Eagle씨 증후군의 치험례

오승환,이상철,윤옥병,지유진,김여갑,류동목 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Eagle's syndrome is the term given to symtomatic elogation of the styloid process or mineralization of the stylohyoid or stylomandibular ligament. Since ossification of stylohyoid ligament at cadeva was fist described by De Manchetics in 1652 and Weinlecher described clinical symptom which produced by elongated styloid process and osteotomy of styloid process in 1872, Clinical symptom which include sensation of a foreign body on the pharynx, dysphagai, dysphonia, referred pain, and mouth opening disturbance was termed by Eagle as Eagle's syndrome. then, case reports of Eagle's syndrome are presented. in these cases, the patient's chief complaints included periauricular radiating pain, mouth opening disturbance, foreign body sensation, dysphagia, tenderness on the neck. Through vairous X-ray examination and palpation of tonsillar fossa, elongted styloid process were confirmed. Under the general anesthesia there were successfully removed out via transoral approach technique, described by Eagle. after resented styloid process, they were freed from the symptoms without further complication. Therefor we reported these cases treated by surgical resection of styloid process with good results.

ADP에 의해서 활성화된 혈관평활근 세포의 증식에 관여하는 Integrin의 종류와 신호 전달 경로

박찬복,이지현,류종철,차태준,주승재,이재우 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: Adenosine diphosphate(ADP), which is usually secreted from activated platelets activates integrin αvβ3. αvβ5, and α5β1 on human vascular smooth muscle cells. Integrins have an important role in the proliferation of vascular smooth muscle cells. ADP may stimulate the proliferation of vascular smooth muscle dells by the activation of integrins. Integrins mediating ADP-stimulate the proliferation of vascular smooth muscle cells and signal transduction pathway of ADP stimulation were investigated in this study. Methods: MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay was used to evaluate ADP or ATP-stimulated proliferation of human aortic smooth muscle cells (HASMC). In some experiments, HASMC were incubated with U73122, an inhibitor of phospholipase C, or monoclonal antibodies (mAb) to integrins after ADP of ATP stimulation. Results: ADP and ATP increased the proliferation of HASMC in a dose-dependent manner. U73122 inhibited ADP or ATP stimulated proliferation of HASMC ADP-stimulated proliferation of HASMC was inhibited either by c7E3, a blocking mAb to integrin β3 or by LM609, a blocking mAb to integrin αvβ3(37% and 26% inhibition, respectively: p<0.05), but neither by P1F5, a blocking mAb to integrin αvβ5 nor by JBSS, a blocking mAb to integrin α5β1. Conclusion: These results indicate that ADP increases the proliferation of human vascular smooth muscle cells through phospholipase C pathway, and only integrin αvβ3 mediates ADP-stimulated proliferation of human vascular smooth muscle cells.

상염색체 우성 다낭신에서 발견된 무증상의 I형 담관낭종

류승지 ( Seung Jee Ryu ),김경훈 ( Kyung Hoon Kim ),김태완 ( Tae Wan Kim ),반우호 ( Woo Ho Ban ),이수림 ( Su Lim Lee ),김성수 ( Sung Soo Kim ),김영옥 ( Young Ok Kim ) 대한내과학회 2013 대한내과학회지 Vol.85 No.2

상염색체 우성 다낭신은 가장 흔한 유전성 신질환의 하나로서 유병률이 인구 약 1,000명당 1명에 이르고 국내 혈액 투석 환자의 약 2%를 차지한다. ADPKD에서 신장 외 낭종은 간에서 가장 흔하게 나타나며 그 외 장기로 췌장, 비장 등에서도 발견되지만 담관낭종이 동반된 경우는 매우 드물다. ADPKD를 진단받고 외래 경과관찰 중이던 60세 여자 환자가 전신쇠약과 식욕 저하로 내원하였고 입원 후 실시한 복부 컴퓨터단층촬영 및 복부 자기공명 담췌관조영술에서 다낭신에 동반된 I형 담관낭종으로 진단되었다. 환자는 담석 혹은 담도염 등의 과거력이 전혀 없고 임상증세가 없으며 영상의학적 검사에서 외부 종괴에 의한 담관 압박 소견이 없이 전형적인 선천성의 담관낭종 형태를 보이고 있어 외과적 수술 등의 치료는 시행하지 않고 외래에서 경과관찰 중이다. 전신적 섬유 다낭종의 일환으로 볼 수 있는 다낭신과 담관낭종의 동반 발생에 대해서는 아직 발생 기전이 명확하게 밝혀지지 않았고 치료방법 또한 정립되어 있지 않다. 앞으로 두 질환의 유전적, 발생학적 상관관계 및 치료에 대한 연구가 필요할 것으로 생각한다. Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disease. Polycystic liver disease is commonly observed in ADPKD but rarely has it been associated with a choledochal cyst. We report a case of a choledochal cyst with ADPKD in a 60-year-old female patient with ADPKD and concomitant chronic renal failure who was admitted because of acute deterioration of kidney function due to poor oral intake. There was no history of a biliary disorder and her kidney function recovered promptly after fluid replacement. Non-enhanced computed tomography was performed to evaluate ADPKD and revealed numerous cysts in both kidneys and liver. It also showed fusiform dilatation of the extrahepatic bile ducts, a finding indicative of a choledochal cyst. Liver function was within the normal range and there was no evidence of extrahepatic biliary obstruction. Magnetic resonance cholangiopancreatography confirmed the diagnosis of a type I choledochal cyst combined with ADPKD. (Korean J Med 2013;85:205-209)

