수술로 호전되지 않은 췌장 농양을 내시경 치료로 완치한 1 예

서희영;전태주;김선영;강미선;허란;박지영;서동대;오태훈 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Necrotizing pancreatitis develops in about 10-20% of patients with acute pancreatitis, and pancreatic abscesses develop in 3% of them. The mortality of pancreatic abscess has been reported up to 40% in one study. Recently, there are several reports that show good results with n on-surgical therapy, such as percutaneous drainage and endoscopic drainage, but if the non-surgical drainage fails, surgical therapy are recommended. However, there is no definite therapeutic method which is suggested yet so far after the failure of the surgical drainage. So we report the case in which we experienced successful treatment of pancreatic abscess by endoscopic removal of necrotic tissue through the gastrocystostomy, after the failure of the surgical debridement and internal drainage through gastrocystostomy.

일광 노출형 및 비일광 노출형 기저세포암에서의 GLI-1 발현에 대한 면역조직화학적 연구

서영주 ( Young Ju Seo ),김철우 ( Chul Woo Kim ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ),박혜림 ( Hye Rim Park ),김용선 ( Yong Sun Kim ) 대한피부과학회 2005 大韓皮膚科學會誌 Vol.43 No.2

Hepatocellular Carcinoma in the Elderly: Clinical Characteristics, Outcomes and Treatment Efficacy, Safety in Older than 75 Years

( Ji Ho Seo ),( Sunmin Kim ),( Eunae Cho ),( Chung Hwan Jun ),( Sun Young Park ),( Sung Bum Cho ),( Chang Hwan Park ),( Hyun Soo Kim ),( Sung Kyu Choi ),( Jong Sun Rew ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) has been increasing because the increase in the longevity of the general population. But there is no proper management based on age stratification in elderly patients. We compared clinical characteristics, outcomes and treatment efficacy, safety between oldest-old (aged more than 85 years), middle-old (aged between 80 and 85 years) and young-old (aged between 75 and 80 years) patients with HCC. Methods: We conducted a retrospective cohort study, from January 2010 to December 2016, at Chonnam National University Hospital. A total of 550 elderly patients whose data included demographics, co-morbidity, etiology of liver disease, presence of cirrhosis, staging of HCC, treatment modality and treatment related adverse event were evaluated retrospectively. Also overall survival was assessed in enrolled patient. Results: Fifty one patients (oldest-old; median 87 years old), 153 patients (middle-old; median 82 years old) and 346 patients (young-old; median 77 years old) were diagnosed with HCC. Both oldest- and middle-old patients, compared to young-old patients had significantly lower rate of alcohol-related disease (13.7% vs 20.9% vs 34.1%, P = 0.001). There were no significant difference in underlying sex, body mass index, presence of co-morbidity, hepatitis C-related disease and stage of HCC. The Child-Pugh class (CPT class A 88.9% vs 84.1% vs 83.6%, CPT class B 11.1% vs 15.9% vs 15.0% and CPT class C 0.0% vs 0.0% vs 1.3%, respectively, P = 0.912) and Model for End Stage Liver Disease score (mean MELD score 7.22±3.34 vs 5.88±3.01 vs 5.77±3.14, P = 0.166) were no significant difference between the patients with active treatment. The modified UICC staging (stage I 5.6% vs 17.1% vs 18.6%, stage II 55.6% vs 46.3% vs 47.3%, Stage III 22.2% vs 24.4% vs 24.8%, Stage IV-A 11.1% vs 6.1% vs 4.9% and Stage IV-B 5.6% vs 6.1% vs 4.4%, respectively, P = 0.826) and Barcelona Clinic Liver Cancer staging (stage 0 5.6% vs 9.8% vs 9.3%, stage A 16.7% vs 17.1% vs 22.1%, stage B 27.8% vs 29.3% vs 24.8%, stage C 50.0% vs 43.9% vs 41.2% and stage D 0.0% vs 0.0% vs 2.7%, respectively, P = 0.878) were no significant difference between the patients with active treatment. Furthermore, there were no difference between the age groups in treatment modality (Surgical resection 0.0% vs 3.3% vs 5.2%, P = 0.166; Radiofrequency ablation 2.0% vs 8.5% vs 11.0%, P=0.113; Transcatheter arterial chemoembolization 21.6% vs 34.6% vs 41.6%, P=0.014; Best supportive care 62.7% vs 40.5% vs 29.2%, P < 0.001), adverse event related treatment (P = 0.731) and disease-free survival days (329 .3±309.1 days vs 271.7 ± 414.2 days vs 357.2 ± 511.6 days, P = 0.336). Multivariate analysis showed that age, performance status, CTP class, MELD score, modified UICC staging, presence of portal vein thrombosis and ruptured HCC are risk factors for mortality. Conclusions: Clinician should make an active treatment in elderly patients with HCC not a age but performance status, liver function and disease status of cancer.

