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부산 일부 대학교 학생들의 니코틴 의존도와 구취의 연관성
김유린(외 5명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-
The purpose of this study is to examine the association of bad breath and nicotine dependency. By use of the findings from this study, This study conducted the survey of 53 smoker who visited dental hygiene lab for delivery from October to November 2012 with structured questionnaires(Fagerstrom Tolerance Questionnaire FTQ) and equipment(CO measuring instrument, Oral Chroma etc). The data were analyzed by using SPSS 20.0 program for χ2-test, ANOVA. Smokers' average age was 23 years old. The more higher nicotine dependence the more the average age was higher. The more higher nicotine dependence the less to nque brushing. No association of nicotine dependence and self-bad breath level. CO State was Significant differences(ND1(M=2.58), ND2(M=3.98), ND3(M=7.41), ND4(M=4.19), ND5(M=13.14))(F=2.616, p=.047). Dimethyl Sulfide was Significant differences(F=3.026, p=.026).
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방소영,백광욱,정진도,남재철,Bang So-Young,Baek Kwang-Wook,Chung Jin-Do,Nam Jae-Cheol 한국환경보건학회 2004 한국환경보건학회지 Vol.30 No.5
The purpose of this paper is to understand the time series and origin of a chemical component and to compare the difference during yellow sand episodes for analysis $PM_{10}$ chemical components in the region of west in Korean Peninsula, 1999-2001. An annual mean concentration of $PM_{10}$ is $29.1\;{\mu}g/m^3$. A monthly mean and standard deviation of $PM_{10}$ concentration are very high in spring but there is no remarkably seasonal variation. Also, water soluble ionic component of $PM_{10}$ be influenced by double more total anion than total cation, be included $NO_{3}^-\;and\;SO_{4}^{2-}$ for the source of acidity and $NH_{4}^+$ to neutralize. Tracer metals of $PM_{10}$ slowly increases caused by emitted for soil and ocean (Fe, Al, Ca, Mg, Na) and Zn, Pb, Cu, Mn for anthropogenic source. According to method of enrichment factor (E.F) and statistics, assuming that the origin of metal component in $PM_{10}$ most of element in the Earth's crust e.g. Mg, Ca, Fe originates soil and Cu, Zn, Cd, Pb derives from anthropogenic sources. The ionic component for $Na^{+}\;Cl^-,\;Mg^{2+}\;and\;Ca^{2+}$ and Mg, Al, Ca, Fe originated by soil component largely increase during yellow sand period and then tracer metal component as Pb, Cd, Zn decrease. According to factor analysis, the first group is ionic component ($Na^+,\;Mg^{2+},\;Ca^{2+}$) and metal component (Na, Fe, Mn and Ni) be influenced by soil. The second group, Mg, Cr also be influenced by soil particle.
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고등학생의 인터넷 사용정도와 학교적응, 친구관계에 대한 연구
이현주,김미연,이희재,권소영,김민정,김민주,방은혜,이경희,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38
Today, almost all families are quipped with computers. At the same time, we can find lots of side-effects because of computers. If young students, who tend to be unable to control their impulses once they are immersed in internet, the problem will be more serious. It could be happened that the young students can't distinguish the real from the image. Therefore, it is important to grasp the actual condition of juvenile Internet addicts and their practical life, and to come up with basic materials necessary for working out countermeasures. This study surveyed 339 high school students from three high schools in the area of Seoul. Data collection were collected from 22nd of December, 2003 to 27th of December 2003. The collected data were analyzed by SPSS program using T-test, ANAVA and Pearson correlation coefficient. The results were as follows: First, of the 333 respondents 9.61% of them were high-risk internet using group, 15.02% of them were potential-risk internet using group. 25% of then were identified as addicted group. Second, the more addicted the subjects are, the lower their level of school adjustment becomes. For the addicted group, it is difficult to adjust their school and to have a good relationship with friend. Third, the more addicted the subjects are, the lower their level of friendship becomes. The subordinate areas of friendship have same results as the level of Internet addiction and the extent of friendship. If students are addicted to Internet, it is difficult to find friends who can give them encouragement in practical life. Firth, there was a negative relationship between Internet addiction and school adjustment, and, there was a negative relationship between Internet addiction and friendship. Through this study we have seized the relationship between Internet addiction and school adjustment and friendship. As a result, the more addicted, the more difficult to adjust to school. And for the students who were addicted, it is difficult to make a friend.
