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( Shin Hyoung Jo ),( Seung Won Jung ),( Dong Cheol Lee ),( Susie Rah ),( Geum Soo Lee ),( Sang Wook Park ),( Gun Young Hong ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Clinostomum complanatum species are fiuke mainly found a bird`s throat or esophagus which eats freshwater fi sh. Rarely the fi uke is attachced on the throat of human who eat raw fi sh and causes the symptom such as pharyngitis. A few cases of Clinostonum complanatum in human have been reported in Korea. We describe a case of human infection with Clinostomum complanatum which was extracted from the larynx endoscopically. Case report: A 46-year-old female patient presented at our clinic with a 2day history of throat discomfort. Throat discomfort developed after a week from eating sliced raw gray mullet. Endoscopic fi nding revealed about 0. 5cm long, fi at and transparent movable fi uke with inner black lines was found on the mucosa of left arytenoid cartilage. The fi uke was endoscopically removed successfully. Histopathological examination of the specimen revealed a parasite known as Clinostomum Complanatum. Conclusion: Clinostomum is usually attached to the membrane of the throat in human and causes acute pharyngitis, or laryngitis called halzoun. Though C. Complanatum rapidly grows after human infection, most case are not serious. Thus endoscopic removal of parasite is the fi rst choice of treatment in human infection with Clinostomum. This case emphasize the importance that pharyx and laryx should be carefully examined especially in patient showing throat discomfort.
Jo, Chris Hyunchul,Shin, Ji Sun,Shin, Won Hyoung,Lee, Seung Yeon,Yoon, Kang Sup,Shin, Sue SAGE Publications 2015 AMERICAN JOURNAL OF SPORTS MEDICINE - Vol.43 No.9
<P><B>Background:</B></P><P>Two main questions about the use of platelet-rich plasma (PRP) for regeneration purposes are its effect on the speed of healing and the quality of healing. Despite recent numerous studies, evidence is still lacking in this area, especially in a representative patient population with medium to large rotator cuff tears.</P><P><B>Purpose:</B></P><P>To assess the efficacy of PRP augmentation on the speed and quality of healing in patients undergoing arthroscopic repair for medium to large rotator cuff tears.</P><P><B>Study Design:</B></P><P>Randomized controlled trial; Level of evidence, 1.</P><P><B>Methods:</B></P><P>A total of 74 patients scheduled for arthroscopic repair of medium to large rotator cuff tears were randomly assigned to undergo either PRP-augmented repair (PRP group) or conventional repair (conventional group). In the PRP group, 3 PRP gels (3 × 3 mL) were applied to each patient between the torn end and the greater tuberosity. The primary outcome was the Constant score at 3 months after surgery. Secondary outcome measures included the visual analog scale (VAS) for pain, range of motion (ROM), muscle strength, overall satisfaction and function, functional scores, retear rate, and change in the cross-sectional area (CSA) of the supraspinatus muscle.</P><P><B>Results:</B></P><P>There was no difference between the 2 groups in the Constant score at 3 months (<I>P</I> > .05). The 2 groups had similar results on the VAS for pain, ROM, muscle strength, overall satisfaction and function, and other functional scores (all <I>P</I> > .05) except for the VAS for worst pain (<I>P</I> = .043). The retear rate of the PRP group (3.0%) was significantly lower than that of the conventional group (20.0%) (<I>P</I> = .032). The change in 1-year postoperative and immediately postoperative CSAs was significantly different between the 2 groups: –36.76 ± 45.31 mm<SUP>2</SUP> in the PRP group versus −67.47 ± 47.26 mm<SUP>2</SUP> in the conventional group (<I>P</I> = .014).</P><P><B>Conclusion:</B></P><P>Compared with repairs without PRP augmentation, the current PRP preparation and application methods for medium to large rotator cuff repairs significantly improved the quality, as evidenced by a decreased retear rate and increased CSA of the supraspinatus, but not the speed of healing. However, further studies may be needed to investigate the effects of PRP on the speed of healing without risking the quality.</P>
Association of ZDHHC8 polymorphisms with smooth pursuit eye movement abnormality
