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Park, Sook Ryun,Kim, Min Ju,Ryu, Keun Won,Lee, Jun Ho,Lee, Jong Seok,Nam, Byung-Ho,Choi, Il Ju,Kim, Young-Woo Lippincott Williams Wilkins, Inc. 2010 Annals of surgery Vol.251 No.3
BACKGROUND:: In the era of pre- or perioperative therapy for gastric cancer, clinical staging before treatment appears to be increasingly important for prognosis, yet there are no data on the subject for resectable gastric cancer patients. OBJECTIVES:: To evaluate the prognostic role of preoperative locoregional staging in gastric cancer patients undergoing curative resection. METHODS:: We reviewed 1964 gastric cancer patients who underwent curative resection without preoperative therapy from 2001 to 2005. We performed computed tomography and clinical staging according to both the International Union Against Cancer (UICC)/American Joint Committee on Cancer (AJCC) (sixth edition) classification system, which bases N stage on the number of involved nodes, and the Japanese Classification of Gastric Carcinoma (JCGC) system, which bases N stage on node location. RESULTS:: The 5-year survival rates for patients with clinical T1, T2, T3, and T4 disease were 94.5%, 83.6%, 57.7%, and 35.5%, respectively (P < 0.001). The 5-year survival rates were 89.4% and 68.3%, respectively, for patients with clinical UICC/AJCC N0 and N1 disease (P < 0.001) and 89.4%, 72.4%, 61.0%, and 41.9%, respectively, for patients with clinical JCGC n0, n1, n2, and n3 disease (P < 0.001). When the JCGC system was applied within the UICC/AJCC N1 category, the 5-year survival rates significantly decreased, going from n1 (72.4%) to n2 (61.0%) to n3 (38.2%) (P < 0.001). In multivariate analysis, clinical T and N stage remained significant prognostic factors for overall survival. CONCLUSIONS:: Clinical stage is an independent predictor of long-term survival in the preoperative setting. It should be incorporated as a stratification factor in a randomized clinical trial of preoperative therapy for gastric cancer patients.
( Sook Ryun Park ),( Jee Hyun Kim ),( Do Yeun Kim ),( Se Hoon Lee ),( Sang Yoon Lee ),( In Sil Choi ),( Sung Soo Yoon ),( Seon Yang Park ),( Byuoung Gook Kim ),( Noe Kyoung Kim ) 대한내과학회 2003 The Korean Journal of Internal Medicine Vol.18 No.1
Background: Because of the relative paucity of data regarding the clinical outcome in adult patients with acute lymphocytic leukemia (ALL) in Korea, we analyzed clinical courses in adult ALL patients treated with VPD (L) regimen (vincristine, prednisolone
Park, Young Soo,Na, Young-Soon,Ryu, Min-Hee,Lee, Chae-Won,Park, Hye Jin,Lee, Ju-Kyung,Park, Sook Ryun,Ryoo, Baek-Yeol,Kang, Yoon-Koo American Society for Clinical Pathology 2015 American journal of clinical pathology Vol.143 No.6
<P><B>Objectives:</B></P><P>Fibroblast growth factor receptor 2 <I>(FGFR2)</I> amplification has been reported to be a target for treatment in gastric cancer. However, an optimal tissue source and method for evaluating <I>FGFR2</I> have yet to be established.</P><P><B>Methods:</B></P><P>Copy numbers were compared by quantitative polymerase chain reaction (qPCR) using frozen vs formalin-fixed, paraffin-embedded (FFPE) tissue and biopsy vs surgical specimens. We correlated the results of qPCR and immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) using stage IV gastric cancer biopsy specimens and validated the results in surgical specimens.</P><P><B>Results:</B></P><P>FFPE tissues were suitable for qPCR, and biopsy specimens were equivalent to or better than surgical specimens. qPCR and IHC results exhibited an excellent correlation with FISH at eight or more copies by qPCR in any kind of tissue, 5% or more by IHC in biopsy specimens, and 10% or more by IHC in surgical specimens. <I>FGFR2</I> amplification was 6.6% in stage IV gastric cancers, and 42% of these showed heterogeneous amplification and overexpression. IHC indicated a good correlation with FISH even in the heterogeneous cases.</P><P><B>Conclusions:</B></P><P>FFPE biopsy tissues are an adequate source for <I>FGFR2</I> evaluation in gastric carcinomas, and a qPCR-based copy number assay can be used for screening. IHC is also a valid and practical method for evaluating <I>FGFR2</I>, considering frequent heterogeneity.</P>
Genetic Polymorphism of Cyp2c9 and Warfarin dose requirements in korean patients
( Sook Ryun Park ),( Yun Tak ),( Sung Soo Yoon ),( Seon Yang Park ),( Byoung Kook Kim ),( Noe Kyeong Kim ),( Sun Pyo Hong ),( Hwan Seok Rhee ),( Hyun Jae Chung ),( Mi Sun Jee ),( Wang Don Yoo ),( Soo 대한내과학회 2002 대한내과학회 추계학술대회 Vol.63 No.-
Park, Sook-Young,Choi, Jaeyoung,Lim, Se-Eun,Lee, Gir-Won,Park, Jongsun,Kim, Yang,Kong, Sunghyung,Kim, Se Ryun,Rho, Hee-Sool,Jeon, Junhyun,Chi, Myung-Hwan,Kim, Soonok,Khang, Chang Hyun,Kang, Seogchan,L Public Library of Science 2013 PLoS pathogens Vol.9 No.6
