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( Soyun Cho ),( Ser Ah Lee ),( Min Jung Lee ),( Dong Hun Lee ),( Chong Hyun Won ),( Sang Min Kim ),( Jin Ho Chung ) 대한피부과학회 2009 Annals of Dermatology Vol.21 No.1
Background: No studies have yet been undertaken to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin. Objective: We wanted to determine whether dietary aloe vera gel has anti-aging properties on the skin. Methods: Thirty healthy female subjects over the age of 45 were recruited and they received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. Their baseline status was used as a control. At baseline and at completion of the study, facial wrinkles were measured using a skin replica, and facial elasticity was measured by an in vivo suction skin elasticity meter. Skin samples were taken before and after aloe intake to compare the type I procollagen and matrix metalloproteinase 1 (MMP-1) mRNA levels by performing real-time RT-PCR. Results: After aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. Type I procollagen immunostaining was substantially increased throughout the dermis in both groups. Conclusion: Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression. However, no dose-response relationship was found between the low-dose and high-dose groups. (Ann Dermatol(Seoul) 21(1) 6∼11, 2009)
P275 : Childhood facial vitiligo: how intractable is it?
( Soyun Cho ),( Sung Ae Kim ),( Soon Hyo Kwon ),( Jung Tae Park ),( Jung Im Na ),( Chang Hun Huh ),( Kyoung Chan Park ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Vitiligo is well known as intractable disease. It is associated with reactive oxygen species and Nutritional support is maybe helpful for vitiligo patients. Objectives: To evaluate the long-term outcome of childhood facial vitiligo who were treated with nutritional education, vitamin E (α-tocopherol 100 - 400 IU/day), folic acid (1 - 2 mg/day) and multivitamin intake and antioxidant cosmetics as the mainstay of treatment as well as the conventional therapies. Methods: Medical data and photographs of 111 pediatric facial vitiligo patients who had been followed up for longer than 1 year from March 1, 2003 to June 30, 2013 were extracted from data warehouse of electric medical records. Photographic evaluation and final visual outcome assessment was performed. Results: By investigator’s assessment, 9% of patients demonstrated no improvement regardless of treatment modality, whereas 91% showed improvement of lesions. Among the latter, 33.3% resulted in >75% improvement; 18% in 50~75% improvement; 26.1% in 25~50% improvement; and 13.5% in 〈25% improvement. In the final visual outcome assessment, “Looking excellent” was seen in 42.3%; “looking very good” in 30.6%; “looking good” in 17.1%; “looking fair” in 9.0%; and “looking bad” in 0.9%. Conclusion: Although childhood facial vitiligo is quite refractory to treatment, the long-term outcome of this condition is not dismal with conventional vitiligo therapy along with basic nutritional therapeutic regimen.
( Soyun Cho ),( Sohee Oh ),( Nack In Kim ),( Dong Kun Kim ),( Joung Soo Kim ),( Young Suck Ro ),( Young Min Park ),( Chun Wook Park ),( Dong Won Lee ),( Sang Jun Lee ),( Weon Ju Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Cosmetics can affect the skin condition profoundly, and yet no survey has been performed in Koreans visiting dermatology clinics. Objectives: To assess knowledge and consumer behavior regarding cosmetics in Koreans visiting dermatology clinics. Methods: A questionnaire consisting of 43 questions concerning demographics, use/knowledge/ selection/ purchase of cosmetics was given to patients and accompanying persons who visited dermatologic clinics in university and private clinic settings. Results: In total 1,015 subjects (73.2% female, mean age 32.5 years) completed the survey. Education level was college or higher in 72.8%. Thirty-one percent had been diagnosed with a skin disorder, atopic dermatitis and seborrheic dermatitis being the most frequent diagnoses (33.7% and 16.8%, respectively). The frequency of makeup/sunscreen/functional cosmetics use, amount of sunscreen use, recognition of functional cosmetics, and knowledge of shelf life were significantly correlated with level of education. Among functional cosmetics, whitening products were used most frequently (29.2%). Regardless of education level, 79.2% purchased cosmetics without checking ingredients, and 85.7% were unaware of the all-ingredient-labeling regulations, and yet subjects considered ingredient the most important factor when purchasing a product. Conclusion: The demographic, knowledge and behavioral data obtained through this survey could serve as a basis for providing better quality care to our outpatients.
Soyun Cho,Chong-Hyun Won,이동훈,Min-Jung Lee,Serah Lee,Seung-Ho So,Seong-Kye Lee,Bon-Suk Koo,Na-Mi Kim,정진호 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
Red ginseng contains many bioactive constituents, including various ginsenosides that are believed to have antioxidant, immunostimulatory, and anti-aging activities. Yet, no controlled human study has explored its effects on photoaged skin. This study determined whether long-term intake of a red ginseng extract-containing Torilus fructus and Corni fructus mixture reduces facial wrinkles and increases collagen synthesis in human skin. Healthy female volunteers over 40 years of age were randomized in a double-blind fashion to receive either red ginseng extract-containing herbal mixture at 3g/day or placebo for 24 weeks. Facial wrinkles, elasticity, epidermal water content, erythema, and pigmentation were measured objectively. Facial skin samples were taken before and after treatment, and real-time polymerase chain reaction and immunohistochemical analyses were undertaken for expression of type I procollagen, matrix metalloproteinase (MMP)-9, and fibrillin-1, which are wrinkle-related biochemical markers. A total of 82 subjects completed the study. Facial wrinkles were significantly improved, type I procollagen gene and protein expression was increased, MMP-9 gene induction was prevented, and fibrillin-1 fiber length was elongated only in the treatment group. No changes were seen in the facial elasticity, epidermal water content, facial erythema and pigmentation, and epidermal thickness in either group. Thus a red ginseng extract-containing Torilus fructus and Corni fructus mixture improves facial wrinkles, a clinical sign of photoaging, and this improvement is associated with biochemical and histological evidence of increased collagen synthesis in the dermis. These results substantiate the alleged beneficial effects of red ginseng on photoaging and support its use as an effective “beauty food.”