Cimetidine과 Phenobarbital 이 Acetaminophen에 依한 急性 肝毒性에 미치는 影響에 關한 硏究

車淳道,姜大榮 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

In an attempt to elucidate the biochemical mechanism and efffects of phenobarbital and cimetidine on acetaminophen-induced hepatic necrosis, the present study in rats was undertaken to evaluate the relation between serum transaminase and pathologic change of the liver at 3, 6, 12 and 24 hours after acetaminophen administration with pretreatment of phenobarbital and cimetidine. The results were as follows: 1. Twenty--four hour mortalities in acetaminophen 600mg/kg administrated groups are 3..3% for the control group, 3.3% for cimetidine pretreatment group and 16.6% for the phenobarbital pretreatment group, respectively. In acetaminophen 1200mg/kg administrated groups, the mortalities are 33.3%, 6.6% and 43%, respectively. 2. The sGOT activity is increased at 3 hours after acetaminophen administration, and is in proportion to the dose of the drugs. In animals pretreated with cimetidine the elevation of the sGOT is decreased, but is increased in phenobarbital preated groups. The change of the sGPT is similiar to the sGOT, and reveal striking elevation at 24 hours after acetaminophen administration. 3. In animals receiving acetaminophen 600mg/kg, the necrotic change of the liver is not observed in the cimetidine pretreated group, but present in the phenobarbital pretreated group at 12 hours afterr acetaminophen administration. 4. In animals receiving acetaminophen 1200mg/kg, necrotic change is well demonstrated in the experimental and control group at 12 hours and 24 hours after acetaminohen administration. The severity of necrotic change is mild in the cimetidine pretreated group but severe in the phenobarbital. pretreated group in contrast to the control group. In summary, the results obtained by the present study indicate the severity of hepatic necrosis in the acetaminophen overdose treated rats is in proportion to the dose, increased by Phenobarbital and decreased by cimetidine.

Shield Disk 상의 Ag-Cu 공정계 합금 도금기술 개발

윤경도,차동관,심기종,민봉기,최순돈,이상기 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.1

The composition and the microstructure of the Ag-Cu alloy electrodeposits electroplated in Succinimide bath were investigated varying the electrolysis conditions such as bath composition, current density and additive agents etc. The cathode overpotential increased with the increase of Succinimide concentration and current density ratio in the bath. The Ag content of the alloy deposits decreased with the increase of current density and pH and temperature in the bath. The optimum condition for 78wt.%Ag-22wt.%Cu code position alloy is an follows : pH10(adjusted by NH_4OH), 0.03M AgNO_3, 0.27M Cu(NO_3)_2 3H_2O, 0.5M Succinimide in bath and 3.5A/dm^2∼5.5A/dm^2 current density.

리튬 - 폴리머 배터리를 이용한 무가선 저상 트램용 추진제어장치 개발 및 적용

차순도(Soon-Do Cha),이광국(Kwang-kuk Lee),권일동(Il-Dong Kwon),정은성(Eun-Sung Chung),김동명(Dong-Myung Kim),한정수(Jung-Su Han) 한국철도학회 2012 한국철도학회 학술발표대회논문집 Vol.2012 No.10

기존에 운행되는 중량전철은 천문학적인 예산이 투입되고, 수송량이 많을 경우 유용하나 수송량이 상대적으로 적은 지방 소도시는 중량전철을 적용하기에 비용의 문제가 있다. 또한 현재 전력소비량이 날로 증가하여 국가적인 차원에서 전력수급이 문제가 되고 있으며 에너지의 효율적인 사용이 점점 중요시 되고 있는 시점이다. 무가선 저상 트램은 건설비용의 절감, 에너지의 재사용, 편안한 승하차 등의 장점으로 기존 중량 전철의 문제점을 극복할 새로운 교통수단으로 대두되고 있다. 본 논문에서는 리튬 - 폴리머를 활용한 무가선 저상 트램에 적용된 추진제어시스템을 소개하고자 한다. Exsiting mass rapid transit needs too much astronomical budget and it is useful in case transported volume is large, but It is a waste of money to apply to local towns that has small transport of volume. Also at the state level, increasing power consumption and power supply are the problem, so efficient use of energy is increasingly important in the present. The advantages of low-floor trams that has advantage of reduce construction costs, the reuse of energy, comfortable rides, etc has emerged as a new transportation to overcome the problems of the existing train. In this paper, we introduce a propulsion system using lithium-polymer is applied to a non-catenary low-floor tram.

