정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

발정동기화에 의해 분만된 한국재래산양의 인공포유시험

梁鑛烈,羅鎭洙,金光鉉 全南大學校 農業科學技術硏究所 1996 農業科學技術硏究 Vol.31 No.-

This trial was conducted on 10 Korean native goat kids which were born by estrus synchrozation and seperated from their dams at 8 days of age. The kids were fed mesh raw milk from Holstein cows at regular intervals of three times daily by infant nursing bottle from 8 up to 59 days of age, and also provided pre-starter as well as Italian ryegrass hay from 14 days of age. Throughout the experimental period, daily amount of milk, pre-starter and Italian ryegrass hay consumed per kid was recorded. Live weight was measured at regular intervals of 3 days from 5 days of age till weaning, and thereafter at intervals of 15 days up to 119 de s of age. Growth rate per day were calculated during the total gain in weight. The average daily amount of milk consumed per kid was about 474 ml at the beginning and thereafter increased progressively until kids reached their peak(about 1,300 ml) by 41 days of age. The average total milk consumption per kid over the experimental period was about 51,000 ml. The kids started eating pre-starter and Italian ryegrass hay regularly around 32 days of age. The average daily amount of pre-starter consumed per kid was 10-l3g during 32-47 days of age and reached about 70g at weaning. The average daily amount of Italian ryegrass hay consumed per kid was 30g around 32 days and reached about 80g at weaning. The average birth weight of experimental kids was 1.79(±0.23) kg. The average daily gains of experimental kids showed 0.1 kg througout the experimental period and the average body weight of kids reached 8.14 kg at weaning .After weaning, the average body weight of kids reached 8.53 kg at 74 days, 9.55 kg at 89 days, 13.3 kg at 119 days of age, respectively.

만성 부비동염에서 섬모운동과 전산화 단층촬영에서의 상악동 점막비후의 상관관계

민양기,전상준,이재서,이철회,이강수,윤자복,이원진,박광석 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

자궁선근증의 방사선학적 진단 : 경질초음파의 유용성과 유용한 소견 Usefulness of Transvaginal Sonogram and Useful findings

양승부,최진수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Object : To evaluate the usefulness of transvaginal sonogram for radiologic diagnosis of adenomysis uteri and useful trasvaginal sonogram findings. Materials and Methods : Thirty five patients who were performed both ulㅅrasonography and hysterectomy proved as adenomyosis were analysed by sonographic finding of myometrial echo texture and also included 4 cases of combined myoma. Results : Four pattern of myometrial echo texture were analyzed. The most common type is ill defined heterogenous echo(19 case) but sensitivity is low(69%). And then ill defined heterogenous echo with multiple small cystic echoes(3 case), multiple alterating striation echo pattern(11 case), and single cystic echo(2 case) were followed. Ill defined heterogenous echo with multiple small cysts and multiple alterating striation echo pattern were most reliable findings(100% of sensitivity). Conclusion : Most reliable myometrial echo texture of adenomyosis are ill defined heterogenous echo with combined multiple small cyst or multiple alterating striation echo pattern. Multiple alteraing striation echo is the suggested charateristic finding of adenomyosis.

동맥색전술을 이용한 객혈의 치료

양승부,최진수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Object : Our purpose of this study is to evaluate the effectiveness of the bronchial and non-bronchial systemic arterial embolization for control of hemoptysis. Materials and Methods : 20 cases of seventeen patients with massive or recurrent hemoptysis underwent percutaneous transcatheter embolization between January 1999 and September 2001. We reviewed 26 cases of bronchial artery embolization and 17 cases of nonbronchial systemic artery embolization. Results : Immediate control of hemoptysis underwent percutaneous transcatheter embolization between January 1999 and September 2001. We reviewed 26 cases of bronchial artery embolization and 17 cases of nonbronchial systemic artery embolization. Results : Immediate control of hemoptysis was achieved in 16 of 20(80%) cases. The cause of hemoptysis was tuberculosis, bronchiectasis, and chronic bronchitis. Conclusion : Bronchial artery embolization is an effective and life saving procedure in non-surgical and preoperative candidates. Recognition and occlusion of non-bronchial systemic arterial that feed to hypervascular pulmonary lesion is essential for successful embolotherapy of hemoptysis.

무우자갈버섯(Hebeloma crustulineforme)을 위시한 한국산 담자균류 46종의 용혈활성 검색

양희정,정수현,김진향,정경수 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

To elucidate the hemolytic toxicities of Korean basidiomycetes, the cold-water extracts of 46 wild mushrooms were tested for hemolytic activity on mouse erythrocytes. Twelve species including Amanita esculenta, A. griseofarinosa, A. longistriata, A. melleicepe, A. phalloides, A. rubescence, A. spissacea, A. vaginata, Hebeloma crustuliniforme, Lepiota cygnea, Macrolepiota procera, and Oudemansiella platyphylla showed strong hemolytic activities. Of these, A. griseofarinosa and H. crustuliniforme showed no decrease in their hemolytic activity even after five minutes' boiling.

