Comprehensive analysis of time- and dose-dependent patterns of gene expression in a human mesenchymal stem cell line exposed to low-dose ionizing radiation.

Jin, Young-Woo,Na, Young-Ji,Lee, Young-Ju,An, Sungkwan,Lee, Jung Eun,Jung, Meeseon,Kim, Heesun,Nam, Seon Young,Kim, Cha Soon,Yang, Kwang Hee,Kim, Seung Up,Kim, Woo Kyung,Park, Woong-Yang,Yoo, Keun-You National Hellenic Research Foundation 2008 ONCOLOGY REPORTS Vol.19 No.1

<P>We focused on the transcriptional responses induced by low and very low doses of ionizing radiation with time effect. Regardless of their importance only a few limited studies have been done. Here we applied a large-scale gene transcript profile to elucidate the genes and biological pathways. Immortalized human mesenchymal stem cells were irradiated with 0.01, 0.05, 0.2 and 1 Gy of gamma radiation and total RNA was extracted from each cell line at 1, 4, 12 and 48 h after exposure. The essential transcriptional responses were identified according to dose and time. A total of 6,016 genes showed altered expression patterns at more than one time point or dose level among the investigated 10,800 genes. Genes that showed dose-dependent expression responses were involved in signal transduction, regulation of transcription, proteolysis, peptidolysis and metabolism. Those that showed time-dependent responses were divided into two distinct groups: the up-and-down group was associated with 'cellular defense mechanisms' such as apoptosis, cell adhesion, stress response and immune response and the down-and-up group with 'fundamental cellular processes' such as DNA replication, mitosis, RNA splicing, DNA repair and translation initiation. Genes showing both dose-and time-dependent responses exhibited a mixture of both features. A highly non-linear relationship between the IR dose and the transcriptional relative response was obtained from the dose-dependent group. The time-dependent group also exhibited a non-linear relationship as the complex effect group did. Some of the early-reactive-phase (1-4 h) genes showed a differential expression response to 0.01, 0.05 and 0.2 Gy but were unresponsive to 1 Gy. Some of the late-recovery-phase (12-48 h) genes showed a differential expression to 1 Gy but were relatively unresponsive to other doses. We further characterized the gene expression patterns that could be implicated in the molecular mechanism of the cellular responses to low and very low-dose irradiation.</P>

환경분쟁에서의 ADR적용방안에 관한 연구

梁承業 江原大學校 比較法學硏究所 2005 江原法學 Vol.20 No.-

Environmental issue is directly related to worldwide survival and one of the most difficult problem in these modernized society. As long as there have been people and communities, conflicts exist in every time and anywhere.(This paper uses conflict and dispute as a same meaning.} But methods for resolving disputes have been developed, ranging from mediation to the highly technical rule systems of our litigation. Environmental conflicts are often caused by an NIMBY between development and preservation. Also, Environmental conflicts have litigious limitations in resolving collisions which are very complicated. In recent years, interest in ADR(Alternative Dispute Resolution) has grown from various angles. ADR is both the oldest and some of the newest way of resolving conflicts that have legal implications. ADR is a system to settle disputes without having to pursue a judgment through the courts. Currently major countries, including the USA, have developed and contrived to activate ADR in order to both choose effective means for dispute resolution and establish the reformation of the judicial system. For example, the USA passed the ADRA for ADR in 1998, Germany revised EGZPO in 1999. Also, Japan passed the law which is related to ADR in 2004. Not only ADR forms such as negotiation, settlement, conciliation, mediation and arbitration but also diverse forms of ADR such as fact-finding, mini-trial, early neutral evaluation are adopted in the US as the method of dispute resolution. ADR is available to resolve a wide range of disputes, but have the defects of its qualities. One specific method is not suitable for all kinds of disputes. In selecting a method, several factors have to be prudently considered after closely reviewing the matter. The most important factor is to make people aware of the fact that ADR has many merits such as a low-cost, smooth agreement, speedy resolution, etc. It was confirmed that the resolution of disputes by formal proceedings is no longer the rational method. In this respect, ADR may well be regarded as the most efficient method to resolve Environmental disputes. When we consider recent worldwide trend, it is desirable that the Relation Law on ADR should be enacted in Korea. In this case, it is necessary to include the provisions of binding force on ADR result.

