A Study on the Effect of Education APPs on the Learning Participation and Learning Effect of University Students

Shi Kun Liu,김영길,Jia Zhao 한국무역연구원 2022 무역연구 Vol.18 No.3

Purpose The education APPs offers new ways of learning and improves the quality of learning for students, who actively use this new learning platform to access more and better teaching resources. However, the current research on learning participation and learning effect of education APPs is mainly focused on establishing a single hypothesis, and there is a lack of systematic interpretation. Therefore, it is imperative to study how education APPs should increase the participation and effectiveness of students. Design/Methodology/Approach This paper takes students who have used trade education APPs as the research object, and uses the method of combining theoretical research and data analysis to conduct in-depth research on the degree of student participation and learning effect, and puts forward corresponding countermeasures and suggestions according to the research results. Findings According to the research questions, on the basis of literature research, it is concluded that education APPs has four characteristics, such as perceived usefulness, perceived ease of use, perceived interactivity, and course content quality. Secondly, according to the empirical analysis results, it is found that perceived usefulness, perceived ease of use, perceived interactivity, and quality of course content have a positive impact on learning engagement, and learning engagement has a positive impact on learning outcomes. Research Implications In terms of theory, this study makes up for the deficiencies of existing theoretical research by investigating the use of education APPs by students and what characteristics of education APPs can improve the learning effect of students. In terms of practice, it provides reference suggestions for providers of education APPs to improve APPs functions and improve business performance in the future.

Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease

Liu Kun,신은석,전은정,박영준,Scot Garg,김태현,손창배,최병주,Lin Hui,Song Lin Yuan,Wang Zhi,Jiang Hao,Shi Zhentao,Tang Qiang 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.11

Purpose: Although drug-coated balloon (DCB) treatment is known to be effective for de novo lesions, the influence of sex on angiographic and clinical outcomes remains unknown. This study aimed to investigate the angiographic and clinical impact of DCB treatment in patients with de novo coronary lesions according to sex. Materials and Methods: A total of 227 patients successfully treated with DCB were retrospectively enrolled and divided into two groups according to sex. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vessel failure (TVF), which included cardiac death, target vessel myocardial infarction, target lesion revascularization, and target vessel thrombosis. Results: The study enrolled 60 women (26.4%) and 167 men (73.6%). Compared to men, women had a smaller vessel size, larger DCB to reference vessel ratio, and more dissections after DCB treatment (55.0% vs. 37.1%, p=0.016). Women also had a significantly higher LLL compared to men (0.12±0.26 mm vs. 0.02±0.22 mm, p=0.012) at the 6-month follow-up angiography. During a median follow-up of 3.4 years (range 12.7–28.9 months), TVF was similar (women 6.7% vs. men 7.8%, p=0.944). In multivariable analysis, women were independently associated with a higher LLL. Conclusion: LLL was higher in women, but there was no difference in TVF between women and men. Based on multivariable analysis, the women sex was an independent predictor of higher LLL (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).

In vitro evaluation of 9-(2-phosphonylmethoxyethyl)adenine ester analogues, a series of anti-HBV structures with improved plasma stability and liver release

Sha Liao,Shi-Yong Fan,Qin Liu,Chang-Kun L,Jia Chen,Jing-Lai Li,Zhi-Wei Zhang,Zhen-Qing Zhang,Bo-Hua Zhong,Jian-Wei Xie 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.11

Chronic hepatitis B virus (HBV) infection maylead to liver cirrhosis and hepatocellular carcinoma, butfew drugs are available for its treatment. Acyclic nucleosidephosphonates (ANPs) have remarkable antivirusactivities but are not easily absorbed from the gastrointestinaltract and accumulate in the kidneys, resulting innephrotoxicity. Therefore, there is a need to find effectiveliver site-specific prodrugs. The dipivaloyloxymethyl esterof 9-(2-phosphonylmethoxyethyl)adenine (PMEA)—adefovirdipivoxil (ADV)—is a first-line therapy drug forchronic hepatitis B with a low therapeutic index because ofrenal toxicity and low hepatic uptake. In this study, a seriesof PMEA derivatives were synthesized to enhance plasmastability and liver release. The metabolic stability of ADV(Chemical I) and its two analogues (Chemicals II and III)was evaluated in rat plasma and liver homogenate in vitro. An ion-pair reverse-phase HPLC–UV method and a hybridion trap and high-resolution time-of-flight mass spectrometry(LC-IT-TOF-MS) were used to evaluate the degradationrate of the analogues and to identify their intermediatemetabolites, respectively. Chemicals I and II were hydrolyzedby cleavage of the C–O bond to give monoesters. Sufficient enzymatic activation in the liver homogenatethrough a relatively simple metabolic pathway, in additionto a favorable stability profile in rat plasma, made ChemicalII an optimal candidate. Next, six analogues based onthe structure of Chemical II were synthesized and evaluatedin plasma and liver homogenate. Compared toChemical II, these compounds generated less active PMEAlevels in rat liver homogenate. Therefore, chemical modificationof Chemical II may lead to new promising PMEAderivatives with enhanced plasma stability and liveractivation.

