가축에서 분리된 Vancomycin 내성 장구균의 내성유전자 구조 분석을 통한 분자생물학적 역학 연구

허지영,이선민,이석호,이위교,용동은,이경원,신완식,이동건 대한임상미샐물학회 2003 Annals of clinical microbiology Vol.6 No.2

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

액체 주방세제 전과정평가에 관한 연구

이재란,안석원,김한수,노승호 한국전과정평가학회 2001 한국전과정평가학회지 Vol.3 No.1

LG생활건가에서 생산되는 액체 주방세제의 환경성을 조사하기 위하여 전과정평가를 실시하였다. 제품별 전과정목록표를 도출하였으며, 이를 이용하여 수계생태독성, 지구온난화, 광화학스모그, 인간독성, 산성화, 부영양화에 대한 영향평가를 수행하였다. 그 결과, 제품 전과정 가운데 제품 계기단계에서 환경영향이 가장 높게 나타났고, 특히 수계생태독성에 의한 영향이 높게 나타났다. 주방세제의 환경지수에 영향을 미치는 원인물질을 찾아내고 개선물질로 대체하여 환경지수가 18% 감소한 제품을 개발하였다. With the kitchen detergents produced by LG Household & Healthcare, we performed life cycle assessment to examine their environmental properties. Life cycle inventories of kitchen detergent were drawn, and the impact assessment on six categories including aquatic eotoxicity, global warming, photochemical oxidant formation, human toxicity, acidification, and eutrophication was made using the inventories. As a result, it was found that environmental load is the highest at the end of life, and the worst impact category is aquatic ecotoxicity. We found the major ingredient determining environmental indicator and replaced it with more environmentally friendly material, so that the product of 18%-improved environmental indicator was developed.

수도용 강관의 용접성에 관한 연구(제2보) : 용접부의 잔류응력 해석 Analysis for residual stress of the weldments

이영호,이규천,나석주 충남대학교 공업교육연구소 1995 論文集 Vol.18 No.1

In this study, the analysis of residual stresses of the weldments were carried out to evaluate the safety of the steel welded pipes using a finite element method for the butt-weld joint and the lap-weld joint. On the other hand, to compare the analytic results with actual ones, the residual stresses were measured experimentally. The main conclusions can be summarized as follows ; 1. It was appeared that the tensile residual stresses were distributed in the weldment and the maximum tensile strength was about 50 ㎏f/㎟ which was the same level of the yielding strength in base metal. 2. In case of the butt-welded joint, the value of tensile strength decreased with increasing the distance from the weld metal or fusion line. On the othe hand, it was appeared that the compressive strength exsisted in the weld-bead. 3. The measurement value of maximum residual stress in the welding direction was 9.2㎏f/㎟ and was much lower than that of the theoretical analysis.

치료 불응성 Still's병에서 자가 조혈모세포 채집시 사용된 G-CSF에 의한 급성 악화 1예

이재웅,박성현,왕준광,오호석,최정혜,배상철,이영열,김인순,최일영,안명주 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.2

치료 불응성 자가면역질환에서 고용량 항암화학요법 및 자가 조혈모세포이식술이 시행되고 있으나 조혈모세포 가동화 및 이식술 시 사용되는 G-CSF에 의해 오히려 기존의 자가면역질환의 증세가 악화되었다는 보고가 있다. 저자들은 만성적으로 재발되는 Still's병 환자에서 조혈모세포 가동화를 위해 사용한 G-CSF에 의해 자가면역질환이 급성 악화된 1예를 경험하였기에 보고하는 바이다. High-dose immunosuppressive therapy with autologous stem cell transplantation is an increasingly used treatment for severe refractory autoimmune disorder including multiple sclerosis, rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus. Although the optimal method of collecting stem cell is not determined, G-CSF-based mobilization is generally considered safe. However, worsening of disease status was reported in autoimmune disease undergoing mobilization with G-CSF. We report a 24-year-old male with refractory Still's disease who developed acute disease flare after administration of G-CSF for stem cell mobilization.

