당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

하지의 동맥부전증 환자에서 동반된 복부 대동맥류

문인성,박장상,고용복,김용귀,홍성곤,김승남 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.1

The early diagnosis of abdominal aortic aneurysms are difficult, especially when they are not clinically evident. Because of the generalized nature of atherosclerosis, there is reason to believe that there is a high incidence of aneurysms of the abdominal aorta in patients with peripheral vascular disease. But the screening test for hidden abdominal aortic aneurysms in patients with peripheral arterial disease has not been used for routine manner. So we retrospectively reviewed the 9 patients who had asymptomatic abdominal aortic aneurysms with symptomatic peripheral arterial disease during the last four and half-year period: among them three aneurysms were screened preoperatively by physical examination with their diameter more than 5 cm and 6 aneurysms were found intraoperatively with their mean diameter of 3.8cm. The ages ranged from 66 through 84 years with the mean age 73 years. There were 7 men and 2 women. The sites of the peripheral occlusive disease is as follows: femoral artery only in 1, iliac artery only in 2, both iliac and femoral arteries in 5, and from iliac artery through tibial artery with thrombus formation in 1. We suggest that ultrasonographic screening for the presence of hidden abdominal aortic aneurysm preoperatively in patients with lower extremity occlusive arterial disease is needed, especially when the ages of patients is older than 65 years and the site of arterial disease include iliac segment.

W-3계 고도 불포화지방산의 혼합비율이 다른 유지가 지질대사에 미치는 영향

박필숙,김성희,정승용,김경숙,문순열 慶尙大學校 1988 論文集 Vol.27 No.1

혈청 콜레스테롤 및 중성지방의 농도와 밀접항 관계가 있으며 혈청 lipprotein의 대사에 영향을 미치는 w-3계의 지방산의 적정한 섭취 비율을 구명하기 위한 일환으로써 들깨기름과 라아드의 혼합비율을 달리하여 흰쥐에게 급이한 결과 다음과 같은 결과를 얻었다. 1. 혈청 총-콜레스테롤 농도는 들깨기름 7.5%+라아드2.5%를 급이한 2군에서 유의성있게 낮은 반면 10%라아드 급이군은 현저히 높았다. 2. 혈청 HDL-콜레스테롤은 3군과 4둔이 1군, 2군에 비해 낮았으며, 혈청 총-콜레스테롤에 대한 HDL-콜레스테롤 비율은 2,3,4군이 5군에 비해 높았다. 3. 혈청 중 인지질과 중성지방 농도는 5군에 비해 2,3군에서 현저하게 낮았다. 4. 간장 중 총-콜래스테롤 농도는 4군이 1,2,3군에 비해 비교적 낮았다. 5. 간장 중 인지질 농도는 각 군간에 유의적인 차이는 없었으나 중성지방의 농도는 5군보다 1,2군에서 유의성 있게 낮았다. 6. 시험유지의 지방산조성은 1군에서 lionenic acid가 dir 58%이었으며, 5군에서는 w-3계 PUFA가 0.1%, oleic acid가 47.5%이었다. 7. 혈청 lipoprotein pattern은 2군에서 HDL함량이 가장 많은 반면 LDL함량은 가장 적은 경향이었다. In order to investigate the suitable composition of the w-3 series polyunsaturated fatty acid on lipoprotein metabolism related with cholesterol and triglyceride concentrations in serum, it was examined the effects of w-3 PUFA contents of mixed fat on oil lipid metabolism in serum and liver of rats. The results were summerized as follow ; 1. The concentration of T-cholesterol in serum of rats was lowest in the group 2 (7.5% perilla oil + 2.5% lard). whereas it was highest in group 5 (10% lard). 2. The concentration of HDL-cholesterol in serum was lower in group 3, 4 than in group 1, 2 and the ratio of HDL-cholesterol to T-cholesterol were higher in group 2, 3, 4 than in group 5. 3. The concentrations of phospholipid and trigyceride in serum were significantly lower in group 2, 3 than in group 5. 4. The concentration of T-cholesterol in the liver was relatively lower in group 4 than in group 1, 2, 3. 5. Phospholipid values in the liver were not significantly different between groups, but the concentrations of triglyceride were remarkably lower in group 1, 2 than those of the group 5. 6. Linolenic acid in group 1 (10% perilla oil), in the fatty acid composition of test lipids used in the experiment. was as much as about 58%, but w-3 PUFA in group 5 was only 0.1% and oleic acid was as much as about 58%, but w-3 PUFA in group 5 was only 0.1% and oleic acid was as much as 47.5%. 7. HDL contents, in lipoprotein composition of serum were the most in group 2 (7.5% perilla oil+2.5% lard), while LDL contents were the least.

