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劉善美,林起龍,嚴基鎭,文永熙 조선대학교 약학연구소 1993 藥學硏究誌 Vol.15 No.1
This study was attempted to examine the effect of Sopung-Tang extract(STE) on anti-inflammatory action in rats, analqesic action and the acute, subacute toxicity in mice. In anti-inflammatory activity in rats, STE was shown to have significant preventive effect in the edema induced by Freund's conplete adjuvant and 5% acetic acid. In analgesic activity in mice, STE was shown to have significant analgesic action on the writhing syndrome in mice induced by 0.7% acetic acid. In acute toxicity test in mice, STE showed 10% mortality at 2000㎎/㎏ . and 1200㎎/㎏ i.p. In subacute toxicity test in mice, STE was not showed for 19 days. Serum uric acid in treated by adjuvant method rats were slightly decreaced by comparing with the control group. During the administration of extracts the body weight increased, but the liver and spleen weight was not changed.
Ji-Young Um(Ji-Young Um),Hye-Yeon Park(Hye-Yeon Park),Sun-Young Yoon(Sun-Young Yoon) The International Academy of Global Business and T 2023 The International Academy of Global Business and T Vol.19 No.1
Purpose - COVID-19 has dramatically changed the business landscape, and the travel industry is no exception. The industry is undergoing a paradigm shift to the platform business, and traditional travel agencies are moving their businesses to online platforms. However, in this irreversible global paradigm shift, it is not easy for travel companies to hire and retain employees, especially companies in the IT sector. Studies typically study consumers, such as selection attributes and satisfaction with travel platforms. However, to the best of our knowledge, there have been almost no studies on employees. This study explored how the empowerment of online travel platform employees influences their perceived person-environment (P-E) fit and work engagement. Design/Methodology/Approach - We analyzed data from 352 employees of 26 domestic online travel platforms who were surveyed in January and February 2021. After coding the collected data, we analyzed it using frequency, exploratory factor, reliability, correlation, and multiple regression analyses using IBM SPSS Statistics, ver. 20.0. Findings - First, enhancing the meaningfulness of work and organizational autonomy influences personjob (P-J) fit and person-organization (P-O) fit. Second, enhancing the meaningfulness of work significantly influences vigor, dedication, and absorption in terms of work engagement, while organizational autonomy significantly influences work engagement vigor. Third, P-J fit and P-O fit influence the vigor of work engagement, and P-O fit influences dedication and absorption. Research Implications - This study demonstrated that the empowerment of travel platform employees can improve perceived P-E fit and work engagement. Thus, if organizations guarantee some degree of empowerment, employees will be energized and engaged more in their workplace. Finally, this helps expand the scope of online travel platform research from the perspective of personnel organization.
Clinical Aspect of Coronavirus Disease 2019 (COVID-19) on HBV Infected Patient
( Young Kul Jung ),( Gi Hyeon Seo ),( Tae Hyung Kim ),( Sun Young Yim ),( Young-sun Lee ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Soon Ho Um ) 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1
Young-Kug Choo, Jae-Sung Ryu, Malg-Um Lim, Mi-Ran Hwang, Hyun-Ki Min, Gislain Moussavou, Ji-Su Kim, Sun-Uk Kim, Kisung Ko, Young-Ho Cho, Sang-Yoon Nam, Kyu-Tae Chang 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.4
Flavonoids have a range of biological activities, including anti-allergic, anti-inflammatory, anti-microbial, and anti-cancer activities, as demonstrated by in vitro studies. In this study, we investigated whether luteolin can be applied to suppression of lipopolysaccharide (LPS)-stimulated inflammatory responses in murine macrophages. Luteolin was found to reduce nitric oxide (NO) production in LPS-stimulated Raw 264.7 cells. In addition, expression of inducible nitric oxide synthetase (iNOS), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokine tumor necrotic factor-α (TNF-α) at the mRNA and protein levels were decreased. These inhibitory effects were found to be caused by the blockade of nuclear factor kappa-light- chain-enhancer of activated B cells (NF-κB) activation and phosphorylation of mitogen-activated protein (MAP) kinase family, extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 MAP kinase. In addition, pre-treatment with luteolin resulted in reduced ganglioside expression levels and inhibited expression of GT1b in Raw 264.7 cells. On the basis of these observations, we suggest that luteolin has potential as an anti-inflammatory drug candidate, and ganglioside GT1b may play a role in the inflammatory process.