김치 발효중 생체활성 아민 생성에 관한 연구

서일원,류춘선,이주돈,이영환,변광의 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

Biogenic amines can be formed and degraded either as the result of endogenous amino acid decarboxylase activity in raw materials or by the growth of decarboxylase-positive microorgannisms under conditions favorable to enzyme activity. Three biogenic amines(Tryptamine, Histamine, Tyramine) were intensively investigated by the HPLC during Kimchi fermentation at 5℃. The patterns of microfloral changes in lactic acid bacterial group, Leuconostoc, Streptococcus and Lactobacillus, were similar to the typical low-temperature fermentation. The population of microbial growth were high after 10 days and gradually decreased. The levels of Tyramine were lowered(10mg/kg) during this mid-periods(8∼16 days) but very high in initial-(15mg/kg) and final-periods (30mg/kg), in which the total acidity ranged between 0.2∼0.35% and 0.4∼0.6%, while the acidity in mid-periods revealed 0.35∼0.4% beginning the initial ripening period. Leuconostoc was highly increased in number in mid-period but slightly declined as the acidity increased, whereas Streptococcus was highly distributed in initial-period and Lactobacillus in final-period. The levels of Tryptamine and Histamine were relatively low throughout the whole fermentation period, but the profile of Tryptamine level was very similar to the case of Tyramine. Histamine was maintained at a certain level after mid-period of fermentation.

Helicobacter pylori 양성인 소화성 궤양 및 위염 환자에서 Helicobacter pylori 제균에 대한 판토프라졸 포함 삼제 요법의 임상효과 및 내약성에 대한 연구

서영호,이완식,주영은,김현수,최성규,유종선,김행재,서순팔,김세종 최신의학사 2000 最新醫學 Vol.43 No.11-12

간장 허혈 및 재관류시 vitamin C와 E가 간장기능에 미치는 영향

서민영,김순애,조태순,이선미 성균관대학교 약학연구소 1995 成均藥硏論文集 Vol.7 No.1

Abstract - This study was done to investigate the effect of vitamin C and E on hepatic biliary and microsomal function during ischemia and reperfusion. Rats were treated with vitamin C, E or with vehicle(saline) and then subjected to 60 min no-flow hepatic ischemia in vivo. Control animals were time-matched sham ischemic animals. After 1 or 5 hr of reperfusion, bile was collected, blood was obtained from the abdominal aorta, and liver microsomes were isolated. In vehicle-treated ischemic rats, serum ALT levels peaked at 5 hr and were significantly attenuated by vitamin C, E individually and combination of vitamin C and E treatment. Similarly hepatic wet weight-to-dry weight ratio was increased in the vehicle-treated ischemic group. Vitamin C and E combination minimized the increase in this ratio. Lipid peroxidation was elevated in vehicle-treated ischemic group, but this elevation was also inhibited by vitamin C or E, respectively. Bile flow and cholate output, but not bilirubin output, were markedly decreased by ischemia/reperfusion. Vitamin C treatment restored the secretion. Cytochrome P-450 content was decreased by ischemia/reperfusion and restored by vitamin E treatment to the level of sham operated group. Aminopyrine N-demethylase activity was decreased and aniline p-hydroxylase activity was increased by ischemia/reperfusion. These changes were prevented by vitamin C or E treatment, but not by vitamin C and E combination treatment. Our findings suggest that vitamin C or E individually significantly ameliorates these ischemia/reperfusion-induced hepatic damages and there is no evidence of synergism between vitamin C and E in our system.

