Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Floristic study of Jang-do (Isl.) in Korea

Son, Hyun-Deok,Gwon, Soon-Gyo,Jang, Jeong-Won,Sun, Eun-Mi,Kim, Byeol-Ah,Im, Hyoung-Tak The National Institute of Biological Resources 2013 Journal of species research Vol.2 No.2

We investigated the flora of Jang-do (Isl.), an island of the Heuksan archipelago, located in Heuksan-myeon, Shinan-gun, Jeollanam-do and discussed the remarkable plants found there. Thirteen-field trips (total 27 days) were completed from May of 2004 to May of 2013. As a result, we identified the distribution of 423 taxa in Jang-do (Isl.), comprising 104 families, 285 genera, 335 species, 78 varieties and 10 forms. There are a total of 95 taxa of floristic regional indicator plants. The floristic regional indicators are as follows; four taxa of level V such as Impatiens furcillata, four taxa of level IV such as Hosta yingeri, 14 taxa of level III such as Ophioglossum vulgatum, 5 taxa of level II, and 58 taxa of level I. In addition 10 red data plants, 2 vulnerable species (VU) including Calanthe striata for. sieboldii, and 4 least concern species (LC) like Ardisia crenata, 2 not evaluated species (NE) such as Hosta yingeri, were found in the investigated area. An unrecorded species, Fragaria (Rosaceae), was found in a forest of Jang-do (Isl.) for the first time in Korea.

국제비서의 역할에 관한 연구

張美仙 제주한라대학 1995 論文集 Vol.19 No.-

This study shows cosequence of introducing professional bilingual secretary, and considers concept of bilingual secretary and its role as a basic study. The bilingual secretary should speak foreign language (mainly English) frequently that is needed in business and Korean. In addition bilingual secretary can conduct general business. The most ideal bilingual secretary has ability of oral communication, flexibility, accuracy and spontaneous personality. The communicational education for training bilingual secretary is available on basis of self-control person. In conclusion, I expect new style of bilingual secretary will be apperared in the future. To cope with this inclination we have to make our own style of education of professional bilingual secretary. I would like to suggest a way of actualization of professional bilingual secretary. Since 1979 Japan, executes C. B. S (Certified Bilingual Secretary) test, and America is well developed in secretary system. In the same manner, we need to carry out study that is needed in training professional bilingual secretary, and provide social environment for bilingual secretary. Finally we should perform more various systematic study for bilingual secretary.

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

증거 평가 활동을 통한 초등학생의 이론과 예상 능력의 변화

장병기,김선미 춘천교육대학교 과학교육연구소 2001 과학교육연구 Vol.25 No.-

국제비서자격 검정시험제도의 도입 가능성에 관한 연구

張美仙 제주한라대학 1996 論文集 Vol.20 No.-

Nowadays enterprises are strongly requested to acquire the special quality to satisfying the needs of information society with a tendency to cosmopolitanism and globalization. Therefore, it is fact that the bilingual secretary with fluent foreign language abilities have been gradually required. The purpose of this study was to reestablish the concepts on bilingual secretary, grasp the present status of a qualifying examination on secretary and examine the possibility on introduction for a qualifying examination system in bilingual secretary. In conclusion, the introduction for a qualifying examination system in bilingual secretary will be needed in the near future. Therefore, these researches are methods, contents and development in question pattern of qualifying examination on bilingual secretary with domestic status.

