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Expression of Cox-2 in lung cancer
Lim, Sung Jig,Kim, Jung Yeon 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3
Cox-2는 대장, 췌장, 폐 그리고 두경부의 종양에서 과발현되는 것으로 알려져 있으며, 또한 전이와 국소 침윤과도 관계 있는 것으로 알려져 있다. 저자들은 86 명의 비소세포성 폐암 환자를 대상으로 면역화학적 염색을 이용하여 Cox-2 단백질의 발현을 살펴보았다. 86명의 환자 중에서 59명(68.6%)에서 Cox-2의 발현을 보였다. Cox-2 발현은 성별, 진단명, 분화, 임파절 전이, 흉막 침범, 임파선 또는 혈관 색전등과 같은 임상병리학적인 요소들과는 의미있는 관계가 없었다. 단지 선암에서 진행된 병기(stage)에 따라 Cox-2 발현이 의미있게 증가하는 것으로 나타났다. Cox-2 과발현은 누적 생존율의 감소와 의미있는 관계를 보였으며, 특히 선암에서 뚜렷하였다. Cox-2 의 발현은 비소세포성 폐암, 특히 선암에서, 발생과 예후에 중요한 역할을 하는 것으로 생각된다.
임승길,김경래,정윤석,이경미,김동익,김현만,이현철,이은직,안광진,김덕희,윤도훔,박용구,김영수,정상섭,이규창,정우희,김태승,허갑범 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.4
TSH secreting pituitary adenoma is a rare disorder and represents about 1% of all pituitary adenomas. About 80 cases have so far been reported. We experienced four cases of TSH secreting pituitary adenoma. Three of them were macroadenomas and 1 was microadenoma. Serum TSH levels varied between 4.1~185.6 uIU/ml. The serum -subunit levels of two patients tested were slightly elevated (0.87, 0.96 mIU/ml). Serum TSH and -subunit response to TSH, dexamethasone, T3, bromocriptine, and octreotide were variable when studied. Three patients underwent transsphenoidal microsurgery. One of them received radiotherapy. They were cured. Treatment with octreotide in 1 patient who did not received surgery resulted in normalization of serum TSH and thyroid hormone levels and reduction in tumor size. (J Kor Soc Endocrinol 7:331~342, 1992)
증례 : 두 종류의 항체를 보유한 자가면역성 저혈당 1예
전성완 ( Sung Wan Chun ),이병완 ( Byung Wan Lee ),강은석 ( Eun Seok Kang ),차봉수 ( Bong Soo Cha ),이은직 ( Eun Jig Lee ),임승길 ( Sung Kil Lim ),이현철 ( Hyun Chul Lee ) 대한당뇨병학회 2009 임상당뇨병 Vol.10 No.2
자가항체로 인한 고인슐린성 저혈당증을 특징으로 하는 자가면역 저혈당은 인슐린 자가면역 증후군과 B형 인슐린저항성으로 나뉘며, 서로 다른 임상적 특성을 보인다. 저자들은 glucocorticoid 치료에 반응하지 않는 자가면역성 저혈당증에 대해 두 가지 종류의 인슐린 항체가 함께 존재함을 확인하고 cyclophosphamide 충격요법으로 저혈당이 호전된 73세 여자 환자 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hypoglycemia is rare kind of autoimmune disease caused by either anti-insulin antibodies (insulin autoimmune syndrome, IAS) or anti-insulin receptor antibodies (type B insulin resistance, type-B IR). We experienced an extremely rare case of the IAS accompanied by type-B IR. A 73-year-old woman presented with recurrent severe hypoglycemic symptoms at dawn for one month was admitted to the Severance hospital. She had several medical histories including 30 years of hypertension, 15 years of type 2 diabetes, and 4 years of coronary artery disease before admission. She had never received an insulin injection. Hypoglycemia was diagnosed at 10 hours in the 72-hour fasting test with glucose, insulin, and C-peptide levels of 42 mg/dL, 280.31 μU/mL, and 7.70 ng/mL, respectively. The insulin autoantibody titer was 130 μU/mL and quantitative assay for insulin receptor antibody was positive. Insulinoma was ruled out by imaging techniques and calcium stimulation test. She has no evidence of other diseases associated with altered immunity. Despite of treatment with prednisolone, symptomatic hypoglycemic events persisted at fasting state. Early induction of 300 mg cyclophosphamide therapy resulted in remission of hypoglycemia accompanied by suppressed antibody titer. The changes in autoantibodies might result in alleviation of the symptoms of hypoglycemia and improvement in insulin and C-peptide levels. (Korean Clinical Diabetes J 10:123-128, 2009)