보건소 건강증진사업 수행과정의 질 평가

서영준,정애숙,박태선,김주경,박남수,이희원 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

This study purports to assess the process quality of health promotion programs at public health centers. The sample used in this study consisted of 242 public health centers in South Korea. Data was collected with self-administered questionnaires between September. 3rd to September. 23rd in 2002. The 95 returned questionnaires were analyzed by SPSS 11.0 version. The major findings are as follows; There is a need to improve (1) a procedure for reviewing and analyzing strategic planning, (2) the quality of the staff in charge of program management, (3) the function of planning and training for monitoring and evaluation, (4) the ability of program managers in advising and consulting with clients, and (5) a procedure for organizing resources and information. In conclusion, in order to improve the process quality of health promotion programs at public health centers, integrated support from various institutions such as public health centers, community, regional and national health authorities and administrative departments is required.

간의 국소결정성과형성 : 3중 시기 CT 소견 Triple-phasic CT Features

김영선,서흥석,조온구,고병희,임현철,이승로 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Focal nodular hyperplasia is a rare benign tumor of the liver. It shares a lot of features with a fibrolamellar hepatocellular carcinoma in their gross morphology and predisposing ages. But differential diagnosis is invaluable because their treatment modality is absolutely contrary. We experienced a case of focal nodular hyperplasia in a young woman, incidentally found at the ultrasonographic examination for the acute appendicitis, and was difficult to differentiate it from fibrolamellar hepatocellular carcinoma radiologically. Dynamic CT, hepatic arteriographic, and pathologic findings will be discussed, especially in a view of their differential diagnostic point from a fibrolamellar hepatocellular carcinoma.

스넥코너에서 채취한 튀김기름의 신선도에 관하여

박규영,박모라,서수경,손순희,정경희,정유선 효성여자대학교 가정대학 학도호국단 1985 家政大論集 Vol.4 No.-

대구 시내 전역에 산재해 있는 튀김 음식점과 스넥코너등에서 튀김중인 기름에 대한 변패도를 알아 보기 위해 여름철과 겨울철 두 계절에 또 튀김물의 종류별로 시료 186개를 채취하여 산가, 과산화물가, carbonyl가 및 TBA가를 측정한 결과는 아래와 같다. 1. 산가, 과산화물가, carbonyl가 및 TBA가는 각각 2.2, 47, 19, 0.7로 나타났다. 2. 여름철로가 겨울철을 비교해 본 결과는 산가, 과산화물가, carbonyl가는 여름철이 높았으나 TBA가는 두 계절이 비슷하였다. 3. 튀김물의 종류에 따른 기름의 변패도는 오뎅, 핫도그, 닭, 야채, 도나스 순으로 나타났다. In order to investigate the degree of changes in quality of frying oils to be used atsnack corners and street stalls in Taegu area. acid value (AV), peroxide value(POV), carbonyl value (COV), and TBA value were measured. 95 samples insummer and 91 samples in winter were collected from oils fried for fish cake, hotdogs,chicken, vegetable and doughnuts. The mean value of AV, POV and COV on the fryingoils collected in summer were higher than those in winter, while TBA value of oilsin summer ·was similar to that in winter. According to the kinds of fried food, thedegree of the change in quality of frying oil was high in order of fish cake, hotdog,chicken, vegetable ana doughnut.

CORBA 기반 SNMP 게이트웨이

정영준,송화선,서희정,김주영 강원대학교 정보통신연구소 1999 정보통신논문지 Vol.3 No.-

As telecommunicaton networks becomes more complex and intelligence, it is essential to develop an integrated network management system between heterogeneous telecommunication networks. To fulfil such demands, one solution is CORBA, which provides a distributed platform, in this paper, we present the design and implementation of a gateway between CORBA and SNMP, called as an Internet management protocol. The proposed scheme allows a CORBA managerto access the SNMP MIB without special transformation of SNMP managed objects and only but using SNMP API which the gateway provides. Also since managed objects are represented in CORBA IDL, a new SMI can be updated only by recompiling the interface. Consequently this gateway approach gives a great of advantages in a point that any changes of managed object implementation on managed agents MIBs are not required.