염화 Cadmium 이 흰쥐 간장에 미치는 영향에 관한 전자현미경적 연구

강신덕,정호삼,이규식,이군자 漢陽大學校 環境科學硏究所 1992 環境科學論文集 Vol.13 No.-

실험동물은 본 실험실에서 순종교배에 의해 육성시킨 Wistar계 흰쥐를 사용하였으며, 순종교배에 의해 출생 제 7일의 신생 흰쥐 (체중 10g내외) 출생 제 40일된 흰쥐 (체중 120g내외)를 사용하였다. 신생 흰쥐와 성숙 흰쥐에 각각 cadmium chloride를 체중Kg당 3.75mg되게 생리적 식염수에 용해하여 0.2ml을 복강내에 투여한 후 3시간, 6시간, 12시간, 24시간 및 36시간 후에 각각 희생하고 개복하여 간장을 절취하였다. 간세포의 미세구조를 관찰하기 위해 조직은 4% glutaraldehyde에 전고정하였으며 10% osmium tetroxide로 후고정 후 초박절편을 제작하여 uranyl acetate 와 lead citrate로 이중 염색을 시행하였으며 전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. cadmium chloride 투여 신생 흰쥐의 간실질세포에서 골지체는 3시간군, 6시간군및 36시간군에서 소조가 위축되었다. 사립체는 3시간군에서 팽대되었고, 24시간군에서는 사립체롱이 소실되었으며 심한 팽대가 관찰되었고, 36시간군에서는 불규칙한 형태를 보이나 사립체롱은 정상적으로 관찰되었다. 조면내형질세망은 3시간 군에서 소조의 팽대와 일부 낭상화가 관찰되었으며 6시간군에서는 낭상화와 막부착 ribosome 과립의 탈락을 볼 수 있었고 24시간군과 36시간군에서는 대부분의 소조가 낭상화되었다. 2. cadmium chloride 투여 성숙 흰쥐의 간실세포에서 골지체는 3시간군에서 소조가 다소 팽대되었고 24시간군에서는 소조의 수가 감소되었다. 사립체는 6시간군에서 팽대되었고, 12시간군에서 불규칙한 형태를 보였으나 36시간군에는 대조군과 유사한 구조로 관찰되었다. 조면내형질세망은 6시간군, 12시간군 및 24시간군에서 소조의 팽대, 낭상화 및 막부착 ribosome과립이 탈락을 관찰할 수 있었고 36시간군에서는 대조군과 유사한 구조로 관찰되었다. Phagosome이 3시간군과 6시간군에서 다수 관찰되었고 12시간군, 24시간군 및 36시간군에서는 자가용해소체와 잔여소체를 볼 수 있었으며 특히 36시간군에서 증가되었다. 이상과 같은 결과로 미루어 cadmium chloride를 신생 흰쥐와 성숙 흰쥐에 투여하였을 때 미세구조상 신생 흰쥐 간세포의 미세구조는 투여후 시간이 지남에 따라 정상구조와 유사한 상태로 회복되는 것으로 사료된다. It is known that cadmium exposure to human results in very harmful adn potenteally toxic to liver and kideny. Therefore, the authors were undertaken to pursue the acute effects of cadmium chloride on the ultrastructures of rat hepatocytes, The 7 days old newborn and adult Wistar rats(40 days old) were used as experimental animals. Both new born and adult rats were injected intraperitoneally with 3.75 mg/kg cadmium chloride, 0.2ml(diluted with 0.9% NaCl solution). The sections of the experimethtal animals were made and observed by electron microscope. The results obtained were as follows. 1. In the hepatocytes of cadmium chloride treated newborn rats, cisternae of Golgi complexes are atrophied in the 3hr, 6hr. and 36hr. groups. The mitochondria are hypertrophied in 3hr. group. Cristae of mitochondria are reduced and swollen in 6hr. group. The cisternae of rough endoplasmic reticulum are dilatated and partly sacculated in 3hr. group and the associated ribosome granules are datached. In the 24hr. and 36hr. group, the most cisternae are sacculated. 2. In the hepatocyte of cadmium chloride treated adult rats, the cisternae of Golgi complexes are slightly dilatated and reduced in 24hr. group. Mitochondria are hypertrophied in 6hr. group and seen irregular shapes in 12hr. group but in 36hr. group, most mitochondria are intact as well as that of control rat groups. Rough endoplasmic reticulum showes dilatation, sacculation and detachment of associated ribosome granules from cisternase in 6hr. 12hr. and 24hr. group. But in 36hr. group. the fine structures of rough endoplasnmic reticulum are intact. The secondary lysosomes, phagosomes, are observed in 3hr. and 6hr. groups and numerous autophagic vacuoles and lipofucin granules are seen in 12hr. and 24hr. gruop. The large lipofucin granules are increased in 36hr. group. Consequently it is suggested that cadmium chloried made several toxic effects to hepatocytes of newborn and adult rat, the damage of hepatocyte increased in adult rats and newborn rat.

