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방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술
채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3
Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.
Button Osteoma: A Review of Ten Cases
( Soo Yuhl Chae ),( Hyun Bo Sim ),( Min Ji Kim ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.4
Background: Button osteoma presents as small circumscribed ivory-like lumps on the skull vault. Although not rare, its diagnosis can be challenging for dermatologists. Objective: To clarify the clinical characteristics of button osteoma by reviewing 10 cases. Methods: Ten patients diagnosed with button osteoma at the Department of Dermatology, Kyungpook National University Hospital, between January 2011 and August 2014 were enrolled. We retrospectively reviewed medical records and analyzed demographic and clinical characteristics including sex, age, sites, number of lesions, symptoms, duration, histopathological finding, radiological findings, and treatment. Results: All patients presented with an asymptomatic small circumscribed hard lump fixed to a bony structure. There were 9 female and 1 male patient, and the mean age was 54 years (range, 28∼61 years). The most common site was the forehead, and disease duration ranged from 2 weeks to more than 20 years. The differential diagnosis included cranial exostosis, ballooned osteoma, epidermal cyst, and lipoma. Simple radiography, ultrasonography, and computed tomography (CT) were used to make a confirmative diagnosis. Histopathological findings showed lamellated bony structures with poor vascularization. Ostectomy was performed for 5 patients, and no recurrence was detected within an average of 13.4 months after treatment. Conclusion: This review characterized button osteoma. Surgical excision is a useful therapeutic modality after CT-based diagnosis. Further studies with more patients are required to confirm the findings. (Ann Dermatol 27(4) 394∼397, 2015)
( Soo Yuhl Chae ),( Hyun Bo Sim ),( Kyung Hea Park ),( Hyun Wuk Cha ),( Hyun Ho Son ),( Hong Dae Jung ),( Mi Yeung Sohn ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Sebocytes express bioactive markers, including antimicrobial peptides (AMPs), inflammatory cytokines, matrix metalloproteinases (MMPs) and differentiation markers. The number of sebocytes and sebum secretion are increased by UV irradiation. Objectives: This study was conducted to clarify changes in bioactive marker expression after treatment of cultured sebocytes with UVB, UVA and visual light. Methods: RT-PCR, enzyme-linked immunosorbent assay, immunocytofluorescence and western blotting for the biomarkers were performed. Changes in the expression of bioactive markers after treatment of cultured sebocytes with UVB (0.5 and 1 MED), UVA (2J, 3J and 5J) and visual light (20 minutes at a distance of 30 cm) were investigated at day 1, 3, and 5 in triplicate. Sebum production was measured after treatment of cultured sebocytes with UVB (0.5 MED). Results: The expression of AMPs (especially, hBD-2 and hBD-3) showed an increased pattern after exposure of cultured sebocytes to UVB (0.5 and 1 MED). Out of inflammatory biomarkers, the expression of IL-1ß and IL-8 showed an increased pattern after exposure of cultured sebocytes to UVB (0.5 and 1 MED). Sebum production was increased after treatment of cultured sebocytes with UVB (0.5 MED). UVA and visual light did not show significant changes in the expression of bioactive markers in cultured sebocytes. Conclusion: UVB influences cultured sebocytes on the expression of bioactive markers, but UVA and visual light do not.
( Soo Yuhl Chae ),( Hyun Bo Sim ),( Kyung Hea Park ),( Hyun Wuk Cha ),( Hyun Ho Son ),( Hong Dae Jung ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Microneedle devices have been useful tools to reduce scarring and wrinkling. In addition, microneedle devices have been used in the treatment of pattern hair loss. Objectives: To investigate the efficacy and safety of home-use microneedle for the treatment of pattern hair loss. Methods: A total of 29 patients were enrolled. They were randomized into 3 groups; 5% minoxidil group, home-use microneedle group and their combination group. They were used twice a week. This study was evaluated through macrophotographic hair count, folliscope hair count, investigator`s global assessment (IGA), subject satisfaction score (SSS) and side effects at 0, 1, 3 and 6 months. Results: In all groups, a significant improvement was not shown in macrophotographic hair count (p>0.05) but in folliscope hair count (p<0.05). There was no statistically significant difference in hair count among the three groups (p>0.05). IGA was increased in three groups and 5% minoxidil group showed a statistically significant increase in IGA (p<0.05). SSS showed an improvement in a combination group. Mild and transient pruritus occurred in one patient of home-use microneedle group. Conclusion: Our study showed that a combination of home-use microneedle and 5% minoxidil is not inferior to 5% minoxidil. Home-use microneedle twice weekly is considered as a safe therapeutic modality to stimulate hair growth and to enhance transdermal delivery.
( Soo Yuhl Chae ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Following topics will be discussed briefly in this session. Chapter 27. Dermatologic surgery Anatomy and approach in dermatologic surgery Skin graft & skin flap Mohs micrographic surgery; mohs surgery Electrosurgery Cryosurgery Hair transplantation Liposuction Autologous fat transplantation Treatment for varicose vein and telangiectasia
P145 : Clinicopathological investigation on button osteoma
( Soo Yuhl Chae ),( Hyun Bo Sim ),( Min Ji Kim ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Although button osteoma is not rare disease, itis not easy for dermatologists to make its diagnosis. Objectives: To investigate the clinicopathological characteristics of button osteoma Methods: Ten patients diagnosed with button osteoma at our hospital from January 2011 to August 2014 were enrolled. We analyzed clinicopathologic characteristics, such as sex,age, distribution, disease duration, histopathological and radiological finding and treatment, by retrospective review of medical records. Results: All of the patients presented with an asymptomatic small circumscribed bony lump. The ratio of male to female was 1 to 9. The mean age was 54 years old (from 28 to 61). It developed most commonly on the forehead. Disease duration varied from 2 weeks to over 20 years. Differential diagnosis included cranial exostosis, ballooned osteoma, epidermal cyst and lipoma. Simple X-ray, ultrasound and computed tomography (CT) were taken to make a confirmative diagnosis. CT is the best radiological tool to make the diagnosis. Histopathological findings showed lamellated bony structure with poor vascularization. Excision was performed on 5 patients and no recurrence was found in an average of 13.4 months after treatment. Conclusion: This study gives us good information on button osteoma. Surgical removal is one of the useful therapeutic modalities after diagnosis with CT. Further study is needed to overcome the limitation of this study, including small number of patients.