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( Wahyuni Lukita Atmodjo ),( Darti Isbandiati Wibisono ),( Stella Marleen Damai ),( Graciella Wahjoepramono ),( Franxicus Clinton ),( George Mathew ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Curcuminoids that exert a strong anti-inflammatory effect has shown to inhibit multiplicity of tumor nodules in liver carcinogenesis. However its efficacy to inhibit the progression of cellular transformation in liver carcinogenesis has not yet been evaluated clearly. Methods: Forty of 5 weeks old male Balb/C mice were divided randomly into 15 weeks and 20 weeks scarifying groups. Each of that group divided into 2 control groups, injected with sterile saline and fed either with basal diet (1), or fed with 0.2% curcuminoids- containing diet (2); and 2 treated groups, injected intra peritoneal with DEN 75mg/kg BW for 3 weeks, continued with 100mg/kg BW for 3 continuous weeks, fed with basal diet (3) or fed with 0.2% curcuminoid-containing diet (4). They were sacrificed at 15 weeks (n=20) and 20 weeks (n=20) after the first injection of DEN. The liver sections were stained with H&E and monoclonal antibody anti-Ki 67. The number of transformed-hepatocytes and Ki 67-positive cells were counted in high-powered fields (X400) surrounding central vein randomly. The results were analyzed statistically using t-test with considered significant at p<0.05. Results: Histologically, liver sections of the treated groups showed disruption of hepatic architecture with dilated sinusoids and degeneration of hepatocytes. Abundant transformed-hepatocytes characterized with enlargement nuclei, hyperchromatin nuclei and prominent nucleoli were scattered within liver parenchyma (fig.1,2). The numbers of transformed-hepatoctes were reduced significantly (p<0.05) when they fed with curcuminoids either in 15 or 20 weeks. Increasing number of Ki 67-positive cells were shown after injections of DEN (fig 2). Conclusions: We suggested that one of the mechanism by which curcuminoids-containing diets inhibit the progression of liver carcinogenesis is possibly through suppressing proliferation of transformed-hepatocytes.
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