http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cohort Profile: The Namwon Study and the Dong-gu Study
Kweon, Sun-Seog,Shin, Min-Ho,Jeong, Seul-Ki,Nam, Hae-Sung,Lee, Young-Hoon,Park, Kyeong-Soo,Ryu, So-Yeon,Choi, Seong-Woo,Kim, Bok-Hee,Rhee, Jung-Ae,Zheng, Wei,Choi, Jin-Su Oxford University Press 2014 International journal of epidemiology Vol.43 No.2
<P>These two cohorts were designed to examine the increasing burden of chronic diseases among Korean populations. The studies investigated determinants for stroke, osteoporosis, dementia and cancer among middle-aged and elderly Korean populations. The Namwon Study baseline survey was performed between 2004 and 2007 (<I>n</I> = 10 667), and followed up 4 years later (<I>n</I> = 8157, follow-up rate = 76.5%). The baseline survey of the Dong-gu Study was administered over 2007–2010 (<I>n</I> = 9260), and will be followed up between 2014 and 2015. Questionnaires included assessment of cognitive function, psychiatric health and lifestyle factors. Clinical examinations, biochemical tests and genotyping focused on evaluating the determinants of target diseases and their intermediate phenotypes. Potential collaborators will be invited to contact the chief investigators.</P>
Kweon, Sun-Seog,Kim, Min-Gyeong,Kang, Mi-Ran,Shin, Min-Ho,Choi, Jin-Su Elsevier 2017 Journal of epidemiology Vol.27 No.7
<▼1><P><B>Background</B></P><P>The aim of this study was to evaluate whether stage at cancer diagnosis differed according to patient economic status.</P><P><B>Methods</B></P><P>A total of 10,528 patients with cancer of the stomach, colorectum, breast, or cervix, which are target organs of the Korean National Cancer Screening Program (NCSP; fully implemented in 2005) were extracted from population-based cancer registries. The patients were classified into four groups based on socioeconomic status (SES), as determined using their National Health Insurance (NHI) monthly premium at the time of cancer diagnosis. Cancer stage at diagnosis was defined as early (in situ/local) or late stage (regional/distant) based on the Surveillance, Epidemiology, and End Results (SEER) summary stage. Multivariable logistic regression analysis was performed to estimate the risk of non-local stage using age, residential area, and community deprivation index as covariates.</P><P><B>Results</B></P><P>The lowest SES subjects showed significantly higher risks of being diagnosed at a later stage for stomach, colorectal, and female breast cancer, but not for cervical cancer, compared with the highest SES subjects. The estimated ORs were 1.28 (95% CI, 1.10–1.49), 1.29 (95% CI, 1.03–1.61), and 1.35 (95% CI, 1.02–1.81) in the lowest SES subjects with stomach, colorectal, and breast cancer, respectively.</P><P><B>Conclusions</B></P><P>In conclusion, later stage diagnoses of stomach, colon, and female breast cancer are still associated with SES in Korea in the era of the NCSP for the lower SES population.</P></▼1><▼2><P><B>Highlights</B></P><P>•<P>Advanced stage was more frequent in cancer patients with lower economic status.</P>•<P>Differences of stage by SES were found in stomach, colorectal, and breast cancer.</P>•<P>Disparities still exist after the National Cancer Screening program in Korea.</P></P></▼2>
권순석(Sun-Seog Kweon),박형철(Hyung-Cheol Park),남현(Hyun Nam),최진수(Jin-Su Choi) 한국역학회 2008 Epidemiology and Health Vol.30 No.2
Objectives: The surveillance of infectious diseases, which is crucial in public health, may also suffer from poor community support. In South Korea, the government operates several national surveillance system for the National notifiable infectious diseases(NNID). Some programs work satisfactorily but other programs may not be fully accepted at the community level which result in low participation and delayed report. Methods: May 2003, to improve the blind side of the National Surveillance System, a district health agency initiated a community based surveillance system for infectious diseases called as Communicable Disease Information Sharing System (CDISS) to complement the national program. As the name suggests, it underscores the mutual benefit of surveillance for public and private health sectors through partnership. With collaboration of participating private clinics and hospitals around the district, the health agency collects data and provides the health practitioners more up-to-dated information on the trend of infectious diseases than National level information. Total population of study area, Dong-gu which locate in the center of Gwangju-metropolitan city, is about 120,000 in 2005. Reporting facilities consist of 6 daycare clinics, 3 hospitals, and 1 university hospital, 2 local public health organizations. Results: CDISS was introduced in May 2003, and full system has been successfully operated since March 2004 with 10 participating facilities. Each reporting facility regularly sends the weekly reporting form, filled with the number of patients in last week, to Dong-gu District Health Center in every Wednesday. All data were organized in tables and graphs by weekly summarizing the reporting data and interpreted information. Feedback is done to reporting facilities until Friday through faxes, email, website (http://kjdisweb.richis.org) at least a week earlier than National Surveillance System.If reported data exceeded epidemic alert level, the community warnings are issued through mass-media and other means of public communication.During the period of CDISS operation, some epidemic events and sporadic outbreak occurred in Dong-gu were detected well-earlier than the notification at national level, such as chickenpox, viral enteritis, and epidemic keratoconjunctivitis(EKC). Conclusions: The program has been functioning successfully with active community participation and revealed to be economic and effective way of disease surveillance in the community. Several episodes of disease epidemic were reported by the program well before the recognition of the epidemic at the national level. We suggest that the community surveillance program may well complement national surveillance system.
