Prognostic significance of the number of metastatic lymph node in early cervical cancer

( Sun Yi Choe ),( Jung Woo Park ),( Myoung Seok Han ),( Jong Woon Bae ),( Yeon Jean Cho ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: The purpose of this study was to determine the significance of the positive pelvic lymph node (PLN) metastasis on progression-free survival (PFS) and overall survival (OS) of early cervical cancer patients. The values of other known poor prognostic factors were also analyzed for prediction of the disease prognosis. Methods: The stage 1A-IIA cervical cancer patients from 1998 to 2014 who underwent radical surgery were retrospectively reviewed. Parameters such as age, FIGO stage, histologic type, tumor size, depth of stromal invasion, PLN metastasis, the number of the PLN metastasis, LVSI, parametrial invasion, vaginal resection margin status were collected then the PFS and OS were evaluated. Results: In univariate analysis, tumor stage, tumor size, stromal invasion, the number of PLN metastasis and LVSI were significantly associated with both PFS and OS. The multivariate analysis showed that the size (P=0.0198), the number of PLN metastasis (P=0.0005) and the LVSI (P=0.0429) had significant association with PFS. Regarding OS, the number of PLN metastasis (P=0.0044) and stromal invasion (P=0.0427) were significantly associated. Conclusion: Tumor size, number of PLN metastasis and LVSI had significant association with PFS and stromal invasion and number of PLN metastasis were also significantly associated with OS in multivariate analysis. Among poor prognostic factors, the number of PLN metastasis is one of the most important prognostic factor, therefore it is important to confirm LN metastasis status after radical surgery.

p, p-DDT induce apoptosis in human endometrial stromal cells through oxidative stress

( Sun Yi Choe ),( Yeon Jean Cho ),( Myoung Seok Han ),( Jong Woon Bae ),( Jung Woo Park ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Organochlorines, such as dichlorodiphenyltrichloroethane (DDT), can cause a various effects on the cells by triggering estrogen receptor. Because of their long half-lives, DDT and its metabolites are still found throughout the world. DDT is associated with reduced mean luteal-phase length, spontaneous abortion, early age at menopause, and reduced duration of lactation. However, their effect on endometrium is not clearly revealed. Here we studied whether DDT causes oxidative stress and apoptosis in human endometrial cells. Methods: Human endometrial stromal cells were obtained from reproductive aged women with normal menstrual cycle. Our study was design to find out whether DDT causes oxidative stress and apoptosis and to investigate its effects on modulators of antioxidative enzymes and caspase pathway in human endometrial cell. Also we have studied association between DDT and estrogen receptors (ER) and NF-B pathways in human endometrium. Results: From flow cytometric analysis, we found that DDT contributed to apoptosis. Fluorescence microscopy showed that DDT induced formation of apoptotic bodies and DNA fragmentation. After exposure to DDT, Bcl-2 with anti-apoptotic potential decreased and BAX, an apoptotic regulator, showed a dose-dependent increase. The expression of caspase-3, 6, 8, and 10 were also significantly increased. Treatment of endometrial cells with DDT resulted in a significant increase in DCF fluorescence and showed significant decrease in GPX and SOD expression. Regarding ER, DDT down-regulated the expression of ER- and reversed by antagonist treatment. Conclusion: Our study showed that when DDT is exposed to human endometrial cells, apoptosis can occur by producing oxidative enzyme and modulating estrogen receptors. Changes in mediators of antioxidative enzymes and caspase pathway also lead to apoptosis. These reactions will have significant effects on human endometrial environment which can determine the pathogenesis of diseases involving endometrium.

협심증이 의심되어 운동부하검사를 받은 여성들의 흉통에 관한 내용분석

최명애,이명선,안경애,임은옥 성인간호학회 2002 성인간호학회지 Vol.14 No.3

Purpose: Experience of chest pain may be different in women from that of men and this discrepancy may cause misdiagnosis of angina contribute to mortality by this disease in women. The purpose of this study was to analyze the characteristics of chest pain and responses to the symptoms in women. Method: A content analysis was conducted with interviewed data obtained from women who underwent the treadmill test Result: Seven major categories were identified from this content analysis: attributes of chest pain; accompanied symptoms; precipitating factors; relief strategies; family support; communication with physicians; and effects of chest pain on their lives. Characteristics of pain were described as heaviness, tightness, heating sensation, tearing, and others. Duration and intensity of pain varied in a wide range. Radiating pain presented in 9 patients, and the locations of radiation were throat, neck, shoulder arm and fingers. Women tended not to respond actively to their chest pain, and didn't get appropriate support either from their family or from their physicians when they reported chest pain. Conclusion: Women express non-typical as well as typical patterns of pain when they experience chest pain. Clinicians have to consider the variability of symptoms when they assess women with suspicions of angina.