Segmental K-means 학습 알고리즘을 이용한 한국어 연결 숫자음 인식의 성능 향상

양진우,이근수 안성산업대학교 1995 論文集 Vol.27 No.-

본 논문은 Segmental K-means training 알고리즘을 이용한 한국어 연결 숫자음 인식의 성능향상에 관한 연구이다. 본 인식시스템은 세그먼테이션부, 표준 음성 작성부, 인식부로 구분된다. 세그먼테이션부에서는 Level-building word segmentation 알고리즘을 사용하여 각 단어 패턴들로 학습 데이터를 세그먼트하고, 표준 음성 작성부에서는 각각의 토큰 파일에 있는 데이터로 단어 표준 패턴을 개선한다. 인식부에서는 Level-building HMM 알고리즘을 이용하여 연결 숫자음을 인식한다. 본 실험은 잡음이 있는 연구실에서 20대 남성 화자 7명이 21종의 7연결 숫자음을 7회 발성한 자료를 사용하여 학습된 데이터에 대해 95.2%, 다중 화자 종속 데이터에 대해 94.5%, 화자 독립 데이터에 대해 86.7%의 인식률을 보였다. This paper represents a study on improvement of the Korean connected digits recognition using the Segmental K-means training algorithm. This recognition system is composed of the segmentation section, the design of standard speech section, and the recognition section. In the segmentation section, the training data is segmented into each word pattern using the level-building word segmentation algorithm and in design of standard speech section, the standard word pattern is improved using data which is in each token file. Using the level-building HMM algorithm, connected degits are recognized by the recognition section. This experiment yielded a recognition rate of 95.2% on the trained data, 94.5% on the multi-speaker dependent data and 86.7% on the speaker-independent data by making use of 21 sort of 7 connected digits. This data were uttered 7 times by 5 male speakers in speakers in their twenties in a noisy laboratory.

Uses and Gratification on eWOM Tourism Information

Yang,Sung-Soo,Huh,Hyang-Jin,Suh,Yong-Kun 세계문화관광학회 2009 Conference Proceedings Vol.10 No.0

This study draw on the uses and gratifications perspective in tourism information research to examine the tourist experience associated with website. The goal of this study is to investigate the extent to eWOM(electronic Word-of-Mouth) using motivation and gratification. In methodological sense, the survey was employed in user of destination search for travel and performed application with AVOVA for analysis. Data collecting method was a convenience sampling with face-to-face interview. A total of 600 questionnaires were collected from the survey and 577 questionnaires were coded for a data for analysis on this study. Data for the study were drawn from the user who have been travel information on eWOM. The findings deriving from this study are followings; First, Perception of using motivation is consist of 5 dimensions such as Self-Development, Information Acquisition, Enjoyment, Community, and Travel Cost. Second, The findings deriving from this study is a statistically significant difference in the relationship between the using dimensions and user propensity of eWOM tourism information. Finally, using motivation was positively related with behavioral intentions of making process.

급성충소돌기염의 임상 : 병리학적 고찰

양기화,조준필,하영천,한진우,정학재,손수창,이성희,황재훈,신철호 최신의학사 1989 最新醫學 Vol.32 No.4

김치저장성 향상을 위한 동결방법이 배추조직의 물성변화에 미치는 영향

양진한,박소희,유진현,임호수,조재선,황성연 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.2

김치를 10˚C에서 8일간 숙성시켜 산도 0.6~0.7%로 숙성된 김치를 -70˚C와 -20˚C로 냉동하며 -20˚C에서 저장하면서 배추 조직의 elasticity, hardness, 세포 조직의 변화, 드립양을 실험한 결과는 다음과 같다. -70˚C에서 급속 동결한 것과 -20˚C에서 완만 동결한 냉동 김치 중 배추조직의 elasticity는 냉동 저장 15일까지 감소하다 일정하게 유지되었고 hardness는 거의 변화가 없었으며 냉동 방법에 따른 변화도 거의 나타나지 않았다. 투과 전자현미경으로 관찰한 결과 control의 경우 세포벽이 매우 두꺼우며 세포의 모양들이 잘 보존되어 잇는 것을 볼 수 있었고 -20˚C로 냉동 처리하여 해동시킨 세포벽들은 많이 손상되어 있음을 볼 수 있었으며 -70˚C로 급속 냉동시료의 경우 세포벽의 손상 정도가 -20˚C로 냉동 처리한 시료보다 덜 파괴되어 있음을 볼 수 있었다.한편 냉동 저장기간 동안 드립의 손실량의 변화는 -70˚C로 냉동 처리한 시료의 드립양은 3~4%정도로 -20˚C로 냉동 처리한 시료의 5~6%에 비해 적은 것을 알 수 있었다. This study was conducted to investigate the effect of freezing methods, show freezing at -20℃ and rapid freezing at -70℃, on physical properties of Chinese cabbage in frozen Kimchi during storage at -20℃. Elasticity of midrib of Chinese cabbage in frozen Kimchi was decreased until 15 days and did not changed thereafter during storage at -20℃, Hardness of that was not changed during storage. Those results of elasticity and hardness of slow frozen sample are similar to rapid frozen sample. By the morphological observation through transmission electron microscope, more of cellular structure of Chinese cabbage in slow frozen was destructed than that of rapid frozen sample. Drip loss was more in slow frozen sample than that in rapid one.