한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

법랑질 접착에 대한 습윤 효과

고근호,조영곤,진철희,유상훈,김종욱,박병철,기영재,최희영,김종진 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3

This study evaluated the microleakage and interfacial gap between enamel and composite resin under the dry and wet condition of the enamel surface, V shaped class 5 cavities were prepared on the occlusal portion of extracted human molars. Samples were divided into three groups: D group (air dry for 10-15s), BD group (blot dry with moist cotton pellet), and DR group (air dry for 10-15s and rewet with Aqua-Prep F for 20s). Cavities were filled using Aelitefil composite resin after applied One-Step. Microleakage was tested by 2% methylene blue dye solution and the data were statistically analysed by Kruskal-Wallis test and Mann-Whitney test. Also Enamel-resin interface was observed under SEM. Group BD showed statistically lower microleakage than group D (p〈0.05). but there was no statistically significant difference between group BD and DR (p)0.05). At the enamel-resin interface, group D showed the gap of 2 ㎛ thickness, but group BD and DR showed close adaptation. In conclusion, the use of blot dry and rewetting agent (Aqua-Prep F) resulted in decreased microleakage and improved adhesion between enamel and resin when using One-Step.

Swivel joint를 이용한 비대칭 발치증례의 교정적 공간폐쇄

고창희,임성훈,김광원,정동기,김도영,박선주,양용근 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1

Extraction therapy is popular treatment protocol in orthodontics. Generally, symmetric premolar extraction is performed. But, in some cases, asymmetric extraction is required to solve asymmetric dental alignment. But asymmetric extraction treatment has side effects and disadvantages like a) collapse of dental arch form. b) canting of occlusal plane, c) extended treatment duration. For a good treatment result, we applied the orthodontic space closing arch wire with swivel joint to allow rotational movement of arch wire segments during space closure, Now we present a case treated with orthodontic space closing arch wire with swivel joint.

확장정보 트리를 이용한 요구 명세의 동적 행위 검증

고상복,이창훈,이경환 중앙대학교 정보통신연구소 1999 정보통신연구소논문집 Vol.1 No.1

요구 명세의 검증은 분석이 올바르게 수행되었다는 것을 보증해 주는 중요한 단계이다. 특히, 객체지향 소프트웨어 개발 주기의 설계 단계 이전에 소프트웨어 시스템의 동적인 행위는 검증 되어져야한다[Bou95]. 그래서, 본 논문에서는 객체지향 요구명세서의 동적 행위에 대한 검증 방법을 제안한다. 제안된 검증 방법의 첫 번째 절차에서 객체지향 요구명세를 구성하고 있는 객체와 동적 모델을 수정 객체 모델과 수정 동적 모델로 변환한다. 그리고 두 번째 절차에서는 수정 객체와 동적 모델을 정형 요구명세로 변환한다. 세 번째로서 정형 요구명세는 소프트웨어 시스템의 정적인 구조와 전체 시스템에 대한 동적인 면을 포함하는 확장 정보 트리로 변환한다. 마지막으로, 객체지향 요구 명세의 동적인 행위는 확장 정보 트리를 사용하여 검증한다. 본 연구에서 제안된 확장 정보 트리는 그래픽 표기법으로서 객체 지향 요구명세의 정적인 구조와 동적인 행위를 표현할 수 있다. 그 트리는 객체지향 요구명세로부터 체계적으로 구축될 수 있고 동적 행위의 검증에 사용되어진다. The verification of requirements specification is an important step to ensure that the analysis is performed correctly. Especially, the dynamic behavior of the software system under development must be verified before the design phase. In the thesis, an approach to verifying the dynamic behavior in object oriented requirements specification is proposed. In our approach, first, object and dynamic models are transformed into a formal specification via modified object and dynamic models, second, the formal specification is transformed into the extended information tree representation, which includes dynamic aspects of the overall system. Finally, the dynamic behavior is to verify against the model developed in the object requirements specification using extended information tree. The proposed extended information tree is a graphical representation that can represent the static structure and dynamic behavior in object oriented requirements specification. The tree can be systematically constructed from object oriented requirements specification and used to verify the dynamic behavior.