( Sun Young Yim ),( Tae Hyung Kim ),( Suh Sang Jun ),( Eun Sun Kim ),( Bora Keum ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Yoon Tae Jeen ),( Hoon Jai Chun ),( Hong Sik Lee ),( Soon Ho Um ),( Chang Duck 대한간학회 2017 Gut and Liver Vol.11 No.3
Background/Aims: We aimed to clarify the association of hepatitis B surface antigen (HBsAg)/hepatitis B core antigen (HBcAg) with the disease status and treatment response in patients with chronic hepatitis B (CHB). Methods: We investigated 171 biopsy-proven entecavir-treated CHB patients (109 hepatitis B e antigen [HBeAg]-positive, 62 HBeAg-negative). HBcAg expression was positive when ≥10% of hepatocytes stained, and classified into nuclear, mixed, and cytoplasmic patterns. HBsAg expressions were intracytoplasmic (diffuse, globular, and submembranous) and membranous. The histologic activity index (HAI) and fibrosis stage followed Ishak system. Results: In HBeAg-positive patients, older age, increased HAI score, advanced fibrosis, and reduced viral load were observed when HBcAg expression shifted from nucleus to cytoplasm in HBcAg-positive patients, and HBsAg expression from non-submembranous to submembranous in HBcAg-negative patients (all, p<0.05). In HBeAg-negative patients, only intracytoplasmic HBsAg expression patterns had clinical relevance with decreased ALT levels and viremia. In HBeAg-positive patients without favorable predictors of virologic response, negative HBcAg and membranous HBsAg expression predicted greater virologic response (both, p<0.05). The probability of HBeAg seroclearance was higher in patients with increased HAI or lacking HBcAg expression (both, p<0.05). Higher serum HBsAg levels and hepatocyte HBcAg positivity were associated with reduced serum HBsAg during first and post-first year treatment, respectively (both, p<0.05). Conclusions: Hepatocyte HBcAg/HBsAg expression is a good marker for disease status and predicting treatment response. (Gut Liver 2017;11:417-425)
( Young-sun Lee ),( Jeong-an Gim ),( Haein Bak ),( Sehwa Kim ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Soon Ho Um ),( Kwan Soo Byun ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Non-alcoholic steatohepatitis (NASH), as subtype of non-alcoholic fatty liver disease (NAFLD), is progressive disease that can result in advanced fibrosis and cirrhosis. The aim of this study was to evaluate diagnostic value using serum miRNA to For distinguish ing NASH from simple steatosis (SS). Methods: RNA extraction and small RNA sequencing were done using sera from 24 patients who were diagnosed with NAFLD by biopsy. miRNA expression levels were compared between 12 SS patients and 12 NASH patients. After selecting miRNAs showing significantly increased expression in NASH group comparing to SS group, diagnostic accuracies of each miRNA and a combination of miRNAs were analysed. For functional relationship between specific signalling pathway and miRNAs that were significantly elevated in sera of NASH patients compared to those in sera of SS patients, miEAA database was used. Results: A total of 2,588 mature miRNA reads were obtained from miRDeep2 Quantifier module. Expression levels of 26 miRNAs were significantly increased in NASH group than in SS group, whereas those of 12 miRNAs were significantly decreased in NASH group than in SS group. Among 38 significant miRNAs, eight miRNAs that showed high expression within the top 25% of all miRNAs were selected and compared. Only four miRNAs showed meaningful area under receiver operating characteristic (AUROC) values for NASH diagnosis (P<0.05). When AUROC values for diagnosis of NASH were compared between a combination of 8 miRNAs (AUROC: 0.924; 95% CI: 0.739-0.992) and a combination of 4 miRNAs (AUROC: 0.875; 95% CI: 0.676-0.973), there was no significant difference (P=0.26). Among 26 miRNAs that showed significantly increased expression in NASH group, 10 miRNAs were included in 17 miRNA group, such as adipocytokine signalling pathway and thyroid hormone signalling pathway (Figure). Conclusions: Combination of serum circulating miRNAs could be used as novel biomarker for diagnosis of NASH. The expression of circulating miRNAs is correlated with specific signalling pathway.
Caveolin-1 Promotes Hepatocarcinogenesis in Cirrhotic Liver
( Sun Young Yim ),( Ji-hyun Shin ),( Yun Seong Jeong ),( Sang-hee Kang ),( Young Nyun Park ),( Yeon Seok Seo ),( Soon Ho Um ),( Ju- Seog Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Liver cirrhosis is a soil for the development of hepatocellular carcinoma (HCC) and prevention of HCC is urgent. However, biomarkers to predict development of HCC from liver cirrhosis are still lacking. We aimed to discover a biomarker directly from protein analysis and relate it with genomics to validate in a larger cohort. Methods: Forty six patients who had surgical resection for HCC that developed from cirrhotic liver and developed HCC recurrence 3 years after resection were enrolled. HCC that recur less than 3 years was considered as intrahepatic metastasis while those that recur 3 years later was defined as de novo recurrence from liver cirrhosis. Systematic analysis was performed using reverse-phase protein array (RPPA) and microarray data acquired from these patients. Results: Proteomics analysis performed after selecting 20 proteins from 201 proteins with AUROC >70 in predicting late recurrence were able to categorize patients into high (n=20) and low risk (n=26) HCC groups. Caveolin-1 was the dominant protein for this categorization and 298 genes that significantly differed between these 2 groups were derived. This proteome derived late recurrence (PDLC) gene signature well predicted the development of HCC in cohort 1 (n=216) with background of liver cirrhosis. The robustness of this signature was also validated in predicting de novo HCC recurrence in cohort 2 (n=259). PDLC gene signature remained significant in multivariate analysis when compared with clinical variables (HR 1.904, P=0.01) and showed the lowest AIC among previously reported gene signature (186-BROAD gene signature and hepatic injury and regeneration gene signature). in vitro experiment revealed that immortalized liver cell overexpressed with CAV1 showed significantly increased proliferation and soft agar colony formation than the control (P<0.001 and 0.033). Immunohistochemical staining of tissue microarray analysis also supported our findings with increased HCC development in CAV1 positive tissues (P=0.047). Conclusions: Expression of CAV1, a structural protein of caveolae in the plasma membrane appears to be an important predictor of HCC development from liver cirrhosis and our study has provided new insight in considering CAV1 as a biomarker and target for prevention strategy.