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P082 : Use of ustekinumab for treatment of moderate to severe psoriasis in Korea
( Sung Min Park ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Ustekinumab, a fully human monoclonal immunoglobulin antibody that targets the interleukin (IL)-12 and IL-23 shared P40 subunit, has emerged as a promising treatment for moderate to severe psoriasis. However, to date, there are no ‘real-world’ data on ustekinumab in Korean patients with psoriasis. Objectives: To assess the clinical efficacy and safety of ustekinumab in Korean patients with psoriasis. Methods: Retrospective data was gathered during the follow-up of 31 consecutive psoriasis patients treated with ustekinumab for minimum of 16 weeks at single referral centre. Patients’ age, gender, Psoriasis Area Severity Index (PASI) score, physicians’ global assessment (PGA), concomitant therapies, and adverse events were reviewed. Results: Thirty-one patients (median age 42.7) had been treated with ustekinumab. Twenty-three of 31 patients (74.2%) had obtained near complete clearance (PASI 90) upon the final follow-up visit, and PASI90 was achieved after an average of 2 administration of ustekinumab. Concomitant systemic treatments, primarily methotrexate, were given to 7 (22.5%) patients. Three patients (9.7%) discontinued treatment, primarily for sub-optimal response or loss of response. No unexpected adverse events other than herpes zoster and elevated liver enzyme were observed. Conclusion: Ustekinumab can be of benefit in the treatment of Korean psoriasis patients, as it was associated with a rapid and satisfactory response and was well tolerated.
P412 : Giant chondroid syringoma appearing as Large protruding telangiectatic tumor on nose
( Sung Min Park ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Je Ho Mun ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
P273 : Tuberous sclerosis presented only with connective tissue nevi: usefulness of genetic testing
( Sung Min Park ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Magaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bun Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Ko, Young Gun,Shin, Seung Su,Choi, Ung Su,Park, Yong Sung,Woo, Je Wan American Chemical Society 2011 ACS APPLIED MATERIALS & INTERFACES Vol.3 No.4
<P>Herein, the effect of the degree of deacetylation (DD) on the gelation of the chitosan dispersed suspension as an electrorheological (ER) fluid under an electric field is presented. The fluids were prepared by dispersing the chitin and the chitosan particles having various DDs into silicone oil, and they were evaluated under various electric fields. The alignment of chitosan particles in the fluid was also observed using an optical microscope under the electric field. The formed fibrous structure between electrodes are though to continue to the viscosity increase, because an attempt to move one electrode relative to the order would be hindered by the drag of the dangling fibrils. A noteworthy result is that the region of the frequency for gel state of the ER fluids increased in the order of chitosan DD 99.3, 93.4, 73.2, 83.8, and 87.3% under electric fields while the modulus of the fluids increased in the reverse order. This order was well-matched with the result of dielectric constants and yield stresses of ER fluids. The study of influence of DD on the gelation of the chitosan dispersed suspension under an electric field shows the relevance of the chemical composition of the heteropolysaccharide (chitin−chitosan copolymer) to the rheological and electric properties of ER suspensions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2011/aamick.2011.3.issue-4/am200091r/production/images/medium/am-2011-00091r_0011.gif'></P>
Inexplicable but real phenomenon: rapidly regressed
( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Kaposi’s sarcoma (KS) is a type of spindle cell malignancy that arises from the vascular endothelium, usually presenting as violaceous papules and plaques. KS development is invariably linked with human herpesvirus (HHV)-8 infection. Almost spontaneous regressions of KS have been previously described in the iatrogenic type. Herein, we present a classic KS in immunocompetent patient showing rapid regression after biopsy. A 78-year-old male presented with relatively well-defined erythematous patches on forehead, Rt. upper eyelid and chin, and violaceous papule on nose. His medical and family histories were noncontributory. The patient denied history of recent overseas travel, homosexual or unnatural sexual practices, and serum anti-HIV antibody was negative. A histopathologic examination from the nose revealed typical findings of KS and tumor cells showed positive staining for CD31, CD34, and factor VIII-related antigen. Polymerase chain reaction in a biopsy specimen was positive for HHV-8. Without specific treatment, the lesion rapidly regressed within 2 weeks. It is generally accepted that immune status plays an important role for KS. As viral wart disappear after biopsy occasionally, it is possible that the biopsy may have then exposed antigens and induced an immunologic reaction, which led to the rapid regression of KS.
Spontaneous intracerebral hemorrhage in a patient with severe psoriasis vulgaris
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Psoriasis is chronic immune-mediated inflammatory skin disorder of unknown etiology. Psoriasis was previously believed to affect only the skin, and in some patients, the joints. Recent evidence suggests that chronic psoriasis may lead to other comorbidities such as cardiovascular disease, obesity, and type 2 diabetes mellitus. However, the association between psoriasis and intracerebral hemorrhage (ICH) has rarely been reported. The patient was 43-years-old female with a history of severe chronic psoriasis vulgaris for 6 years refractory to conventional immunomodulatory treatments and phototherapy. She was unregularly followed-up and 2 month ago, she was treated with cyclosporine (2.5mg/kg), but the disease aggravated. Four days ago, abruptly, she started to notice weakness of right lower extremity and dysarthria. She denied any history of trauma. On magnetic resonance imaging study, bilateral ICH in basal ganglia was observed. She did not have any risk factors such as trauma, advanced age, and hypertension for ICH. Therefore, we suspected that severe chronic psoriasis vulgaris may have played an important role in occurrence of spontaneous ICH.