노년 청각손상자와 청각장애의 삶의 질 관련성 연구

劉俊榮,張勝成 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.2

The hearing impairment happened extensively in the elderly and often resulted in the hearing handicap. A lot of study confused the hearing impairment with the hearing handicap and replaced the score of quality of life by the hearing handicap score to calculate the quality adjusted life years and analyzed the cost-utility of aural rehabilitation. In this study, the confusion of hearing impairment and hearing handicap was clarified, and the relevance between hearing handicap and quality of life was explored in order to examine the fitness of replacing the score of quality of life by the hearing handicap score. The result of this study indicated that the correlation between the hearing handicap and the quality of life. The fitness of correlating model of the hearing handicap and the quality of life was not accepted. So, it was not suggested that replacing the score of quality of life by the hearing handicap score. The inventory of disease-specific quality of life should be developed. Secondly, the poor fitness of correlating model of the hearing handicap and the quality of life could be resulted from the other variables that shall be included in the model. It was proposed to include relevant variables into the model in the future. 청각손상은 노년기에 광범위하게 발생하는 문제이다. 심각한 청각장애를 자주 일으킨다. 많은 연구는 청각손상과 청각장애를 혼돈하는 것 뿐 만아니라 자주 청각장애 검목표의 득점으로 피실험자의 생활 품질을 대표한다. 심지어 청각장애 검목표의 득점으로 생활 품질 조정년을 계산한다. 이것으로 청각 재활의 성공 효과를 분석한다. 본 연구는 청각 손상과 청각장애의 다른 점을 밝히는 것 외에도 주요 목적은 청각장애와 생활 품질의 관련성을 이해하고자 하는 것이다. 이것으로 청각장애 검목표를 생활 품질을 삼는 정당성을 관찰한다. 연구결과에 나타나는 것은 청각 표현과 생활품질의 관련성은 높지 않은 결과를 얻었다. 이 두 가지의 관련 양식은 일반화 하기는 제한점을 갖는다. 그래서 이론적 개념에서 청각 표현과 생활품질은 각자 다른 내용을 갖추고 있다. 자료 통계의 분석 결과도 이 두 가지의 관련 양식에 대해서 유의한 결과를 얻지 못했다. 그래서 청각표현 능력으로 피실험자의 생활 품질을 대신할 수 없다. 마땅히 청각 손상자에게 맞는 적합한 생활 품질 설문지를 발행해야한다. 그 다음에 두 가지의 관련 양식의 관련도 적다. 아마도 청각 손상자의 청각 표현과 생활 품질 간에는 많은 변인의 영향이 존재하기 때문이다. 미래의 연구는 더 많은 상관 관련 인소를 귀납해서 이 이론구조를 검증해야한다는 것을 건의한다.

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.

5-Aza-2'-deoxycytidine Induces Hepatoma Cell Apoptosis via Enhancing Methionine Adenosyltransferase 1A Expression and Inducing S-Adenosylmethionine Production

Liu, Wei-Jun,Ren, Jian-Guo,Li, Ting,Yu, Guo-Zheng,Zhang, Jin,Li, Chang-Sheng,Liu, Zhi-Su,Liu, Quan-Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

In hepatocellular cancer (HCC), lack of response to chemotherapy and radiation treatment can be caused by a loss of epigenetic modifications of cancer cells. Methionine adenosyltransferase 1A is inactivated in HCC and may be stimulated by an epigenetic change involving promoter hypermethylation. Therefore, drugs releasing epigenetic repression have been proposed to reverse this process. We studied the effect of the demethylating reagent 5-aza-2'-deoxycitidine (5-Aza-CdR) on MAT1A gene expression, DNA methylation and S-adenosylmethionine (SAMe) production in the HCC cell line Huh7. We found that MAT1A mRNA and protein expression were activated in Huh7 cells with the treatment of 5-Aza-CdR; the status of promoter hypermethylation was reversed. At the same time, MAT2A mRNA and protein expression was significantly reduced in Huh7 cells treated with 5-Aza-CdR, while SAMe production was significantly induced. However, 5-Aza-CdR showed no effects on MAT2A methylation. Furthermore, 5-Aza-CdR inhibited the growth of Huh7 cells and induced apoptosis and through down-regulation of Bcl-2, up-regulation of Bax and caspase-3. Our observations suggest that 5-Aza-CdR exerts its anti-tumor effects in Huh7 cells through an epigenetic change involving increased expression of the methionine adenosyltransferase 1A gene and induction of S-adenosylmethionine production.

