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Activity Guided Isolation of Antioxidant Tannoid Principles from Anogeissus latifolia
Raghavan Govindarajan1*,Madhavan Vijayakumar1,,Annie Shirwaikar2,,Ajay Kumar Singh Rawat1,,Shanta Mehrotra1,,Palpu Pushpangadan1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
Oxidative stress is an important causative factor in several human chronic diseases, such asatherosclerosis, cardiovascular disorders, mutagenesis, cancer, several neurodegenerative disorders, and the agingprocess. Phenolics and tannins are reported to be good antioxidants. Anogeissus latifolia (Combretaceae) bark hasnot available till date. Hence the present study was undertaken to isolate antioxidant compounds by activity-guided isolation. Inhibtion of diphenyl picryl hydrazyl (DPH) and Xanthine oxidase along with photoc-hemiluminescence assay were used as bioassay for antioxidant activity. Activity guided isolation was carried outusing silica column and the compounds were quantified using HPLC. Ethyl acetate and butanol fraction exhibitedpotent antioxidant activity. Bioassay-guided isolation led to isolation of ellagic acid (1) and dimethyl ellagic acid(2these three major tannoid principles present in A. latifolia, are responsible for the antioxidant potential andpossibly their therapeutic potential.
Standardization and Quality Evaluation of Banafsha
Shanta Mehrotra,A. K. S. Rawat,Usha Shome 한국생약학회 1998 Natural Product Sciences Vol.4 No.1
`Banafsha` is an important herbal drug of indigenous systems of medicine. Flowers of Viola odorata L. (Violaceae) are considered to constitute the genuine drug `Banafsha`. However, due to limited distribution of this plant, another species of Viola, i.e. V. pilosa having almost similar medicinal properties, is mostly used under this vernacular instead. Ethnobotanically also different species of Viola i.e. V. odorata, V. pilosa and V. betonicifolia are used for various ailments at different places in our country. In the present study two species of Viola, namely V. pilosa and V. betonicifolia along with the commercial samples of `Banafsha` were studied and authenticated. It was observed that the market samples procured from Dehradun, Mumbai, Lucknow, Palampur, Ramnagar and Ranikhet showed close resemblance with Viola pilosa in having similar morphological characters like uniseriate hairs on the ovary, geniculate and clavate style, truncate stigma and almost similar TLC profiles. On the other hand the Almora sample was identified as Viola betonicifolia by the presence of large purple flowers, clavate style and convex stigma forming hump like structure. However, the market sample procured from Pathankot was found to be a mixture of two species of Viola namely, V. pilosa and V. odorata having dominance of the former species.
Pharmacognostic Evaluation of the Flower of Alcea rosea L.
Shanta Mehrotra,A. K. S. Rawat,Usha Shome 한국생약학회 1999 Natural Product Sciences Vol.5 No.1
The flowers of Alcea roses L., Malvaceae, sold in the Indian market under the trade name `Gulkhairo`, are well known for their expectorant, cooling and diuretic properties and used in many indigenous cough mixtures in India. The present paper deals with the detailed pharmacognosy of the floral parts including morphological, anatomical, phytochemical and fluorescence characters. Some of the diagnostic features of the drug are : pedicel characterized by multicellular appendages, stellate hairs, rosette crystals of Ca-oxalate. starch sheath and large sized mucilage canals; sepals having distinctive multicellular appendages arranged in a semilunar fashion present adaxialty at their base; monadelphous stamens, pollen grains pentaporate provided with dimorphic spines; placentation axile, ovules campylotropous; dark green fluorescence of the powder with nitrocellulose in amyl acetate and yellow fluorescence of trichomes under Fluorescence microscope.
Neeta Misra,Shanta Mehrotra 한국원예학회 2006 Horticulture, Environment, and Biotechnology Vol.47 No.1
We have established callus culture of Indian sarsaparilla (Hemidesmus indicus) and have attempted to increase the yield of three medicinally important secondary metabolites lupeol, vanillin, and rutin by treatment with γ-rays, ethylmethane sulfonate, colchicines, and sodium azide (NaN₃). Vanillin content was found to increase with all the treatments whereas lupeol and rutin specifically increased when treated with 3 Krads of γ-rays and 0.05% NaN₂, respectively. Biomass was generally found to decrease on treatment with the mutagens.
