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자가 Fibrin Glue와 연골세포를 이용한 연골조직 공학 기법에 관한 연구
홍성표,범진식,박재경,김진영,이두형 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3
Neomorphogenesis of cartilage using chondrocyte-polymer constructs is a potential source for development of cartilage reconstruction. Current tissue engineering techniques of neocartilage rely on in vivo implantation of polymer-chondrocyte constructs. The purpose of this study was to find a way to bioengineer cartilage in vitro by entrapping chondrocytes in a molded autologous fibrin glue. Chondrocytes isolated from the cartilage of rabbit joints were combined with fibrinogen extracted by a single cryoprecipitation of autologous plasma, and they were then polymerized with thrombin to create a fibrin glue with a final cell density of 2.5x10?? cells/ml. The collagen for a control study was used as a polymer. The polymer-chondrocyte constructs were cultured for 4 weeks and the fibrin-chondrocyte constructs molded in the shape of a human ear were cultured for 6 weeks in vitro. Morphometric, histochemical, and histomorphometric analysis including glycosaminoglycan quantitation confirmed the following results: 1) Highly-concentrated autologous fibrinogen was easily extracted by a single cryoprecipition of autologous olasma. 2) The fibrin-chondrocyte constructs demonstrated the presence of actively proliferating chondrocytes with the production of cartilaginous matrix(collagen and glycosaminoglycan) at 1 week after culture, as well as gross and histologic evidence similar to those of normal cartilage at 3∼4 weeks after culture. 3) The collagen-chondrocyte constructs demonstrated lower degrees of hardness and transparency, as well as a lower density of cells and glycosaminoglycan during the culture period. 4) Neocartilage generated from fibrin-chondrocyte constructs in the shape of a human ear nearly retained their original configuration and size without degeneration for 6 weeks of culture in vitro. This study demonstrated a novel method for bioengineering the molded cartilage in vitro using autologous fibrin glue as a matrix scaffold. The generated cartilage showed gross and histologic evidence similar to those of normal cartilage, retaining the original gross dimension. With further refinement, this may be a new application of tissue engineering for the reconstruction of cartilage.
0.412 MeV 감마선에 대한 원주형 NaI(Tl) 섬광체의 총 절대검출효율 계산
홍권표,신희성,이상윤,노성기 대한방사선 방어학회 2002 방사선방어학회지 Vol.27 No.4
Total absolute detection efficiencies of a 7.62 cm(dia.) and 7.62 cm(height) cylindrical NaI(Tl) crystal have been calculated for 0.412 MeV r -rays from a source(point, circular disk, square and line type). In this calculation the linear energy-absorption coefficients based on Hubbell's data have been considered and then calculated total absolute detection efficiencies compared with those from Grosjean and Bossaert. Besides, the source axis-to-detector axis shift distance which, could give rise to about 0.05% deviation in the total absolute detection efficiencies has been calculated for a line-type source of 0.5 cm in its length when a source-to-detector distance is 5 cm. It is revealed that the total absolute detection efficiencies obtained in this study are considerably different from those of Grosjean and Bossaert. In addition it is found that the deviation induced due to an imperfect center of a line type source may be within 0.05% if the shifted discrepancy is no larger than 1.74mm.
홍상표 청주대학교 산업과학연구소 2003 産業科學硏究 Vol.20 No.2
Most EIA(environmental impact assessment) programs require the consideration of human health impacts This paper examines how, why, and to what extent health impacts are analysed in environmental impact assessments An empirical study of EIS(environmental impact statements) found that more than half didn't mention about health impacts. This paper investigates these problems and provides recommendations to improve human health impact assessment, using strategic environmental assessment, qualitative health data, health outcomes in addition to cancer, and precautionary approach to risk
衛生埋立地 粘土遮水膜에서 重金屬 分布 特性에 關한 硏究
홍상표 서울保健大學 1995 論文集 Vol.15 No.1
The purpose of this study is to analyse the concentration of heavy metals in leachate, effluent, stream and soil at Kimpo Metropolitan Landfill Site. The results are epitomized as follows; 1. Concentrations of heavy metals in leachate were, As 0.710ppm, Ni 0.377ppm, Cd 0.024ppm, Cr 0.937ppm, Cu 0.033, Pb 1.435 ppm and Zn 0.718ppm. 2. Concentrations of heavy metals in effluent were, As 0.530ppm, Ni 0.368pprn, Cd 0.0l8ppm, Cr 0.852ppm, Cu 0.039ppm, Pb 1.064ppm and Zn 0.838ppm. 3. Concentration ranges of heavy metals in the adjacent stream were, As 0.076~0.093ppm, Ni 0.0l8~0.059ppm, Cd N.D., Cr 0.038~0.096ppm, Cu N.D.~0.042, Pb 0.020~0.092ppm and Zn 0.093-0.230ppm. 4. Concentration ranges of heavy metals in soil were, As 1.329~1.609pprn, Ni 0.321~0.463 ppm, Cd 0.021~0.046ppm, Cr 0.503~0.954ppm, Cu 0.311~1.182ppm, Pb 1.729~2.945ppm and Zn 0.979~4.304ppm. 5. Concentrations of all analysed heavy metals except Cu and Zn in leachate were attenuated after passing through the leachate treatment facility. 6. Concentrations of all analysed heavy metals in soil decrease with soil depth.