Surface Approximation Using Developable Strips with Global Error Bounds

Yong-Jin Liu,Yu-Kun Lai,Shi-Min Hu (사)한국CDE학회 2007 한국CAD/CAM학회 국제학술발표 논문집 Vol.2007 No.8

Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid

( Jin Fu Peng ),( Li Liu ),( Cheng Xian Guo ),( Shi Kun Liu ),( Xiao Ping Chen ),( Li Hua Huang ),( Hong Xiang ),( Zhi Jun Huang ),( Hong Yuan ),( Guo Ping Yang ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5

MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATPbinding cassette transporter and organic cation transporter. We sought to evaluate the effect of miR-511 on the regulation of OATP1B1 expression by free fatty acids. When using free fatty acids to stimulate Chang liver cells, we found that the expression of miR-511 increased significantly while the expression of OATP1B1 decreased. We also proved that SLCO1B1 is the target gene of miR-511 with a bioinformatics analysis and using the dual luciferase reporter assay. Furthermore, the expressions of SLCO1B1 and OATP1B1 decreased if transfecting Chang liver cells with miR-511, but did not increase when transfecting the inhibitors of miR-511 into steatosis cells. Our study indicates that miR-511 may play an important role in the regulation of OATP1B1 expression by free fatty acids.

An Empirical Analysis of Sino-Russia Foreign Trade Turnover Time Series: Based on EMD-LSTM Model

GUO, Jian,WU, Kai Kun,YE, Lyu,CHENG, Shi Chao,LIU, Wen Jing,YANG, Jing Ying Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.10

The time series of foreign trade turnover is complex and variable and contains linear and nonlinear information. This paper proposes preprocessing the dataset by the EMD algorithm and combining the linear prediction advantage of the SARIMA model with the nonlinear prediction advantage of the EMD-LSTM model to construct the SARIMA-EMD-LSTM hybrid model by the weight assignment method. The forecast performance of the single models is compared with that of the hybrid models by using MAPE and RMSE metrics. Furthermore, it is confirmed that the weight assignment approach can benefit from the hybrid models. The results show that the SARIMA model can capture the fluctuation pattern of the time series, but it cannot effectively predict the sudden drop in foreign trade turnover caused by special reasons and has the lowest accuracy in long-term forecasting. The EMD-LSTM model successfully resolves the hysteresis phenomenon and has the highest forecast accuracy of all models, with a MAPE of 7.4304%. Therefore, it can be effectively used to forecast the Sino-Russia foreign trade turnover time series post-epidemic. Hybrid models cannot take advantage of SARIMA linear and LSTM nonlinear forecasting, so weight assignment is not the best method to construct hybrid models.

Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid

Peng, Jin Fu,Liu, Li,Guo, Cheng Xian,Liu, Shi Kun,Chen, Xiao Ping,Huang, Li Hua,Xiang, Hong,Huang, Zhi Jun,Yuan, Hong,Yang, Guo Ping The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5

MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate the effect of miR-511 on the regulation of OATP1B1 expression by free fatty acids. When using free fatty acids to stimulate Chang liver cells, we found that the expression of miR-511 increased significantly while the expression of OATP1B1 decreased. We also proved that SLCO1B1 is the target gene of miR-511 with a bioinformatics analysis and using the dual luciferase reporter assay. Furthermore, the expressions of SLCO1B1 and OATP1B1 decreased if transfecting Chang liver cells with miR-511, but did not increase when transfecting the inhibitors of miR-511 into steatosis cells. Our study indicates that miR-511 may play an important role in the regulation of OATP1B1 expression by free fatty acids.