정상섭,김창미,허갑범,이현철,임승길,이은직,김경래,안광진,김미림,정윤석,이규창,유경자,윤도흠 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.3
We strudied the characterization and measurement of estrogen receptors in 21 patients with pituitary adenomas. The follwing results were obtained. 1) The concentrations of cytosolic estrogen receptors(fmole/mg protein) of lactotrope(241.2±93.8) and gonadotrope adenomas (308±138.1) were higher than those of somatotrope adenomas(49.4±19.2)(p$lt;0.05), but not different form those of corticotrope(151.4±40.3)and null cell adenomas(122.3±41.6). The concentrations of nuclear estrogen receptors of the pituitary adenomas were not significantly different from each others. 2) Macroprolactinoma had a high concentration of cytosolic(300.9±102.5 fmole/mg protein)and nuclear estrogen receptor(859.7±470.6 fmole/mg protein) comparing to microprolactinoma (62.2, 140.2 fmole/mg protein). 3) Srum prolactin levels had a correlation with the concentration of cytosolic estrogen receptors(r=0.66, p=0.001), but no correlation with nuclear estrogen receptors(r=0.12, p=0.3). 4) Cytosolic and nuclear estrogen receptors of the a(except corticotrope adenoma) with serum prolactin levels higher than 50ng/ml were higher than those of ones with prolactins lower than 50ng/ml. These results demonstrated the various levels of estrogen receptors in pituitary adenomas. The concentrations of estrogen receptors were higher in patients with high serum prolactin levels and macroprolactinomas. (J Kor Soc Endocrinol 7:208~215, 1992)
이은직(Eun Jig Lee),이현철(Hyun Chul Lee),안광진(Kwang Jin Ahn),임세중(Se Joong Rim),정윤석(Yoon Sok Jung),이관우(Kwan Woo Lee),임승길(Sung Kil Lim),김경래(Kyung Rae Kim),허갑범(Kap Bum Huh),양우익(Woo Ik Yang),박찬일(Chan Il Park),최 대한내과학회 1991 대한내과학회지 Vol.41 No.6
N/A This retrospective study concerns 73 patients with nonfunctioning pituitary adenoma who were operated on during an 9-year period from 1981 to 1989. Among them, 7 men showed positive immunocytochemistry for FSH and negative for other pituitary hormones. Six of them had elevated serum FSH levels, and LH levels were normal. Testosterone levels were low in six patients tested. Their major symptoms were visual impairment, headache, and impotence, which had developed from two months to 2 years before sugery. Primary hypogonadism could be eliminated on clinical grounds (recent onset of hypogonadism, previous fertility, and posttreatment-improvement). Transsphenoidal adenomectomies were performed in all patients, and radiation-therapies were paralleled in 6 of them. Clinical recovery occurred in all patients. One patient who did not received radiation therapy showed regrowth of tumor mass after 18 months. In remaining 6 patients, we haven't found any evidence of tumor recurrence during follow-up period from 10 months to 6.3 years. We conclude that these 7 men had primary gonadotrope adenoma of the pituitary, and present them with a literature review.
윤영직(Young Jig Yoon),허준(Joon Heo),홍충선(Choong Seon Hong),주성호(Sung Ho Ju),임용훈(Yong Hun Lim) 한국정보과학회 2007 한국정보과학회 학술발표논문집 Vol.34 No.2D
전력선을 이용한 통신 기술(Power Line Communication, PLC)은 현재 국내외에서 큰 관심을 받는 연구분야로 국내에서도 이에 대한 연구와 개발이 활발히 진행되고 있다. 이 기술은 전력선을 이용하여 음성 · 데이터 · 인터넷 등을 고속으로 이용할 수 있는 서비스를 제공하며 나아가 가정의 모든 가정기기들을 연결하는 홈네트워크를 구성할 수도 있다. 하지만 전력선 통신 기술에는 보안상 많은 문제가 존재한다. 그 이유는 전력선 통신 네트워크가 전력선과 IP망을 둘 다 사용하는 혼합형 네트워크로 구성되어 있기 때문이다. 이로 인해 기존 IP망에서 사용하던 보안 기술들을 그대로 전력선 통신 네트워크에 적용하기에는 많은 어려움이 따르며 새로운 기술을 개발하고 그것을 기존 인프라에 적용하는 것 또한 많은 어려움이 따른다. 이에 본 논문에서는 기존 IP망에서 사용하던 공개키와 대칭키 방식을 이용하여 서로 다른 네트워크로 구성되어 있는 전력선 통신 네트워크의 보안을 위한 혼합형 보안구조를 제안한다.