천명음이 동반된 기관 평활근종 1례

이혜승,김화종,강은정,김용현,김양기,이영목,김기업,어수택,황정화,김동원 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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지방자치단체의 공공시설에 대한 입장료 및 사용료 징수에 관한 고찰

양승업(Yang Seung-Up) 한국비교공법학회 2007 공법학연구 Vol.8 No.4

경기도 가평군은 청평양수발전소와 협약을 체결하고 발전소 내부(호명호수)를 개방하여 관광객을 입장시키고 그 입장객으로부터 입장료를 징수하고자 하였다. 이 사안에서의 쟁점은 가평군이 호명호수를 공공시설로 보아 지방자치법 제127조(사용료)를 근거로 하여 입장료를 징수 할 수 있는지의 여부이다. 일반적으로 공공시설은 공물뿐만 아니라 공공용의 영조물, 공기업을 포함하는 넓은 의미로 이해함이 통설적 견해이다. 이러한 맥락에서 ‘한국남부발전주식회사 청평양수발전소’ 상부저수지(호명호수)는 공공시설로 보아야 한다. 사전적 의미에서는 공물이용에 대한 반대급부를 사용료라 하고, 시설 내에 들어가기 위하여 내는 요금을 입장료라고 한다. 입장료 및 사용료에 관한 예시규정으로서는 자연공원법이 있다. 협약은 이해당사자간의 계약행위에 기초한 공법상 계약이라 할 수 있는바, 이 사안에서 가평군은 직접 공공시설을 설치하지 않고 타유시설인 청평양수발전소 시설을 협약에 의하여 이용토록 하고자 하였다. 협약은 MOA(Memorandum of Agreement), MOU((Memorandum of Understanding) 및 협약서 형태로 구분되어 적용되고 있다. 가평군과 청평양수발전소 간에 체결된 협약은 공공시설(호명호수)에 입장하는 자로부터 가평군이 조례를 제정하여 입장료 및 시설사용료를 징수할 수 있도록 한 것으로서, 가평군으로서는 입장료의 징수가 가능하다고 판단되지만 그 근거를 지방자치법 제127조의 사용료 규정에 근거하고 있음이 타당한지는 의문이다. 지방자치법 제127조가 공공시설의 이용 또는 재산의 사용을 규정하면서 사용료 개념만을 규정한 것은 불합리하다. 지방자치법 제127조는 공공시설의 이용 또는 재산의 사용에 대하여 사용료뿐만 아니라 입장료도 징수할 수 있도록 개정하여야 한다. 협약에 근거하여 판단하건대 가평군으로서는 호명호수 시설에 대한 인건비와 관리비 등을 실질적으로 부담하고 있는 점, 시설물설치와 관리에 관한 사항 등을 규정하고 있는 점 등에 비추어 이를 공공시설로 보아 입장료를 징수 할 수 있다고 판단된다. Gapyeong County concluded an agreement with Chung Pyung power plant with pumped-up water place and opened the Ho-Myung Lake inside the power plant, and made a tourist enter, tried to collect the entrance fee from the visitor. An issue in this pending problem is that Gapyeong County treats the Ho-myung Lake as public facilities, whether the entrance fee can be collected on the ground of a local autonomy law 127th article(the rental fee) or not. Public facilities are generally the wide meaning including the public works as well as public property and the public enterprise. In this connection, I concluded that 'Korean southern generating electricity corporation Chung Pyung power plant with pumped-up water' upper part reservoir is public property(public facilities). An agreement is contract on the public law(administrative contract) based on a contract act between the interest person concerned. In this pending problem, Gapyeong County tried to use Chung Pyung power plant with pumped-up water facilities by an agreement without establishing public facilities personally. Gapyeong County established a ordinance so that it might be possible to collect the entrance fee and the rental fee of facilities from the person who enters public facilities (Ho-Myung Lake) by an agreement. Gapyeong County is judged to be possible to collect the entrance fee. But the basis, the one based on a rental fee regulation of a local autonomy law 127th article is curious. A government has to revise a local autonomy law 127th article so that it may be also possible to collect the entrance fee as well as the rental fee to use in public facilities or use of assets. When it depends on agreement, regard the Ho-myung Lake facilities as public facilities, Gapyeong County can collect the entrance fee. It's because Gapyeong County bears the personnel expenses and administrative expense to the Ho-myung Lake facilities, and the establishment of facilities, a matter about facilities's management is prescribed in agreement.

