정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Immobilization with Ketamine HCI and Tiletamine-Zolazepam in Cynomolgus Monkeys

Myung-cheol Kim,Sung-hyeok Hong,Soo-jin Lee,Young-suk Kim,Jae-il Lee 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus MonkeysJae-il Lee, Sung-hyeok Hong, Soo-jin Lee, Young-suk Kim and Myung-cheol Kim*Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, KoreaReceived March 4, 2003 / Accepted July 2, 2003J. Vet. Sci. (2003), 4(2), 187-191JOURNAL OFVeterinaryScience*Corresponding author: Myung-cheol Kim Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea Tel: +82-42-821-6757, Fax: +82-42-822-4216 E-mail: mckim@cnu.ac.kr

구리 지역에서 조사한 고혈압의 인지도, 치료률 및 관리률

홍철호,김순길,홍택원,이제,신진호,이재웅,김경수,김정현,임헌길,이방헌 대한간질학회 2003 대한간질학회지 Vol.9 No.1

배 유과 가공제품의 품질 특성 및 저장 중 생균수 변화

민진홍, 현세희1, 나광출, 이종수, 김하근 배재대학교 자연과학연구소 2012 自然科學論文集 Vol.23 No.1

To develop the functional pear fruitlet product, we prepared dried pear fruitlet and fermented pear fruitlet, respectively. Then we investigated their general characteristics, and viable cell number changes during the storage at room temperature. We also determined preference for their tastes. Dried pear fruitlet contained more ash and crude proteins as well as minerals than fermented pear fruitlet. However fermented pear fruitlet contained higher amount of edible fiber than dried pear fruitlet. Fungi were not detected from dried pear fruitlet during the storage experiment at room temperature. Numbers of bacteria from dried pear fruitlet were increased from 1.1☓105/g at the beginning to2.6☓106/g at the last day of experiment. When we determined change of fungi number during the storage of fermented pear fruitlet, we cannot detect fungi at the beginning but we detected 4.4☓102/g of fungi at the last day of storage experiment. Bacteria from fermented pear fruitlet were detected at around 1.0☓109/g during the storage periods. Preference for fermented pear fruitlet was superior to dried one.

치환 Thiobenzamide류와 Benzyl Bromide의 반응에 관한 반응속도론적 연구

홍순영,여수동,임용진 경북대학교 공과대학 1971 工大硏究誌 Vol.1 No.-

The kinetics of the reactions of m­or p-substituted thiobenzamides with benzyl bromde in acetone have been determined by an electric conductivity method. From these reactions, a positive Hammett plot is obtained and a mechanistic possiblity is proposed to account for the results. Some activation parameters have been also calculated.

정신보건법의 주요 쟁점 조항에 대한 선진국과의 사례 비교

홍진표,황순찬,박수빈,서동우,정은기,김진학,박종익,안주연,김수정,장홍석 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives The Mental Health Act is an initiative aimed at changing and shaping mental health services and protecting human rights of persons with mental disorders. Since the Mental Health Act was legislated in 1995, four amendments have been made according to the issues that arose from public concerns. However, there are still many debates about the human rights protection of the mentally iII. This study aimed to provide information regarding major aspects of the Mental Health Act by comparing them among several developed countries. Methods Current Mental Health Acts of the state of Michigan in the United States, Scotland in England, the state of Victoria in Australia, and Japan were reviewed. Issues regarding the Korean Mental Health Act were collected from seminar materials, news media contents, and mental health professionals Results The definition of subjects in Korean Mental Health Act was more inclusive than other countries and was derived from a medical classification of mental illness. Family members or guardians were granted important responsibilities for deciding the involuntary admission of mentally ill patients in Korea and Japan. In Western countries, Mental Health Review Tribunals or courts have the primary responsibility for important decisions about mentally ill patients. The regulation of immediate dis- charge after request by voluntarily admitted patients was not enacted in all countries except Korea. The mandatory procedure for involuntary admission in Western countries includes an individual case review with personal interview by a Mental Health Review Tribunal or court. Conclusion The Korean Mental Health Act appears to meet the basic standards of Guidelines from international organizations. Our traditional culture and inherent health systems seem to influence the legal regulation of mental health service and might be related to the problems of human rights protection of mentally ill patients in Korea.

