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송강영,안정덕,김이정 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3
The main purpose of this study is to investigate the influence of the participation in leisure activities on Communication. The subjects of this study are married women residing in Seoul using a systematic stratified cluster random sampling. From our target sample of 1,360, excluding those who dropped out in the course of research or those questionnaires that were judged unreliable, the sample number used in actual analysis was 952 people. In order to analyze the data, this study used a SPSSWIN 11.0 program for statistical analysis. MCA and ANCOVA were conducted to examine hypothesis Based on the above research methods and procedures, this study produced the following results. The Types in leisure activities influences on communication. In case of participation in sports activities was best communication. The Frequency in leisure activities influences on communication. In case of participation in 2-3 days a week was best communication.
송강영,양광희,김이정 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1
The main purpose of this study is to investigate The Contribution Frequency of Leisure Participation to Leisure attitude among Married Women. The subjects of this study are married women residing in Seoul using a systematic stratified cluster random sampling. From our target sample of 500, excluding those who dropped out in the course of research or those questionnaires that were judged unreliable, the sample number used in actual analysis was 349 people. In order to analyze the data, this study used a SPSSWIN 11.0 program for statistical analysis. Correlation and Regression Analysis were conducted to examine hypothesis Based on the above research methods and procedures, this study produced the following results. The frequency of leisure participation influences leisure attitude. The higher the frequency of leisure participation the greater leisure attitude.
( Myungjin Song ),( Jisoo Choi ),( Bora Yoon ),( Ah Young Leem ),( Joo Han Song ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Purpose:?The aims of this study were to assess frequency of stress induced cardiomyopathy (SCMP) and predictors for incidence of SCMP in patients who admitted to medical ICU. We also explored the predictors of in-hospital mortality in patients with SCMP.?Method:?It is a retrospective cohort study. A total of 338 patients admitted to medical ICU and underwent transthoracic echocardiography (TTE) between January 2015 and December 2015 were enrolled. Definition of SCMP was defines as follows: 1) transient hypokinesis, akinesis of the left ventricular mid segments with or without apical involvement or the regional wall motion abnormalities extend beyond a single epicardial vascular distribution; 2) absence of obstructive coronary disease; 3) new EKG abnormalities or modest elevation in cardiac troponin; 4) absence of pheochromocytoma, myocarditis. Logistic regression model was used to analysis predictors for incidence of SCMP and predictors of in-hospital mortality in SCMP respectively. Cox regression model was used to analysis the influence of SCMP to mortality.?Results:?Of the 338 patients, SCMP was observed in 42 patients (12.4%). Compared to 296 patients without SCMP, patients with SCMP had lower frequency of DM (19% vs 29.2%, p=0.01), COPD (4.8% vs 16.9%, p=0.04) and higher prevalence of using mechanical ventilator (MV, 90.5% vs 71.9%, p=0.03), and lower ejection fraction (EF, 38.0±15.6 vs 61.7±11.8, p<0.001). In multivariate analysis, lower BMI (odd ratio, 0.88; 95% CI, 0.78 to 0.99; p=0.04) and lower EF (odd ratio, 0.90; 95% CI, 0.87 to 0.92; p<0.01) were associated with development of SCMP. In a Cox regression model adjusted with several confounders (age, DM, malignancy, liver cirrhosis, shock, acute kidney injury, use of MV) SCMP showed trend to increase of 60-day mortality (p=0.052). Among 42 patients with SCMP, acute kidney injury(AKI) was the only risk factor for predicting in-hospital mortality (odd ratio, 8.19; 95% CI, 1.35 to 47.75; p=0.02).?Conclusions:?Our study showed that prevalence of SCMP was 12.4% and trend to increase of 60-day mortality of critically ill patients. In patients with SCMP, AKI was the only risk factor for predicting in-hospital mortality.