홍상표 청주대학교 2015 産業科學硏究 Vol.33 No.1
To assess the environmental risk of biological products manufacturing, 28 specific hazardous water contaminants such as heavy metals, tetrachloroethylene and epichlorohydrin from 4 manufacturers were analyzed based on U.S.EPA Method and Korean Official Test Criteria of Water Contamination. As a result, 0.13㎎/ℓ Cu and compounds was detected only one manufacturer. The other 27 specific hazardous water contaminants except Cu and compounds were not detected within the detection limit. 0.13㎎/ℓ Cu and compounds can even satisfy the criteria of drinking water. Therefore, biological products manufacturing is considered as acceptable level of environmental risk. Because biological products manufacturing is characterized as treating pathogenous micro organisms and highly dangerous toxins. the impact on human health and ecological stability can not be neglected. To address this uncertainty of biological products manufacturing, the study of accurate biological risk assessment is necessary afterwards
홍석표,최상구,강석근,이화우 全北大學校 1995 論文集 Vol.39 No.-
Epoxy resins were mixed with asphalt solution in the range of 0 - 60phr for the total components. The blending properties, curing properties, and surface properties for mixtures were investigated experimentally. Compatability of epoxy resins with asphalt were relatively good over mixture temperature 50℃. Interpenetrated polymer networks(IPNs) were partially formed between epoxy resins and asphalt. Increase of hardness was depended on the crosslinking density of epoxy resins and oxidation of asphalt. Defects of coated surface including crater, pinhole, and crack could be improved by adding epoxy resins 20 phr.
메모리 공유형 다중 프로세서의 동기화를 위한 Spin-Lock 기법의 성능 분석
홍춘표,이종임,남상균 대구대학교 과학기술연구소 1997 科學技術硏究 Vol.4 No.3
Most of the shared-memory multiprocessor system provide a hardware primitive for supporting mutually exclusive accesses to shared data. The hardware primitive consists of instructions that atomically read and write a single memory location. When a processor is accessing a shared data, the lock is set to busy, and other processors must wait until the lock is released. This paper analyse the characteristics of four spin-lock alternatives, and compare the performance of the proposed scheme through the simulation on shared-memory multiprocessor (Sequent-Balance). The simulation results show that all the spin-lock alternatives for synchronization degrade overall performance as the number of spinning processors increases. In addition, a variant of Ethernet backoff scheme shows good performance even for large numbers of spinning processors. Because of its simplicity, backoff scheme has better performance when there is no contention for the lock.
벽시계틀 소재로 사용되는 목재와 플라스틱의 접착력 향상에 관한 연구
洪錫杓,崔相久,金鍾石 全北大學校 1991 論文集 Vol.33 No.-
Wood and plastic were used as elemental materials of the frame of clock. In this research, it was studied to improve adhesive strength between this materials by new adhesion process. Vinyl or acryl emulsion(H-403, H-422, Y-840, Y-850) was used as the adhesive. The adhesive properties was tested experimantally on various partial process including sanding, cleaning of sanded surface and pressing of bonded areas. The results obtained in this experiments were follows : 1) Y-850 represented most excellent adhesive properties. 2) The maximum of adhesive strength could be obtained by sanding with sand paper #600, pressing of 0.3∼0.5kg/㎠, and cleaning with acetone. In that case, increase of 20% in adhesive strength was showed than obtained by traditional process.
홍원표,박성현 중앙대학교 기술과학연구소 2001 기술과학연구소 논문집 Vol.31 No.-
지반조사에서는 원위치시험으로는 표준관입시험, 정적콘관입시험, 동적콘관입시험, 스웨덴 식사운딩시험, 베인시험 등이 실시되고 있다. 특히, 이들 가운데 표준관입시험은 간편하면서도 유용한 원위치시험으로 가장 널리 이용되어져 오고 있다. 표준관입시험으로부터 얻어진 N치는 지반의 지지력, 침하량, 점착력, 내부마찰각, 상대밀도, 변형계수 등 다양한 해석정보를 얻는데 활용되고 있으나, N치의 지반특성과의 관계의 상관성에 대하여 아직 명확히 조사되어있지 않은 실정이다. 본 연구에서는 점성토지반에서의 표준관입시험에 의한 N치와 지반특성의 상관성을 규명하여 보고자 우리나라 서남해안지역의 연약한 점성토 및 내륙지역의 견고한 점성토에 대한 현장지반조사 및 실내시험 자료를 분석하였다. 본 연구의 결과는 결국, Atterberg한계, 자연함수비, 습윤 및 건조밀도, 일축압축강도와 압축지수 등과 같은 물리적, 역학적 특성의 예측에 이용될 수 있을 것이다. In soil investigations, in situ tests, such as standard penetration test, static cone penetration test, dutch cone penetration test, Swedish sounding test, vane test, etc, are performed as a part of main investigation. Especially, standard penetration test is most widely used as useful test in situ. N-value from the standard penetration test could give a numerous interpretation such as judgement of ground bearing capacity, settlements, cohesion, internal friction angle, relative density, modulus of deformation, etc. Nevertheless, in some respect to clear the correlations between N-value and soil properties are not enough yet. In this study, in order to find the correlations between N-value and soil properties in cohesive soils, the soil test data have been analyzed. The data was given by both the field soil investigation and laboratory test performed on soft clay in west and south coasts and stiff clay of inland areas in Korea. The results of this study might be available to predict some soil properties, such as the Atterberg limit, natural water content, wet and dry densities, unconfined compression strength and compression index, by use of the standard penetration test results in fields.
홍정표,한성진,주수원 東亞大學校 附設 情報通信硏究所 1998 情報通信硏究所論文誌 Vol.6 No.1
The Synchronous reluctance motor is a sinewave ac motor and it has cylindrical surfaces on both sides of teh air gap. The stator is conventional polyphase ac stator, while the rotor has internal flux barriers shaped to maximize the ratio of d-axis to g-axis reactance. This paper presents the finite element analysis and parameter measurement of the synchronous reluctance motor(SRM). The model motor is a 3-phase SRM with the segmental rotor and its rating is 0.175kw. The torque characteristic is analysed by finite element method and compared with that from measurement.