Contract Costs and Priority Structure of Debt

Yi, Jae-Sun,Choe, Hyuk 서울대학교 증권금융연구소 1997 증권 금융연구 Vol.3 No.2

Expanding on ideas implicit or explicit in Fama (1990), this paper develops empirical predictions with respect to the priority structure of debt securities in the context of the overall contract structure of a firm. I develop a hypothesis that higher fractions of fixed-payoff contracts should lower the fraction of higher-priority debt in the capital structure Using Compustat data, supporting evidence is found for this specific prediction implied by Fama's contract-cost hypothesis of financing decisions.

Antibody Responses One Year after Mild SARS-CoV-2 Infection

Choe Pyoeng Gyun,Kim Kye-Hyung,Kang Chang Kyung,Suh Hyeon Jeong,Kang EunKyo,Lee Sun Young,Kim Nam Joong,Yi Jongyoun,Park Wan Beom,Oh Myoung-don 대한의학회 2021 Journal of Korean medical science Vol.36 No.21

Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.

Effects of Parity and Breast Feeding Duration on the Risk of Osteoporosis in Postmenopausal Korean Women: A Systematic Review and Meta-Analysis

이은남,Sun Yi Choe,최은희,Min Ju Lee 대한폐경학회 2019 대한폐경학회지 Vol.25 No.2

Objectives: To summarize the evidence regarding the association of parity and breast feeding duration with the risk of osteoporosis in postmenopausal Korean women. This was because studies have been inconsistent regarding the effect of parity and breast feeding duration on the risk of osteoporosis. Methods: A systematic literature search of relevant studies published by December 26, 2018 was conducted in PubMed, EMBASE, the Cochrane Library, CINAHL, RISS, KISS, KMbase, and KoreaMed. Outcome estimates of odds ratio (OR) or standardized mean difference were pooled with fixed or random-effect model. In case of heterogeneity, subgroup analysis was conducted. Results: Seven cross-sectional studies (with 3,813 subjects) were included in the analysis. OR for osteoporosis was 1.43 (95% confidence interval [CI] = 1.09–1.88, P = 0.010) in postmenopausal women with higher parity compared to those with less parity. Moreover, OR for osteoporosis was 1.93 (95% CI = 1.28–2.93, P = 0.002) in postmenopausal women with longer durations of breast feeding than in those with shorter durations of breast feeding. Conclusions: This study revealed that duration of breast feeding increased the risk of osteoporosis in postmenopausal Korean women. More cohort studies with high quality research designs are needed to confirm our results.

고등학생의 충동성과 도박행동의 관계에서 도박동기의 매개효과

선혜민(Sun Hye Min),박진희(Park Jin Hee),조은희(Cho Eun Hi),양정하(Yang Jeong Ha),최지이(Choe Ji Yi),신현주(Sin Hyon Ju),천성문(Cheon Seong Moon) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.11

