. In an animal model, CT-26 cells were injected into Balb/c mice to induce tumor; YB-1 antisense oligonucleotides were injected into the tail vein or tumor tissue of the mice; change of tumor size was then measured. Results: Phosphorothioated YB-1 antisense oligonucleotides suppressed the proliferation of the immortalized liver cells (Chang liver cells) and a variety of cancer cells (HepG2 and CT-26 cells); however, it did not inhibit normal cell growth. The DOTAP/antisense oligonucleotide mixture showed stronger effects on cell proliferation than did the antisense oligonucleotide alone. The YB-1 antisense oligonucleotide decreased specific expression of the YB-1 mRNA in the immortalized cancer cell lines. Flow cytometric analysis revealed that the inhibition of cell proliferation might have been due to a decrease in the S phase of the cell cycle. We found that in an animal tumor model, the administration of the YB-1 antisense oligonucleotide, in the vein or tumor tissues, decreased the tumor size significantly. Conclusions: These results suggest that the YB-1 antisense oligonucleotide may inhibit growth of a variety of cancer cells.(Korean J Med 71:293-301, 2006)

비후성심근증의 임상적 관찰

전상중(Sang Joong Jeon),정진홍(Jin Hong Chung),홍경순(Kyung Soon Hong),전재은(Jae Eun Jun),박의현(Wee Hyun Park),박희명(Hi Myung Park),김윤년(Yoon Nyun Kim),김권배(Kwon Bae Kim),장성국(Sung Kug Chang),이종주(Jong Joo Lee) 대한내과학회 1987 대한내과학회지 Vol.33 No.4

N/A The clinical and laboratory features of hypertrophic cardiomyopathy were studied in 30 cases. They consisted of 21 males and 9 females, and the age ranged from 21 to 74 years with an average of 50. The cardinal presenting symptoms were dyspnea, chest pain and palpitation in the order of decreasing frequency. Physical examination revealed apical systolic murmur in 27 cjases (90%), with thrill in 10 (33%), and the routine chest films showed enlargment of cardiac silhouette in 15 cases (50%). Abnormal electrocardiographic findings are noted in 27 cases (90%). Among them repolarization abormalities and left ventricular hypertrophy were the most common, occurring in 71% and 66 % of the cases, respectively, follower1 by left atrial enlargment in 24% and the abnormal Q waves in 20% Among various echocardiographic abnormalities, the mean of septal thickness and its ratio to left ventricular posterior wall thickness were 19 mm and 2,1 respectively, and the mean of the degree of systolic anterior motion of mitral valves was 9 mm. The mean of preejection period and left ventricular ejection time as well as their ratio determined in 10 cases were within normal limits. Out of 20 eases treated with beta or calcium blockers. for a mean of 22 months, 14 (70) experienccd symptomatic improvement. □ (5%) deteriorated and in the remainder (25%) there were no noticeable changes.

국내 육성 포도 "두누리" 품종의 성숙 시기별 과실특성과 포도주 품질특성

장은하 ( Eun Ha Chang ),정성민 ( Sung Min Jeong ),노정호 ( Jung Ho Noh ),박교선 ( Kyo Sun Park ),임병선 ( Byung Sun Lim ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2012 한국식품저장유통학회지 Vol.19 No.6

