한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

한의학(韓醫學)의 좌우리론(左右理論)에 관(關)한 고찰(考察)

박승미 ( Seung Mi Park ),박히준 ( Hi Joon Park ),이향숙 ( Hyang Sook Lee ),손양선 ( Yang Sun Son ),임사비나 ( Sabina Lim ),이혜정 ( Hye Jung Lee ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right (男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul: 氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

한의학(韓醫學)의 좌우이론(左右理論)에 관(關)한 고찰(考察)

박승미,박히준,이향숙,손양선,임사비나,이혜정,Park Seung-Mi,Park Hi-Joon,Lee Hyang-Sook,Son Yang-Sun,Lim Sa-Bi-Na,Lee Hye-Jung 경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right(男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul:氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

「유아교육·보육기관 평가인정제 모형(안)」의 평가인정 기준에 대한 타당화 연구

양옥승,이혜원,최경애 덕성여자대학교 고등교육연구소 2000 敎育硏究 Vol.8 No.-

감마선 조사 육류, 가금류에서 저장전과 후의 조사선량에 따른 DNA fragmentation의 변화

이혜진,김상미,박유경,양재승,강명희 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.2

The changes in DNA damage were investigated during storage after irradiation. Beef, pork and chicken were irradiated at 1.0, 3.0 and 5.0 kGy and stored for 6 months at 20℃. The comet assay was applied to the sample muscles at the beginning of irradiation and at the end of storage. Muscles were isolated, sliced, and the suspended cells were embedded in an agarose layer. After lysis of the cells, they were electrophoresed for 2 min. and then stained. DNA fragmentation in tissues caused by irradiition was quantified as tail length and taii moment (tail length x % DNA in tail) by comet image analyzing system. Right after irradiation, the differences in tail length between unirradiated and irradiated muscles were significant(p<0.05) in beef, pork and chicken. With increasing the irradiation doses, statistically significant longer extension of the DNA from the nucleus toward anode was observed. Similarly even 6 months after irradiation, all the irradiated muscles significantly showed longer taii length than the unirradiated controls. The results represented as tail moment showed similar tendency to those of tail length, but the latter parameter was more sensitive than the former. These results indicate that the comet assay could be one of the simple methods of detecting irradiated muscles. Moreover, this method suggest that using comet assay, we were able to detect DNA damage differences even after 6 months after irradiation.

고양이 위 평활근에서 KCI에 의한 근수축에 대한 Protein Kinase의 조절

심상수,김승록,심혜선,이덕주,한상준,윤신희,조양혁,김명석 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

정서유발단어에 대한 주의이동시 뇌신경망의 활성 양상

김연희,장은혜,고명환,신승훈,양경혜,손진훈 한국뇌학회 2002 한국뇌학회지 Vol.2 No.2

본 연구는 fMRI를 사용하여 정서유발단어에 의한 주의이동과 관련한 뇌신경망을 규명하기 위하여 12명의 오른손잡이 여대생을 대상으로 수행하였다. fMRI 실험을 위한 뇌활성화 과제는 예비실험을 통하여 선정된 행복, 슬픔, 위협에 해당하는 각각 36개씩의 단어와 각 단어의 짝을 이루기 위한 중성단어를 이용하여 변형된 Posner 패러다임을 블록디자인으로 고안하였다. fMRI 영상은 1.5T Simens Vision scanner를 사용하여 실시하였으며, single-shot EPI 기법으로(TR/TE:3840/40ms, flip angle: 90, FOV: 220, 64x64 matrix, Slice thickness: 6mm) 이미지를 얻었고 피험자의 반응시간을 기록하였다. 자료분석은 SPM-99 소프트웨어를 사용하였다. 정서유발단어는 중성단어에 비하여 반응시간이 의미있게 빨라 효과적인 주의이동이 일어났음을 알 수 있었다. 정서유발단어와 중성단어에 의한 뇌활성화 상태를 감산분석한 결과, 좌측 상두정엽, 양측 후두엽 및 소뇌에서 뇌활성화를 보였고, 이들 영역은 정서유발단어에 의한 주의이동시 특징적으로 활성이 일어나는 뇌영역임을 보여주었다. 또한 여러 가지 정서가를 가진 단어에 의해 유발되는 주의의 정도가 특징적인 신경망의 활성과 관련되어 있음을 알 수 있었다. The purpose of this study is to delineate the neural network related to the shift of attention and its modulation by emotion-provoking words using functional MRI (fMRI). Twelve right-handed normal female volunteers participated in fMRI study. Their mean age was 24 years and the mean modified Edinburgh score was +90. Emotion-provoking words representing happy, sad, threatened, and neutral emotional valences respectively were chosen by the assessment of 60 normal volunteers using semantic differentiation and Mannequin scales. The activation tasks were designed using modified Posner's paradigm to have 4 blocks of each emotional and control periods, Imaging was conducted on a 1.5T Siemens Vision scanner. Single-shot echoplanar images (TR/TE = 3840/40 ms, flip angle = 90, FOV = 220, matrix = 62 ? 64, slice thickness = 6㎜) were acquired in 20 contiguous slices parallel to the AC_PC line as well as conventional T1-weighted images. Response times were obtained during the scanning, Imaging data were realigned, coregistered, normalized, smoothed, and statistically analyzed in group using SPM-99 software. The results showed that emotional valence of word stimuli produced the effect of attentional engagement. The left superior parietal, inferior frontal, bilateral occipital lobes and cerebellum were main area of modulation of attentional network by emotional words stimuli. The different extent of brain activation induced by different emotion-provoking words were determined.

