셀레나이트로 유도되는 백내장에서 선삼 성분에 따른 백내장 억제효과의 비교 분석

이상목,정문선,정진호,김미금,위원량,박정일,이진학,Sang Mok Lee,MD,Jung Moon Sun,MD,Jin Ho Jeong,MD,Mee Kum Kim,MD,Won Ryang Wee,MD,Jeong Hill Park,PhD,Jin Hak Lee,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To compare the protective effects of saponin and non-saponin Sun-ginseng extract fractions in a selenite-induced rat cataract model. Methods: A total of 101 Sprague-Dawley rat pups were divided into four groups by treatment: Sun-ginseng, saponin fraction, non-saponin fraction, and control. For induction of cataracts, sodium selenite 15 nmol/g was injected subcutaneously in 13 day-old rat pups. Sun-ginseng extract 100 μg/g (Group I, Ginseng Science, Seoul, Korea), saponin fraction 100 μg/g (Group II), non-saponin fraction 100 μg/g (Group III), and phosphate buffered saline (Control group) were injected intraperitoneally every two days for a total of seven injections. The rats were sacrified and their lenses were dissected and photographed at day 7 and 14, and the cataracts were graded according to the ratio of the cataract area to the total lens area. The blind method was used for the evaluation of the cataract area. Results: At day 14, cataract formation rates (CFR) were 33.3% in group I, 76.4% in group II, 41.2% in group III, and 77.7% in the control group. The mean cataract area (MCA) was 13.4±20.8% in group I, 14.4±11.7% in group II, 5.7±7.7% in group III, and 15.8±12.1% in the control group. Group III showed statistically significant results compared with those of control group (CFR p=0.001, MCA p=0.001). We observed significantly lower incidence and smaller mean cataract area in Group I and Group III at day 7 compared with the control group (Group I, CFR p=0.018; Group III, CFR p=0.032, MCA p=0.005). Conclusions: The protective effects of Sun-ginseng extract are caused by the components in the non-saponin fraction, not by those in the saponin fraction, in a selenite-induced cataract rat model. J Korean Ophthalmol Soc 2010;51(5):733-739

인삼 사포닌의 흰쥐 취효소 분비에 대한 devazepide의 억제작용

이상호,이범구,이선미,박종대,조태순 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-Recent studies have suggested that Panax ginseng saponins may stimulate pancreaticobiliary secretion. However, the precise mechanisms underlying the alterations in pancreaticobiliary function associated with ginseng saponins remain uncertain. We studied the effects of ginseng saponins and devazepide, cholecystokinin receptor antagonist, on pancreaticobiliary secretion in male Sprague-Dawley rats. The saponins tested were crude saponin (TS) and panaxatriol saponin (PTS). After single or two weeks administration of saponins, pancreaticobiliary juice of rats was collected for 8hrs. Single administration of TS and PTS did not change the volume of pancreaticobiliary juice compared with control group. In contrast, the pretreatment of devazepide significantly increased the volume of pancreaticobiliary juice. The amylase activity was significantly increased by acute TS treatment, but this increase was inhibited by devazepide pretreatment. In animals with two weeks administration of TS and PTS, the volume of pancreaticobiliary juice was not increased as compared to the control group. However, the volume of pancreaticobiliary juice was significantly increased by devazepide treatment. The amylase activity was significantly increased by two weeks administration TS and PTS, respectively. This increase was inhibited by devazepide treatment. Our findings suggest that ginseng saponins, especially panaxatriol, increase the amylase activity in pancreaticobiliary juice, and this is, in part, caused by release of endogenous cholecystokinin.

적채를 첨가한 스폰지 케이크의 품질특성

이미나,정예선 부산여자대학 2009 釜山女子專門大學 論文集 Vol.31 No.-

This study was performed to evaluate the quality characteristics of the sponge cakes with red cabbage. The sponge cake with red cabbage was prepared with different ratios from 0 to 9%. The specific gravities of the batter with red cabbage were higher than control one. The specific volumes of the sponge cake was gradually decreased as increasing of content levels of red cabbage powders. The Hunter’s colorimetric lightness(L), redness(a) and yellowness(b) of the sponge cakes were effected by the color of red cabbage. The addition of red cabbage powders increased moisture contents of the products. The crude ash contents of the cakes were increased as higher content levels of red cabbage powders. TDF (total dietary fiber) contents were significantly increased by the substitution ratios. In texture analysis, hardness, gumminess, and brittleness of sponge cake were increased as increasing of seaweed and vegetable powders added, while cohesiveness was decreased. Springiness showed no significant differences among the substitution ratios. In the sensory evaluations, preferences of the cakes with red cabbage powders were significantly higher than those of control cakes,especially 3% level of the powder showed the highest preference. The results show that the most recommendable sponge cake was in the substitution ratios of 3% red cabbage powder. They can possibly contribute to improving the nutritional and functional well-being of foods.

