각종 사고사의 감소가 기대여명에 미칠 효과

신승수,이은설 한국보건통계학회 1995 한국보건정보통계학회지 Vol.22 No.1

Unintentional injuries account for about 15% of all deaths and nearly one-half of these accidental deaths are due to motor vehicle accidents. These events occur disproportionately among the young and the elderly. The impact of accidental deaths among various segments of the population is examined in the life table framework, adjusting for several known defects in mortality data and simulating various levels of possible reduction in accidental deaths. In adjusting for defects in data and interpreting the results the US nonwhite population was used as a reference. Korea's 1990 life expectancy is about the same as that of the US nonwhite population with a favorable outlook for the economically productive ages and a unfavorable prospect for dependent age groups : children and the elderly, suggesting injuries impact the dependent age groups more severely than expected. Males are more accident prone than females but the gender difference tends to disappear among the dependent. The magnitude and differentials in partial life expectancies resulting from various levels of reduction in accidential deaths and their implications for public health policies are discussed.

Association between ischemic stroke and pyogenic spondylitis in Korea: Nationwide longitudinal cohort study

Soo-Hyun Lee,Hakyung Kim,In Bo Han,Seung Hun Sheen,Je Beom Hong,Seil Sohn 대한뇌혈관외과학회 2023 Journal of Cerebrovascular and Endovascular Neuros Vol.25 No.2

Objective: The purpose of this nationwide age- and sex- matched longitudinal study was to determine the pyogenic spondylitis (PS) increases the incidence of ischemic stroke (IS) in Korea.Methods: From the National Health Insurance Service (NHIS), we collected the patient data for the period from January 1, 2004 to December 31, 2015. PS was classified according to the International Classification of Disease codes M46.2-M46.8, M49.2, and M49.3. By using a 1:5 age- and sex- stratified matching, a total of 628 patients and 3140 control subjects were included in the study. The IS incidence rates in PS and control group was calculated by using the Kaplan-Meier method. The outcome of hazard ratio of IS was estimated by Cox proportional hazards regression analyses. This study did not exclude PS as a result of postoperative complications.Results: According to the study, 51 patients (8.12%) in the PS group and 201 patients (6.4%) in the control group experienced IS. The adjusted hazard ratio of IS in the PS group was 3.419 (95% CI: 2.473-4.729) after adjusting individual medical condition and demographics. Following the results of subgroup analysis, the risk ratio of IS was greater in most of the subgroup categories (male, female, age <65, age >65, non-diabetic, hypertensive, non-hypertensive, dyslipidemic and non-dyslipidemic subgroup). However, the risk of IS did not differ significantly in diabetic subgroup (95% CI: 0.953-4.360).Conclusions: The risk rate of IS increased in patient with pyogenic spondylitis.

척수원위부위 혈관모세포종(血管母細胞腫) 치험 1례 : 증례보고 A Case Report

신승훈,신문수,정봉섭,최훈규,이병희,이용희 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.12

Thoracic Spinal Angiolipoma: A Case Report and Literature Review

Lee Soo Hyun,Bock Min Sung,Sheen Seung Hun,Han In-bo,Sohn Seil 대한말초신경학회 2023 The Nerve Vol.9 No.2

Spinal angiolipoma (SAL) is a rare benign tumor, accounting for 0.14% to 1.2% of all spinal tumors and approximately 3% of epidural spinal tumors. SAL is composed of mature adipocytes and abnormal blood vessels. Its gradual growth can cause spinal cord and root compression. No additional treatment is required after total surgical resection, and its prognosis is good. We report the c case of an 81-year-old man who had thigh pain and numbness in both feet, along with gait disturbance. High signal intensity was observed on T2- and T1-weighted magnetic resonance imaging. Contrast enhancement showed a highly contrasting epidural mass with spinal cord compression, spreading to the left neural foramen. The tumor was totally removed by laminectomy and facetectomy. After surgery, the patient’s symptoms gradually improved, and a pathological examination concluded that the tumor was an angiolipoma. SAL is an uncommon benign tumor, for which total surgical excision is the treatment of choice.

뇌동맥류 환자에서 수술과 백금코일 색전술의 비교 - 98 예에서의 전향적 연구 ( The Management of Intracranial Cerebral Aneurysms Surgery Versus GDC Embolization )

신승훈(Seung Hun Sheen),정봉섭(Bong Sub Chung),최훈규(Hun Kyu Choi),신문수(Moon Soo Shin),안정용(Jung Yong Ahn),이병희(Byung Hee Lee) 경희대학교 경희의료원 1999 慶熙醫學 Vol.15 No.4

Free Paper Presentation : OS-41 ; Clinical Efficacy and Adverse Events Between Indacaterol and Tiotropium in COPD: Meta-Analysis of Randomized Controlled Trials

