한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

活性슬럿지法에 의한 炭化水素 함유 廢水의 淨化

고정삼,김재하,강경수,고영환 濟州大學校工科大學附屬産業技術硏究所 1991 尖端技術硏究所論文集 Vol.2 No.-

Activated sludge process which has been widely applied to the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3%(W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21%(W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A.calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

멕시코와 네팔에서 도입한 고추 유전자원의 풋마름병 및 역병 저항성

고보환,김정훈,전수경,이지선,김병수 慶北大學校 農業科學技術硏究所 2005 慶北大農學誌 Vol.23 No.-

Above 130 accessions of pepper consisting of 50 introductions from Mexico and Nepal, and resistant and susceptible controls were tested for resistance to bacterial wilt and to Phytophthora root rot at seedling stage by artificial inoculation. As the results, KC897, KC939, KC936 were newly found resistant to bacterial wilt in addition to already known resistance sources such as KC126, KC350, KC351, KC353. No new sources of resistance to Phytophthora root rot were found among the introductions from Mexico and Nepal.

고등학교 지구과학Ⅱ 교과서의 ‘화성암의 조직’에 대한 내용 분석

고정선,윤성효,한종수 부산대학교 과학교육연구소 2007 교사교육연구 Vol.46 No.2

이 연구는 7차 고등학교 공통과학 교과서의 내용 중 화성암 암석의 조직 개념에 대한 본문진술과 제시된 그림 및 도표들을 분석하고 오개념 유발과 관련하여 문제점을 지적하고 그 개선방안을 모색하였다. 과학교과서의 개념진술이 정확하지 않아 학습자들에게 오개념을 유발하거나 재강화할 가능성이 있는 여러 진술문을 발견하였고 학생의 과학적 개념형성에 부적절한 그림이나 도표들도 발견되었다. 이들은 화성암 조직 분류체계의 기준의 혼란에 관련된 것들이다. 이들 개념진술을 대체할 개선방안들을 제시하였다. The purpose of this study is to analyze the seventh curriculum textbooks of high school Earth Science-II courses in relation to the igneous rock texture concept and find incorrect descriptions of that concept and then suggest some improved schemes. Some incorrect descriptions, pictures and tables on the igneous rock texture concept were found in texts. They might contribute to forming and/or reinforcing misconceptions about the confusion of criterion about the igneous rock texture. Therefore some improved schemes were suggested.

금귤 젤 및 금귤- 벌꿀절임의 製造와 그의 品質特性

고정삼,김찬식,고명수,양영택 濟州大學校 亞熱帶農業硏究所 1992 亞熱帶農業硏究 Vol.9 No.-

제주산 금귤을 소재로 한 금귤 젤리화 식품과 금귤-벌꿀절임을 제조하고, 이들의 물성, 기호성, 저장성 등에 관한 특성을 검토하였다. 젤라틴 2.5%와 물엿을 사용한 젤리화 금귤은 硬度가 195g-force이며, 탄성은 114%로서 後食用 製品으로 알맞은 것으로 평가되었다. 금귤-벌꿀절임은 20% 이내의 벌꿀을 함유한 제품이 官能評價에 좋은 結果를 얻었다. 加熱處理하여 밀봉한 製品은 32℃˚에서 20일간 貯藏하였을 경우에도 전혀 微生物 검출이 되지 않았으나, 加熱處理하지 않은 製品의 경우 製造工程 등에서 오는 汚染으로 인하여 벌꿀함유량에 관계없이 일부 微生物 增殖이 일어나 저장 및 유통중에 變質이 우려된다. In order to utilize Kumquats, a Fortunella variety produced in Cheju island, sensory evaluation and texture parameter of Kumquats processed foods were invesigated. Hardness and springiness of Kumquats jelly made with addition of 2.5% gelatin and maltose syrup was 195 g-force and 114% respectively, and the commodity was suitable for a dessert food in sensory evaluation. Kumquats slice contained below 20% honey was also evaluated as good for a tea of dessert food. Honey-Kumquats slice with heat treatment was safe for microbial growth during storge for 20 days at 32℃, but molds, bacteria and yeasts contaminated during processing were grown on Kumquats-honey commodities without heat treatment.

어깨 근막통 증후군에서 어깨 관절운동범위에 대한 분석

김정수,김인아,이수진,김용규,박시복,고재우,송재철 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objective: This study was carried out to investigate if the measurement of range of motion(ROM) could be applied in the diagnosis of Myofascial Pain Syndrome(MPS) and to determine the severity by analyzing ROM in MPS patients. Methods: The study subjects were 476 female telephone number information service workers. Southampton Protocol and Pittsburgh Protocol were used to diagnose MPS and to measure ROM. ROMs were measured by 2 inclinometers exercising each shoulder passively and actively in 5 directions ; abduction, forward flexion, extension, external rotation, and internal rotation. Results: Compared to the normal group (n=147), the mean of right side ROM in the subjects (n=270) with same side MPS was 2.1˚ (SD=11.5) lesser in active extension and 1.7˚ (SD=10.4) lesser in passive extension. Compared to the mild group (n=210), the mean of right side ROM in the patients with same side severe MPS (N=58) was lesser in all directions. Especially in active forward flexion, passive forward flexion, active extension, passive extension and active external rotation, ROM in the subjects with severe MPS was lesser by 6.5˚ (SD=13.1), 5.1˚ (SD=12.8), 5.9˚ (SD=11.8), 5.0˚ (SD=10.6) and 3.9˚ (SD=9.8), respectively, than those of the subjects with mild MPS. Compared to the subjects with left side mild MPS(n=172), ROM in the subjects with left side severe MPS (n=59) was 5.3˚ (SD=13.3) lesser in active forward flexion. Conclusions: In this study, ROMs in the subjects with severe MPS tended to be lesser than those in mild patients. This tendency was more prominent in the right side than the left, active range of motion than passive and forward flexion and extension than others. The results of this study are expected to help diagnose shoulder MPS and determine severity.