국내 포도주 가공용 육성 품종인 ``두누리`` 포도의 양조 가능성과 고품질의 포도주 양조를 위한 적정 성숙시기를 검토하고자 성숙 시기별 과실의 품질특성과 적정 성숙시기를 판단하는 여러 가지 지표를 검토하였고, 포도주 양조후 전문가 관능평가를 통해 포도주 품질에 가장 적합한 성숙 시기를 구명하고자 하였다. ``두누리`` 포도의 과실특성을 조사한 결과 °Brix 당함량은 변색기 이후 급격히 증가하였고 성숙완료 시 17 °Brix를 나타내었으며 과숙기에는 약 20 °Brix까지 증가하였다. 산함량은 변색기 이루 급격히 감소하기 시작하여 성숙 완료 시 거의 0.66%까지 감소하였고 이후에도 서서히 감소하여 과숙기에는0.51%까지 감소하였다. 총폴리페놀과 총안토시아닌 함량은 변색기 이후 급격히 증가하는 것으로 나타났다. 특히 산함량이 0.55%정도 되었을 때 총안토시아닌 및 총폴리페놀의 함량이 최고에 도달하지만 포도가 과숙되면 오히려 함량이 감소하는 것으로 나타났다. 총안토시아닌의 축적과 당, pH, 산함량, brix/acid 비율과의 상관관계를 살펴본 결과 0.87~0.95(p<0.05)의 양 또는 음의 높은 상관관계를 나타내었다. 포도의 적정 성숙시기를 판단하는 지표인 brix×pH(2) 값과 brix/acid 비율을 적용해 본 결과 두 지표를 모두 만족시키는 성숙 시기는 산함량이 0.53~0.55 정도, 당함량이 17 °Brix일 때였다. ``두누리`` 포도주의 성숙 시기별 품질특성을 조사한 결과 산함량은 성숙 시기가 늦을수록 감소하였고, 총안토시아닌, 탄닌 함량 및 포도주의 적색도와 색의 포화도를 나타내는 a*와 C*는 증가하다가 포도가 과숙될수록 함량이 오히려 감소하는 것으로 나타났다. ``두누리`` 포도주의 관능평가를 조사한 결과 산함량은 포도 성숙 후 가장 늦게 수확하여 제조한 포도주에서 가장 안정적인 산미를 나타낸다고 평가하였지만 색, 향기, 전체적인 조화에서는 포도주의 산함량이 0.60%(포도의 산함량으로 0.53~0.55%) 정도일 때 가장 좋은 품질을 나타낸다고 평가하였다. 따라서 ``두누리``포도주를 제조할 경우 포도의 산함량이 0.55% 정도 일 대 포도의 당함량, 색 및 폴리페놀의 함량은 최고에 도달하고, 기존의 성숙시기 판단 지표인brix×pH(2) 값과 brix/acid 비율을 만족시키는 것으로 나타났다. This study was conducted to investigate several indicators of fruit maturity, and expert sensory evaluation was done to determine the most appropriate maturity time for the new Korea grape cultivar ``doonuri`` for high quality winemaking. The grape component changed dramatically during ripening, after veraison. Considerable drops in berry firmness (<0.60 kgf/cm2) and titratable acidity (<0.66%) were found at the ripening stage while the soluble solid content significantly increased in the ripening process. Most of the organic acids contained were tartaric and malic acid. The malic acid content was about twice the tartaric acid content in the fruit-growing period but was less than the tartaric acid content in the maturity period. The total anthocyanin and polyphenol contents increased sharply after veraison. In particular, the total anthocyanin and polyphenol contents reached their maximum levels when the acidity was 0.55%, and after that, there was almost no change. Correlations between anthocyanin accumulation and several factors were found in sugar 0.7811 (p<0.05), pH 0.9315 (p<0.05), and Brix/acid ratio 0.9409 (p<0.05). Brix×pH2 and brix/acid ratio were used as indicators of the proper maturation of the grapes when the acidity was 0.53 to 0.55%, and at sugar 17 Brix. When surveyed, the quality characteristics and sensory evaluation of the wine made using the latest harvested grapes showed the most reliable sourness. The color, aroma, and overall harmony of the wine, however, were evaluated to be the best when the wine acidity was about 0.60% or when the grape acidity was below 0.55%

The Return of an Old Worm: Cerebral Paragonimiasis Presenting with Intracerebral Hemorrhage

Koh, Eun Jung,Kim, Seung-Ki,Wang, Kyu-Chang,Chai, Jong-Yil,Chong, Sangjoon,Park, Sung-Hye,Cheon, Jung-Eun,Phi, Ji Hoon The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.11

<P>Paragonimiasis is caused by ingesting crustaceans, which are the intermediate hosts of <I>Paragonimus</I>. The involvement of the brain was a common presentation in Korea decades ago, but it becomes much less frequent in domestic medical practices. We observed a rare case of cerebral paragonimiasis manifesting with intracerebral hemorrhage. A 10-yr-old girl presented with sudden-onset dysarthria, right facial palsy and clumsiness of the right hand. Brain imaging showed acute intracerebral hemorrhage in the left frontal area. An occult vascular malformation or small arteriovenous malformation compressed by the hematoma was initially suspected. The lesion progressed for over 2 months until a delayed surgery was undertaken. Pathologic examination was consistent with cerebral paragonimiasis. After chemotherapy with praziquantel, the patient was monitored without neurological deficits or seizure attacks for 6 months. This case alerts practicing clinicians to the domestic transmission of a forgotten parasitic disease due to environmental changes.</P>

복합운동이 고령여성의 건강관련체력과 Dehydroepiandrosterone Sulfate 및 Testosterone 농도에 미치는 영향

박상갑(Sang-Kab Park),김은희(Eun-Hee Kim),김창선(Chang-Sun Kim),권유찬(Yoo-Chan Kwon) 한국생활환경학회 2005 한국생활환경학회지 Vol.12 No.2