Association between Heart Rate Variability Indices and Depressed Mood in Patients with Panic Disorder

Sumin Hong(Sumin Hong),Doo-Heum Park(Doo-Heum Park),Seung-Ho Ryu(Seung-Ho Ryu),Jee Hyun Ha(Jee Hyun Ha),Hong Jun Jeon(Hong Jun Jeon) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4

Objective: Heart rate variability (HRV) reflects the regulation of the autonomic nervous system. Panic disorder is highly associated with autonomic dysfunction, and is often accompanied by depression. The aim of this study is to determine the association between depression and HRV indices in patients with panic disorder. Methods: A total of 110 outpatients diagnosed with panic disorder participated in this study. The medical records of patients with panic disorder who visited the outpatient clinic of Konkuk University Hospital between December 2018 and March 2020 were retrospectively reviewed. Measurements used in this study include the Panic Disorder Severity Scale-Self Report, Beck Depression Inventory (BDI-II), Insomnia Severity Index, and HRV. Patients were divided into depressive and non-depressive groups based on their BDI-II scores. The association between HRV indices and depressive symptoms was statistically analyzed. Results: The low frequency/high frequency (LF/HF) ratio was reduced in patients with depression (mean = −0.095, p = 0.004 in the above moderate depressive group, mean = −0.120, p = 0.020 in the severe depressive group). Significant correlations were found between depressive symptoms and standard deviation of NN interval (SDNN) (ms) (−0.19, p = 0.044), very low frequency (VLF) (ms2/Hz) (−0.22, p = 0.021), LF (−0.25, p = 0.008), HF (−0.19, p = 0.043), and LF/HF (−0.25, p = 0.009). Multiple linear regression analysis showed that BDI predicted SDNN (ms), VLF (ms2/Hz), LF, HF, and LF/HF. Conclusion: We confirmed that the LF/HF ratio decreases when depression is accompanied by panic disorder. HRV indices may be useful markers for detecting depressive symptoms in patients with panic disorder.

A clinicopathological analysis of metastasis in Korean acral melanomas

( Ryu Geon Wook ),( Jee-bum Lee ),( Seung-chul-lee ),( Young Ho Won ),( Sook Jung Yun ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: The prognosis of acral melanomas depends on metastasis. Objectives: The purpose of current study was to investigate the prognostic factors for metastasis of acral melanomas. Methods: We retrospectively reviewed all patients with melanoma located on acral sites from 1996-2016. Only patients who had followed-up for at least 3 years were included. We divided total 189 acral melanoma patients into groups of no metastasis, first lymph node metastasis, and first distant metastasis. Demographic and clinicopathological characteristics were obtained. Results: The median age was 63 years and 51.3% of patients were male. The number of patients who were diagnosed as melanoma in situ was 46 (24.3%), and that of invasive melanoma without metastasis was 29 (15.3%). Among 114 patients with invasive acral melanomas with metastasis, the first metastasis to regional lymph nodes was predominant (99, 86.8%), whereas the first metastasis to distant organs was detected in only 15 patients (13.2%). Acral melanomas deeper than T3 stages, ulceration, and higher mitotic rate more than 7 per square mm are associated with metastasis with statistical significance. However, there was no statistically significant difference in age, sex, site, height, and duration to the first metastasis among patient groups. Conclusion: Breslow thickness, ulceration and mitotic rate are significant prognostic factors for prediction of metastasis in acral melanomas.

Monodisperse Micrometer-Ranged Poly(methyl methacrylate) Hybrid Particles Coated with a Uniform Silica Layer

Seung Jin Han,Kyo Min Shin,Kyung Do Suh,Jee Hyun Ryu 한국고분자학회 2008 Macromolecular Research Vol.16 No.5

Combined Angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia

Ryu, Ji-Kan,Cho, Chung-Hyun,Shin, Hwa-Yean,Song, Sun U.,Oh, Seung-Min,Lee, Minhyung,Piao, Shuguang,Han, Jee-Young,Kim, In-Hoo,Koh, Gou Young,Suh, Jun-Kyu Elsevier 2006 MOLECULAR THERAPY Vol.13 No.4