腹腔內出血의 實驗的觀察

車順道 大韓産婦人科學會 1965 大韓産婦人科學會雜誌 Vol.8 No.8

자궁내 피임장치와 연관된 방사선균증 1례

차순도,이탁 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.1

An unusual case of tubo-ovarian abscess due to actinomycosis, which was drained into rectum, associated with an intrauterine device, is reported with a brief review of literatures.

자궁내막암의 조기진단

차순도 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.1

자궁 경부암에서의 pap smear와 같이 다수인을 상대로 쉽게 외래에서 자궁내막을 채취하는 이상적인 방법이 아직까지는 고안되지 않았고 충분한 민감도 및 특이도를 가진 혈액검사가 발견되지 않았다. 그러므로 많은 사람들에 대한 집단검사는 실용적이 아니다. 그러나 자궁내막암에 대한 고위험도 부인들에 대한 선별검진은 가치가 있다. 고위험군 환자, 즉 ① 폐경기후의 출혈, 자궁내막 증식증 또는 폴립 ② 40세 이후의 과다한 자궁출혈 EH는 불규칙한 자궁출혈 ③ 체형이 큰 여성(비만 또는 키가 큰 여성 ④ 유방암 또는 난소암의 기왕력 ⑤ 장기간 unopposed estrogen에 자극을 받은 경우 ⑥ 폐경이 52세 이후에 된 여성 ⑦ 무배란성 주기를 가지고 있는 폐경전의 여성(다낭성 난소질환등) ⑧ 자궁농양을 가진 폐경기 환자 ⑨ 자궁경부 세포진에서 자궁내막 세포를 보이는 무증상의 폐경기 여성 등은 1년에 2-4회의 외래검진을 요하며 적절한 자궁내막검사를 반드시 해야하고 가급적 난포호르몬 요법을 중지하여야 한다. 그리고 심한 폐경기 증후군 환자에 대하여는 지속적인 unopposed estrogen 치료를 피하고 주기적으로 저용량의 estrogen, estrogen-progestin 또는 estrogen-androgen 혹은 progestin 주사로 대치하여야 한다.

胃癌의 組織學的 形態에 따른 浸透像의 差異

車淳道,李東久,洪錫宰 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.22 No.2

胃癌의 組織學的 形態에 따라 浸透像에는 어떠한 差異가 있는지를 알아보고자 117例의 切除胃癌標本을 對象으로 比較한 結果를 要約하면 다음과 같다. 癌型別로는 中分化管狀腺癌이 42例(35.9%)로 가장 많았으며 다음은 低分化腺癌, 高分化管狀腺癌의 順이었다. 浸潤幅은 癌型에 關係없이 腫塊의 크기가 클수록 넓었으며 癌型別로는 膠樣腺癌이 近位部로 1.7㎝, 遠位部로 1.6㎝를 浸潤하여 가장 甚하였고 高分化管狀腺癌은 近位部 0.4㎝, 遠位部로 0.8㎝로 浸潤幅이 가장 짧았다. 또한 全體的으로 近位部보다는 遠位部로의 浸潤이 좀더 깊은 傾向이었다. 深遠度로는 印環細胞癌이 79.7%에서 奬膜을 浸透하였으며 膠樣腺癌은 73.1%, 低分化腺癌은 66.9%였다. 반면에 分化程度가 좋은 乳頭腺癌과 高分化管狀腺癌에서의 奬膜浸透는 30%以下였다. 以上의 成績으로 보아 胃癌細胞의 浸透는 腫塊의 크기와 腺巢의 分化度에 正比例하는 것으로 보아지며 生檢組織의 分化度에 따라 手術範圍가 고려되어야 한다고 생각된다. This study was conducted to investigate some differences of the infiltrative profile of stomach cancer according to the histological type. One handred seventeen cases of gastric carcinoma resected by gastrectomy were classified by a method of Japanese Research Society for gastric cancer. The results obtained were as follows: Moderately differentiated tubular adenocarcionma was most common type and accounted for 42 cases(35.9%). And were followed by poorly differentiated adenocarcinoma and well differentiated tubular adenocarcinoma in order. On the infiltrative width, it showed the larger tumor mass, the wider infiltration with no relation of the cancer type. Histologically mucinous adenocarcinoma was most severely infiltrated, 1.7cm into the proxi-mal portion and 1.6cm into the distal portion, and well differentiated tubular type was least, 0.4cm into the proximal and 0.8cm into the distal portion. And generally showed a tendency of invasion more widely in distal than proximal portion. Concerning the infiltrative depth, 79.7% of signet ring cell carcinoma is Infiltrated into serosa, mucinous carcinoma 73.1% and poorly differentiated adenocarcinoma 66.9%, while well differented tubular and papillary carcinoma were less than 30%. In regard to above results, it summerizes that the extent of infiltration of gastric cancer cell paralelled to the degree of differentiation and we consider that the extent of surgery should be planned according to the degree of differentiation in surgical specimen.