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Bang, So-Young,Han, Tae-Un,Choi, Chan-Bum,Sung, Yoon-Kyoung,Bae, Sang-Cheol,Kang, Changwon BioMed Central 2010 ARTHRITIS RESEARCH AND THERAPY Vol.12 No.3
<P><B>Introduction</B></P><P>Anti-cyclic citrullinated peptide autoantibodies (anti-CCP) are the most specific serologic marker for rheumatoid arthritis (RA). Genetic polymorphisms in a citrullinating (or deiminating) enzyme, peptidyl arginine deiminase type IV (PADI4) have been reproducibly associated with RA susceptibility in several populations. We investigated whether <I>PADI4 </I>polymorphisms contribute to anti-CCP-negative as well as -positive RA, whether they influence disease severity (erosive joint status), and whether they interact with two major risk factors for RA, Human Leukocyte Antigen-DRB1 <I>(HLA-DRB1</I>) shared epitope (SE) alleles and smoking, depending on anti-CCP and erosive joint status.</P><P><B>Methods</B></P><P>All 2,317 unrelated Korean subjects including 1,313 patients with RA and 1,004 unaffected controls were genotyped for three nonsynonymous (padi4_89, padi4_90, and padi4_92) and one synonymous (padi4_104) single-nucleotide polymorphisms (SNPs) in <I>PADI4 </I>and for <I>HLA-DRB1 </I>by direct DNA sequence analysis. Odds ratios (OR) were calculated by multivariate logistic regression. Interaction was evaluated by attributable proportions (AP), with 95% confidence intervals (CI).</P><P><B>Results</B></P><P>A functional haplotype of the three fully correlated nonsynonymous SNPs in <I>PADI4 </I>was significantly associated with susceptibility to not only anti-CCP-positive (adjusted OR 1.73, 95% CI 1.34 to 2.23) but also -negative RA (adjusted OR 1.75, 95% CI 1.15 to 2.68). A strong association with both non-erosive (adjusted OR 1.62, 95% CI 1.29 to 2.05) and erosive RA (adjusted OR 1.62, 95% CI 1.14 to 2.31) was observed for <I>PADI4 </I>haplotype. Gene-gene interactions between the homozygous RA-risk <I>PADI4 </I>haplotype and SE alleles were significant in both anti-CCP-positive (AP 0.45, 95% CI 0.20 to 0.71) and -negative RA (AP 0.61, 95% CI 0.29 to 0.92). Theses interactions were also observed for both non-erosive (AP 0.48, 95% CI 0.25 to 0.72) and erosive RA (AP 0.46, 95% CI 0.14 to 0.78). In contrast, no interaction was observed between smoking and <I>PADI4 </I>polymorphisms.</P><P><B>Conclusions</B></P><P>A haplotype of nonsynonymous SNPs in <I>PADI4 </I>contributes to development of RA regardless of anti-CCP or erosive joint status. The homozygous <I>PADI4 </I>haplotype contribution is affected by gene-gene interactions with <I>HLA-DRB1 </I>SE alleles.</P>
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( So Young Bang ),( Jeong Hun Shin ),( Soon Gil Kim ),( Hye Soon Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease, and levels of early preclinical markers of atherosclerosis, such as those that refi ect increased arterial stiffness, are commonly found to be higher in RA patients than healthy individuals. The aim of this study was to investigate the effects of Tai Chi exercise on endothelial function and arterial stiffness in middle-aged women with RA. Methods: The total of 44 female patients with RA were allocated to either a Tai Chi exercise group, receiving a 3 months Tai Chi exercise intervention, once a week, orcontrols receiving only information about the benefits of exercise. Assessment of endothelial function and arterial stiffness were performed by using fi ow-mediated dilatation (FMD) and brachial-ankle pulse wave velocity (baPWV), respectively. Data werecollected at baseline and at the end of the intervention (3 months). Results: The demographic, clinical characteristics as well as baPWV and FMD were similar between both groups at baseline. Mean (±SD) baseline and 14-week DAS28 scores for the tai chi group were 3. 58 ± 0. 95 and 2. 96 ± 0. 54, respectively (change from baseline; P = 0. 01). After 14-weeks of Tai Chi exercise, FMD (p=0. 008) and baPWV (p=0. 025) were signifi cantly improved in the Tai Chi exercise group versus the control group. Conclusions: Practicing Tai Chi exercise can improve the endothelial dysfunction and arterial stiffness of middle-aged women with RA. Therefore, Tai Chi exercise can be safely recommended to patients with RA as a complementary medical approach to improve cardiovascular risk. The potential long-term benefi cial effects of Tai Chi exercise at reducing cardiovascular risk in RA patients merit further exploration.
