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증 례 : 새로 진단된 제2형 당뇨병에서 초승달 반흔이 동반되고 말기 신부전으로 급속 진행된 당뇨사구체경화증 1예
고영선 ( Young Sun Ko ),윤혜진 ( Hyae Jin Yun ),이은영 ( Eun Young Lee ),장기석 ( Kiseok Jang ),이주학 ( Joo Hark Yi ),한상웅 ( Sang Woong Han ) 대한내과학회 2016 대한내과학회지 Vol.90 No.1
Diabetic nephropathy is a chronic microvascular complication of type 2 diabetes and the leading cause of end-stage renal disease. We report the case of a 34-year-old male, newly diagnosed with type 2 diabetes mellitus, who had advanced-stage nephropathy with glomerular crescents. A moderately-to-severely decreased glomerular filtration rate with nephrotic syndrome was seen at the time of diagnosis of diabetes. Proliferative diabetic retinopathy was detected, but there was no positive finding in serology tests for glomerulonephritis. Non-necrotizing cellular crescents and nodular glomerulosclerosis were observed in a kidney biopsy, and renal function declined rapidly to the end stage. We review data on diabetic glomerulosclerosis with cellular crescents and the rapid progression of nephropathy. (Korean J Med 2016;90:46-49)
The Role of Nkx2.5 in Keratinocyte Differentiation
( Chul Hwang ),( Sun Hyae Jang ),( Dae Kyoung Choi ),( Su Jong Kim ),( Joong Hwa Lee ),( Young Lee ),( Chang Deok Kim ),( Jeung Hoon Lee ) 대한피부과학회 2009 Annals of Dermatology Vol.21 No.4
Background: Nkx2.5 is a homeodomain-containing nuclear transcription protein that has been associated with acute T-lymphoblastic leukemia. In addition, Nkx2.5 has an essential role in cardiomyogenesis. However, the expression of Nkx2.5 in the skin has not been investigated. Objective: In an attempt to screen the differentially regulated genes involved in keratinocyte differentiation, using a cDNA microarray, we identified Nkx2.5 as one of the transcription factors controlling the expression of proteins associated with keratinocyte differentiation. Methods: To investigate the expression of Nkx2.5 during keratinocyte differentiation, we used a calcium-induced keratinocyte differentiation model. Results: RT-PCR and Western blot analysis revealed that the expression of Nkx2.5, in cultured human epidermal keratinocytes, increased with calcium treatment in a time-dependent manner. In normal skin tissue, the expression of Nkx2.5 was detected in the nuclei of the keratinocytes in all layers of the epidermis except the basal layer by immunohistochemistry. In addition, the expression of Nkx2.5 was significantly increased in psoriasis and squamous cell carcinoma, but was barely detected in atopic dermatitis and basal cell carcinoma. Conclusion: These results suggest that Nkx2.5 may play a role in the change from proliferation to differentiation of keratinocytes and in the pathogenesis of skin disease with aberrant keratinocyte differentiation. (Ann Dermatol 21(4) 376~381, 2009)