Testosterone 多量長期投與가 家兎子宮. 腦 및 肝組織의 水分과 電解質에 미치는 影響

車順道,李壽鍾 우석대학교 의과대학 1971 우석의대잡지 Vol.8 No.2

Author has attempted to clarify the effects of sex hormone on electrolytes in the tissue of the uterus the cerebral cortex and liver tissue of mature female rabbits weighing about 2㎏. Determination of electrolytes' level of the uterus the cerebral cortex and liver tissue after administration of testosterone 100㎎ daily for 2 weeks after castration were undertaken. Levels of Cl, Na, K, Ca, Mg and water contents in the organ tissue mentioned in the foregoing were determined and then changes in electrolytes level, comparison of the electrolytes and water contents in these organ tissues were undertaken after a long term administration of testosterone in large doses to castrated rabbits. Flame-photometry was utilized for the determination of Na and K level, Schales and Schales method for Cl content and Kovacs and Tarrnoky's method for Ca and Mg content. The Results obtained are summarized as follows: 1. Serum electrolytes level of rabbits following castration produced no appreciable changes but a long term administration of testosterone in large doses to castrated rabbits produced a decrease in Cl, K and Mg levels. 2. Castration of female rabbits produced an increase in Ca levels and decrease in Mg level of the uterine tissue. A long term administration of testosterone in large doses to castrated rabbits produced a increase in Mg, K and water content. 3. Castration produced a marked decrease in water content of the cerebral cortex. A long term administration of testosterone in large doses to castrated rabbits produced an increase in water content and Na, Ca levels whereas a decrease in Cl and K levels. 4. Castration of female rabbits produced an increase in Na, Mg and decrease in K level of the liver tissue. A long term administration of testosterone of large doses to the castrated rabbits produced a increase in Cl, Na, K and Ca levels. 5. Water contents of the liver tissue of normal rabbits showed lower level than that of the uterine tissue but the water content levels of the uterine tissue and cerebral cortex were equal to each other. The water content of the cerebral cortex and liver tissue of the castrated and large doses of testosterone administered rabbits showed lower levels than of the uterine tissue respectively. 6. Cl contents of the cerebral cortex and liver tissue of normal, castrated, and large doses of testosterone administered rabbits showed marked lower levels than Cl content of the uterine tissue. 7. Na contents of the cerebral cortex and lier tissue of the normal, castrated and large doses of testosterone administered rabbits showed marked lower levels in comparison with of the uterine tissue of normal, castrated and testosterone administered female rabbits. 8. K contents of the cerebral cortex and liver tissue of the normal and castrated rabbits showed a marked higher levels in comparison with K content of the uterine tissue whereas K content of the cerebral cortex of large doses of testosterone administered showed marked higher level in comparison with K content of the uterine tissue. 9. Ca content of the cerebral cortex of the normal rabbits showed increased level but Ca content of the liver tissue showed decreased level in comparison with that of the uterine tissue. Ca contents of the cerebral cortex and liver tissue of the castrated female rabbits showed decreased level whereas Ca content of the cerebral cortex of large doses testosterone administered showed increased level and Ca content of the liver tissue of testosterone administered decreased level in comparison with Ca content of the uterine tissue of testosterone administered female rabbits. 10. Mg content of the liver tissue of normal female rabbits showed marked decreased level but Mg content of the castrated rabbits cerebral cortex showed marked increased and Mg content of the liver tissue marked decreased levels. Mg content of the cerebral cortex of large doses of testosterone administered rabbits showed decreased level and that of the liver tissue marked decreased level in comparison with that of the uterine tissue of testosterone administered rabbits.