허혈 및 재관류에 의한 간장손상에 있어 활성산소의 역할

이선미 성균관대학교 약학연구소 1992 成均藥硏論文集 Vol.4 No.1

Ischemia/reperfusion injury of the liver is an important clinical problem, e.q., hepatic failure after shock, liver transplantation, or liver surgery. There is a rapidly growing body of evidence which indicates that oxygen free radicals play a major role in producing parenchymal and microvascular damages associated with reperfusion of ischemic tissues. Two enzymes are frequently invoked to explain oxygen free radical production after ischemia/reperfusion, i.e., xanthine oxidase and neutrophilic NADPH oxidase. The primary objective of this review is to summarize the studies that implicate oxygen radicals and xanthine oxidase (as their source) in ischemica/reperfusion injury to the liver. Evidence supporting a role for oxygen radicals in ischemia/reperfusion injury in other organs (small intestine, stomach, pancreas and skin) is also presented.

불임 고환 생검례의 병리학적 연구

이선경,설미영 부산의대 1991 부산의대잡지 - 부산대학교 의과대학 Vol.31 No.2

한인진 추출물의 간장보호 작용에 관한 연구

이순복,조태순,윤기욱,이종찬,이선미,심성보 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was investigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 ㎎/㎏ b.wt. in CCl_4-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 ㎎/㎏ b.wt. in CCl_4-induced chronic liver disease, 30 ㎎/㎏ b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.

임상실습 교육개선을 위한 간호학생의 간호활동시간 분석

이애경,김정애,주미경,정안순,장은정,김정수,강정희,이정애 경복대학 2001 京福論叢 Vol.5 No.-

신규간호사의 능력은 간호학생 때의 다양한 임상경험에 기초를 둔다. 따라서, 간호대학의 교수, 병원 지도자, 임상지도자는 간호학생들이 다양한 지식을 획득하고 간호기술을 경험할 수 있도록 도와주는 중요한 역할을 한다. 이 연구의 목적은 이러한 간호학생들의 임상실습에서 수행하는 간호활동과 간호활동 시간을 분석하고자 하는데 있다. 연구결과 간호학생 1인당 직접간호활동 시간은 185.5분(직접간호비율은 56.7%)으로 141.65분(간접간호 비율은 43.3%)인 간접간호활동 시간보다 많았다. 직접간호활동 시간 중 활력징후 측정이 51.9분으로 가장 많은 시간을 차지하였고, 간접간호활동 시간 중에는 차트보기가 22.98분으로 가장 많은 시간을 차지하였다. 전반적으로 기본적인 임상간호 수행기술에 소요되는 시간이 고도의 숙련된 간호기술을 수행하는데 드는 시간보다 많은 것으로 나타났다. 따라서, 본 연구결과를 토대로 간호대학의 지도자와 병원의 지도자 및 임상지도자가 함께 임상실습 교육과정의 지침서와 평가서를 평가할 필요가 있다고 제언하는 바이다. The competence of newly graduated nurses is based on various clinical experiences gained when they were students. Therefore, professors in nursing schools, directors in hospitals or preceptors must play a critical role in assisting them to obtain various knowledge and experienced nursing skills. The purpose of this study is to investigate nursing care activities and nursing care hours practiced by nursing students in clinical experience. The results of this study showed that the direct nursing care hours per each nursing student are 185.5 mins(direct nursing care rate 56.7%) and it is higher than indirect nursing care hours, 141.65 mins(indirect nursing care rate 43.3%). The hours of checking vital signs are the longest(51.9mins) among the direct nursing care activities, and the hours of reviewing chart are the longest(22.98mins) among the indirect nursing care activities. In general, the time of performing basic clinical nursing technique was higher than that of performing high skilled nursing technique. And nursing observation was higher than that of directly performing task. So, we suggest based on the results of this study as follows. It is needed for nursing instructors in nursing schools and hospitals together to evaluate the guidelines and check-list of clinical practice courses.

