환자의 비강으로부터 분리된 메티실린 내성 황색 포도알균의 분자 아형 분석

Sang-Ha Kim,Sung-Bae Park,Heechul Park,Jun Seong Kim,Jungho Kim,Jiyoung Lee,임재원,Young Kwon Kim,Sunghyun Kim 대한임상검사과학회 2020 대한임상검사과학회지(KJCLS) Vol.52 No.2

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that causes infections in different parts of the body and causes skin and soft tissue infections (SSTI). The present study examined the antimicrobial resistance patterns and molecular epidemiological characteristics of MRSA isolated from nasal swabs in clinical patients. SCCmec type of MRSA isolates from clinical patients were analyzed: 24 cases were SCCmec type-II; two cases were type-II/IVa; one case was type-II/V; one case was type-IVa; 11 cases were not-typeable. The mec complex type of MRSA isolates from clinical patients were analyzed: 29 cases were mec complex type A, and 10 cases were not-typeable, but type B was not found in the present study. In conclusion, SCCmec type-II and mec complex type A were the most dominant MRSA subtypes among the MRSA isolates from a nasal swab of patients, and the results were similar to other studies on hospital-acquired MRSA (HA-MRSA). These results can not only provide basic data for hospital infection management but also be a good guideline for MRSA infections in the Republic of Korea. 본 연구에서는 환자의 비강으로부터 분리 배양된 총 39건의 MRSA 분리 배양 균주를 이용해 mecA 유전자 검출, SCCmec typing과 mec complex typing을 분석해 보고자 하였다. 임상 환자의 비강으로부터 분리 배양된 MRSA 총 39주 중 SCCmec type-II가 24건, type-II/IVa가 2건, type-II/V가 1건, type-IVa가 1건, not-typeable이 11건으로 분석되었으며, mec complex type A가 29건, not-typeable이 10건이었으며, type B는 없는 것으로 분석 되었다. 결론적으로, 환자의 비강으로부터 분리된 MRSA 분리 배양 균주 중 SCCmec type-II와 mec complex type A 아형이 가장 많이 분포하고 있었으며, 이 결과는 의료기관 획득 MRSA에 관한 다른 연구결과와 유사한 결과를 나타냈다. 이후 환자의 비강으로부터 분리 배양된 not-typeable 아형의 MRSA 균주를 대상으로 국내에서 발견되는 새로운 MRSA 아형 규명에 관한 추가 연구가 필요할 뿐만 아니라, MRSA 분리 배양 균주의 아형을 분석함으로써 그 분자적 특성을 분석한 결과를 바탕으로 병원 감염관리를 위한 기초자료를 제공할 수 것으로 사료된다.

담도에 국한되어 증상을 유발한 석회쓸개즙 2 예

윤성우,이지영,하경호,이수경,한나,배효근,박선자 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Limy bile is a rare condition characterized by excessive precipitation of calcium carbonate in the gallbladder or bile duct. Recently we experienced two cases with obstructive jaundice in which limy bile in the common bile duct but not in the gallbladder for one case, and in the common bile duct and intra hepatic duct but not in the gallbladder for another case. The patients were treated by endoscopic sphincterotomy. Here, we report the cases and review the literature.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

사람 M21 유전자 과발현 형질전환생쥐에서의 심근비후증

배성원,이원하,김철홍,박행기,이상철,고영혜,박승우,Takuro Arimura,Akinori Kimura,박정의 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

대용량 온라인 게임 서버 설계 및 구현

배성우,오하령 국민대학교 생산기술연구소 2003 공학기술논문집 Vol.26 No.-

In this paper, a distributed game server system architecture for massively multiplayer online games is designed and implemented. For load distribution, the entire game region is partitioned into a set of smaller regions. Then each partitioned region is implemented by a game process. A connection server is a bridge between game clients and servers. Communication loads can be distributed by use of connection servers. The proposed system is implemented on a FreeBSD environment.

베트남 하이퐁항의 투자방안

하명신,장병기,배상욱 한국물류학회 2005 물류학회지 Vol.15 No.1

베트남은 동남아시아 국가들중 가장 경제성장가능성이 높은 국가 중의 하나이다. 본 연구는 베트남의 항만들중 하이퐁항을 선택하여 재무분석 및 그에 근거한 진출전략을 제시하고자 하였다. 재무분석의 결과 기본조건하에서는 재무적 타당성이 있는 것으로 식별되었으며, 민감도 분석에서도 투자타당성은 유지되는 것으로 나타났다. 즉, 건설비의 20% 증가시 처리실적이 30%이상 감소하지 않거나, 건설비의 40%증가시 처리실적이 20%이상 감소하지 않고, 심지어 건설비의 60%증가시 처리실적이 10%이상 감소하지 않는다면 여전히 투자타당성은 유지되는 것으로 식별되었다. 그러나 베트남은 사회주의 국가들 중의 하나이므로 하이퐁항의 투자시 전략적 접근이 필요한 상황이다. 주요사항은 베트남 정부와의 장기적 우호관계 유지, 유력한 현지 파트너의 선정, 철저한 계약관계 형성, 이종문화에 대한 이해 등을 들 수 있다. Vietnam is one of the most economically promising countries in Southeast Asia. This study aims at suggesting the entry strategies for the Vietnamese port development on the basis of the financial analysis. For the purpose of the study, first, the Vietnamese port industry is briefly introduced and the best port to invest is revealed. Second, the financial analysis is conducted on Hai Phong, selected as the best port for investment. Positive results are found in the basic conditions for the port development. Its results also indicate that the financial validity will be maintained when the construction cost increases up to 60 percent and that the financial validity will still be maintained when the construction cost increases up to 100 percent provided that containerised cargoes increase by about 20 percent. This study also suggests strategies for future development and significant issues for investors. It is supposed that the actual investment in the Hai Phong port development will be fairly acceptable in terms of the rapidly developing Vietnamese economy and the significantly increasing economic exchange between Korea and Vietnam.