( Hyung Woo Kim ),( Joo Han Song ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Azathioprine is widely used as an immunosuppressive drug in infiammatory bowel disease, many autoimmune disease and after organ transplantation to avoid rejection. Azathioprine has adverse reactions like hepatotoxicity. We report a case of azathioprine induced cholestatic hepatitis in patient with bronchiolitis obliterans organizing pneumonia(BOOP). A-37-year old woman was admitted because of pruritus and jaundice. She took transbronchial lung biopsy, bronchoalveolar lavage for cough, dyspnea and GGO patterns on chest computed tomography(CT) scan before she admitted. And it was revealed that she had BOOP. So she had been followed and treated for BOOP with prednisolone from 23th Nov 2012 and azathioprine from 8th Jan 2013. 42 days after taking Azathioprine, routine blood test was taken. Serum bilirubin, alkaline phosphatase(ALP), aspartate transaminase(AST), and alanine aminotransferase(ALT) was elevated(Bilirubin 4.4mg/dL, AST 75IU/L, ALT 104IU/L) and. Other laboratory test, including prothrombin time, serum albumin, and serum protein were within normal range. There was no history of alcohol abuse or herbal medication intake at this period. To exclude other reasons for hepatotoxicity, serological test was performed. The patient tested to negative for Hepatitis A, B, and C as well as for other markers of autoimmune hepatitis. CT scan showed hepatomegaly with lymph node enlargement and there was no evidence of bile duct obstruction. And TPMT(thiopurine methyltransferase) genotyping was done and revealed to be wild type. Azathioprine was stopped and she was monitored for laboratory changes. Because it was regarded as azathioprine induced cholestatic hepatitis and jaundice, we considered not to do liver biopsy. Day 55 after starting azathioprine therapy, total bilirubin reached peak (12.3mg/ dL). The patient was discharged on day 63 with cholestatic parameters of 115U/L(ALP), 36U/L(γ-GT), and 11.5mg/dL(total bilirubin). After 2 months, total bilirubin was decreased to normal(0.8mg/dL). Treatment of BOOP has been continued only with oral steroid.
Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3
Kim, Jin-Mo,Yoo, Hyun,Kim, Jee-Youn,Oh, Sang Ho,Kang, Jeong Wook,Yoo, Byung Rok,Han, Song Yee,Kim, Cha Soon,Choi, Won Hoon,Lee, Eun-Jung,Byeon, Hyeong Ju,Lee, Won Jai,Lee, Yun-Sil,Cho, Jaeho S. Karger AG 2018 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY Vol.48 No.3
<P><B><I>Background/Aims:</I></B> Radiation-induced skin fibrosis is a common side effect of clinical radiotherapy. Our previous next-generation sequencing (NGS) study demonstrated the reduced expression of the regulatory α subunit of phosphatidylinositol 3-kinase (PIK3r1) in irradiated murine skin. Metformin has been reported to target the PIK3-FOXO3 pathway. In this study, we investigated the effects of metformin on radiation-induced skin fibrosis. <B><I>Methods:</I></B> Metformin was orally administered to irradiated mice. Skin fibrosis was analyzed by staining with H&E and Masson’s trichrome stain. The levels of cytokines and chemokines associated with fibrosis were analyzed by immunohistochemistry and quantitative RT-PCR. The roles of PIK3rl and FOXO3 in radiation-induced skin fibrosis were studied by overexpressing PIK3rl and transfecting FOXO3 siRNA in NIH3T3 cells and mouse-derived dermal fibroblasts (MDF). <B><I>Results:</I></B> The oral administration of metformin significantly reduced radiation-induced skin thickening and collagen accumulation and significantly reduced the radiation-induced expression of FOXO3 in murine skin. Additionally, the overexpression of PIK3r1 reduced the radiation-induced expression of FOXO3, while FOXO3 silencing decreased the radiation-induced expression of TGFβ <I>in vitro</I>. <B><I>Conclusions:</I></B> The results indicated that metformin suppresses radiation-induced skin injuries by modulating the expression of FOXO3 through PIK3r1. Collectively, the data obtained in this study suggested that metformin could be a potent therapeutic agent for alleviating radiation-induced skin fibrosis.</P>
The Effect of Germination Temperature on Malt Quality of Malting Barely ‘Hopum’
Song-Yee Lee,Eun-Ju Song,Young-Eun Song,Hyun-Ah Han,Tae-Hee Kim,So-Hee Shin,So-Ra Choi 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The purpose of this study was to investigate malt characteristics according to the germination temperatures of tow-row variety ‘Hopum’. Hopum has been widely cultivated in Korea for beer-making. In this study, hopum material with germination rate of 97% was used and was malted at five temperatures, 10, 16, 18, 20, 25℃. The higher the germination temperature, the lower the malt yield, and EBC (European Brewery Convention) color index of the wort was darker. There was no significant differences in sugar content, pH and Kolbach index of malt germinated at a germination temperature of over the 16℃. Both α-amylase and β-amylase was induced in malts germinated at all temperatures. β-glucan remaining excessively in the malt makes it difficult to filter the wort during brewing, lowers the filtration rate, and causes problems such as haze and sediment formation in beer. In this experiment, the contents of β-glucan was lower as the germination temperature was higher. We intend to expand the diversity of beer brewing using domestic barley varieties by providing information on quality malt with different germination temperatures.