지역사회 건강한 성인에서 알코올 섭취량 및 폭음과 동맥경직도의 관련성
권순석(Sun-Seog Kweon),이영훈(Young-Hoon Lee) 한국농촌의학 지역보건학회 2012 농촌의학·지역보건 Vol.37 No.1
지역사회 성인을 대상으로 알코올 섭취량과 동맥경직도의 관련성을 파악하였으며, 아울러 폭음과 동맥경직도의 관련성을 살펴보았다. 지역사회기반 코호트 연구에 참여한 50세 이상 성인 5944명을 대상으로 하루 평균 알코올 소비량(g/day)과 월 폭음 빈도를 조사하였다. 상완-발목동맥 맥파전도속도(baPWV)를 측정한 후 남녀 각각에서 baPWV 4사분위에 해당하는 집단을 ‘high baPWV’로 정의하였다. 남성 알코올 섭취군의 교차비는 비음주군과 비교해서 유의한 차이가 없었지만, >40.0 g/d 알코올섭취군의 교차비는 유의하게 증가하였다. 모든 여성 알코올 섭취군의 교차비는 비음주군에 비해서 유의한 차이가 없었다. 남성에서는 비폭음군에 비해 주 1회 미만 폭음군 및 주 1회 이상 폭음군의 high baPWV에 대한 교차비가 유의하게 증가하였다. 여성에서는 비폭음군에 비해 주 1회 이상 폭음군의 교차비가 유의하게 증가하였다. 남녀 모두에서 적당한 음주는 동맥경직도의 위험성이 낮은 반면, 과도한 음주는 동맥경직도의 위험성이 증가하였으며, 전반적으로 알코올 섭취량과 baPWV로 측정한 동맥경직도 사이에는 J자 형태의 관련성이 있었다. 또한 알코올 섭취량을 포함한 기존의 심혈관 위험요인과는 독립적으로 남녀 모두에서 폭음이 동맥경직도와 유의한 관련성이 있었다. Objectives: The purpose of this study was to investigate the association of the average volume of alcohol consumption and binge drinking with arterial stiffness. Methods: The study population consisted of 5944 community-dwelling healthy adults aged 50 years and older. Average volume of alcohol consumption was calculated and frequency of binge drinking defined as the consumption of 7 or more drinks for men and 5 or more for women on a single occasion, was assessed using a structured interview. High brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, was defined as the highest gender-specific quartile of maximal baPWV distribution in the study population. Results: Compared to never drinkers, the multivariate-adjusted odds ratio (OR) of men who consumed 0.1-10.0, 10.1-20.0, 20.1-40.0, and >40.0 g/day was 0.93, 1.18, 1.38, and 2.36, respectively. The OR was 0.90, 0.97, 1.45, and 1.82 in women consuming 0.1-5.0, 5.1-10.0, 10.1-20.0, and >20.0 g/day, respectively. Binge drinking of <1 day/week (OR=1.66, 95% confidence interval [CI]=1.13-2.42) and ≥1 day/week (OR=1.61, 95% CI=1.04-2.50) were associated with increased risk for high baPWV in men, and binge drinking of ≥1 day/week (OR=3.12, 95% CI=1.16-8.34) was associated with increased risk for high baPWV in women. Conclusions: A J-shaped relationship between the average volume of alcohol consumption and high baPWV was observed, suggesting the detrimental effects of heavy alcohol drinking on arterial stiffness. Binge drinking was also significant risk factors for increased arterial stiffness, independently of the average volume of alcohol consumption.
HCV epidemiology in Korea: Focused on community based HCV epidemiological investigation at Jindo-gun
권순석 ( Sun-seog Kweon ),조성범 ( Sung-bum Cho ) 대한간학회 2016 간학회 싱글토픽 심포지움 Vol.2016 No.1
Hepatitis C virus (HCV) is not endemic to South Korea, its seroprevalence is generally about 1%. Recently, an hepatocellular carcinoma(HCC) epidemic involving an island community resulted in a age-standardized incidence ratios based on Korean national data of 2.2 (95% confidence interval [CI] 1.9-2.5) and 2.2 (95% CI 1.8-2.7) in males and females, respectively, was noted between 1999 and 2008. To identify the cause of the high HCC rate, we conducted serologic surveys for hepatitis in study and control areas involving 2,068 and 2,950 residents (age ≥20 years), respectively, who had been sampled randomly in a previous community survey. We found an approximately four-fold higher HCV seroprevalence in the study area (5.5% vs. 1.3%). No significant difference in HBV was seen. A difference in the exposure to acupuncture was also identified. Ecological data suggest that the excessive HCC burden in the study community was closely associated with an HCV epidemic. Frequent exposure to acupuncture might be a risk factor in the HCV epidemic in this community.
BRAF Mutations and KIT Aberrations and Their Clinicopathological Correlation in 202 Korean Melanomas
Jin, Sun A,Chun, Seung Min,Choi, Yoo Duk,Kweon, Sun-Seog,Jung, Sung Taek,Shim, Hyun Jeong,Yun, Sook Jung The Society for Investigative Dermatology, Inc 2013 The Journal of investigative dermatology Vol.133 No.2