( Jung Soo Kim ),( Hye Yun Park ),( Yeon Mok Oh ),( Kwang Ha Yoo ),( Yong Bum Park ),( Seung Soo Sheen ),( Jinkyeong Park ),( Ji Ye Jung ),( Seong Yong Lim ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Current guidelines recommend the use of inhaled long-acting bronchodilators as the first-line therapy in patients with stable chronic obstructive pulmonary disease (COPD). In Korea, nationally, two, once daily inhaled bronchodilator are available: the beta2 agonist indacaterol and the anticholinergic tiotropium. We aimed to compare the clinical efficacy and safety between indacaterol and tiotropium. Methods: Data sources were Medline, EMBASE, Cochrane Central Register of Controlled Trials (to July, 2014). Randomized prospective trials that compared tiotropium with indacaterol in COPD for more than 12 weeks were included. The primary outcome was trough FEV1 at 12th week, and secondary outcomes included trough FEV1 at 26th week, St. George`s Respiratory Questionnaire (SGRQ) total score at 26th week, and adverse events. Results: Four RCTs were eligible for inclusion. Trough FEV1 at 12th and 26th week were not significantly different between tiotropium and indacaterol by a standard deviation mean difference (SMD) of 0.00 (95% CI: -0.01, 0.02, I2 =12%) and 0.02 (95% CI: -0.07, 0.12,I2 = 0%), respectively. Regarding to quality of life, indacaterol and tiotropium showed similar SGRQ total score at 26th week (SMD of -0.01, 95% CI: -0.07, 0.08, I2 = 50%). Adverse events such as cardiovascular event and nasopharyngitis, and serious adverse events were similar between indacaterol and tiotropium, while cough was more common in indacaterol than tiotropium (OR: 1.65, 95% CI 1.33, 2.06). Conclusions: The evidence is equivocal as to clinical efficacy and serious adverse events between tiotropium and indacaterol, while patients with indacaterol had complained for cough more than those with tiotropium.

S-681 Adverse Events and Persistency of Biologics in RA Patients with Interstitial Lung Disease

( Dam Kim ),( Soo-kyung Cho ),( Soyoung Won ),( Hoon-suk Cha ),( Chan-bum Choi ),( Seung-jae Hong ),( Jisoo Lee ),( Dong Hyuk Sheen ),( Dae-hyun Yoo ),( Sang-cheol Bae ),( Yoon-kyoung Sung ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Objectives: We aimed to compare the incidence of adverse events (AEs) and persistency of biologics in RA patients with or without ILD. Methods: A total of 981 RA patients with chest radiograph or chest computed tomography (CT) data at enrollment were extracted from BIOlogics Pharmacoepidemiologic StudY (BIOPSY) cohort, a nationwide multicenter prospective cohort for biologic users of RA patients in Korea. We classified them into two groups: 1) RA-ILD group as patients with ILD, and 2) RA-non ILD group as patients without ILD. We compared the incidence of AEs during use of biologics between two groups, and then tested the differences of drug discontinuation rates due to AEs, infection, and respiratory infection between RA-ILD and RA-non ILD groups using Kaplan-Meier survival analysis and log-rank test. In addition, Cox proportional hazard model were used to identify the impact of ILD on AEs in RA patients with biologics. Results: The 42 patients (4.3%) revealed to have RA-ILD by chest radiograph or chest CT. Patients in RA-ILD group were older (p<0.01), and male patients were more in RA-ILD group (p<0.01). During mean follow-up of 20 months with 1,611 person years (PY), the incidence of AEs was higher in RA-ILD group (IRR 1.55, CI 1.11-2.17). In addition, the incidence of infection and respiratory infection were higher in RA-ILD group (IRR 2.38, CI 1.32-4.30 for infection, IRR 3.00, CI 1.50-5.99 for respiratory infection, respectively). The biologics discontinuation rate due to AEs was comparable in two groups (p=0.13), whereas the biologics discontinuation rate due to infection (p=0.03) and respiratory infection (p<0.01) were significantly higher in RA-ILD group. After adjusting for variables, age (HR 1.27, CI 1.15-1.41) and having ILD (HR 10.77, CI 2.26-51.41) were risk factors for mortality in RA patients with biologics. Conclusions: The incidence of adverse events, especially respiratory infections were higher in RA-ILD patients with biologics compared with RA-non ILD patients. In addition, the biologics discontinuation rate due to infection, especially respiratory infection was significantly higher in RA-ILD patients. Concerning the mortality, ILD increased the mortality in RA patients with biologics.

Statins and risk for new-onset diabetes mellitus : A real-world cohort study using a clinical research database

Yoon, Dukyong,Sheen, Seung Soo,Lee, Sukhyang,Choi, Yong Jun,Park, Rae Woong,Lim, Hong-Seok Wolters Kluwer Health 2016 Medicine Vol.95 No.46

