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강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-
과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.
과학 수행 평가 문항의 선정 및 제작을 위한 평가 준거의 개발
김은진,박현주,강호감,노석구 한국과학교육학회 2003 한국과학교육학회지 Vol.23 No.1
본 연구에서는 과학교육에서 수행평가의 올바른 사용과 정착을 위하여 과학 수행평가문항의 선정과 제작을 위한 평가준거를 개발하였다. 이를 위하여 과학과 평가목표 및 수행평가에 대한 이론적 논의를 통해 평가준거의 대범주로 평가 목표의 충실도(Fidelity), 수행평가의 특징과 구성 요소에 대한 만족도(Satisfaction), 문항의 내용 타당도(Content Validity), 학습자에 대한 내용의 적합도 및 공정성(Suitability & Fairness), 문항의 신뢰도와 객관도(Reliability & Objectivity), 사용상의 편의성 및 실용성(Usability)의 6가지 범주를 개발하였고, 각 대범주별 하위항목을 선정하여, 총 25개의 하위 항목을 가진 평가준거표를 개발하였다. 그리고 개발된 평가준거표의 타당도는 과학교육 연구자 5명의 안면타당도로 보았고, 신뢰도는 3가지 종류의 과학 수행평가문항을 과학교육 전문가 2명과 초등예비교사 6명이 평가하교, 그 결과를 Kendall계수를 통한 평가자간 합치도로 검증하였다. 그 결과 합치도는 통계적으로 유의한 수준으로 나타났다. 이상의 과정을 통하여 최종적인 평가준거표를 완성하여 제시하였다. We have developed of a criterion that would help to select and develop performance assessments in science education. There are six categories of a criterion: Fidelity, satisfaction, content validity, fairness & suitability, reliability & objectivity, and usability. There are the total of 25 sub-categories under the six categories. Five science educators evaluated the validity of the criterion. For reliability of the criterion, Kendall's tau-b was used. Eight science educators and elementary teachers evaluated three performance assessment tasks for the correspondence of the criterion. This study also discuss the implications of this criterions as well.
林錫鳩,張殷永,金元厚 한국항공대학교 1991 論文集 Vol.29 No.-
TDX-10 및 EWSD 기종의 과부하 제어방식을 검토한 후 프로세서 점유율 측면에서 성능이 향상된 제어방식을 3가지로 분류하여 제안하며, 각각을 가정된 모델에 따라 시뮬레이션을 수행하여 성능평가를 행하였다. 그 결과 TDX-10L방식을 제외한 제안한 방식은 과부하 상태에서도 시스템 설계용량인 90%의 프로세서 점유율로 유지함을 확인하였다. The performance analysis of proposed three overload control methods is conducted to present the more optimal than methods using in conventional TDX-10 and EWSD by simulation with the assumed model. From simulation result, the two methods except TDX-10L are satisfied with 90% of the designed processor engineered capacity.
Kim Ye-Seul,Choi Jae-Woong,Song Sang Hoon,Hwang Ho Young,Sohn Suk Ho,Kim Ji Seong,Kang Yoonjin,Gu Ja-Yoon,Kim Kyung-Hwan,Kim Hyun Kyung 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.4
Background: Point-of-care testing (POCT) coagulometers are increasingly used for monitoring warfarin therapy. However, in high international normalized ratio (INR) ranges, significant discrepancy in the INR between POCT and conventional laboratory tests occurs. We compared the INR of POCT (CoaguChek XS Plus; Roche Diagnostics, Mannheim, Germany) with that of a conventional laboratory test (ACL TOP 750; Instrumentation Laboratory SpA, Milan, Italy) and explored possible reasons for discrepancy. Methods: Paired POCT and conventional laboratory test INRs were analyzed in 400 samples from 126 patients undergoing warfarin therapy after cardiac surgery. Coagulation factor and thrombin generation tests were compared using the Mann–Whitney U test. Correlations between coagulation factors and INRs were determined using Pearson correlation coefficients. Results: The mean difference in the INR between the tests increased at high INR ranges. Endogenous thrombin potential levels were decreased at INR <2.0 for CoaguChek XS Plus and 2.0< INR <3.0 for ACL TOP 750 compared with those at INR <2.0 for both tests, indicating a better performance of ACL TOP 750 in assessing thrombin changes. The correlation coefficients of coagulation factors were stronger for ACL TOP 750 INR than for CoaguChek XS Plus INR. Vitamin K-dependent coagulation factors were found to contribute to the INR discrepancy. Conclusions: Decreases in vitamin K-dependent coagulation and anticoagulation factors can explain the significant discrepancy between the two tests in high INR ranges. Since conventional laboratory test INR values are more reliable than POCT INR values, a confirmatory conventional laboratory test is required for high INR ranges.