ALMA Reveals Sequential High-mass Star Formation in the G9.62+0.19 Complex

Liu, Tie,Lacy, John,Li, Pak Shing,Wang, Ke,Qin, Sheng-Li,Zhang, Qizhou,Kim, Kee-Tae,Garay, Guido,Wu, Yuefang,Mardones, Diego,Zhu, Qingfeng,Tatematsu, Ken’ichi,Hirota, Tomoya,Ren, Zhiyuan,Liu, Sheng-Yu American Astronomical Society 2017 The Astrophysical journal Vol.849 No.1

<P>Stellar feedback from high-mass stars (e.g., H II regions) can strongly influence the surrounding interstellar medium and regulate star formation. Our new ALMA observations reveal sequential high-mass star formation taking place within one subvirial filamentary clump (the G9.62 clump) in the G9.62+0.19 complex. The 12 dense cores (MM1-MM12) detected by ALMA are at very different evolutionary stages, from the starless core phase to the UC H II region phase. Three dense cores (MM6, MM7/G, MM8/F) are associated with outflows. The mass-velocity diagrams of the outflows associated with MM7/G and MM8/F can be well-fit by broken power laws. The mass-velocity diagram of the SiO outflow associated with MM8/F breaks much earlier than other outflow tracers (e.g., CO, SO, CS, HCN), suggesting that SiO traces newly shocked gas, while the other molecular lines (e.g., CO, SO, CS, HCN) mainly trace the ambient gas continuously entrained by outflow jets. Five cores (MM1, MM3, MM5, MM9, MM10) are massive starless core candidates whose masses are estimated to be larger than 25 M-circle dot, assuming a dust temperature of <= 20 K. The shocks from the expanding H II regions ('B' and 'C') to the west may have a great impact on the G9.62 clump by compressing it into a filament and inducing core collapse successively, leading to sequential star formation. Our findings suggest that stellar feedback from H II regions may enhance the star formation efficiency and suppress low-mass star formation in adjacent pre-existing massive clumps.</P>

Ship information system: overview and research trends

Liu, Sheng,Xing, Bowen,Li, Bing,Gu, Mingming The Society of Naval Architects of Korea 2014 International Journal of Naval Architecture and Oc Vol.6 No.3

Ship Information Systems (SISs) have been one of the main research focuses in ship design and become a multidisciplinary area. With these growing research trends, it is important to consolidate the latest knowledge and information to keep up with the research needs. In this paper, the SIS and its different forms are introduced and discussed. The beginning of this paper discusses the history and evolution of SIS. The next part of this paper focuses on different fields and research areas such as networking technology, information fusion, information decision, message display, ship control in real-time SISs. A Semi-Physical Simulation Platform (SPSIM) designed for SIS research and its running effect through a new Fuzzy-PID fusion algorithm are introduced in this paper then. A brief literature survey and possible future direction concerning each topic is included.

In-vitro elution of cisplatin and fluorouracil from bi-layered biodegradable beads

Liu, Kuo-Sheng,Pan, Ko-Ang,Liu, Shih-Jung Techno-Press 2015 Biomaterials and Biomechanics in Bioengineering Vol.2 No.2

This study developed biodegradable bi-layered drug-eluting beads and investigated the in-vitro release of fluorouracil and cisplatin from the beads. To manufacture the drug-eluting beads, poly[(d,l)-lactide-co-glycolide] (PLGA) with lactide:glycolide ratios of 50:50 and 75:25 were mixed with fluorouracil or cisplatin. The mixture was compressed and sintered at $55^{\circ}C$ to form bi-layered beads. An elution method was employed to characterize the release characteristic of the pharmaceuticals over a 30-day period at $37^{\circ}C$. The influence of polymer type (i.e., 50:50 or 75:25 PLGA) and layer layout on the release characteristics was investigated. The experiment suggested that biodegradable beads released high concentrations of fluorouracil and cisplatin for more than 30 days. The 75:25 PLGA released the pharmaceuticals at a slower rate than the 50:50 PLGA. In addition, the bi-layered structure reduced the release rate of drugs from the core layer of the beads. By adopting the compression sintering technique, we will be able to manufacture biodegradable beads for long-term drug delivery of various anti-cancer pharmaceuticals.