장거리 달리기 선수에서 횡문근융해와 생화학적 지표의 변화에 대한 연구

안선호,최석채,김태현,나용호,송주흥,이영진,조지현,최석준 대한신장학회 2000 대한신장학회잡지 Vol.19 No.5

불화물의 첨가가 아연화유지놀의 압축강도, 이차 우식에 대한 저항성, 변연누출에 미치는 영향에 관한 실험적 연구

정호석,김대업,이광희 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

The purpose of this study was to investigate the effect of addition of fluoride to conventional zinc oxide eugenol on compressive strength, resistance of enamel to secondary caries and marginal leakage. Groups were divided by adding materials and their content. Group 1 was control group that did not contain fluoride, Group 2 was 10% sodium fluoride group, Group 3 was 20% sodium fluoride group, Group 4 was 10% stannous fluoride group and Group 5 was 20% stannous fluoride group. Each of four experimental groups was compared with control group. The results were as follows : 1. In compressive strength after 3 days, 10% stannous fluoride group was highest and then 20% sodium fluoride group, 10% stannous fluoride group, 10% sodium fluoride group, and non-fluoride group were in order. Compressive strength after 1 day water soakong after 3 days was stastically not significant(p>0.05). 2. In resistance of enamel to secondary caries, hardness reduction rate of experimental groups was lower than control group. There was no significant difference among groups (p>0.05). 3. Sodium fluoride group showed less marginal leakage than stannous fluoride group(p<0.05). 4. The amount of fluoride release was largest in 20% sodium fluoride group, and then 10% sodium fluoride group, 20% stannous fluoride, 10% stannous fluoride group were in order.

Mitomycin이 Mouse 간장의 인산염분해 효소에 미치는 영향

정호삼,신규석,이군자,이규식 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

Mitomycin (MC), a wide spectrum antibiotic and anticancer drug, is isolated from streptomyces caespitosus. MC decomposes DNA in cancer cell by forming a complex with DNA and inhibits division of cancer cells by interfering with the biosynthesis of DNA. In the normal cell, MC cross linkes with DNA and inhibits synthesis of RNA and protein. Therefore MC causes many complication in the MC treated patient. The authers have investigated the effect of MC on the mouse liver histochemically observing the change in the activities of alkaline phosphatase and ATPaes. Male mouse, DDY strain, weighing about 20 grams was used as experimental animals. The experimental animals were divided into the control and MC treated group and given food and water unlimited. The animals treated with 4mg of MC per kilogram of body weight were sacrificed at 6, 12, 24, 36 and 48 hour after administration. The animals of control groups were administered only water for injection. The liver specimens were fixed in 10% formalin solution at 4℃ and sliced at 14㎛ thickness in a frozen cryostat. The activities of alkaline phosphatase were observed by the Gormori's method and those of ATPase were observed by the Wachstein-Meisel's method for histochemical study. The result are as follows. 1. As the time passed, the activity of alkaline phosphatase activity was decreased in the hepatic lobule. Negative reactions were showed in the central and intermediate zone of the lobule of 36 hours of MC treated group. Trace activities of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. 2. As the time goes by, the activity of adenosine triphosphatase was decreased in the hepatic lobule. Negative reactions were observed in the entire hepatic lobule of 36 hours of MC treated group. Weak activity of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. Consequently, it is suggested that MC causes decrease in activities of hepatic alkaline phosphatase and ATPase due to live damage by cross linking of DNA with the drug in the hepatocyte and destructive change of organelles of the cell.

Sports Massage에 따른 혈액성분 변화에 대한 연구

성영호,이석영,권지윤 龍仁大學校 體育科學硏究所 1997 體育科學硏究論叢 Vol.7 No.1

The objective of this study was to determine if sports massage exert influence upon change of blood ingredient. 1) R.B.C is exposed that the mean value of rest before a surgical operation is 487, and after taking exercise 528. The mean value of rest after a surgical operation is 500, and after taking exercise 563. 2) W.B.C is exposed that the mean value of rest before a surgical operation is 7.610㎎/㎗, and after taking exercise 8.574㎎/㎗. The mean value of rest after a surgical operation is 8.718㎎/㎗, and after taking exercise 9.717㎎/㎗. 3) Hematocrit(Hct) is exposed that the mean value of rest before a surgical operation is 44.11㎎/㎗, and after taking exercise 47.1㎎/㎗. The mean value of rest after a surgical operation is 46㎎/㎗, and after taking exercise 51.7㎎/㎗. 4) Hemoglobin(HB) is exposed that the mean value of rest before a surgical operation is 14.4㎎/㎗, and after taking exercise 15.2㎎/㎗. The mean value of rest after a surgical operation is 15.4㎎/㎗. and after taking exercise 16.5㎎/㎗. 5) Albumin(ALB) is exposed that the mean value of rest before a surgical operation is 4.5㎎/㎗. and after taking exercise 4.8㎎/㎗. The mean value of rest after a surgical operation is 4.7㎎/㎗, and after taking exercise 5.1㎎/㎗. 6) Cholesterol is exposed that the mean value of rest before a surgical operation is 129㎎/㎗. and after taking exercise 140㎎/㎗. The mean value of rest a surgical operation is 14㎎/㎗, and after taking exercise 152㎎/㎗.