Naphthaquinones from some Boraginaceous Taxa-A Chemical Review
Khatoon, Sayyada,Mehrotra, Shanta The Korean Society of Pharmacognosy 1996 Natural Product Sciences Vol.2 No.2
The naphthaquinones-isohexenylnaphthazarins-are mostly found in the ceratenchymatous cells of the roots of some boraginaceous taxa. A total of 34 naphthazarins and their derivatives have been isolated from these taxa till date.
Pharmacognostic evaluation of the roots of Berberis lycium royle
Sharad Kumar Srivastava,Ajay Kumar Singh Rawat,Shanta Mehrotra 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.3
Berberis lycium (family Berberidaceae) has a close affinity with B. aristata, used in India Traditional Systems of Medicine as a drug ‘Daruharidra’ for skin disease, jaundice, affection of eyes, and rheumatism. Various species of Berberis are being sold in India herbal drug market. During the market surveillance of different herbal drug markets of India, it was observed that almost all the markets either comprise of Berberis lycium or Berberis asiatica. Keeping this in view, in the present study attempts have been made to identify marker characters of this potent species.
Pharmacognostic evaluation of the roots of Berberis lycium royle
Srivastava, Sharad Kumar,Rawat, Ajay Kumar Singh,Mehrotra, Shanta Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.3
Berberis lycium (family Berberidaceae) has a close affinity with B. aristata, used in India Traditional Systems of Medicine as a drug 'Daruharidra' for skin disease, jaundice, affection of eyes, and rheumatism. Various species of Berberis are being sold in India herbal drug market. During the market surveillance of different herbal drug markets of India, it was observed that almost all the markets either comprise of Berberis lycium or Berberis asiatica. Keeping this in view, in the present study attempts have been made to identify marker characters of this potent species.
Pharmacognostic Evaluation of Pipper longum Linn. Fruit
Manjoosha Srivastava,Meenu Gupta,Sharad Srivastava,Shanta Mehrotra,Vinita Sharma,AKS Rawat 한국생약학회 2007 Natural Product Sciences Vol.13 No.2
present study includes macro and microscopical details, powder study, physico-chemical studyand HPTLC fingerprinting of the Piper longum fruits. Microscopic studies revealed the presence of stone cells,starch grains and thin walled fragments of parenchymatous cells. Physico-chemical studies showed alcohol andether soluble extract 24.53 and 6.7, sugar 0.35, starch 21.33 and tannin 0.83% respectively. Successive soxhletextract showed maximum percentage of hexane soluble fraction i.e. 22.52. The HPTLC profile has also beenperformed against the reference marker piperine, which was identified at Rf 0.42. pharmacognostical evaluation of fruit has been undertaken.KeywordsPiper longum, Pharmacognosy, HPTLC.
Comparative Study of Processed (Shodhit) and Unprocessed Seeds of 'Gunja'-Abrus precatorius L.
D. N. Singh Gautam,P. N. Singh,Shanta Mehrotra 한국생약학회 1999 Natural Product Sciences Vol.5 No.3
`Gunja` is attributable to the plant Abrus precatorius L. (Leguminosae). Three forms with red, brown and another with white seeds are known to occur in this species and are employed for different therapeutic uses viz: as purgative, emetic, aphrodisiac, tonic and also as an abortifacient. According to some Ayurvedic literature the seeds are poisonous and should be given to the patients after proper processing (`Shodhan`). A comparative study of various phytochemical parameters, namely, percentage of successive extractives, total proteins, tannins, total ash and acid insoluble ash of these three forms of the processed (with cow`s milk and Kanji) and unprocessed seeds was done. TLC and densitometric scanning of successive extractives was also carried out to serve as markers for processed and unprocessed seeds. The percentage of proteins, tannins, alcohol and water soluble extractives decreased in the processed material. Besides, their acute toxicity, CNS activity were also studied in albino mice and it was found that white seeds are mare toxic as compared to the red and brown. The toxic effect was reduced with the processing. Further, the `Kanji` processed seeds are less toxic than the milk processed one.