Kim, Jun Sik,Son, Dae Gu,Choi, Tae Hyun,Kim, Nam Gyun,Lee, Kyung Suk,Han, Ki Hwan,Kim, Jun Hyung,Lee, Sang-Il,Kang, Dawon Lippincott Williams Wilkins, Inc. 2008 Annals of plastic surgery Vol.60 No.6
In the 1990s, skin island flaps supplied by the vascular axis of sensitive superficial nerves, like the sural and saphenous nerves, were introduced. Flaps supplied by the superficial peroneal nerve accessory artery (SPNAA), however, are still not commonly used. The aim of this study is to understand the anatomic structure of the SPNAA and its perforators in the anterior intermuscular septum and to use SPNAA perforator flaps in the clinic.We dissected 16 cadavers and assessed the location and number of the SPNAA, its perforators, and the septocutaneous perforators originating from the anterior tibial artery. A SPNAA perforator flap was applied to 12 patients, the free flap was applied to 11 patients, and the pedicled flap was applied to 1 patient.SPNAA varied from 7 to 16 cm in length, with an average of 4.5 perforators to supply the lateral aspect. An average of 3.13 septocutaneous perforators originated from the anterior tibial artery. The mean size of the SPNAA perforator flaps was 65.5 cm. The complete follow-up period was 3–20 months. Although 1 flap was lost as a result of arterial thrombosis, the procedure was successful in the remaining 11 patients. In addition, reduced flap thickness made them more esthetically appealing.SPNAA perforator flaps could be an excellent alternative to perforator flaps that use the lower leg as a donor site.
Kim, Jung Han,Kim, Jong Gu,Song, Junghyun,Bae, Tae-Sung,Kim, Kyou-Hyun,Lee, Young-Seak,Pang, Yoonsoo,Oh, Kyu Hwan,Chung, Hee-Suk Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.436 No.-
<P><B>Abstract</B></P> <P>We investigated the semiconductor-catalyzed formation of semiconductor nanowires (NWs) – silver sulfide (Ag<SUB>2</SUB>S)-catalyzed zinc sulfide (ZnS) NWs – based on a vapor-liquid-solid (VLS) growth mechanism through metal-organic chemical vapor deposition (MOCVD) with a Ag thin film. The Ag<SUB>2</SUB>S-catalyzed ZnS NWs were confirmed to have a wurtzite structure with a width and length in the range of ∼30 nm to ∼80 nm and ∼1 μm, respectively. Using extensive transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS) analyses from plane and cross-sectional viewpoints, the ZnS NWs were determined to have a c-axis, [0001] growth direction. In addition, the catalyst at the top of the ZnS NWs was determined to consist of a Ag<SUB>2</SUB>S phase. To support the Ag<SUB>2</SUB>S-catalyzed growth of the ZnS NWs by a VLS reaction, an in situ heating TEM experiment was conducted from room temperature to 840 °C. During the experiment, the melting of the Ag<SUB>2</SUB>S catalyst in the direction of the ZnS NWs was first observed at approximately 480 °C along with the formation of a carbon (C) shell. Subsequently, the Ag<SUB>2</SUB>S catalyst melted completely into the ZnS NWs at approximately 825 °C. As the temperature further increased, the Ag<SUB>2</SUB>S and ZnS NWs continuously melted and vaporized up to 840 °C, leaving only the C shell behind. Finally, a possible growth mechanism was proposed based on the structural and chemical investigations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ag<SUB>2</SUB>S catalyzed ZnS nanowires were synthesized using a VLS method. </LI> <LI> Chemical and structural analyses were performed from the plane and cross-sectional viewpoints. </LI> <LI> An in situ heating TEM experiment was conducted from room temperature to 840 °C. </LI> <LI> A possible growth mechanism was suggested based on the structural and chemical investigation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
김정자,최현주,김영신,김기범,심상인,김수평,강창석,이헌영,나종구,백은정,한구택,여경아,권순만,이교영 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.3
The incidence of malignant change of ovarian mature teratoma is 1∼2%. The majority is squamous cell cancer, the others was adenocarcinoma. Neuroepithelial tissue was frequently detected in mature cystic teratoma, but their malignant change was extremely rare. Only, two cases of neuroblastoma of ovarian teratoma were reported in the world. We report one case of neuroblastoma arising in ovarian mature teratoma with a brief review. Our case is the third reported one in the world.