Analysis of Correlation between Thyroid Cancer Incidence and Socioeconomic Status Using 10-year Sample Cohort Database

Seung Up Yang,Hojin Chang,Chi Young Lim 대한갑상선-내분비외과학회 2019 The Koreran journal of Endocrine Surgery Vol.19 No.1

Purpose: The authors hypothesized that increases in socioeconomic status (SES) have enabled patients to access medical services more frequently, resulting in the increased detection of small thyroid cancers. This retrospective cohort study was designed to analyze the correlation between thyroid cancer incidence and SES using a 10-year sample cohort database. Method: Sample cohort database between January 2004 and December 2013 with 1,000,000 cases for each year was enrolled in this study. Thyroid cancer incidence was analyzed by sex and by age. Public health insurance payment was used to reflect SES. The correlation between SES and thyroid cancer incidence was analyzed, and medical checkups done under government programs based on SES were analyzed. Results: When the results were considered according to SES, the high SES group showed a higher incidence of thyroid cancer than low SES group. Also, participation in government-supported health checkup programs was higher in the high SES group higher in the high SES group compared to low SES group. Conclusion: SES and incidence of thyroid cancer have positive correlation.

수자원분쟁에서의 전문가 역할에 관한 고찰 : 미국의 Special Master제도를 중심으로

양승업 ( Seung Up Yang ) 韓國環境法學會 2007 環境法 硏究 Vol.29 No.2

What are ‘true normal’ liver stiffness values using FibroScan^®?: a prospective study in healthy living liver and kidney donors in South Korea

Kim, Seung Up,Choi, Gi Hong,Han, Woong Kyu,Kim, Beom Kyung,Park, Jun Yong,Kim, Do Young,Choi, Jin Sub,Yang, Seung Choul,Choi, Eun Hee,Ahn, Sang Hoon,Han, Kwang-Hyub,Chon, Chae Yoon Blackwell Publishing Ltd 2010 Liver International Vol.30 No.2

<P>Abstract</P><P>Aims</P><P>To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea.</P><P>Methods</P><P>Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome.</P><P>Results</P><P>LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of <5% of the hepatocytes. The mean age of our study population was 38.9 ± 11.9 years (35 men and 34 women), with a mean LS value of 4.6 ± 0.5 kPa (range 3.3–5.6 kPa). LS values were not significantly different between men (4.6 ± 0.6 kPa) and women (4.5 ± 0.5 kPa, <I>P</I>=0.636), nor were they significantly different according to age (<I>P</I>=0.851). Using the fifth and 95th percentiles, we determined the normal range of LS values to be 3.9–5.3 kPa.</P><P>Conclusions</P><P>We identified the normal range of LS values and found that LS values were not significantly influenced by age and gender.</P>