Shin, Hyoung Doo,Park, Byung Lae,Bae, Joon Seol,Park, Tae Joon,Chun, Ji Yong,Park, Chul Soo,Sohn, Jin-Wook,Kim, Bong-Jo,Kang, Yeo-Hwa,Kim, Jae Won,Kim, Ki-Hoon,Shin, Tae-Min,Woo, Sung-Il Wiley Subscription Services, Inc., A Wiley Company 2010 American Journal of Medical Genetics. Part B Vol.b153 No.6
<P>The zinc finger DHHC domain-containing protein 8 (ZDHHC8) is located in the 22q11 microdeletion region and may contribute to the behavioral deficit associated with 22q11 deletion syndrome. Although polymorphisms of ZDHHC8 have been reported to be associated with the risk of schizophrenia, those associations are still controversial. This study was performed to validate the genetic association of ZDHHC8 polymorphisms with the risk of schizophrenia, and also to scrutinize the association with smooth pursuit eye movement (SPEM) abnormality in a Korean population. Five SNPs of ZDHHC8 were genotyped by TaqMan assay. Their genetic effects on the risk of schizophrenia were analyzed in 354 patients and 396 controls using allele-based χ<SUP>2</SUP> analyses. Association of ZDHHC8 polymorphisms with SPEM abnormality among 166 schizophrenic patients were analyzed using multiple regressions. No ZDHHC8 polymorphisms were found to be associated with the risk of schizophrenia. However, four SNPs and one haplotype (ht4) were strongly associated with the risk of SPEM abnormality even after multiple correction (P = 0.00005–0.0007, P<SUP>corr</SUP> = 0.0001–0.002). The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia. © 2010 Wiley-Liss, Inc.</P>
김문형 ( Mun Hyoung Kim ),조유미 ( Yu Mi Jo ),유현조 ( Hyun Jo You ),장하연 ( Ha Yeon Jang ),남승호 ( Seung Ho Nam ),신효필 ( Hyo Pil Shin ),김윤신 ( Yoon Shin Kim ) 한국언어정보학회 2012 언어와 정보 Vol.16 No.1
This study introduces set-denoting time expressions in Korean, which can be divided into simple and complex types. It was found that while the simple type expressions are easily represented within ISO-Time ML, a time-expression markup language, some complex type set-denoting pressions are not. Therefore, this study analyzes the reason for these difficulties in representing complex type expressions, as well as suggests the introduction of @measure and @interpretation attributes in the TIMEX3 tag. The @measure attribute represents the time interval, and the @interpretation attribute is used to distinguish distributive readings from cumulative readings. Additionally this paper suggests that a mapping between these and other attributes are required in TLINK.
Jo, A-ra,Han, Hee-soo,Seo, Seunghwan,Shin, Ji-Sun,Lee, Jae Yeol,Kim, Hyoung Ja,Lee, Kyung-Tae Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.23
<P><B>Abstract</B></P> <P>Seeds of <I>Carthamus tinctorius</I> L. (Compositae) have been used in Korean traditional medicines for the treatment of cardiovascular and bone diseases. In this study, we investigated the anti-inflammatory effects of known serotonin derivatives (<B>1</B>–<B>9</B>) isolated from the ethyl acetate (EtOAc) soluble fraction from the seeds of <I>C. tinctorius</I>. Compound <B>2</B>, identified as moschamine, most potently inhibited lipopolysaccharide (LPS)-induced production of prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and nitric oxide (NO) in RAW 264.7 macrophages. Moschamine concentration-dependently inhibited LPS-induced PGE<SUB>2</SUB> and NO production in RAW 264.7 macrophages. Consistent with these findings, moschamine suppressed the protein and mRNA levels of cyclooxygenase-2 (COX-2), microsomal prostaglandin E<SUB>2</SUB> synthase (mPGES)-1, and inducible NO synthase (iNOS), interleukin (IL)-6, and IL-1β. In addition, pretreatment of moschamine significantly inhibited LPS-stimulated the transcriptional activity of activator protein-1 (AP-1) and the phosphorylation of signal transducer and activator of transcription (STAT)1/3 in RAW 264.7 macrophages. Moreover, moschamine inhibited LPS-induced the phosphorylation of p38 mitogen-activated protein kinase (p38) and extracellular signal-regulated kinase (ERK), but it had no effect on c-Jun N-terminal kinase (JNK). These results suggest that the mechanism of anti-inflammatory activity of moschamine is associated with the downregulation of COX-2, mPGES-1, iNOS, IL-6, and IL-1β expression through the suppression of AP-1 and STAT1/3 activation in LPS-induced RAW 264.7 macrophages.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>