치골결합의 외상성 분리에 대한 치료

하상호,유재원,이상홍,신동민,표영배,안병관 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2

The separation of symphysis pubis as a result of injury is uncommon, but it is increasing in number in parallel with today's speedy development of car industry. Most cases of the separation of symphysis pubis are amenable to closed treatments, but unstble separation where the reduction is difficult to maintain may require open techniques. Authors analyzed 27 cases of traumatic separation of symphysis pubis with 16 months follow-up on an average, who had been treated at the Orthopaedic Department, Chosun University Hospital. The results obtained were as follows; 1. The most common cause was traffic accident (81.5%). 2. Among of 27 patients, instability on the posterior stabilizer of pelvic bone was noticed in 18 patients. 3. Fifteen patients were treated with closed methods(bed rest, hammock, traction)and twelves were treated by the open reduction and internal fixation. 4. Internal fixations were carried out with plate and screw(5 cases), screw and wiring(4 cases), and wiring (3 cases). 5. The separation of symphysis pubis with minimal disruption of posterior stabilizer were treated by closed treatment or internal fixation of the separation of symphysis pubis diastasis alone, and its result was good or excellent. 6. We think that the symphysis pubis diastasis with severe disruption of posterior stabilizer should be fixed anteriorly and posteriorly both.

전기집진 장치내의 대전체 극성구조 형태에 따른 집진손실량과 에너지 관계 연구

하상안,박진식,김일배,김장호,장부규,서정민 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.2

This stduy carried out to investigate the precipitating loss amount und energy by structural polarity of electrostatic precipitator at the different conditions of precipitatation time, high voltage and gas speed. As part of this wark was the dependence of the amount in the collector zone of a one- and two stage set up feld by precipitating time and gas speed. This advanced Model1 is developed by Research of the different parameter as the conventionnal study of modell. In order to investigate Opeartion efficiency of electrostatic precipitator, the amount of knocking losss was measured with concentration-Measuring of Monitik-treubung.

Cathelin-related antimicrobial peptide (CRAMP)의 화학합성 및 구조- 항생물활성

하종명,이상현,하배진 신라대학교 자연과학연구소 1998 自然科學論文集 Vol.5 No.-

CRAMP, a cathelin-related antimicrobial peptide was identified from cDNA sequence derived from mouse bone marrow cells. In this study, in order to investigate the structure-antibiotic function relationships of CRAMP, the mature CRAMP was synthesized by solid phase method using Fmoc-chemistry. CRAMP showed more potent antimicrobial activity against gram-positive bacteria than gram-negative bacteria. Minimum inhibitory concentrations of CRAMP against Bacillus subtilis and Escherichia coli were 3.125-6.25μM and 50μM, respectively. CRAMP displayed a powerful antitumor activity against human small cell lung cancer cell lines (50% growth inhibitory concentration : 13 μM). However, CRAMP did not show hemolytic activity against human erythrocytes at peptide concentration of 50 μM. CD spectra analysis showed that CRAMP will form an amphipathic α-helical structure similar to other antimicrobial peptides such as cecropins, melittin and magainins.

경골 분절 골절의 골수강내 금속정을 이용한 수술적 치료

하상호,유재원,이상홍,신동민,표영배,허민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The Fracture of the tibia is the most common on fracture of the long bone and has high complication rates due to it's anatomical property. Segmental fractures are characterized by two or more fractures on different levels of the shaft with an intermediate segment. In addition to general characteristics of tibial fracture, segmental fractures are commonly combined with extensive soft tissue injury comminution and displacement with poor blood supply in it's intermediate segment. Recently, closed intramedullary nailing under the image intensifier has been widely used and its good results have been reported. The purpose of this study is to compart the bony union, functional result and complication between Ender nail and interlocking nail which we treated with intramedullary nailing in 20 segmental tibial fractures of 19 patients from 1990 to 1991. Minimum follow up period was 12 months. The results were as follows : 1. The most common type of fractures was Melis type Ⅰ. 2. All fractures were united and average union time was 24.9 weeks. 3. The major complications were delayed union (6 cases) joint stiffness (6 cases), superficial infection (3 cases), and angular deformity (2 cases). The complication rate in Ender nail was higher than Interlocking nail. 4. According to the criteria of functional results by Klemm and Borner. we obtained a 87.5% of excellent and good resulted in Ender nailing group and 91.7% of excellent and good results in Interlocking nail group.