조기위함에서 침윤, 유형 및 분화도에 따른 p53, bcl-2의 발현

권오선,조현득,오미혜,김의한,양승하 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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유방선암의 유형에 따른 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현

강영근,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Breast carcinoma is a common malignant tumor in female of the korea. Various oncogenes have been found in malignant tumor cells. There were many reports or correlation between the prognosis of patients and c-erbB-2, p53, bcl-2, and c-myc, but is controversial. We performed immunohistochemical stain for above antigenic protein for 80 cases of breast carcinoma and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients. The results were as follow; 1) The expression rates in breast carcinoma was c-erbB-2 80%, p53 56.3%, bcl-2 51.3% and c-myc 53.8%. 2) c-erbB-2 showed no significant difference according to histologic types, grade, and lymph node metastatic status of breast carcinoma. 3) p53 showed higher expression rate in metastatic cases compared to non-metastatic cases, and it showed higher expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 4) The expression rate of bcl-2 in breast carcinoma be lowed according to increasing of grade. There was no significant difference according to types, side, and status of lymph node metastasis. 5) c-myc showed higher expression rate in non-metastatic cases compared to and metastatic cases, and it showed decreasing expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 6) p53 and bcl-2 in breast carxinoma showed reverse corre1ation(P < 0.05), and bc1-2 and c-myc showed close correlation without statiscally significance. Above results showed that p53 may be related to poor prognosis of the patients and c-myc may be related good prognosis in breast carcinoma. There was reverse correlation between p53 and bcl-2 and bcl-2 and c-myc may be correlated closely. c-erbB-2 and bcl-2 showed no interrelation to prognosis.

조기위암에서 침윤, 유형 및 분화도에 따른 p53, bcl-2의 발현

권오선,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Purpose: For evaluation of the role of tumohgenesis of p53 over expression and bcl-2 inhibition in early gastric cancer, the immunohistochemical tissue status of 31 primary early gastric cancer patients was investigated, and also the association between p53 , bcl-2 expression status and clinicopathologic parameters was analyzed for evaluation of prognostic relevance. Materials and Methods: DO7, a monoclonal antiserum to p53 protein and clone 124, monoclonal antibody to bcl-2 protein were used for the immunohistochemical analysis in 31 primary early gastric cancer tissue. The expressions were scored and divided into negative, positive, low expression, and over expression. Results: The clinocopathologic parameters; tumor depth of invasion, histologic type and differentiation were not related with the expression status of p53 and bcl-2. In 31 cases, the p53 over expression was 14 cases(45.2%), and the bcl-2 positive expression was 15 cases(48.4%), and 9 cases(29.0%) were the status of p53 over expression and bc1-2 positive expression. Conclusions: These results suggest that altered cell cycle and apoptosis control by p53 and bcl-2 may be an event in carcinogenesis of early gastric cancer but there are many other mediators that may fascilitate tumorigenesis.