Long non-coding RNA NEAT1 decreases the chemosensitivity of gastric cancer cells via regulating P-glycoprotein expression

Jian Wang,Qiong Niu,Ning Shi,Chengxia Liu,Haifeng Lian,Jiancheng Li,Kun Li,K. Li 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.3

Drug resistance remains to be one of the major challenges in clinical treatment of gastric cancer (GC). Accumulating evidences have highlighted the involvement of long non-coding RNA (lncRNA) in carcinogenesis, chemoresistance, and metastasis. NEAT1, a recently identified lncRNA, was identified as an oncogene to regulate carcinogenesis. This present study aimed to investigate the role of NEAT1 in the drug resistance in GC. Our study found that NEAT1 expression was significantly upregulated in relapsed GC patients and cisplatin (CDDP)-resistant cell lines compared with primary GC patients and parental GC cell lines. NEAT1 upregulation was largely companied with the induction of P-gp. Overexpression of NEAT1 significantly increased the expression of several drug-resistance proteins, thereby compromising the sensitivity of GC cells to CDDP. In contrast, NEAT1 knockdown by RNAi did the opposite. Therefore, lncRNA NEAT1 is an important modulator for drug resistance of GC via promoting the expression of P-gp and other associated proteins.

Associations between the 1-deoxy-d-xylulose-5-phosphate synthase gene and aroma in different grapevine varieties

Xiaoxu Yang,Yinshan Guo,Junchi Zhu,Guangli Shi,Zaozhu Niu,Zhendong Liu,Kun Li,Xiuwu Guo 한국유전학회 2017 Genes & Genomics Vol.39 No.10

Linalool, α-terpineol, citronellol, nerol, geraniol, and geraniol acid are the main monoterpenes in the grapevine (Vitis vinifera L.) with the concentrations of these substances differing in different varieties. This research performed association analyses using a core collection of 92 grape accessions to identify causal SNPs in the gene 1-deoxy-d-xylulose-5-phosphate synthase (VvDXS), a regulator of monoterpene metabolism. We evaluated the free linalool, α-terpineol, citronellol, nerol, geraniol, and geraniol acid content of 92 grape varieties in two consecutive years (2014 and 2015). Twenty-two SNPs were found in the VvDXS coding region and were used in an association analysis. We found that the linalool, α-terpineol, nerol, and geraniol acid levels were higher in varieties with a G/T genotype at P852 than in varieties with other genotypes at this site. Additionally, we found a novel polymorphism site P1678 (A/G) with a functional effect on terpenoid content that was related to the regulation of gene transcription. This study revealed the relationship between VvDXS and aroma, with the identified polymorphism site potentially assisting in the screening of aroma compounds at early stages in fruit development in grapevines.

Effects of Lactobacillus plantarum SCS2 on blood glucose level in hyperglycemia mice model

Xiao Meng,Yu Qian,Li-Shi Jiang,Jin-Mei Kang,Yan Chen,Juan Wang,Shu-Kun Liu,Zhen-Ming Che,Xin Zhao 한국응용생명화학회 2016 Applied Biological Chemistry (Appl Biol Chem) Vol.59 No.1

In this study, the hyperglycemia mice model was established with 1-week high sugar and fat diet plus with 70 mg/kg body weight of streptozotocin injection for 3 days. Sixty male Kunming mice of 3 weeks old in a specific-pathogen-free grade were divided into six groups randomly, which includes normal group (NG), prevention group (PG), treatment group for low dose (TGL), middle dose (TGM), high dose (TGH), and model group (MG). NG and MG mice were fed with sterile physiological saline (10 mL/kg body weight). PG mice were fed with the concentration of 6.0 × 109 CFU/mL L. plantarum SCS2 suspensions from the second to third week. TGL, TGM, and TGH mice were fed with the concentration of 2.0 × 109, 4.0 × 109, and 6.0 × 109 CFU/mL L. plantarum SCS2 suspensions (10 mL/kg body weight), respectively from fourth to tenth week. The results showed that the fasting and postprandial 2 h blood glucose levels of TGH mice were reduced by L. plantarum SCS2 significantly (p < 0.05) as compared with MG. The body weight of TGH mice came to normal level at tenth week. Content of K+ in plasma of TGH mice was increased and contents of Na+ and Cl− in the plasma of TGH mice were decreased as compared with MG. Meanwhile, content of glycogen in TGH mice was reduced. However, the effect of L. plantarum SCS2 on the prevention of hyperglycemia in PG mice was not significant as compared with NG mice during the experiment. These results suggested that L. plantarum SCS2 showed a hypoglycemic effect on hyperglycemic mice model.