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전윤식,이성해,정영홍,박선자,김상구 釜山大學校 學生生活硏究所 1988 硏究報 Vol.24 No.1
The purpose of this study was to explain the factors that effect on a academic achievement of Pusan National University(PNU) students. In order to achieve the above purpose, two research problems were established as follows: 1. What are the personal-internal factors which effect on a academic achievement of PNU students? 2. What are the personal-exteranl factors which effect on a academic achievement of PNU students? Statistical methods applied were general descriptive statistics, Pearson's correlation method, multiple regression analysis. The statistical computations were done by SPSS. The results of this study are summarized as follows: 1.The personal-internal factor that effect on a academic achievement of PNU students is the learning skill. 2. The personal-external factors that effect on a academic achievement of PNU students are professor's fulfilling prophecy and the times of review of studies.
전윤식,이성해,정영홍,박선자,김상구 釜山大學校 學生生活硏究所 1988 硏究報 Vol.24 No.1
The purpose of this study was to explain the factors that effect on ego-identity of Pusan National University(PNU) freshmen. In order to achieve the above purpose 2,743 freshman class of 1988 were selected. Statistical methods applied were general descriptive statistics, Pearson's collelation method, multiple regression analysis. The statistical computations were done by SPSS. The results of this study are summarized as follows: 1. The personal and domestic factors that effect on ego-identity of PNU freshman class of 1988 are mother's attitude of rearing the adaptation confidence of the university life, religion, the participation of the social reality, the experience of the acquaintance with the other sex, the self-conceit and health. 2. The personality factors that effect on ego-identity of PNU freshman class of 1988 are the social introversion and the social responsibility. 3. The factors that effect on ego-identity of PNU freshman class of 1988 are the social introversion, the social responsibility, mother's attitude of rearing religion, the participation of the social reality, a sense of superiority, the experience of the acquaintance with the other sex, the adaptation confidence of the university life.
Gujrati, Vipul,Lee, Miriam,Ko, Young-Joon,Lee, Sangeun,Kim, Daejin,Kim, Hyungjun,Kang, Sukmo,Lee, Soyoung,Kim, Jinjoo,Jeon, Hyungsu,Kim, Sun Chang,Jun, Youngsoo,Jon, Sangyong National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.3
<P>Despite the appreciable success of synthetic nanomaterials for targeted cancer therapy in preclinical studies, technical challenges involving their large-scale, cost-effective production and intrinsic toxicity associated with the materials, as well as their inability to penetrate tumor tissues deeply, limit their clinical translation. Here, we describe biologically derived nanocarriers developed from a bioengineered yeast strain that may overcome such impediments. The budding yeast Saccharomyces cerevisiae was genetically engineered to produce nanosized vacuoles displaying human epidermal growth factor receptor 2 (HER2)-specific affibody for active targeting. These nanosized vacuoles efficiently loaded the anticancer drug doxorubicin (Dox) and were effectively endocytosed by cultured cancer cells. Their cancer-targeting ability, along with their unique endomembrane compositions, significantly enhanced drug penetration in multicellular cultures and improved drug distribution in a tumor xenograft. Furthermore, Dox-loaded vacuoles successfully prevented tumor growth without eliciting any prolonged immune responses. The current study provides a platform technology for generating cancer-specific, tissue-penetrating, safe, and scalable biological nanoparticles for targeted cancer therapy.</P>