The TOP-SCOPE Survey of <i>Planck</i> Galactic Cold Clumps: Survey Overview and Results of an Exemplar Source, PGCC G26.53+0.17

Liu, Tie,Kim, Kee-Tae,Juvela, Mika,Wang, Ke,Tatematsu, Ken’ichi,Francesco, James Di,Liu, Sheng-Yuan,Wu, Yuefang,Thompson, Mark,Fuller, Gary,Eden, David,Li, Di,Ristorcelli, I.,Kang, Sung-ju,Lin, Yuxin Published by the University of Chicago Press for t 2018 The Astrophysical journal Supplement series Vol.234 No.2

<P>The low dust temperatures (< 14 K) of Planck Galactic cold clumps (PGCCs) make them ideal targets to probe the initial conditions and very early phase of star formation. 'TOP-SCOPE' is a joint survey program targeting similar to 2000 PGCCs in J = 1-0 transitions of CO isotopologues and similar to 1000 PGCCs in 850 mu m continuum emission. The objective of the 'TOP-SCOPE' survey and the joint surveys (SMT 10 m, KVN 21 m, and NRO 45 m) is to statistically study the initial conditions occurring during star formation and the evolution of molecular clouds, across a wide range of environments. The observations, data analysis, and example science cases for these surveys are introduced with an exemplar source, PGCC G26.53+0.17 (G26), which is a filamentary infrared dark cloud (IRDC). The total mass, length, and mean line mass (M/L) of the G26 filament are similar to 6200 M-circle dot, similar to 12 pc, and similar to 500 M-circle dot pc(-1), respectively. Ten massive clumps, including eight starless ones, are found along the filament. The most massive clump as a whole may still be in global collapse, while its denser part seems to be undergoing expansion owing to outflow feedback. The fragmentation in the G26 filament from cloud scale to clump scale is in agreement with gravitational fragmentation of an isothermal, nonmagnetized, and turbulent supported cylinder. A bimodal behavior in dust emissivity spectral index (beta) distribution is found in G26, suggesting grain growth along the filament. The G26 filament may be formed owing to large-scale compression flows evidenced by the temperature and velocity gradients across its natal cloud.</P>

문화 차이가 제품 디자인에 미치는 영향에 대한 연구 : 홉스테드(Geert Hofstede)의 문화변수를 중심으로

Liu, Pei Sheng,김원경 한국디지털디자인학회 2014 디지털디자인학연구 Vol.14 No.2

문화는 소비자의 행동에 가장 강한 영향을 미치는 요인으로 받아들여지고 있다. 하지만 문화에 관련된 내용은 매우 많기 때문에 파약하기가 다소 어렵다. 지금까지는 디자이너가 다른 나라 제품을 디자인 할 때 대부분 설문조사를 통해 그 나라 문화의 통계적인 경향을 파악하였다. 그러나 소비자에게 영향을 준 근본적인 문화 배경적 원인을 파악할 수 없다면 지속적인 디자인을 하기가 어렵다. 문화 배경적 원인을 파악하기 위해서 본 연구에서는 선행 연구를 통해 문화의 정의와 대표적인 홉스테드, 에드워드 홀, 데이비드 빅터, 폰스 트롬페나즈 네 학자의 비교문화 모형을 논의하였고, 그 중에서 높이 평가되고 있는 홉스데드의 ‘권력차이’ ‘집단주의 대 개인주의’ ‘남성주의 대 여성주의’ ‘불확실 회피성’ ‘장기지향성 대 단기지향성’ 그리고 2010년에 추가된 ‘방종 대 규제’까지 여섯 가지 문화변수를 이용하여 Keng-Yu Tien, van den Berg-Weitzel, van de Laar, Patrick W Jordan, Aaron Marcus, Emilie W. Gould 등 학자의 이론을 통해 홉스데드의 문화변수와 디자인 연관성을 논의하였다. 또한, 휴대폰 사용 환경, 색상, 형태, 재질, 기능 등의 측면에서 한중일 휴대폰 디자인 비교 분석을 통하여 홉스테드 문화변수와 제품디자인은 연관성이 존재한다는 것을 밝혀내었다. 홉스테드의 문화변수가 제품디자인에 적용이 가능하다는 이론적 검증을 통해 향후 문화적인 디자인 개발이 필요한 제품에 문화 변수가 활용될 수 있다는 것은 이 연구의 의의로 찾을 수 있다. Today"s cyber education based on internet technology(IT) can be approach portal site concept to be background with Internet environment cyber space and knowledge exchange and commons. In this Portal Site type, hub portal site, that is the sectionized portal type which produce professional information deeply. Today"s web site for cyber education follow the form of hub portal mostly, but they have many problem like different standards of contents design and sides of visual and cognitive interface. In this study, we grafted cyber education sites into hub portal concepts, analyzed Interface design types for cyber education contents based on hub portal, and deduced the usability index, so there is the meaning of trying approach of web interface design. Culture is one of the most important factors, which can affect customers’ behaviors. However, there are so many contents about culture that we can"t grasp easily. So far, most of designers conclude some statistical conclusions through surveys to grasp the culture. But if designers could not grasp the customers" fundamental culture background, it would be difficult to do continual design. Thus, in order to grasp the fundamental factor of culture background, this paper arranges the definition of culture and the model of comparative culture, proves that the cultures dimensions of Hofstede ("power distance" "collectivism versus individualism, masculinity versus femininity, uncertainty avoidance, long-term orientation versus short-term orientation, indulgence versus restraint) is related to design through the combination of the dimensions of Cultures theory of Hofstede, which is the most valued in comparative culture, and theories of Keng-Yu Tien, van den Berg-Weitzel, van de Laar, Patrick W Jordan, Aaron Marcus, Emilie W. Gould etc. What’s more, it proves further the cultures dimensions of Hofstede is deeply related to design, through the analysis of comparison of hand phone design based on colors, materials, function and usage environment etc. among China, Korea, and Japan.