활성슬럿지법에 의한 탄화수소 함유 폐수의 정화

고영환,강경수,김재하,고정삼 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

Activated sludge process which has been widely applied t o the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3% (W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21% (W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A. calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

Adding Radiotherapy to Immunotherapy Improves Survivals in Patients with Non-small Cell Lung Cancer

( Jeong Suk Koh ),( Yoon Ju Kim ),( Song-i Lee ),( Da Hyun Kang ),( Dongil Park ),( Hee Sun Park ),( Sung Soo Jung ),( Ju-ock Kim ),( Jeong Eun Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Radiation therapy for lung cancer can be very effective for destroying cancerous cells locally. And systemic immune response from radiation therapy is emerging as an interesting issue in immune checkpoint inhibitors (ICIs) era. Here, we present the findings of a retrospective study investigating the impact of radiation therapy on outcomes with ICI treatment in patients with advanced NSCLC. Method Patients with NSCLC treated with radiotherapy for any reason and ICI between May 2016 and May 2020 were retrospectively analyzed. The optimal timing and site of radiotherapy in ICI treatment were analyzed via the difference in overall survival (OS) by sequence of radiation therapy. Results A total of 180 patients were diagnosed with NSCLC and received pembrolizumab, nivolumab and atezolizumab. The mean age was 67.0±9.4 years, and most patients were male. The major histological types were adenocarcinoma (47.2%) and squamous cell carcinoma (42.8%). Most patients had stage IV NSCLC (77.8%). The number of patients receiving radiation therapy was 41.7%, of which 52% received radiotherapy to the primary lesion, and 48% received radiotherapy to the distant metastatic lesion. 42 patients received radiation therapy before immunotherapy, 26 patients added concurrent radiation therapy to immunotherapy, and 16 patients received radiation therapy after immunotherapy. Whether radiotherapy was performed was not a statistically significant factor for OS (p=0.0831). when radiotherapy was introduced during ICI treatment, OS (p=0.016) and time to progression (TTP) of ICI treatment (p<0.001) were prolonged significantly. The median OS of patients who added radiotherapy during immunotherapy was significantly longer than receiving immunotherapy alone. (993 days vs 233 days, p=0.015) Conclusion Concurrently added radiotherapy augmented OS and TTP of ICI monotherapy in patients with advanced NSCLC. Radiation therapy Before and after ICI is not related with better survival outcome. We should consider radiation therapy adding on immunotherapy to gain more favorable patient outcome.

Acute Tubular Necrosis Associated with Pembrolizumab Treatment: A Case Report

( Jeong Suk Koh ),( Da Hyun Kang ),( Ki Ryang Na ),( Yoon Ju Kim ),( Song-i Lee ),( Dongil Park ),( Hee Sun Park ),( Sung Soo Jung ),( Ju-ock Kim ),( Jeong Eun Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Introduction Immune checkpoint inhibitors have recently led to significant improvement of clinical outcomes in patients with metastatic non-small cell lung cancer (NSCLC). Renal toxicity associated with immune checkpoint blockade was uncommonly reported. We report the case of a 72-year-old male who had acute tubular necrosis after pembrolizumab treatment. Case A 72-year-old male was diagnosed with primary lung squamous cell carcinoma with multiple metastatic lymph nodes in July 2018. The patient has received the chemotherapy of gemcitabine/cisplatin for 4 cycles, and chest computed tomography (CT) followed up periodically, showed the progressive disease. Next, the patient treated with pembrolizumab, PD-1 inhibitor, for 4 cycles, the patient’s serum creatinine elevated from 0.91 to 2.0mg/dL. One week after receiving 5 cycle treatment, he was hospitalized with dyspnea and generalized edema. Emergency dialysis was performed under the diagnosis of acute kidney injury because renal function was worse and urine output was not maintained. A renal ultrasound showed normal kidney size and no hydronephrosis or other abnormalities. He was performed a renal biopsy to evaluate the cause of renal dysfunction. His renal biopsy findings showed acute tubular necrosis, thickening of capillary walls with mesangial expansion, with global sclerosis (20%). With suspicion for pembrolizumab as a potential cause for acute tubular necrosis (ATN), future infusions were held. Considering the possibility that ATN may have occurred as an immune-related adverse event, the patient was given a dose of IV methylprednisolone 500mg for 3 days. However, his renal function did not recover and he continued to require dialysis treatment. Unfortunately, he passed away by sepsis despite active treatment. Conclusion We report an interesting case of adverse events associated with pembrolizumab in lung cancer. This case suggests the importance of closely monitoring renal function in lung cancer patients treated with PD-1/PD-L1 inhibitors.

The Interleukin-6 -572C〉G Promoter Polymorphism is Associated with Type 2 DM in Koreans

Soo Jeong Koh,Ju Yeon Park,So Eui Kim,Bum Sik Kim,Young Duk Song,Hwang Hye Jin,Jeon Dong Woon,Yang Soo Jang,Jong Ho Lee 한국지질동맥경화학회(구 한국지질학회) 2007 한국지질동맥경화학회 추계학술발표논문집 Vol.2007 No.-