박완서 소설의 서술성 연구 : 「나목」,「그해 겨울은 따뜻했네」를 중심으로

이선미 한국여성문학학회 2001 여성문학연구 Vol.5 No.-

박완서 소설은 삶의 ‘이면’으로서 ‘내면’적 자아를 부각시키려는 성격화 방식을 보여준다. 이는 전쟁과 분단, 전체주의적인 근대화의 경험을 통해 은폐되고 ‘억압’된 역사적 사실들을 복원하려는 작가의 방법론에서 연유한 것이다. ‘기억’과 ‘복원’의 방법론은 바로 역사적 과정에서 억압된 사실들을 ‘내면’적 자아의 형상으로 복원하려는 작가 나름의 정치적 의도가 전제된 서술방식으로서 ‘이면지향적 사유’와 연관된다. 특히 박완서 소설에서 정치적 의도를 읽어내고, 그것을 통해 문학사적 의미를 부여하려는 것은 ‘기억’하고 ‘복원’하려는 역사적 경험이나 ‘사실’은 단순한 증언과는 다르기 때문이다. 은폐하고 억압하도록 하는 현실의 이해관계까지도 비판하는 현실비판의식과 내면화된 이데올로기의 허위성을 비판하려는 자기성찰이 이 기억의 방법론을 역사적으로 의미있게 한다. 『나목』의 이경과 『그해 겨울은 따뜻했네』의 수지는 전쟁이라는 극적 상황을 통해 허구적 ‘가족 관념’에 의해 부정된 자기 삶의 진상(眞相)을 발견한다. 그러나 그 ‘관념’은 자기 삶의 근거이기도 하여 자기를 발견함과 동시에 은폐할 수밖에 없는 역설적 상황에 놓임으로써 극심한 내명갈등을 겪는다. 이 내면갈등을 내색하지 못하고 내면에만 담아두어야 하는 인물의 이중적 상황은 인물의 삶이 얼마나 심각한 것인가를 역설적으로 강조한다. 이런 이중적 인물의 성격화방식은 서술의 <역설성>이라 할 수 있다. 자기를 발견함과 동시에 자기를 은폐할 수밖에 없는 현실을 받아들이는 인물의 내면갈등은 자기를 소외된 자, 즉 타자로 인식하는 자기인식으로서 고아의식이 된다. 지배적인 이데올로기나 규범의식에 의해 자기가 소외되었다고 여기는 고아의식은 60ㆍ70년대의 전체주의적 ‘근대화’ 과정에서 내면화되었던 획일적인 자아를 부정하고 억압된 자아를 복원하는 자아의 서사라 할 수 있다. This thesis studies the novels of Park Wan-seo, focusing on the narrative method that construct the characters. Her works embody the true picture of lives of the ages after Korean War, based on her real experience. The real experience comes into the novel for her strong wish to recall. The narrative method, which is the main subject of this study, is related closely with her wish to represent the experiences. She wants to 'recall' and novelize the experience because it is the experience of the oppression. The memory is itself the 'experience of the oppression', because the experience cannot be expressed openly. And it is resurrected by her novel through recollection. The author's memory, which is the shade of the socio-historical oppression, is related with her unique method of figuring the characters. Most characters of her novel have private and confidential experience only confined in inner side, because of the outer conditions of oppressing, as the author herself write the novel because of the surroundings which disturb the immediate speaking of her experience. The method of writing to resurrect the oppressed experience yields the peculiar characters. This character is <the disguised character>, which is a kind of dual personality, inner side and outer side. The heroines of 『The naked tree』 and 『That winter was mild』 realized the real state of the life, which is denied the false idea of the family. By the way, the false idea is a basis of their life. They faced a crisis. It is that they must cover up the real stste of their life although realizing. And not opening their real state, they have troubel in the inner side. This dual personality is paradoxically showing the serious life. This characterization is <Paradox of narrative>. These charaters have the consciosness of the orphan, which is thrown away. The historical meaning of Park-Wanseo' novel is in this point.

고지방식을 섭취한 랫드에서 김치유산균의 콜레스테롤 저하효과

조미선, 노정미, 임형준, 한선경, 신명수, 이완규 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

간호 학생의 임상실습 효율을 위한 기초 조사 연구

이애경,김정애,주미경,정안순,배경진,김정수,이정애,장은정 경복대학 2000 京福論叢 Vol.4 No.-

임상실습 교육은 간호이론을 실무에 적용하는 기회를 제공하는 과정으로서 임상실습이 간호교육의 중요한비중을 차지하고 있다는 것은 주지의 사실이다. 이러한 중요성에도 불구하고, 임상실습 교육에 즉각적인 해결이 어려운 많은 문제점이 있음도 이미 알고 있는 사실이다 이에 임상실습 교육의 기초 자료로 활용되고 있는 실습목록표에 대한 간호 학생들의 실습목표의 명확한 이해와 더불어 이론과 실습의 연계성을 강화시키고자 하였다. 성인간호, 모성간호, 이동간호 3개 영역 모두에서 공통적으로 기본임상간호 항목이나 기본간호술과 관련된 항목에서 직접수행의 빈도가 높았고 숙련된 기술적인 처치나 전문성을 필요로 하는 항목에서는 관찰과 수행경험이 부족한 것으로 나타났다. Clinical performance is not only the process of providing the opportunity for applying nursing theory into practice but also it is a well-known fact that clinical performance is an important part in nursing education. lnspite of this importance, it is also true that many problem with no immediate solution exist in clinical performance of nursing students. thus, through measuring and analyzing the degree of clinical experience of the nursing students, on the nursing checklist that is being used as the basic guide in clinical education, we tried to clearly understand the objectives of clinical performance and to emphasize the connection between theory and clinical performance. The results of the study showed that the frequency of directly performing tasks was high in all areas of adult health nursing, maternity nursing, and child nursing for the items of basics clinical nursing and items related with basic nursing techniques, and that the experiences of observation and execution were lacking in the items needing skilled treatment or speciality.