Phelan-McDermid syndrome presenting with developmental delays and facial dysmorphisms
Kim, Yoon-Myung,Choi, In-Hee,Kim, Jun Suk,Kim, Ja Hye,Cho, Ja Hyang,Lee, Beom Hee,Kim, Gu-Hwan,Choi, Jin-Ho,Seo, Eul-Ju,Yoo, Han-Wook The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1
Phelan-McDermid syndrome is a rare genetic disorder caused by the terminal or interstitial deletion of the chromosome 22q13.3. Patients with this syndrome usually have global developmental delay, hypotonia, and speech delays. Several putative genes such as the SHANK3, RAB, RABL2B, and IB2 are responsible for the neurological features. This study describes the clinical features and outcomes of Korean patients with Phelan-McDermid syndrome. Two patients showing global developmental delay, hypotonia, and speech delay were diagnosed with Phelan-McDermid syndrome via chromosome analysis, fluorescent in situ hybridization, and multiplex ligation-dependent probe amplification analysis. Brain magnetic resonance imaging of Patients 1 and 2 showed delayed myelination and severe communicating hydrocephalus, respectively. Electroencephalography in patient 2 showed high amplitude spike discharges from the left frontotemporoparietal area, but neither patient developed seizures. Kidney ultrasonography of both the patients revealed multicystic kidney disease and pelviectasis, respectively. Patient 2 experienced recurrent respiratory infections, and chest computed tomography findings demonstrated laryngotracheomalacia and bronchial narrowing. He subsequently died because of heart failure after a ventriculoperitoneal shunt operation at 5 months of age. Patient 1, who is currently 20 months old, has been undergoing rehabilitation therapy. However, global developmental delay was noted, as determines using the Korean Infant and Child Development test, the Denver developmental test, and the Bayley developmental test. This report describes the clinical features, outcomes, and molecular genetic characteristics of two Korean patients with Phelan-McDermid syndrome.
Crystal structure and its proposed nucleolytic site of the single domain catalytic antibody 3D8-VH
Suk-Youl Park,Bo-Na Kim,Dong-Ki Choi,Pil-Won Seo,Do-Heon Gu,Yong-Sung Kim,Jeong-Sun Kim 한국구조생물학회 2016 Biodesign Vol.4 No.1
Catalytic antibodies are monoclonal antibodies with catalytic activities. An anti-DNA antibody can bind DNA and hydrolyze it with modest catalytic activity. The monoclonal antibody 3D8 from the autoimmune-disease prone MRL-lpr/lpr mouse has been used to make a recombinant single-chain variable-fragment antibody (3D8 scFv) that hydrolyzes DNA. The catalytic site is composed of several hyper-variable loops. Two His residues from the variable domains of the heavy chain (VH) and the light chain (VL) are responsible for DNA hydrolysis. Interestingly, two single domain antibodies derived from 3D8 scFv, called 3D8-VH and 3D8-VL, also bind and hydrolyze DNA although their activities are significantly lower than those of 3D8 scFv. Here, we report the crystal structure of 3D8-VH, which revealed no significant difference compared to the VH domain from 3D8 scFv. The 3D8-VH antibody is also structurally very similar to 3D8-VL that has a catalytic metal ion on the newly exposed surface-curvature. The observed structural features of 3D8-VH, along with the fact that it retained catalytic activity when the His residue that was catalytic in the 3D8 scFv was replaced, suggest that 3D8-VH also has its DNA binding and cleavage activity on the newly exposed surface. These findings provide new insights into substrate recognition and catalysis by single domain anti-DNA antibodies.