여름에 비정형 폐렴으로 발현한 쯔쯔가무시병 1예

박상돈,정문현,이혜명,김미경,강재승 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

Scrub typhus usually occurs in October and November in Korea. Its typical clinical manifestations are fever, rash, eschar, and lymphadenopathies. Pneumonitis may occur, however it occurs as a complication at the late phase of scrub typhus, when it is inappropriately treated. We encountered a case of pneumonitis that was an initial manifestation of scrub typhus which was confirmed by rickettsial culture, Positive seroconversion, and polymerase chain reaction. The case was a 16-year-old high school adolescent who presented with fever and headache that lasted for 1 day in July, 2007, He denied of any outdoor activities. A chest radiograph showed patchy infiltrates in the left lower lung, which improved with the administration of cefotaxime and azithromycin for empirical treatment of community-acquired pneumonia. Blood taken on the second febrile day showed a positive culture for Orientia tsutsugamushi and was also positive for O. tsutsugamushi DNA polymerase chain reaction. Immunofluorescent antibody (IFA) test for O. tsutsugamushi showed that the initial antibody was negative, but convalescent serum tested positive with an antibody titer of 1:80. IFA for Coxiella burnetii showed false positive results; the initial IgM and IgG liters were 1:128 and 1:256, respectively, and the IgM and IgG titers in convalescent serum were 1:128 and 1:128, respectively.

Increased expression of P53 and Bax in the spinal cords of rats with experimental autoimmune encephalomylitis

문창종,김승준,위명복,김희석,정종태,박전홍,지영흔,Tanumab, Naoyuki,Matsumoto, Yoh,신태균 濟州大學校 農科大學 動物科學硏究所 2000 動物科學論叢 Vol.15 No.1

The expression of pro-apoptotic molecules, p53 and Bax, in the spinal cord of rats with experimental autoimmune encephalomyelitis (EAE) was examined. Apoptosis was confirmed by the terminal deoxynucleotidyl transferasemediated dUTP nick end-labeling (TUNEL) method. TUSEL (+) apoptotic cells were mainly either ED1 (+) macrophages or T-cells in the parenchyma of E N . Western blot analysis showed that both p53 and Bax expression significantly ( p < 0.01) increased in the spinal cords of EAE rats at the peak stage, and thereafter declined. An immunohistochemical study showed that inflammatory cells (notably T cells) in the parenchyma express p53 and Bax, while brain cells, includng neurons and glia, were devoid of these nuclear staining of these molecules. The nuclear expression of p53 largely matches apoptotic cells in the parenchyma of EAE. These finchngs suggest that pro-apoptotic molecules, p53 and Bax, may play an important role in eliminating T cells in the parenchyma in EAE.

말초성 신경아세포종 : 두개골 발생 증례 보고 Involving Skull

박양화,권익승,류연석,신미경,최문배,홍승관,문명선 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.4