상악확장술 치료효과의 메타분석 : 견치간 폭경과 대구치간 폭경 확장의 비교 및 급속과 완속 확장의 비교 comparison of intercanine/intermolar expansion and rapid/slow expansion

고창희,임성훈,윤영주,김광원 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.1

본 연구의 목적은 다수의 연구들로부터 추출한 각각의 결과를 체계적이고 객관적인 방법으로 병합, 개관하는 통계분석법인 메타분석을 이용하여 상악확장술에서의 견치간 폭경과 대구치간 폭경의 확장 및 급속과 완속 확장에서의 확장량과 재발량을 비교하는 것이었다. 메드라인 검색을 통해 1979년부터 2000년까지의 문헌들 중 사람을 대상으로 상악확장술의 효과에 관해 조사한 문헌 388개를 찾은 후 논문 선택 및 제외 범주에 따라 최종적으로 7개의 문헌을선정하여 메타분석을 시행하여 다음과 같은 결과를 얻었다. 1. 상악확장술에 의한 상악 제 1대구치간 폭경은 평균 6.0mm의 확장되었으며, 보정 후 측정에서 평균4.8mm가 유지되어 평균 20.0%(1.2mm)의 재발경향을 보였다. 2. 상악 견치간 폭경은 제 1대구치간 폭경의 확장보다 2.3mm적은 평균 3.7mm 확장되었으며, 보정 후 측정에서 평균 2.6mm가 유지되어 평균 29.7%(1.1mm)의 재발경향을 보였다. 3. 급속 상악확장술과 완속 상악확장술의 치료효과의 차이는 확장량과 보정 후 재발량 및 유지량에서 6% 미만(0.1-0.3mm)이었다. 그러나 상악 견치간 및 제1대구치간 폭경 변화에 있어서 두 방법 간에 골격성 및 치성 확장량의 비율에서 차이가 있을 수 있다. As a research method that weighs and combines evidence, meta analysis produces evidence that is more powerful than the original studies. The purpose of this study was to compare the intercanine/intermolar expansion and rapid/slow expansion in the maxillary expansion treatment using meta analysis. Medline was searched from 1979 to 2000 for all studies examining the stability of transverse expansion of the human maxilla, and 388 articles were found. Then these articles were reduced to 7 based on the defined inclusion and exclusion criteria, and a cumulative Meta evaluation score was computed for each study. The results were as follows; 1. The mean expansion in intermolar width was 6.0mm. Of the 6.0mm, 4.8mm was retained and 20.0%(1.2mm) was relapsed while wearing retainers. 2. In intercanines width, the mean expansion was 3.7mm. Of the 3.7mm, 2.6mm was retained and 29.7%(1.1mm) was relapsed while wearing retainers. 3. The differences in the amount of expansion and relapse between rapid expansion group and slow expansion group were less than 6%(0.1-0.3mm). But, there might be differences in the skeletal/dental exapnsion ratios according to the expansion method.

대퇴 전자간 골절에서 금속정 고정술 시행결과 : 감미정과 근위 대퇴정의 비교 Comparision Gamma Nail and proximal Femoral Nail

고상봉,조명래,김태훈,장일웅 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적: 대퇴 전자간 골절 환자에서 감마정과 근위 대퇴정으로 내고정을 시행하고 방사선학적, 임상적 결과 및 합병증을 비교하여 각각의 장단점을 분석하고자 하였다. 대상 및 방법: 1999년 1월부터 2002년 2월까지 대퇴 전자간 골절로 감마정과 근위 대퇴정을 이용하여 고정한 환자 중 방사선학적 및 임상적으로 6개월 이상 추시가 가능하였던 63예를 대상으로 하였으며 감마정군이 31예, 근위 대퇴정군이 32예이었다. 연령, 골절의 형태와 안정성에 따른 분류, 동반 질환, 골다공증의 정도, 환자의 활동 능력 등이 양 군에서 차이가 없었다. 평가방법으로는 두 군 사이의 수술시간, 출혈량, 안정정복 획득의 감입 정도 등을 비교하였다. 결과: 수술시간은 감마정군은 평균 103±40분, 근위 대퇴정군에서 101±28분으로 통계적인의미는 없었으며 (p=0.801), 수술 중 출혈량은 근위 대퇴정군에서 적은 경향을 보였으나 통계적인 의미는 없었다(p=0.601). 술 후 골절의 안정성 획득 여부는 감마정군 30%, 근위 대퇴정군 31%에서 안정 정복을 얻어 사용기구에 따른 고정의 안정성 획득에는 유의한 차이가 없었으며(p=0.934), 술 후 내반 고정의 빈도와 골절부위의 1.28단계의 보행능력 감소를, 근위 대퇴정군에서 평균 0.86단계의 보행능력 감소를 보여 역시 통계적으로 의미있는 차이는 없었다(p=0.383). 결론: 대퇴 전자간 골절치료에 있어서 임상적 및 방사선학적인 결과에서는 의미있는 차이는 없었으나, 근위 대퇴 골수정이 수술시간, 출혈량 등의 수술 수기의 측면에서 조금 더 우수한 경향을 보였다. Purpose: To evaluate the clinical and radiologic results of the fracture using the Proximal Femoral Nail(PFN) or Gamma nail in patient with the intertrochanteric fracture. Materials and Methods: From January 1999 to February 2002, we reviewed 63 patients of intertrochanteric fractures including 31 patients managed with Gamma nail and 32 patients with PFN. In variate analysis of age, the pattern and stability of fracture, bone density(Singh index), preoperative patient activity, there was no difference between two groups. We evaluated the operation time, blood loss, stable reduction rate and varus reduction rate as operation-related factors, and radiologically investigated union, time, the frequency of delayed union and nonunion, failure of fixation, status of the fracture line and complications. Functional results were evaluated by the possibility of early ambulation, ambulation ability at last follow up, and the pre and postoperative difference of ambulatory ability. Results: Mean operation time was 103±40 minutes in Gamma nail group 101±28 minutes in PFN group. It was not statistically significant(p=0.801). Even though intraoperative blood loss was less in PFN group, it was significant(p=0.601). Postoperative stable reduction rate was 31% in Gamma nail group and 30% in PFN group(p=0.934), suggesting not significant. Postoperative varus reduction and impacted amount of the fracture ling was not significant. Delayed union developed in one case of Gamma nail group and 2 cases of PFN group. Mean loss of ambulation ability was 1.28 grade in Gamma nail group and 0.86 grade in PFN(p=0.383). Statistical analysis was performed with the use of Student T test and Chi-square test. Analyses resulting in a p value of <0.05 were considered to show significance. Conclusion: Generally, the radiologic and clinical results of intertrochanteric fractures were comparable for the PFN group and Gamma nail group. Even though it was not statistically significant, PFN group had superior results in operation time blood than Gamma nail group for the fixation of the patients with interchanteric fracture.

