한방 이화주의 미백 및 피부 주름 개선 효과

이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4

본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

유해화학물질 운송 파이프의 안정성 진단 센서 개발을 위한 기초연구

신상희(Shin, Sang_Hee) 대한토목학회 2019 대한토목학회 학술대회 Vol.2019 No.10

이온화에너지 처리 아이스크림 및 우유의 단회투여 독성시험

이희준,최현종,한선경,구본철,신명수,함준상,조철훈,이완규 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

Periotron을 이용한 소아 치은 상태의 평가

신정근,백병주,김재곤,양연미,김성희 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3

急性中毒肝의 組織學的 및 組織化學的 變化와 肝機能檢査에 關한 硏究

申誠姬,崔三任,金象皓 (사)한국여자의사회 1983 한국여자의사회지 Vol.8 No.1

문자 교육에 대한 유치원과 초등학교 교사의 인식 조사

신동로,고재희,홍성근 全北大學校 敎育大學院 1997 敎育論叢 Vol.17 No.-

The purpose of the study was to investigate the perceptions of teachers in preschools and primary schools, in order to research the sequence of literacy curriculum. The results of study were as follows : ⑴ there was a lot of gap of teachers' perceptions between private and public preschools, as well as primary schools. ⑵ most of primary teachers recognized young children's literacy lower than preschool teachers, and ⑶ most of primary teachers, as well as preschool teachers, wanted to adapt formal instruction of literacy in preschools, although they responsed the negative effect of that method. The conclusions of study were as follows : ⑴ literacy curriculum in preschool is reviewed to prescripe the level explicitly, ⑵ preschool education is taken the resposibility on Nation Insitute, in order to reduce the gap of level between private and public preschools, and ⑶ in order to reduce the gap of the perception of teachers between preschool's and primary school's curriculum, it is reformed that the teacher's qualification of the first grade in primary school intergrates that of preschool and inservice education need to be taken together.

메타 전자 쇼핑몰의 설계 및 구현

신민화,김승희,배상현,김판구 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.1

최근 전자상거래의 상업성이 부각되면서 많은 기업들과 개인사업자들이 독자적인 웹서버를 구축하고 자사의 상품 또는 기업에 대한 광고 내용을 인터넷을 통해 서비스를 하고 있다. 그러나 소비자들에게 인지도가 낮은 기업이나 전국의 각 지방의 특산품과 토산품 관련 웹사이트들은 소비자에게 홍보가 부족하고, 상품의 종류와 정보의 부족으로 외면을 당하고 있는 것을 많이 본다. 본 논문에서는 이러한 기업들의 카탈로그를 수집하여 재구성한 후, 한 사이트에서 여러 기업의 상품을 검색할 수 있도록 하여 소비자의 접근과, 각 기업의 상거래 사이트를 활성화 할 수 있는 메타 전자 쇼핑몰 개발에 관해 기술한다. 본 시스템의 특징은 로봇이 자동으로 데이터 베이스를 구축하여 소비자가 쉽게 검색 할 수 있도록 주제어 검색과 디렉토리 검색 및 폴더형맵 검색 인터페이스 구성을 가지고 있다는 점이다.

일개지역 저소득층 주민과 일반주민의 우울에 관한 연구

신성희,김정숙 동신대학교 2005 論文集 Vol.15 No.-

Purpose: This research is a descriptive comparative study to compare and analyze the depression-degree of low-income group citizens and middle-class citizens and to investigate the affecting factors to the depression to establish fundamental data in propulsion of regional mental-health care project. Method: The subjects of total 388 were selected from 203 low-incomers of dense rental apartments and 185 middle-class citizens of general apartments in J-gu, Seoul from Sept. to Nov. 2003. The measurement was used by Beck Depression Measurement Tool and the data were analyzed with SPSS program. Conclusion: The study confirmed that the low-income group citizens has more moderate and severe depression than the middle-class citizens. Also education, family income, one-parent family, religion among social and demographic characteristics are affective factors to the depression.

중학교 남녀학생별 가정교과에 대한 인식 및 학습효과 : 경남지역을 중심으로

신동순,김상희,오화자,정효숙,정혜경 한국 가정과 교육 학회 1997 한국가정과교육학회지 Vol.9 No.1

The aims of this research study is to clear the differences of the learning effects and the cognition of Home Economics by sex in the middle school and to collect the future-oriented educational datas, after implementing the 6th education curriculum. The results of the study are as follows ; 1. Most of students had the cognition that Home Economics is a subject matter of a needful knowledge and skill for the family life, half students a cultural subject matter for the modern life. The former was supported by female students, the latter by male students. 2. Most of students were interested in actual training fields of cooking and hand-sewing, had a strong interest about a field of physical and social-psychological growth. The differences by sex were statistically significant in these fields. 3. Most of students had positive responses in the learning effects of Home Economics. The most useful field was cooking and the worst was the structure and method of sewing machine. 4. The shortage and the dissatisfaction in the learning of Home Economics were lacking of the actual training hours, the old-fashioned teaching methods and the shortage of teaching materials etc.

근관감염균에 대한 polyphosphate의 항균효과

신정희,박상진,최기운 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.6

This study was performed to observe the antibacterial effect of polyphosphate (polyP) with various chain lengths (P3~P75) on virulent. invasive strains of P. gingivalis A7A1 28 and W50, and multidrug resistant E. faecalis ATCC29212. P. gingivalis strains were grown in brain heart infusion broth (BHI) containing hemin and vitamin K with or without polyP. PolyP was added at the very beginning of the culture or during the exponential growth phase of the culture. Inhibition of the growth of P. gingivalis was determined by measuring the absorbancy at 540nm of the grown cells. Viable cell counts of the culture and release of intracellular nucleotide from P. gingivalis were measured. E. faecalis was grown in plain BHI with antibiotics alone or in combination with polyP(calgon: 0.1-1.0%) and the bacterial absorbancy was measured. The overall results suggest that polyP has a strong antibacterial effect on the growth of the virulent strains of P. gingivalis and the antibacterial activity of polyP seems largely bactericidal. accompanying bacteriolysis in which chelation phenomenon is not involved. Although polyP does not exert antibacterial activity against E. faecalis, it appears to increase antibacterial effect of erythromycin and tetracycline on the bacterium. Therefore, polyP alone or in combination with antibiotics may be developed as a candidate for the agent controlling oral infections including endodontic infection.