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Bang, So-Young,Kwon, So Hee,Yi, Sang-Hoon,Yi, Sang Ah,Park, Eun Kyung,Lee, Jae-Cheol,Jang, Choon-Gon,You, Jueng Soo,Lee, Sang-Hun,Han, Jeung-Whan Mary Ann Liebert 2015 STEM CELLS AND DEVELOPMENT Vol.24 No.4
<P>Dysregulation of forkhead box protein A2 (Foxa2) expression in fetal ventral mesencephalon (VM)-derived neural precursor cells (NPCs) appears to be associated with the loss of their potential to differentiate into dopaminergic (DA) neurons after mitogenic expansion in vitro, hindering their efficient use as a transplantable cell source. Here, we report that epigenetic activation of Foxa2 in VM-derived NPCs by inducing histone hyperacetylation rescues the mitogenic-expansion-dependent decrease of differentiation potential to DA neurons. The silencing of Foxa2 gene expression after expansion is accompanied by repressive histone modifications, including hypoacetylation of histone H3 and H4 and trimethylation of H3K27 on the Foxa2 promoter, as well as on the global level. In addition, histone deacetylase 7 (HDAC7) is highly expressed during differentiation and recruited to the Foxa2 promoter. Induction of histone acetylation in VM-derived NPCs by either knockdown of HDAC7 or treatment with the HDAC inhibitor apicidin upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions, leading to the expression of DA neuron developmental genes and enhanced differentiation of DA neurons. These effects are antagonized by the expression of shRNAs specific for Foxa2 but enhanced by shRNA for HDAC7. Collectively, these findings indicate that loss of differentiation potential of expanded VM-derived NPCs is attributed to a decrease in Foxa2 expression and suggest that activation of the endogenous Foxa2 gene by epigenetic regulation might be an approach to enhance the generation of DA neurons.</P>
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So-Young Kim,Sung-Hyuk Bang,Shunichi Honda,Takao Tsuji 대한예방치과학회 2012 International Journal of Clinical Preventive Denti Vol.8 No.1
Objective: Oral health and relative factors causing dental caries and periodontal disease for high students were examined in order to determine the correlations between each factor. Methods: 58 male students and 12 female students participated in this study through oral examination for caries and laboratory tests for GCF, the Snyder Test, salivary glucose measurements, and microscopic analysis of oral micro-organisms, and a correlation was derived between each factor. Results: The degree of caries formation was highly related to results from the Snyder Test, salivary glucose, a higher degree of oral moisture, and lower levels of GCF and DMF. There was no influence by oral micro-organisms causing caries directly in young adults except for the amount of filamentous type oral micro-organisms, and there was positive relationship between the amounts and motility for this type of micro-organism when compared to other types. There was a relationship between the salivary glucose and the amounts and motility of bacillus type micro-organisms. Otherwise, GCF was revealed to have a negative relationship with the motility of bacillus type oral micro-organisms. Conclusion: For high school students, modified Snyder Tests and salivary glucose checks are recommended to predict the formation of caries. Tests for GCF; and the amount and motility of bacillus, filamentous and spiral type micro-organisms, are recommended to predict the incidence of periodontal disease.
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Bang, So-Young,Na, Young-Ji,Kim, Kwangwoo,Joo, Young Bin,Park, Youngho,Lee, Jaemoon,Lee, Sun-Young,Ansari, Adnan A,Jung, Junghee,Rhee, Hwanseok,Lee, Jong-Young,Han, Bok-Ghee,Ahn, Sung-Min,Won, Sungho BioMed Central 2014 ARTHRITIS RESEARCH AND THERAPY Vol.16 No.5
<P><B>Introduction</B></P><P>Although it has been suggested that rare coding variants could explain the substantial missing heritability, very few sequencing studies have been performed in rheumatoid arthritis (RA). We aimed to identify novel functional variants with rare to low frequency using targeted exon sequencing of RA in Korea.</P><P><B>Methods</B></P><P>We analyzed targeted exon sequencing data of 398 genes selected from a multifaceted approach in Korean RA patients (<I>n</I> = 1,217) and controls (<I>n</I> = 717). We conducted a single-marker association test and a gene-based analysis of rare variants. For meta-analysis or enrichment tests, we also used ethnically matched independent samples of Korean genome-wide association studies (GWAS) (<I>n</I> = 4,799) or immunochip data (<I>n</I> = 4,722).</P><P><B>Results</B></P><P>After stringent quality control, we analyzed 10,588 variants of 398 genes from 1,934 Korean RA case controls. We identified 13 nonsynonymous variants with nominal association in single-variant association tests. In a meta-analysis, we did not find any novel variant with genome-wide significance for RA risk. Using a gene-based approach, we identified 17 genes with nominal burden signals. Among them, <I>VSTM1</I> showed the greatest association with RA (<I>P</I> = 7.80 × 10<SUP>−4</SUP>). In the enrichment test using Korean GWAS, although the significant signal appeared to be driven by total genic variants, we found no evidence for enriched association of coding variants only with RA.</P><P><B>Conclusions</B></P><P>We were unable to identify rare coding variants with large effect to explain the missing heritability for RA in the current targeted resequencing study. Our study raises skepticism about exon sequencing of targeted genes for complex diseases like RA.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s13075-014-0447-7) contains supplementary material, which is available to authorized users.</P>
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