van Hieles 이론에 근거한 도형학습 수준 분석과 자료 개발에 관한 연구

강신포,양규모 부산교육대학교 교육대학원 2002 논문집 Vol.4 No.-

The purpose of this study is to investigate whether the van Hieles level of text contents is consistent with students's actual thought level, to explore what kinds of material can enhance students' thought level and to develop such materials. The followings were set as research problems. 1. Analyse van Hieles thought level in figure domain of the 7th mathematics curriculum. 2. Identify students' geometrical thought level by van Hieles Level Test. 3. Search a teaching method of learning figure based on van Hieles thought level to improve students' thought level. The results of this study are followings. First, most of contents in figure domain of the 7th mathematics curriculum were consistent with can Hieles's thought level. Contents of level 2 and 3 are much more than that of level 1. Hence it is needed to develop manipulating actibities so that students of level 2 and 3 can experience with. Second, by van Hieles's level test, about 85% of students were proved to come up to the standard. This result is almost the same as other related studies and reconfirms the validity of van Hieles's theory. The thinking level of elementary students carried from 0 to 4. Many of them remained in level 1 and 2, and there were some students who were beyond level 0. It implied that many students felt difficulties in figure learning, and had a low learning level of figures. The necessity to teach them figures became more important. Third, as the level of textbook seemed to be lower than that of students' thinking, customized teaching materials according to the thinking level of students were proposed.

Antegonial notch depth 에 따른 하악골 성장에 관한 두부방사선 계측학적 연구

강신애,유영규 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.1

The purpose of the present study were to disclose whether the depth of the mandibular antegonial notch can be used as an indicator of mandibular growth potential. The patients composed of 76 samples and were classified following 3 groups, based on the depth of mandibular antegonial notch : Deep notch group (more than 3mm), Neutral notch group (1-3mm), Shallow notch group (less than 1mm) For each case, the first lateral cephalograms were taken prior to the start of treatment and the second films 3-4 years after. The results were as follows; 1. Deep notch group had a shorter corpus, less ramus height and greater gonial angle than did Shallow notch group. 2. Deep notch group had a more retrusive mandibular position than Shallow notch group. 3. Deep notch group had longer total anterior facial height and longer anterior lower facial height group. 4.Deep notch group grow vertical clockwise growth pattern, while Shallow notch group grow horizontal counterclockwise growth pattern. 5. Deep notch group had less mandibular growth than Shallow notch group during observation period.

連續回分式 反應器에서 有機性 廢水의 分解 Phenol이 미치는 影響

朴永圭,姜信寬,李哲熙 嶺南大學校 環境問題硏究所 1985 環境硏究 Vol.5 No.2

The synthetic Wastewater mixed with the sewage and phenol was treated by the sequencing batch reactor process to investigate the effect of phenol toxidity on the biodegradation. According as the phenol concentration of the raw wastewater was increased, the rate coefficient of the substrate removal, ??, by the adsorption during the fill period and the rate coefficient of the substrate biodegradation, ??, during the aeration period were decreased for phenol toxidity, but the activated energy of the substrate biodegradation, the sludge volume index and the suspended soild concentration were increased. It was found that the removal efficiency of COD was obtained more than 90% after the aeration period below 267(mg/l) of the phenol concentration, and that the removal efficiency was remarkably decreased for the toxidity at 333(mg/l) of the phenol concentration.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

Unitarity constraints in the standard model with a singlet scalar field

Kang, Sin Kyu,Park, Jubin Springer-Verlag 2015 Journal of high energy physics Vol.2015 No.4

Scotogenic dark matter stability from gauged matter parity

Kang, Sin Kyu,Popov, Oleg,Srivastava, Rahul,Valle, José,W.F.,Vaquera-Araujo, Carlos A. North-Holland Pub. Co 2019 Physics letters. Section B Vol.798 No.-

<P><B>Abstract</B></P> <P>We explore the idea that dark matter stability results from the presence of a matter-parity symmetry, arising naturally as a consequence of the spontaneous breaking of an extended SU ( 3 ) ⊗ SU <SUB> ( 3 ) L </SUB> ⊗ U <SUB> ( 1 ) X </SUB> ⊗ U <SUB> ( 1 ) N </SUB> electroweak gauge symmetry with fully gauged B-L. Using this framework we construct a theory for scotogenic dark matter and analyze its main features.</P>

Lightest Higgs boson mass in the minimal supersymmetric standard model with four generations

Kang, Sin Kyu 서울대학교 이론물리학연구센터 1997 연구논문집 Vol.6 No.1

Effects of large threshold corrections in supersymmetric type-I seesaw model

Kyu Kang, Sin,Morozumi, Takuya,Yokozaki, Norimi Springer-Verlag 2010 Journal of high energy physics Vol.2010 No.11

Prediction of leptonicCPphase from perturbatively modified tribimaximal (or bimaximal) mixing

Kang, Sin Kyu,Kim, C. S. American Physical Society 2014 PHYSICAL REVIEW D - Vol.90 No.7