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Although concern regarding the increased risk for new-onset diabetes mellitus (NODM) after statin treatment has been raised, there has been a lack of evidence in real-world clinical practice, particularly in East Asians. We investigated whether statin use is associated with risk for NODM in Koreans. We conducted a retrospective cohort study using the clinical research database from electronic health records. The study cohort consisted of 8265 statin-exposed and 33,060 matched nonexposed patients between January 1996 and August 2013. Matching at a 1:4 ratio was performed using a propensity score based on age, gender, baseline glucose levels (mg/dL), and hypertension. The comparative risks for NODM with various statins (atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin) were estimated by both statin exposure versus matched nonexposed and within-class comparisons. The incidence of NODM among the statin-exposed group (6.000 per 1000 patient-years [PY]) was higher than that of the nonexposed group (3.244 per 1000 PY). The hazard ratio (HR) of NODM after statin exposure was 1.872 (95% confidence interval [CI], 1.432–2.445). Male gender (HR, 1.944; 95% CI, 1.497–2.523), baseline glucose per mg/dL (HR, 1.014; 95% CI, 1.013–1.016), hypertension (HR, 2.232; 95% CI, 1.515–3.288), and thiazide use (HR, 1.337; 95% CI, 1.081–1.655) showed an increased risk for NODM, while angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker showed a decreased risk (HR, 0.774; 95% CI, 0.668–0.897). Atorvastatin-exposed patients showed a higher risk for NODM than their matched nonexposed counterparts (HR, 1.939; 95% CI, 1.278–2.943). However, the risk for NODM was not significantly different among statins in within-class comparisons. In conclusion, an increased risk for NODM was observed among statin users in a practical healthcare setting in Korea.</P></▼2>

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-056 : COPD ; Gender and the Prevalence of COPD in Korean Adult Smokers: A Population-Based Study

( Keu Sung Lee ),( Seung Soo Sheen ),( Ji Ye Jung ),( Sang Haak Lee ),( Yu Il Kim ),( Jae Yeol Kim ),( Eun Mi Chun ),( Kwang Ha Yoo ),( Chul Min Ahn ),( Tae Hoon Jung ),( Joo Hun Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The objective of this study was to investigate smoking effect on gender and the prevalence of chronic obstructive pulmonary disease (COPD). Method: Data for this study were obtained from Korean National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2012 containing demographics, smoking histories and spirometry data. We recruited 6,159 ever-smokers (male 5,543 and female 616) aged over 40 who adequately performed spirometry according to American Thoracic Society (ATS) guidelines. Subjects with FEV1/FVC<0.7 were defi ned as COPD. To evaluate the loss of lung function per pack-year smoked, we used susceptibility index (SI), calculated using the formula: (% predicted FEV1 - 100)/pack-years. Results: Mean age was lower in male than female (56.7 vs. 58.0, p<0.001) and total amount of smoking expressed as a pack-year was greater in male than female (25.7 vs. 11.0, p<0.001). Total 1,453 (23.6%) subjects were diagnosed with COPD. Even though the prevalence of COPD was higher in male (24.5%) than female (5.4%)(p<0.001), female showed more loss of lung function per pack-year smoked than male (SI in female = -1.43% vs. SI in male= -0.79, p<0.001). To evaluate smoking effect precisely, 3,440 subjects (male 3,337 and female 103) who smoked more than 20 pack-years through life were selected. Mean age was also lower in male than women (57.7 vs. 63.7, p<0.001) and total amount of smoking (pack-year) was greater in male than female (36.3 vs. 31.8, p=0.0029). However the prevalence of COPD was not different between in male (29.0%) and in females (24.3%) (p=0.567). Female stillshowed more loss of lung function per pack-year smoked than male (SI in female = -0.56% vs. SI in male = -0.39, p=0.0003). Conclusion: Korean female ever-smokers have a susceptibility to smoking effect on lung function decline.

Free Paper Presentation : OS-54 ; Hazards of Smoking in Korean Population

( Keu Sung Lee ),( Seung Soo Sheen ),( Ji Ye Jung ),( Sang Haak Lee ),( Yu Il Kim ),( Jae Yeol Kim ),( Eun Mi Chun ),( Kwang Ha Yoo ),( Chul Min Ahn ),( Tae Hoon Jung ),( Joo Hun Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Smoking is a major cause of many noncommunicable diseases and leads to the reduction of life span. However, there are few population based studies on how smoking is associated with our general health in Korea. Therefore, we performed this study to investigate hazards of smoking on our health and major diseases associated with smoking in Korean population. Methods: Data of 12,762 subjects aged 40 years or older were obtained from Korea National Health and Nutrition Survey (KNHANES) V from 2010 to 2012. Demographic data, laboratory findings, and major diseases were analyzed based on smoking status. Results: Blood pressure, leukocyte count, and serum glucose level were higher in smokers, however, serum cholesterol level and body mass index were higher in non-smokers (p<0.05). Smoking was associated with higher prevalence of COPD (23.6% vs 7.0%), diabetes mellitus (14.3% vs 10.5%), cerebral stroke (3.3% vs 2.2%), and coronary artery disease (4.7% vs. 3.5%), whereas depression (2.9% vs 6.1%) was more prevalent in non-smokers (p<0.05). Multivariate analysis after adjustment for age and sex showed that smoking was independently associated with COPD (OR = 2.37, 95% CI = 1.93 -2.92) and diabetes mellitus (OR = 1.32, 95% CI = 1.11 - 1.58), and no smoking (OR = 1.52, 95% CI = 1.16 - 1.99) was with depression (p<0.05). Conclusions: Our analyses suggest smoking has harmful effects on health in various aspects. Especially, smoking was an independent risk factor for COPD and diabetes mellitus.