<▼1><P>Because most efforts to understand the molecular mechanisms underpinning fungal pathogenicity have focused on studying the function and role of individual genes, relatively little is known about how transcriptional machineries globally regulate and coordinate the expression of a large group of genes involved in pathogenesis. Using quantitative real-time PCR, we analyzed the expression patterns of 206 transcription factor (TF) genes in the rice blast fungus <I>Magnaporthe oryzae</I> under 32 conditions, including multiple infection-related developmental stages and various abiotic stresses. The resulting data, which are publicly available via an online platform, provided new insights into how these TFs are regulated and potentially work together to control cellular responses to a diverse array of stimuli. High degrees of differential TF expression were observed under the conditions tested. More than 50% of the 206 TF genes were up-regulated during conidiation and/or in conidia. Mutations in ten conidiation-specific TF genes caused defects in conidiation. Expression patterns <I>in planta</I> were similar to those under oxidative stress conditions. Mutants of <I>in planta</I> inducible genes not only exhibited sensitive to oxidative stress but also failed to infect rice. These experimental validations clearly demonstrated the value of TF expression patterns in predicting the function of individual TF genes. The regulatory network of TF genes revealed by this study provides a solid foundation for elucidating how <I>M. oryzae</I> regulates its pathogenesis, development, and stress responses.</P></▼1><▼2><P><B>Author Summary</B></P><P>Rice blast disease, caused by <I>Magnaporthe oryzae</I>, destroys rice crop enough to feed 60 million people every year and has served as a model pathosystem for understanding host-parasite interactions. However, little is known about how <I>M. oryzae</I> globally regulates and coordinates its gene expression at the whole-genome scale. We analyzed the expression patterns of 206 <I>M. oryzae</I> genes encoding transcription factors (TFs) under 32 conditions, including infection-related developmental stages and various abiotic stresses, using quantitative real-time PCR. We focused on identifying the TF genes that are induced during the two most important infection-related morphogenetic changes; conidiation and infectious growth in rice. We identified 57 conidiation-specific TF genes and functionally characterized ten of them. Our data also showed that infectious growth <I>in planta</I> and oxidative stress responses <I>in vitro</I> involve largely overlapping groups of TFs. Comprehensive TF expression data and functional validation provided new insights into the regulatory mechanism underpinning pathogenicity and stress responses in <I>M. oryzae</I>. These data will also serve as a guide in studying the role of individual TF genes and the coordination of their expression in controlling development, pathogenicity, and abiotic stress responses in <I>M. oryzae</I>.</P></▼2>
Modeling of Recycling Oxic and Anoxic Treatment System for Swine Wastewater Using Neural Networks
Park, Jung-Hye,Sohn, Jun-Il,Yang, Hyun-Sook,Chung, Young-Ryun,Lee, Minho,Koh, Sung-Cheol The Korean Society for Biotechnology and Bioengine 2000 Biotechnology and Bioprocess Engineering Vol.5 No.5
A recycling reactor system operated under sequential anoxic and oxic conditions for the treatment of swine wastewater has been developed, in which piggery slurry is fermentatively and aerobically treated and then part of the effluent is recycled to the pigsty. This system significantly removes offensive smells (at both the pigsty and the treatment plant), BOD and others, and may be cost effective for small-scale farms. The most dominant heterotrophic were, in order, Alcaligenes faecalis, Brevundimonas diminuta and Streptococcus sp., while lactic acid bacteria were dominantly observed in the anoxic tank. We propose a novel monitoring system for a recycling piggery slurry treatment system through the use of neural networks. In this study, we tried to model the treatment process for each tank in the system (influent, fermentation, aeration, first sedimentation and fourth sedimentation tanks) based upon the population densities of the heterotrophic and lactic acid bacteria. Principal component analysis(PCA) was first applied to identify a relationship between input and output. The input would be microbial densities and the treatment parameters, such as population densities of heterotrophic and lactic acid bacteria, suspended solids(SS), COD, NH$_4$(sup)+-N, ortho-phosphorus (o-P), and total-phosphorus (T-P). then multi-layer neural networks were employed to model the treatment process for each tank. PCA filtration of the input data as microbial densities was found to facilitate the modeling procedure for the system monitoring even with a relatively lower number of imput. Neural network independently trained for each treatment tank and their subsequent combined data analysis allowed a successful prediction of the treatment system for at least two days.