오렌지로부터 아플라톡신B₁의 정량분석에 관한 연구

장향동,백광균,구경림,옥선미,최진석,고은주,류성렬 한국공업화학회 2004 응용화학 Vol.8 No.2

Aflatoxin B₁ was known to have the strongest poisonous character among Aflatoxin compounds. To search the production of Aflatoxin B1 according to the change of temperature, relative humidity and incubation days, orange incubated with Aspergillus parasiticus KCCM 35078 was incubated at 20℃, 25℃, 30℃ at relative humidity 60%, 70%, 80% and for incubation time 3, 4, 5, 6, 7 days.. Production of Aflatoxin B₁ shows that the highest production appeared at 25℃ and its relative humidity 70%. The result that was quantitatively analyzed by using HPLC was 77.41ppm, and by using Fluoroscence detector was 87.87ppm. - Production of Aflatoxin B₁ shows that the lowest production appreared at 20℃ and its relative humidity 80%(HPLC), 60%(Fluoroscence detector). The result that was quantitatively analyzed by using HPLC was 4.47ppm, and by using Fluoroscence detector was 4.17ppm. The structure of Aflatoxin B₁ was identify with authentic sample by using instrumental analysis methods of GC/MS, ¹H-NMR, FT-IR respectively.

외국인을 위한 한국어교육의 측면에서 양상조동사 '보다'의 담화기능

張美仙 제주한라대학 1994 論文集 Vol.18 No.-

The function of conversation about the modal auxiliary "Boda" has been shown up at real conversation by experiences, assumption, euphemism, intention, concern, emphasis, trial and supposition. The Purpose of this study is to compare and survey how Koreans and foreigners understand the conversational function on the modal auxiliary verb "Boda". The objects of this test are as follows : 1) For Korean : 20 University students (Sophomore, Secretarial Dept. of Ewha Womans University) 2) For Foreigners : 20 students of Ewha Language Institute They have learned Korean for 40 - 50 weeks. 40 questions were given and 30 minute-test was executed under the supervision. The results of test are as follows : 1. After statistical analysis results, for Koreans, their recognition on the conversational function about the modal auxiliary verb "-a Boda" between 'experience' and 'assumption' showed difference by Pearson correlation 0.009. 2. After statistical analysis results, for foreigners, their recognition on the conversational function about the modal auxiliary verb "-a Boda" between 'experience' and 'assumption' showed difference by Pearson correlation 0.027. 3. For foreigners, their recognition on the "-ㄴ ga boda, -na boda" and "-a boda" didn't show much difference by Pearson correlation above 0.05. 4. For foreigners, their recognition on the conversational function between "-a boda" and "-ㄹ ga boda" with 'experence' and 'emphasis' showed difference by Pearson correlation 0.045.

음양오행의 공학적 해석에 의한 체질 분류 및 섭생법

최혜선,김혜숙,신미수,장동순 忠南大學校 環境問題硏究所 1997 環境硏究 Vol.15 No.-

This paper describes the application of Yin-Yang & Five Element Theory for the prevention and diagnosis of diseases due to environmental pollution by the scientific interpretation of the basic properties of five elements. The five elements considered are Mok(木,wood), Hwa(火,fire), To(土,soil), Geum(金,metal), SU(水,water). The basic properties of these are explained as warm energy, explosively dispersive heat, agglomerating force, tension or crystallization force, and finally cool & soft energy respectively. Utilizing these basic properties, the constitution classification can be modeled by the shape of face, which is attributed by the relative strength of the major organs, that is, five elements. Further, the vulnerable disease according to the constitution are briefly described together with the therapy method by diet, especially emphasizing the taste of food.

역류식 충진탑에서 수력학적인 분석과 이산화탄소의 탈착에 관한 연구

楊善惠,崔東勳,지혜미,金恩貞,金彰昊 동아대학교 환경문제연구소 1996 硏究報告 Vol.19 No.1

This study was carried out to interpret hydraulic behavior and CO₂gas desorption in countercurrent packing tower which packed 50 mm plastic Hiflow-ring. The results are as follows: 1. To compare with conventional packing, 50mm Hiflow-ring could save energy because of low pressure drop under high load. 2. As relative error between calculated value and investigated value was less than 6% in the loading point and flooding point we found that we can predict results mathematically which occurres in the packing tower. 3. The unique magnituteds of packing which was used are as follows. C_(L) = 2.1×10^(-4), n = 0.787 so we can predict efficency which occurres.