어린이 공공전문진료센터의 진료 역량: 상급종합병원과의 비교를 중심으로

오정윤,조수진,정진선,조진숙,박춘선 건강보험심사평가원 2022 HIRA RESEARCH Vol.2 No.2

소아청소년 복합만성질환자 수 및 진료비의 변화: 2011-2021년 건강보험청구자료 분석

오정윤,조수진,정진선,조진숙,박춘선 건강보험심사평가원 2023 HIRA RESEARCH Vol.3 No.2

Background: The number of children and adolescents has decreased by more than 3 million over the past 10 years. We analyzed changes in the number of children and adolescents with complex chronic conditions (CCCs) and their medical expenditures between 2011 and 2021. Methods: We used National Health Insurance claims data of patients under the age of 20 from 2011 to 2021. CCCs were classified as pediatric CCCs by Feudtner et al. Patients who repeatedly utilize medical services due to CCCs were defined as patients who sought medical care twice or more within the past 3 years. Their sex, age, CCC categories, and the number of CCC categories were presented using descriptive analyses. Results: The number of children and adolescents with CCCs increased from 345,320 (3.04%) in 2011 to 451,238 (5.33%) in 2021. Patients who repeatedly utilized medical services due to CCCs increased by 71,889 during the same period. The proportion of patients with two or more CCC categories increased from 35.80% in 2011 to 43.67% in 2021. In 2021, patients with other congenital or genetic defect were most common. Medical expenditures associated with CCCs increased from 475,654 million won (12.34%) in 2011 to 768,467 million won (19.11%) in 2021. Conclusion: The number of patients with CCCs and their medical expenditures increased in Korea between 2011 and 2021. The results indicate that consistent national efforts are required to maintain the specialized pediatric care. Further studies are needed to identify pediatric patients who require specialized medical services through various methods.

Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

퍼지 이론을 이용한 해저면 분류 기법

조진석,윤관섭,박순식,나정열,석등우 한양대학교 이학기술연구소 2003 이학기술연구지 Vol.6 No.-

음파를 이용한 해저면 분류를 위하여 2003년 5월 19-25일까지 남해해역에서 음향 실험을 실시하였다. 실험 해역은 해저 구성물질이 각기 다른 6개의정점을 선정하였으며 5개의 주파수(30,50,80,100,12 kHz)를 이용하여 해저면 반사 신호를 측정하였다. 또한 피스톤 코어를 이용하여 해저 퇴적물의 입도분석을 실시하였다. 해저면의 분류를 위해서는 펴지 이론(fuzzy logic)을 사용하였으먀, 이때의 입력 소속함수(input membership function)는 주파수 종속성을 갖는 해저면 반사손실 모텔(HYBRL, Hanyang University Bottom Reflection Loss)이 이용되었으며 출력 소속함수(out membership function)는 해저면의 평균입도 값으로 출력되도록 구성하였다. 퍼지이론을 통해 역산된 평균입도(mean grain size)와 코어 분석 자료를 비교하여 퍼지이론을 이용한 해저면 분류 방법의 가능성을 확인하였다. Acoustic experiments are performed for seafloor classificaton from 19 May to 25 May 2003. The six differnet sites of bottom composition are settled and the bottom reflecton losses with frequencies(30, 50, 80,100,120 kHZ) are measured. The fuzzy logic is used to classify the seabed. In the fuzzy olgic, HYBRL(HanYang Univ. Bottom Refleciton Loss) of frequency dependence is used as a input Membership functions and the output membership functions are composed of the values of the mean grain size of the bottom. The possibility of the seafloor classsification is verified comparing the inversed mean grain size using fuzzy logic with the results of the coring.

강원도산 감자의 품질 개량을 위한 연구 1.재배종 감자 품종들의 단백질, 환원당, 총폐놀성화합물 함량 및 Lipoxygenase Isozyme류 활성

조진숙,김화영,조순영 강릉대학교동해안지역연구소 1999 東海岸硏究 Vol.9 No.2

In order to develop potatoes with good processing qualities, we determined the protein content, reducing sugar content, total phenolic compounds content, and lipoxygenases activities in the tubers of five cultivated potato varieties. Superior variety contained the highest protein content among the five tested potato varieties. In addition, the reducing sugar content of Superior was lowest as compared with those of the five tested potato varieties. The lipoxygenase-2 activities of Superior and Chopung varieties were higher than those of Atlantic, Daegwan No. 52, and Daegwan No. 53 varieties. The five tested varieties showed no difference in the content of total phenolic compounds. The results suggest that Superior is the most acceptable material for processing such as potato chips and French fries.