Effects of Ribosomal Protein L39-L on the Drug Resistance Mechanisms of Lung Cancer A549 Cells

Liu, Hong-Sheng,Tan, Wen-Bin,Yang, Ning,Yang, Yuan-Yuan,Cheng, Peng,Liu, Li-Juan,Wang, Wei-Jie,Zhu, Chang-Liang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: Cancer is a major threat to the public health whether in developed or in developing countries. As the most common primary malignant tumor, the morbidity and mortality rate of lung cancer continues to rise in recent ten years worldwide. Chemotherapy is one of the main methods in the treatment of lung cancer, but this is hampered by chemotherapy drug resistance, especially MDR. As a component of the 60S large ribosomal subunit, ribosomal protein L39-L gene was reported to be expressed specifically in the human testis and human cancer samples of various tissue origins. Materials and Methods: Total RNA of cultured drug-resistant and susceptible A549 cells was isolated, and real time quantitative RT-PCR were used to indicate the transcribe difference between amycin resistant and susceptible strain of A549 cells. Viability assay were used to show the amycin resistance difference in RPL39-L transfected A549 cell line than control vector and null-transfected A549 cell line. Results: The ribosomal protein L39-L transcription level was 8.2 times higher in drug-resistant human lung cancer A549 cell line than in susceptible A549 cell line by quantitative RT-PCR analysis. The ribosomal protein L39-L transfected cells showed enhanced drug resistance compared to plasmid vector-transfected or null-transfected cells as determined by methyl tritiated thymidine (3H-TdR) incorporation. Conclusions and Implications for Practice: The ribosomal protein L39-L gene may have effects on the drug resistance mechanism of lung cancer A549 cells.

Overlapping Stents-Assisted Coiling for Vertebral Artery Dissecting Aneurysm : LVIS Stent within Neuroform EZ Stent

Liu, Xing-Long,Wang, Bin,Zhao, Lin-Bo,Jia, Zhen-Yu,Shi, Hai-Bin,Liu, Sheng The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.4

Objective : To evaluate the safety and efficacy of an overlapped stenting-assisted coiling technique in treating vertebral artery dissecting aneurysm (VADA) via Low-profile Visualized Intraluminal Support (LVIS) stent-within-Neuroform EZ stent. Methods : From January 2017 to June 2019, 18 consecutive patients with VADAs (ruptured : unruptured=5 : 13) were treated with the overlapping stents assisted-coiling technique in our center. The overlapping manner was a Neuroform EZ stent being deployed first, followed by LVIS stents placement using the 'shelf' technique. The patients' clinical characteristics, technical feasibility and safety, and immediate and follow-up angiographic results were retrospectively reviewed. Results : Seventeen (94.4%) procedures were technically successful with an exact deployment of the stents and patent parent or perforator arteries. The immediate angiographies after procedure confirmed Raymond class I, II, and III occlusion of VADAs were in 12 (66.7%), two (11.1%), and four cases (22.2%), respectively. Post-procedural complications developed in one patient (5.6%) with minor brainstem infarctions, which resulted from an in-stent thrombosis during the procedure. Angiographic follow-up at 5.7 months (range 3 to 9 months) demonstrated Raymond class I and II occlusion were in all cases (100%). The modified Rankin Scale scores at 21.3 months (range 15 to 42 months) 0-2 in 17 cases (94.4%) and three in one case (5.6%). Conclusion : Overlapping stents via LVIS stent-within-Neuroform EZ stent combined with coiling is safe and effective for patients with VADA in the midterm results.