The peripheral neuroblastomas are malignant neoplasms that originate from the adrenal gland and sympathetic nervous tissues. They usually occur in childhood. They exhibit such malignant features that they metastasize early to lung, liver, bone, rarely skull and other structures. The patients with peripheral neuroblastoma have short duration of symptom and short survival period. They reveal the characteristic light microscopic features that resemble other small cell carcinomas. The establishment of final diagnosis of peripheral neuroblastoma needs various special stainings for small cell carcinomas, and the electron microscopic findings are the most reliable. The authers recently experienced a case of peripheral neuroblastoma in a 26-year old man which involved right frontoparietal skull vault. The only chief complaint was a local non-tender mass at right frontoparietal scalp. Neither headache nor any neurological deficits was detected. Simple skull X-ary revealed a punched out rediolucency at right frontoparietal bone and brain CT showed a superficial elliptical high density mass that enhanced strongly. The mass was totally removed by wide craniectomy. The tumor invaded and penetrated the dura but the arachnoid membrane. at the tumor bed was not invaded by the tumor. The tumor was confirmed as peripheral neuroblastoma by various special stainings for small cell carcinomas. Following surgical resection of the mass, post-operative radiotherpy was offered(4800 rads for about 5 weeks). The patient aggrevated progressively and showed numerous metastases to such bones as lumbar vertebrae, pelvis and humerus to became paraplegic. 8 months after the operation, the patient died.

CFRP 적층복합판의 충격 손상 예측 : PartⅡ: 실험 PartⅡ: Experiment

박승범,김문생 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.52 No.-

본 논문에서는 충격하중에 의하여 적층복합재의 내부에 발생하는 충격 손상의 발생과 진전에 대하여 연구하였다. 이를 위하여 강구에 의하여 횡방향 충격을 받는 CFRP 복합재료에 대하여 충격실험을 행하여, 초음파 탐조영상장치로 충격손상을 관찰하였다. 개발한 충격손상 유한해석에 의하여 예측된 결과와 비교 검토하였다. 충격에 의하여 발생하는 손상중 가장 큰 손상의 형태는 층간분리 손상으로서 충격이 계속 진행됨에 따라 경계면을 따라 진전되며, 길이방향은 경계면에 인접한 아래 단층의 섬유방향을 향한다. 충격을 가하는 외부 물체의 충격속도가 증가함에 따라 층간분리의 길이와 폭은 거의 선형적으로 증가하였다. 그리고 횡방향의 폭의 증가율 보다 종��향의 길이의 증가율이 더 크게 나타났으며, 층간분리의 진전은 주로 종방향인 길이방향으로 진행되었다. An investigation was performed to study the initiation and propagation of impact damages in laminated composites subjected to transversely impact of steel ball. For this purpose, transversely impact experiments for CFRP laminated composite plates were conducted, and impact damages were observed using the ultrasonic image scan system. As a results, interface delamination was a major impact damage mode and the longitudinal direction of the dilamination paralled to the fiber direction of the bottom layer below the interface. A linear relationship holds between impact velocity and the longiudinal length and transverse width of delmaination, and the ratio of growth in the longitudinal direction is high than in the transverse direction.