Development of animal experimental periodontitis models

Do, Min-Jae,Kim, Kyuri,Lee, Haeshin,Cha, Seho,Seo, Taegun,Park, Hee-Jung,Lee, Jeong-Soon,Kim, Tae-Il Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.4

Purpose: An animal periodontitis model is essential for research on the pathogenesis and treatment of periodontal disease. In this study, we have introduced a lipopolysaccharide (LPS) of a periodontal pathogen to the alveolar bone defect of experimental animals and investigated its suitability as a periodontitis model. Methods: Alveolar bone defects were made in both sides of the mandibular third premolar region of nine beagle dogs. Then, the animals were divided into the following groups: silk ligature tied on the cervical region of tooth group, Porphyromonas gingivalis LPS (P.g. LPS)-saturated collagen with silk ligature group, and no ligature or P.g. LPS application group as the control. The plaque index and gingival index were measured at 0 and 4 weeks postoperatively. The animals were then euthanized and prepared for histologic evaluation. Results: The silk ligature group and P.g. LPS with silk ligature group showed a significantly higher plaque index at 4 weeks compared to the control (P<0.05). No significant difference was found in the plaque index between the silk ligature group and P.g. LPS with silk ligature group. The P.g. LPS with silk ligature group showed a significantly higher gingival index compared to the silk ligature group or the control at 4 weeks (P<0.05). Histologic examination presented increased inflammatory cell infiltration in the gingival tissue and alveolar bone of the P.g. LPS with silk ligature group. Conclusions: An additional P.g. LPS-saturated collagen with silk ligature ensured periodontal inflammation at 4 weeks. Therefore, P.g. LPS with silk ligature application to surgically created alveolar bone defects may be a candidate model for experimental periodontitis.

Control of corrosive water in advanced water treatment plant by manipulating calcium carbonate precipitation potential

Do-Hwan Kim,Jae-Hwan Cha,Soon-Heon Hong,김창원,Dong-Youn Kim 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.1

The corrosion of metal pipes in water distribution networks is a complex electrochemical and physicochemical phenomenon between a metal surface and corrosive water. The level of corrosion in water distribution systems was controlled by manipulating the calcium carbonate precipitation potential (CCPP) concentration, and the corrosive water quality was controlled in two steps within the advanced water treatment plant (AWTP) constructed at the Institute of Water Quality Research (IWQR), Busan Metropolitan City, Korea. The 1st control step was located before a coagulation process included on a rapid mixer, and the 2nd control step was located after a biological activated carbon (BAC) process. The capacity of the AWTP in IWQR was 80 m3/day. The CCPP concentration was controlled from the calcium hardness, alkalinity, and pH by adding calcium hydroxide (Ca(OH)2), sodium carbonate (Na2CO3), and carbon dioxide (CO2) in the above two steps. A CCPP control system was installed and operated according to the developed algorithm to maintain a CCPP range of 0-4 mg/L. The CCPP range was reasonably controlled to induce the formation of a CaCO3 film on the surface of the simulated water distribution system (SWDS). From the result of the corrosive water control, the CCPP formed greater than 0.0 mg/L. The crystalloid structure of the scale produced by CCPP control in the inner surface of pipe was zinc carbonate hydroxide hydrate (Zn4CO3(OH)6·H2O).