지방 중소도시 근대건축에 관한 연구 : 충남 공주지역 근대건축의 형성 및 변천과정을 중심으로 Focused on the Formation and the Transition Process of Modern Architecture in Kong-ju

조흥석,오진안,김정동 牧園大學校 建築·都市硏究센터 1999 建築·都市環境硏究 Vol.7 No.-

The local city the fundamental research for the public recognition and architecture-cultural characteristic of modern architecture is very weak. When the characteristic of Korean modern architecture and mutual relation of systematic history is important, in a various side the research for other area is very urgent. From this point of view, the purpose of this research is by considering a positive date for formation and the transition process of existing modern architecture in a Kong-ju from the opening port to classify systematically existing actual condition of modern architecture in Kong-ju. To analyze each functional characteristic of modern architecture in Kong-ju in Korea modern architectural history and finally to establish historical meaning and to endow existing modern architecture with preservable value of Kong-ju architecture.

연근속의 Niacin 분석에 관한 연구

조인호,정석진 全北大學校 基礎科學硏究所 1981 基礎科學 Vol.4 No.1

Niacin contents in Lotus Corniculatus L. has been determined by high pressure liquid chromatography(HPLC), microbiological assay and manual chemical methods. It is concluded that the HPLC method was more precision than microbiological assay, or manual chemical methods.

强靭鑄鐵의 熔接性에 關한 硏究

曺東震,韓俊澤,劉憲一,朴龍鎭,金錫胤,慶在浩 弘益大學校 1974 弘大論叢 Vol.6 No.-

The matrix of ductile cast iron are welded by pre-heating it at 300℃ in the room temperature. Through the mechanical, non-desbructive testing and analysis of the composition. the possibility if arc welding of ductile cast iron are studied as follows; 1. L electrode is the best among them in weldability, impact value and machinability. The next is LB electrode followed by S electrode. C electrode is last. However, the tensile strength showed in the following order: LB, S, L, C. 2. LB, S, L, C, all are available for the welding of cast iron. 3. The above experiment showed that L and LB are good in general. In addition LB is low in price, we therefore prospect that it will be widely used as the electrode for cast iron.

한국인의 언어의식 : 언어접촉과 관련된 사회언어학적 연구

조준학,박남식,장석진,이정민 서울대학교 어학연구소 1981 語學硏究 Vol.17 No.2

The present study is an attempt to provide a rough profile of lingustic consciousness, as reflected in the day-to-day use of present-day Korean. The underlying assumption throughout is that the drastic socio-political changes in post-Liberation Korea must have left strong imprints in the popular Korean psyche and that there must be linguistic reflexes for these imprints, The present study does indeed come up with an interesting assortment of linguistic changes attributable to such socio-political changes as ① the coming of democracy and the nuclear family and ② an ever increasing encounter with other dialects and languages. As such, the present study can serve as a basis for a systematic formulation of language policy or for a principled 'purification' of Korean. A 50-item questionnaiare is used for the present study. The 784 respondents range from middle-school students to college graduates and represent both sexes and most of the major dialects of Korean.

요통환자의 요부 안정화 운동 방법이 통증감소에 미치는 효과에 대한 연구

조미숙,최윤희,김경,이지연,김진섭 대구대학교 특수교육재활과학연구소 2010 再活科學硏究 Vol.28 No.1

요통이란 근 골격의 이상으로 인한 통증으로 흉추 10번 이하의 허리부위에서 통증이 3일 이상 지속되는 경우를 말하며 인구의 약80% 이상이 일생을 통해 적어도 한번쯤은 겪게 된다. 이러한 요통은 체간의 연부조직의 손상이나 근력의 약화가 주요원인으로 작용하며, 이로 인해 통증, 지구력 감소, 관절가동범위 제한, 보행능력 감소를 유발한다. 이는 요통과 운동이 많은 관련성을 가지고 있다고 사료되며 그 중 요부 안정화 운동이 요통 환자의 통증 감소에 미치는 효과에 대해 선행연구들을 살펴봄으로써 효과적인 요부 안정화 운동방법과 적용에 도움을 주고자한다. Damage of soft tissue in lumbar interbody and weakness of muscular strength are the major causes of lower back pain, which results in inducing pain sensation, reducing muscular endurance and flexibility, limiting range of motion, and lowering locomotive capacity. Lower back pain is considered to be closely related to exercise. Exercise intervention in patients with low back pain being used as one of the spinal stabilization exercises and low back pain patients that exercise is effective in reducing the pain has been reported. Therefore, patients with low back pain of spinal stabilization exercises for pain reduction, previous studies on the effect of spinal stabilization exercise by examining how effective and will give help to apply.