한국 초파리집단의 선택불리에 관한 지구 자기장의 5배인 자기장의 영향

박은규,정승문,김중현,최오목 圓光大學校 1995 論文集 Vol.29 No.2

본 연구에서는 한국 선유도의 자연집단 야생형 초파리와 가시돌연변이형 황색체-소시 초파리를 Helmholtz coils 장치를 이용해서 유도한 지구 자기장의 5배인 자기장내의 집단과 비교 집단인 지구 자기장내의 집단에서 발생율 변동과 성적 선택빈도를 조사하여, 선택불리에 관한 유전적 행동을 관찰해서 다음과 같은 결과를 얻었다. 1.야생형 유전자(+)를 운반하는 염색체의 선택빈도는 15세대까지 평균 빈도가 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단이 각각 0.6489, 0.6553으로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 더 강한 선택불리 행동을 보여 주었다. 2.초파리 집단의 발생율 변동은 지구 자기장의 5배인 자기장내의 초파리 집단 3세대(13.60%), 지구 자기장내의 초파리 집단 6세대(22.35%), 8세대(22.30%)에서 아주 낮은 발생율의 변동을 보여주었으며, 2개의 상이한 자기장내 초파리 집단의 전체 평균 발생율은 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단에서 각각 58.07%, 41.93%로 관찰되었으며, 후자보다 전자에서 발생율이 증가함을 보여 주었다. 3.돌연변이형 황색체-소시 유전자(ym)를 운반한 염색체의 선택빈도는 각각의 자기장내의 초파리 집단에서 0.0542, 0.0646으로 관찰되었다. 이 결과는 지구 자기장의 5배인 자기장내의 초파리 집단에서 0.0542로 상대적으로 강하게 선택불리 행동을 보여 주었다. 4.돌연변이형 황색체 유전자(y)를 운반한 염색체의 선택빈도는 각각의 초파리 집단에서 0.0185, 0.0144로 관찰되었다. 이 결과는 비교 집단인 지구 자기장내의 초파리 집단에서 0.0144로 더 강한 선택불리 행동을 보여 주었다. 5.돌연변이형 소시 유전자(m)을 운반한 염색체의 선택빈도는 각각의 조절된 자기장내의 초파리 집단에서 0.0328, 0.0190으로 관찰되었다. 이 결과도 지구 자기장내의 초파리 집단에서 0.0190으로 상대적인 강한 선택불리 행동을 보여 주었다. 6.수컷이 가지고 있는 Y-염색체의 선택빈도는 각각의 초파리 집단에서 0.2457, 0.2467로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 0.2457로 더 높은 선택불리 행동을 보여 주었다. 7.Duncan's multiple range test의 LSD값으로 유의 차이 유무 검정을 하였던 바 야생형 유전자의 A 그룹과 돌연변이형 유전자들의 B 그룹사이에서 고도의 유의 차이가 있음이 밝혀졌다. To elucidate the genetic behavior of selective disadvantage among visible mutants of Drosophila melanogaster bred and kept by the genetic study laboratory room. Wonkwang University and the wild type collected at Sunyoudo island in Korea, and reared under the influence of two different strength of magnetic fields, i.e. the quintuple and the ambient magnetic field, this study was carried out at the above indicated laboratory room. 1.The mean selective frequencies of wild gene(+)-carry chromosome up to 15th generation, affected by two different magnetic fields, showed 0.6489 and 0.6553 with the magnetic field strength as mentioned order before. The data explains that the population of Drosophila melanogaster reared in the quintuple magnetic field showed higher selective disadvantage. 2.The variations of emergence rates of the populations of Drosophila melanogaster altering by generation showed the drastic lowest values at the specified generation, for example, 13.60% under the quintuple magnetic field at the third generation and 22.35% and 22.30% under the ambient magnetic field at the 6th and 8th generation. The over-all mean emergence rates of the populations of Drosophila melanogaster reared in controlled magnetic fields, i.e. the quintuple and the ambient magnetic fields using Helmholtz coils, showed 58.07% and 41.93% respectively. Referring to these data, the population of flies raised in the quintuple magnetic field showed a relatively higher emergence rate than the ambient magnetic field. 3.The mean selective frequencies of the individual of ym gene-bearing chromosomes showed 0.0542 and 0.0646 by the same order of magnetic field strength indicated above. It was shown that the population of flies reared in the quintuple strength generated by Helmholtz coils cleared the relatively strong selective disadvantage being 0.0542. 4.The mean selective frequencies of the mutant that carries y gene-bearing chromosome showed 0.0185 and 0.0144 from the two different magnetic fields in the same magnetic order. The results indicated that the population of flies from the ambient magnetic field showed higher selective disadvantage frequency, 0.0144. 5.The mean selective frequencies for the mutant carrying m gene-bearing chromosome were calculated as to be 0.0328 and 0.0190 for the same order of magnetic field strength. The found from this results is that the selective disadvantage behavior for the mutant rearing m gene chromosome in the ambient magnetic field was stronger than the one, being 0.0190. 6.The mean selective frequencies of the male flies which carries Y-chromosome showed 0.2457 and 0.2467 respectively. The results indicated that the male flies from the quintuple magnetic field showed higher selective disadvantage being 0.2457. 7.Through Duncan's multiple range test and LSD value, the highly significant differences between A group of the wild type and B group of the other three mutants were calculated.