본 연구는 고등학생을 대상으로 충동성과 도박행동과의 관계에서 도박동기의 매개효과를 확인하고자 하였다. 이를 위해 부산, 경남지역 소재 고등학생 779명을 대상으로 충동성 척도, 도박동기 척도, 청소년 도박행동 척도를 사용하여 설문조사를 실시하였다. 수집된 자료를 바탕으로 주요 변인들 간의 관련성을 살펴보기 위해 상관관계 분석을 하였으며, 매개효과를 알아보기 위하여 Baron과 Kenny(1986)의 3단계 분석을 사용하였다. 결과를 살펴보면, 첫째, 충동성은 도박행동과 유의한 정적 상 관을 보였다. 또한 충동성과 도박동기의 하위유형인 흥분동기, 회피동기, 금전동기와 통계적으로 유의한 정적 상관을 보였으며, 사교동기와 유희동기는 통계적으로 유의한 상관이 존재하지 않는 것으로 나타났다. 둘째, 흥분동기, 회피동기, 금전동기 는 각각 충동성과 도박행동 간의 유의하게 부분 매개하는 것으로 나타났다. 본 연구 결과를 토대로 후속연구에 대한 제언과 시사점을 논의하였다. This study investigated the relationship among gambling motivation, impulsivity and gambling behaviors in high school students. For this purpose, 784 high school students in Busan and Kyungnam area were surveyed using impulsivity scale, gambling motivation scale, and youth gambling behavior scale. A correlation analysis was conducted to examine the relationship between the main variables on the basis of the collected data and mediate the relationship between impulsiveness and gambling behavior, Baron and Kenny(1986). In this paper, First, impulsiveness showed significant positive correlation with gambling behaviors. In addition, there was a statistically significant correlation with the sub factor of impulsivity and gambling motivation, excitement motivation, avoidance motivation, and money motivation. There was no statistically significant correlation between social motivation and play motivation. Second, the excitement motivation, the avoidance motivation and the money motivation each was significantly mediated between impulsivity and gambling behavior. Also, in this study, we examined the mediating effect of gambling motivation, There are important implications. Finally, the implications and limitations of the study were discussed.

New Paradigm Approach for Nursing Knowledge Development in the 21st Century : Paper Presentations ; Experience of Mothers with Babies by In Vitro Fertilization

이명선 ( Myoung Sun Yi ),( So Woo Lee ),( Myoung Ae Choe ),( Keum Soon Kim ),( Yun Mi Kim ) 서울대학교 간호과학연구소 2000 서울대학교 간호과학연구소 학술대회 자료집 Vol.2000 No.2

Clinical application of serum anti-Müllerian hormone in women

Oh, So Ra,Choe, Sun Yi,Cho, Yeon Jean The Korean Society for Reproductive Medicine 2019 Clinical and Experimental Reproductive Medicine Vol.46 No.2

Anti-$M{\ddot{u}}llerian$ hormone (AMH), a peptide growth factor of the transforming growth $factor-{\beta}$ family, is a reliable marker of ovarian reserve. Regarding assisted reproductive technology, AMH has been efficiently used as a marker to predict ovarian response to stimulation. The clinical use of AMH has recently been extended and emphasized. The uses of AMH as a predictive marker of menopause onset, diagnostic tool for polycystic ovary syndrome, and assessment of ovarian function before and after gynecologic surgeries or gonadotoxic agents such as chemotherapy have been investigated. Serum AMH levels can also be affected by environmental and genetic factors; thus, the effects of factors that may alter AMH test results should be considered. This review summarizes the findings of recent studies focusing on the clinical application of AMH and factors that influence the AMH level and opinions on the use of the AMH level to assess the probability of conception before reproductive life planning as a "fertility test."

바이오 휘드백 훈련을 통한 이완요법이 생리통 및 스트레스반응경감에 미치는 영향

이소우,김금순,최명애,이명선 서울대학교 간호대학 간호과학연구소 1999 간호학 논문집 Vol.13 No.1

The purpose of this study was to investigate the effects of a 4-week relaxation therapy using biofeedback on menstrual pain and stress for 35 sophomore and junior baccalaureate nursing students. A quasi-experimental pretest-posttest control group design was used. The relaxation therapy group included training sessions using respiration therapy augmented with biofeedback techniques for self-relaxation. A significant reduction of pain (P<.05) on the 1st and 2nd day of menstruation was reported on the visual analogue scale by the experimental groups, while that the control groups remained relatively unchanged. Also a significant reduction of pain (P<.05) was reported on the delivery pain scale by the experimental groups on the 2nd day of menstruation, while that of the control groups remained unchanged. However, there were no significant differences of pain on the 3rd and 4th day of menstruation between the two groups. A significant reduction of state of anxiety (P<0.5) was reported by experimental groups, while that of the control groups remained relatively unchanged. There were no significant changes in stress measured by the symptom of stress. The results of the study support the benefits of relaxation therapy using biofeedback on pain relief and stress.