Converging Thermal Wave 측정법에 의한 고체 재료의 열전도도 측정

홍진수,한용진,채희백,박훈 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1

The conductivity of CVD(chemical vapor deposited) diamond wafer and Cu-foil were measured with converging thermal wave technique. Annular shape of pulsed laser beam is used as a heating source and the temperature excursion is measured with liquid nitrogen cooled IR-detector. This measurement method is independent of specimen shape and size if the specimen is a thin plate. This technique is non-contacting and non-destructive.

Critical role of bile acid (BA) in the cellular entry and permissiveness of Hepatitis B virus in vitro

Hong‑Jai Lee,Bo‑Young Shin,Jae‑Seung Moon,Ailyn Fadriquela,Selikem Abla Nuwormegbe,Chun‑Chang Ho,Jin‑Su Shin,Jee‑Sang Yoon,Sang‑Kyou Lee,Soo‑Ki Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Lack of universal replication system for hepatitis B virus with narrow host range and organ tropism has hampered to uncover the pathogenesis of HBV. Previously, we reported the essentiality of humoral milieu and its components toward HBV and hepatitis C virus survival/viability in vitro. Of these components, the precise role of enterohepatic humoral milieu such as bile acid (BA) on HBV cultivation in vitro and in vivo is unknown. Objective We explored whether BA, specifically taurochenodeoxycholic acid (tCDCA) would directly regulate the viral DNA and surface antigen expression of HBV in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. Result We found that higher concentration of taurochenodeoxycholic acid (tCDCA) is able to preserve the genomic stability of HBV in cell-free DMEM, showing higher the surface antigenicity than taurocholic acid (tCA). In line, we found that in vitro cell culture condition (100 μmol/L of tCDCA coupled with 1 × 108 g e/mL HBV) would be optimal for HBV entry into target cells. Using this, human (HepG2, Huh7), and rodent (Hepa1c1c7, H4-II-E) hepatoma cell lines were infected by HBV, as evidenced by the presence of HBV biomarkers (HBsAg, and HBV DNA in culture supernatant, as well as HBcAg in cell). Further, cellular entry test revealed that HBV is able to infect 12 different non-hepatic cell lines regardless of species, and organ/tissue, consequently reproducing progeny as confirmed by HBV biomarkers. Last, reinfection test showed that the progenies of HBV from immortalized HepG2, and Hepa1c1c7 cells are able to enter into each or vice versa naïve HepG2, and Hepa1c1c7 cells with or without BA. Conclusion This study demonstrates that enterohepatic humoral milieu such as BA, specifically tCDCA would directly regulate HBV DNA and its surface antigen expression in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. This is the first note to render HBV permissive to human or rodent hepatic and non-hepatic cells via sole manipulation of humoral milieu, thus establishing the platform for in vitro robust replication system of HBV.