열환경인공기후실의 설계

고경태,정성일,황병렬,박종일,김경훈 경희대학교 자연과학종합연구원 1997 자연과학논문집 Vol.3 No.-

The purpose of this study is the design of the climate chamber. Experiments was performed in a climate chamber that was running Under Floor Air-Conditioning System (UFAC). The chamber has a diffuser in the middle of the floor, and exhausts on the ceiling, simulating underfloor air conditioning system.

The Comparision of Outcomes Between Lateral Rectus Muscles Re‐recession and Medial Rectus Muscles Resection in Recurrent Exotropia

Ko‐,i Chun,Sang‐,hoon Rah 대한안과학회 2008 Korean Journal of Ophthalmology Vol.22 No.2

Purpose: To compare the surgical outcomes between bilateral lateral rectus muscles (BLR) re‐recession and bilateral medial rectus muscles (BMR) resection in recurrent exotropia. Methods: The medical records of patients with recurrent exotropia who underwent surgery for intermittent exotropia during the 6 years from January 2001 to December 2006 and followed up for more than 6 months were reviewed retrospectively. Results: In group A, BLR recessions was performed at the first surgery and BLR re‐recession was performed at the second surgery. In group B, BLR recession was performed at the first surgery and BMR resection at the second surgery. Success rates at the last follow‐up after the second operation were 81.9% in Group A and 83.3% in Group B, showing no statical difference between the two groups. In group A, no significant underaction of the BLR was noted. Success rates were not statistically different between the 2 mm rerecessed subgroup and 3 mm re‐recessed subgroup. Conclusions: The results support the notion that BLR re‐recession successfully corrects recurrent exotropia without producing significant limitation of abduction. Korean Journal of Ophthalmology 22(2):111-114, 2008

9,10-Dimethyl-1,2-Benzanthrance 투여 후 백서 뇌하수체 Prolactin 분비세포의 변화

이상훈,박철근,고경혁 慶尙大學校 1990 論文集 Vol.29 No.2

An immunohistochemical study on the prolactin cells was carried out to investigate the change of number of prolactin-secreting cells in 9,10-dimethy1-1,2-benzanthracene (DMBA)-treated rats. Female Sprague-Dawley rats were givenDMBA suspended in sesame oil by gastric intubation using oral zonde needle. At 70 days of age, each animal received a single feeding of DMBA(12mg/100 gm body weight). Five rats bearing DABA-induced mammary carcinoma and ten rats not bearing mammary carcinoma after DMBA adminstration were used as experimental group. Nine rats were given sesame oil at 70 days of age, and were used as control group. Representative transverse sections of the pituitary gland from each rat were immunostained with rabbit anti-rat prolactin by Avidin-Biotin-Peroxidase Complex(ABC) method. Following results were obtained : 1. Prolactin-secreting cells were more frequently observed in the peripheral region than in the central region of adenohypophysis, in both DMBA-treated and untreated rats. 2. The number of prolactin-secreting cells of DMBA-treated rat bearing mammary carcinomas was significantly greater than that of DMBA-treated rats not bearing mammary carcinoma. 3. The number of prolactin-secreting cells of DMBA-treated rats was significantly greater than that of untreated rats. Based on the findings above, it is assumed that mammary carcinoma of DMBA-treated rats is induced by increase of prolactin-secreting cells in pituitary gland.