The purpose of this study was to investigate the changes of health related fitness and Dehydroepiandrosterone sulfate (DHEAs) after 12 weeks of combined exercise. Subjects were consisted of fourteen elderly women. The training program included stretching for 10 minutes, aerobic exercise (weight bearing exercise and balance exercise at an intensity above 40~59% of HRR during 1~6 weeks, and 60~84% of HRR during 7~12 weeks) for 30 minutes and 20 minutes of resistance exercise (muscle strengthening+posture correction). The program was conducted 3 times a week for 12 weeks. We found that LBM (lean body mass) was significantly (p<.05) increased and gait ability were significantly improved after combined exercise. Also DHEAs concentration was significantly increased after combined exercise but testosterone was not changed. In conclusion, the combined exercise showed a positive influence on body composition and health related fitness. In particular DHEAs concentration were significantly improved after combined exercise. Therefore, it might be thought that combined exercise would be a positive role in the of aging.

Surface Morphology Control of Polymer Films by Electron Irradiation and Its Application to Superhydrophobic Surfaces

Lee, Eun Je,Jung, Chan-Hee,Hwang, In-Tae,Choi, Jae-Hak,Cho, Sung Oh,Nho, Young-Chang American Chemical Society 2011 ACS APPLIED MATERIALS & INTERFACES Vol.3 No.8

<P>A simple and controllable one-step method to fabricate superhydrophobic surfaces on poly(tetrafluoroethylene) (PTFE) films is developed on the base of electron irradiation. When the thickness of PTFE films is higher than the penetration depth of electron beams, electrical charging occurs at the surface of the films because of the imbalance between the accumulation of incident electrons and the emission of secondary electrons. Local inhomogeneity of charge distribution due to this electrical charging results in the nonuniform decomposition of PTFE molecular bonds. As electron fluence increases, surface morphology and surface roughness of the films are dramatically changed. An extremely rough surface with micrometer-sized pores is produced on the surface of PTFE films by electron irradiation at a fluence higher than 2.5 × 10<SUP>17</SUP> cm<SUP>–2</SUP>.Because of high surface roughness, the irradiated PTFE films exhibit superhydrophobic property with a water contact angle (CA) greater than 150° at fluences ranging from 4 × 10<SUP>17</SUP> to 1 × 10<SUP>18</SUP> cm<SUP>–2</SUP>. The surface morphology and corresponding water CA can be controlled by simply changing the electron fluence. This electron irradiation method can be applicable to the fabrication of superhydrophobic surfaces using other low-surface-energy materials including various fluoropolymers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2011/aamick.2011.3.issue-8/am200464a/production/images/medium/am-2011-00464a_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am200464a'>ACS Electronic Supporting Info</A></P>

Which Environmental Factors Caused Lammas Shoot Growth of Korean Red Pine?

Lee, Chang-Seok,Song, Hye-Gyung,Kim, Hye-Soo,Lee, Bit-Na-Ra,Pi, Jeong-Hoon,Cho, Yong-Chan,Seol, Eun-Sil,Oh, Woo-Seok,Park, Sung-Ae,Lee, Seon-Mi The Ecological Society of Korea 2007 Journal of Ecology and Environment Vol.30 No.1

Lammas growth, a rare phenomenon for Korean red pine (Pinus densiflora), occurred in 2006. Lammas shoots showed higher frequency and longer length in Seoul's hotter urban center than in urban boundary or suburban forest sites. Frequency and length showed a close correlation with urbanization density and vegetation cover expressed in NDVI. Air temperature in the late summer of 2006 was more than $1^{\circ}C$ higher than an average year. Of the predominant environmental signals that modulate bud flush, only temperature changed significantly during the year. Differences in temperature between the urban centers, urban boundaries and suburban forests correlated with varying land-use density. The rise in temperature likely spurred lammas growth of the Korean red pine. Symptoms of climate change are being detected throughout the world, and its consequences will be clearer in the future. Considerate interest in the responses of ecological systems to the variable changes is required to prepare for unforeseeable crises. Monitoring of diverse ecological phenomena at Long Term Ecological Research sites could offer harbingers of change.