장애인의 성공적인 직장진입을 위한 선별면접 실태조사 분석연구

진홍섭,강필수 한국장애인고용촉진공단 고용개발원 2006 장애와 고용 Vol.16 No.2

면접형태에 대한 높은 관심에도 불구하고 장애인 채용관리 및 면접형태 연구의 전반적 수준은 일반노동시장과 비교할 때 매우 미흡한 실정이다. 이에 본 연구는 장애인 채용형태 및 면접경험에 대한 새로운 동향을 살펴보았으며 기업의 채용 형태 및 면접전형 과정, 장애인 구직자들의 면접 경험에 주완점을 두고 연구를 수행하였다. 채용방법, 채용절차, 선발도구 및 면접형태를 분석하여 장애인력 채용형태를 규명하고, 면접경험 분석을 통해 면접 준비행동 및 면접형태를 규명하는데 그 목적이 있다. 본 연구에서는 공단의 정책고객시스템(PCRM Policy Customer Relationship Management)에등록된 장애인을 채용아였거나 채용의사가 있는 기업체 인사담당자들과 구직은 희망하는 장애인을 대상으로 이메일을 통해 설문조사를 실시하였다. 본 연구에서 제시된 연구문제에 대한 분석을 위하여 SPSS WIN12.0을 이용하였으며 채용형태 및 면접관련 문항에 대한 빈도분석과 교차분석을 실시하였다. 본 연구를 통해 알아본 나타난 결과는 다음과 같다. 첫째, 기업의 채용· 면접 형태 분석 결과 면접시험의 중요성이 크게 강조되고 있었다. 장애인 신규재용시장에서도 전통적인 선발기법에서 벗어나 면접의 비중이 점차 커지고 있으며 이에 대한 대비가 필요하다. 둘째, 장애인 채용 면접 시 주된 평가는 능력적인 요소보다 인성적인 요소가 강조되고 있다. 성실성과 장애정도, 긍정적인 가치관과 적극성을 장애인 채용면접 시 주된 평가 요소로 제시하고 있다. 셋째, 채용 면접 시 시각적 요소가 언어적 요소와 음성적 요소에 비해 더 중요한 요소로 확인되었다. 넷째, 채용 면접 시 장애인이 가장 부족한 부분은 장애로 인한 능력의 부족이 아니라 자기효능감과 연결된 자신감부족과 면접경험과 면접교육의 부재로 인한 면접스킬 부족이었다. 다섯째, 면접의 중요성이 다른 선발기법에 비해 선호도와 중요성이 점차 중시되고 있는 실정이나 이에 대한 실증적인 연구가 매우 미흡한 현실이다. 본 연구는 국내에서 유일하게 장애인을 대상으로 면접 경험에 대한 조사를 실시하고 장애인을 채용하고있거나 채용하고자 하는 기업의 인사담당자들을 대상으로 면접형태에 대한 연구를 실시했다는 점에서 그 의의가 있다. Despite the growing importance of job interviews, study on the types of intervlewlng and recruiting process for people with disabilities is lacking compared to those for the non-disabled. This study reflects the new tendency of the recruitment process and interviewing process of people with disabilities. The various recruiting processes of companies, Job interviewing process, and interview experiences of job-seekers with disabilities was the main point of focus. The purpose of this study is to identify the various recruiting types for people with disabilities by analyzing recruitlng methods, recruiting processes, recruitment tools and types of interviewing. Furthermore, this study examines job interview preparations and types of job interviews by analyzing interview experiences of people with disabilities. An e-mail questionnaire was distributed to job-seekers with disabilities and corporate human resource personnels who have recruited people with disabilities or who plan to recruit people with disabilities that are registered in the Policy Customer ReIationship Management(PCRM) database of the Korea Employment Promotion Agency for the Disabled. SPSS WIN12.0 was used to analyze the results and crossstabulation analysis and frequency study was carried out on questions regarding recruiting type and job interview. The results are as follows: First, job interview plays a decisive role in a corporata's recruitment process. Therefore, people with disabilities need to prepare for job interviews, which their importance is growing compared to traditional recruiting methods. Second, the Interviewee's character is more important than their ability. Sincerity, seventy of disability, positive attitude, and active personality are the main factors that influence the decision of the interviewer. Third, appearance is more important than the Interviewee's speech and voice during the job interview process. Fourth, the main problem of job seekers with disabilities during the job interview was not their lack of ability but their lack of self confidence and interview skills. Flnally, few studies are conducted on job interviews even though they have become more important in the recruiting process.

초임계 유체에서 용해도 파라미터에 의한 고체 용해도 예측

洪仁權,金炯辰,林秀貞 단국대학교 1994 論文集 Vol.28 No.-

Solubility of solids was calculated by using a Peng-Robinson EOS and Flory-Huggins theory with solubility data of solids in supercritical carbon dioxide which was studied recently. Theoretical solubility data of solids were obtained by applying Peng-Robinson EOS with k_ij data, interaction parameter which was calculated by nonlinear regression method. Experimental solubility data which were studied by many researchers were compared with solubility data which were calculated by Peng-Robinson EOS. And, it was assumed that Peng-Robinson binary interaction parameter, k_ij(k_ii = k_jj = 0, k_ij = k_ji) is independent on temperature, pressure, and component, but k_ij is dependent on temperature in high pressure nonideal fluid mixture. Interaction parameter, β_12 between solvent and solute which was calculated by using a Flory-Huggins theory is dependent on solubility parameter of solvent, δ. There's relationship that interaction parameter, β_12 and solubility parameter δ are independent on temperature. It was modeled using a Cubic Spline method.