골프회원권에 대한 취득세 부과처분의 적법성에 관한 고찰

양승업 ( Yang Seung-up ) 한국외국어대학교 법학연구소 2008 외법논집 Vol.30 No.-

It's developing in the direction with the new management environment of the enterprises. Enterprises and others insisted on introduction of a holding company system. CJ group introduced a holding company system on September 1st in 2007. CJ Cheiljedang Corporation in a business company raised a suit to acquisition tax assessment disposal related to a golf ticket for a registered member. An acquisition tax assessment disposal to a golf ticket for a registered member is that went without legal grounds, and interpretation of property and assets has a problem. Therefore such as acquisition tax assessment disposal's having to be cancellation. A golf ticket for a registered member is the right for which a golf course can be used as a member in a country club according to Local Tax Law. It's possible to classify a golf course at a country club and a popular golf course. And a country club is classified by a corporation system, a stockholder membership system and a deposit membership system. There are most deposit member organizations among these. The legal nature of the stockholder membership is a credit-like right. Acquisition taxes are the circulation tax, the act tax and the policy tendency on which a tax is imposed to the acquisition of the assets. A 9th number of tax special case restriction law 120th article puts the regulation from which an acquisition tax is exempted. The tax relief system is prepared court equipment for the taxpayer who gets an unfair tax assessment punishment and receives so that correction can receive this by set fixed procedure. CJ Cheiljedang Corporation partitioned humanly, and was a division newly-established corporation. And succession acquired a golf ticket for a registered member. When the property taken over is a taxation-object of an acquisition tax, it's a principle that a division newly-established corporation bears the acquisition tax. But the tax special case restriction law is prescriptive so that division may exempt an acquisition tax when the continuity of the business made a fixed important matter even. We have to think a golf ticket for a registered member is the intangible fixed asset it's possible to exchange for sell. An established rule is one kind of administrative regulations generally. And the order to which the standard of administration work is shown. There are no effects to which a people and a courthouse are bound externally for an established rule. The Supreme Court of Korea decided, a golf ticket for a registered member was a taxation-object of an acquisition tax. A tax suit is the suit to which an invaded taxpayer raises a right by illegal disposal of a tax government agency. An acquisition tax gets the declaration principle way to declare and pay the amount of tax by a Local Tax Law regulation. A corporation tax and its implementing ordinances 82nd article prescribes only tangible fixed assets in relation to inclusion in expenses. It's legitimate that a tax office did acquisition tax assessment disposal to a golf ticket for a registered member for CJ Cheiljedang Corporation. Therefore it isn't possible to cancel the tax office's taxation disposal.

하천과 공유수면의 점용허가와 채광계획인가에 관한 고찰

양승업(Yang Seung-Up) 한국토지공법학회 2008 土地公法硏究 Vol.40 No.-

  An exclusive use permission right of a River and Public Water Surface is the use of res publica by a patent. When doing exclusive use permission, a problem of the order of priority can occur. A government agency can"t cancels or withdraw the administrative disposition in optional way.<BR>  The third person who makes the profit on the law can raise a revocation suit of disposal. When getting main permission, consider to have got related permission by other laws. This is called a Permission Legal Fiction system.<BR>  The target for Legal Fiction is unlimited. But when it"s always groundless legally, it won"t be. We have the biggest effect of a Permission Legal Fiction on unification at the permission part. Before permitting it mainly, it has to be under the conference beforehand with a permission government office for Legal Fiction.<BR>  Occupation Permission of a River and Public Water Surface must receive a rightful person"s agreement. When it"s a harmful mine in the environment, an interest person can suffer the environmental damage.<BR>  When the environmental damage is expected, it"s possible to consult an opinion of an environmental impact assessment person. Because Occupation Permission Disposal of a River and Public Water Surface is a patent, an administrative agency doesn"t permit it.

일제강점기 청주 도시공간구조 변화과정 연구

양승필(Yang, Seung-Pil),이강업(Lee, Kang-Up) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.11

The characteristics of Cheongju urban space is that spatial structure of Korean traditional Eup Fortress and basic skeleton of Japanese urban plan coexist intact. The aim of this study is to understand today’s Cheongju urban space by analysising the period of installation and maintenance of social infrastructure during the Japanese occupation and that of construction and transfer of modern architectures to classify the period of changing process and to define relationship between social infrastructure, urban spatial structure and the changes that had played important role during the process. Based on the transfer of provincial capital, the changing process of Cheongju urban space can be classified into 1st phase, (1908∼1921) when the modern city was formed, 2nd phase, (1921∼1932) when the city was expanded to north due to railroad construction, 3rd phase, (1932∼1937) when lots were formed in the south due to construction of embankment and the existing city was repaired, and 4th phase, (1937∼1945) when the city was expanded to be promoted to Boo(府). Looking into characteristics of changing process of urban spatial structure by period, first, the 2nd and 3rd phase are important period when modernization of urban scape was formed due to the construction of railroad, embankment and new buildings. Second, its form was made by employing modern grid pattern while maintaining the form of existing Eup Fortress. Third, the expansion of social infrastructures centered on Korean society after 4th phase built up the foundation of today’s Cheongju’s center.