신정부 과학기술정책 방향 모색

홍성주(Sung Joo Hong),이다은(Da Eun Lee),홍창의(Chang Ui Hong),강민지(Min Ji Kang),우청원(Chung Won Woo),강홍렬,전찬미 과학기술정책연구원 2017 정책연구 Vol.- No.-

With the presidential election in 2017 as a momentum, many people in science and engineering and social organizations gave various science and technology policy proposals. Most of them were reflected in each party’s election pledges. The media also covered lots of science and technology policy issues, which mainly included agendas reflecting the voices of the fields of R&D like research autonomy and people-oriented investment. This task aims to understand how the landscape of science and technology policies changed in an era of political change. To achieve this, we pursued to answer three research questions. First, how are we going to look at the vitalization of science and technology policy issues that occurred in the presidential election and its results? Second, what was it like in the past? Did the previous governments faithfully carry out their science and technology pledges in their science and technology policies? Third, what is the blind spot of policies that failed to attract attention or became a dilemma despite the change in science and technology policies? In order to answer these questions, the research team analyzed the way of establishing the window for science and technology policies during the presidential election in 2017, while also looked at the path taken for science and technology pledges to be implemented as policies during the past 15 years after the Rho Moo Hyun Government. The analysis results showed that we need to take largely four different approaches to science and technology issues. From the medium and long term perspective, it can be divided into issues that need access, issues that need enhancement, issues that need to gain political interests and issues that need to improve rationality. The research team’s results presented important perspective and methodology of looking at science and technology policy by not only being applied as a standard and means, but also provided a framework for devising various methods and means by policy issue. Hopefully, our researches are helpful in the planning and implementation of science and technology policy by the new government, which will be inaugurated in May 2017.

심리전문가 수련생을 위한 집단상담 프로그램 개발의 예비연구: 심리도식 및 수용전념치료를 중심으로

조주성(Ju Sung Cho),장은진(Eun Jin Chang),전은영(Eun Young Jeon) 한국발달지원학회 2020 발달지원연구 Vol.9 No.3

본 연구는 심리전문가 수련생을 대상으로 전문가로서의 성장을 목적으로 심리도식치료 및 수용전념치료에 기반한 집단상담 프로그램 개발을 위한 예비연구를 실시하고 그 효과성을 검증하고자 하였다. 이를 위하여 프로그램 개발에 관한 모형을 통해 관련 변인과 총 18회기의 내용을 개발하고 내용타당도를 검증하였으며, D지역 심리전문가 수련생 7명을 대상으로 해당 프로그램을 실시한 후 대응표본 t검증과 효과크기(Cohen’s d)를 산출하여 효과성을 검증하였다. 그 결과, 자기성찰(t=-2.04, df=6, p=.04), 정서인식의 명확성(t=-3.16, df=6, p=.01), 정서적 안정성(t=2.81, df=6, p=.01)이 통계적으로 유의미한 변화를 나타내었으며, 자기수용은 유의미한 수준의 변화를 나타내지는 않았지만(t=-.1.34, df=6, p=.11), 효과크기는 중간수준임으로 나타나(d=-0.50) 더 많은 대상자들을 상대로 실시할 경우, 통계적으로 유의미한 결과를 산출할 가능성이 있음을 확인하였다. 본 연구는 심리도식치료와 수용전념치료를 적용한 집단상담 프로그램을 통하여 심리전문가 수련생들에게 교육분석에 필요한 내용을 체계적으로 제공하고 그 효과성을 검증하였다는 점에서 의의가 있다. 본 예비연구에서 효과성이 검증되었으므로 향후 프로그램의 완성도를 높인 후, 비교집단을 활용한 무선 통제집단연구나 종단연구 등을 통하여서도 반복적인 효과성 검증을 할 것을 제안하였다. The purpose of this study is to develop and verify the effectiveness of group counseling program, based on the Schema Therapy(ST) and the Acceptance-Commitment Therapy(ACT), for the growth of psychological professional trainees. For this purpose, psychological professional trainees(n=7) were surveyed, and research participants were selected. Based on program development model, this study conducted content validity verification, conducted a paired samples t-test, and calculated effect size (Cohen s d) to verify the effectiveness of the 18 session program. As a result, introspection (t=-2.04, df=6, p=.04), clarity of emotional recognition (t=-3.16, df=6, p=.01), and emotional stability (t=2.81, df=6, p=.01) showed statistically significant changes. Although acceptance (t=-1.34, df=60, p=.11) did not show a significant change, its effect size being middle level(d=-0.50) indicates that if the test is conducted in a larger sample, a statistically significant outcome could result. This study is meaningful in that it verified the effectiveness of a systematic expert training program that applies the ST and the ACT. Since the program’s effectiveness has been verified in this preliminary study, it is suggested that a controlled or longitudinal study should be conducted to re-verify the effectiveness of this program.