<P><B>Abstract</B></P><P>Hypercholesterolemia-related endothelial cell dysfunction and decreased endothelium-derived nitric oxide formation may account for impaired angiogenesis and subsequent erectile dysfunction. Angiopoietin-1 (Ang1) is a critical angiogenic factor for vascular maturation and enhances vascular endothelial growth factor (VEGF)-induced angiogenesis in a complementary manner. We hypothesized that combined adenovirus-delivered human Ang1 (ad-Ang1) and VEGF165 (ad-VEGF165) gene transfer might promote angiogenesis cooperatively in a rat model of hypercholesterolemic erectile dysfunction and result in a recovery of erectile function. Ad-Ang1 and ad-VEGF165 were injected either alone or in combination into the corpus cavernosum of the penis. Combined gene transfer of both ad-Ang1 and ad-VEGF165 significantly increased cavernous angiogenesis, eNOS phosphorylation, and cGMP expression compared with that in the groups treated with either therapy alone. Erectile function, as evaluated by electrical stimulation of the cavernous nerve 2 and 8 weeks after treatment, was completely restored in the combined treatment group, whereas intracavernous injection of either ad-Ang1 or ad-VEGF165 alone elicited partial improvement. The results indicate that combined application of angiogenic factors may enhance cavernous angiogenesis cooperatively by reinforcing the endothelium both structurally and functionally, which results in an additive effect on erectile function in hypercholesterolemic rats.</P>

A Case of Rectal Cancer with Stemal Metastasis as Initial Presentation

Jin Hyuk Choi Korean Academy of Medical Science 1995 Journal of Korean medical science Vol.10 No.4

성별에 따라서 사전지식과 ICT활용능력이 디지털교과서의 학업성취에 미치는 영향

류지헌,변호승,서정희 이화여자대학교 사범대학 교육과학연구소 2009 교육과학연구 Vol.40 No.2

이 연구의 목적은 성별에 따른 사전지식 및 ICT활용능력이 디지털교과서의 학업성취에 미치는 영향을 검증하기 위한 것이다. 컴퓨터기반의 학습환경에서는 성차문제가 발생할 수 있기 때문에 디지털교과서가 적용되는 학습환경에서도 이러한 성차문제가 존재하고 있는지를 확인하는 것은 중요한 연구과제라고 할 수 있다. 또한 컴퓨터기반 학습환경에서는 학습자가 갖고 있는 컴퓨터활용능력이 학업성취를 예언하는 중요한 변수중의 하나이다. 이 연구에서는 성차와 컴퓨터활용능력이 학습자의 학업성취에 어떠한 영향을 미치고 있는지를 검증하였다. 연구대상은 도시권역에 거주하는 초등학교 5학년이며, 남학생 297명(51.74%)과 여학생 277명(48.26%)이었다. 구조방정식 분석방법을 적용하여 다집단 분석을 실시하였으며, 이를 위하여 형태동일성과 측정동일성 가정을 검증하였다. 검증결과에 따르면 다집단분석을 위한 기본가정을 충족하고 있는 것으로 나타났다. 이 연구에서 구성한 연구모형에 대한 적합도 판정에서 대체로 양호한 수준의 적합도를 갖고 있는 것으로 평가 되었다. 디지털교과서 활용에 따른 학업성취에서 사전지식에 의한 영향은 유의미한 것으로 나타났다. 그러나 ICT활용능력에 따른 효과는 여학생집단과 남학생집단 사이에서 서로 상이한 결과를 보였다. 여학생집단에서는 ICT활용능력이 학업성취에 유의미한 영향을 주 고 있지 않았지만, 남학생집단에서는 유의미한 것으로 나타났기 때문이다. 이러한 결과에도 불구하고 성차효과가 존재한다고 볼 수는 없는 것으로 나타났다. 즉, ICT활용→사후성적 경로에 대한 여학생집단과 남학생집단의 모수치의 차이는 통계적으로 유의미한 것은 아니었기 때문이다. 따라서 디지털교과서 적용연구에서는 성차효과는 없는 것으로 볼 수 있으며, 이러한 결과가 도출된 것은 노트북효과(laptop effect) 때문인 것으로 보인다. The purpose of this study was to identify how ICT competency and gender have affected the use of digital textbooks in elementary school settings. The literature reviews on computer assisted learning consistently show gender gaps in various aspects. These gender gaps was based on some of the following reasons, comfortableness of using computers, computer accessibility, ICT competency, and computer efficacy rather than on biological factors. Additionally, the literature suggests that these gender gap factors may not only come from school factors but also from social and environmental factors. Along with these literature reviews, it is worth identifying if there is a gender gap effect on the use of digital textbooks. The structural equation model was employed to analyze the data for this study. The analysis focused on testing how ICT competency and gender affects the effectiveness of digital textbooks. The results showed that students' ICT competency level mediating the effectiveness of digital textbooks was also significant for male students. There was no significant difference between genders perhaps because of the laptop effect of applying digital textbooks. Providing opportunities for students to use laptops, therefore, may decrease the gender gap.

Phospholipase C를 투여한 랫트의 간장에서의 Cytochrome P450의 발현양상

지영흔,이차수,박청규,박상준,정원일,도선희,박승춘,류시윤,정규식 한국수의공중보건학회 2001 예방수의학회지 Vol.25 No.4

Alpha-toxin, produced in large amounts by Clostridium perfringens type A strain, is phospholipase C(PLC) and is believed to be the major factor responsible for several biological damages of animals and humans. We attempted to know the expressions of drug metabolism related enzymes, cytochrome P450s(P450s) and membrane lipid peroxidation product, 4-hydroxy-2-nonenal(HNE) after injection of PLC or purified alpha-toxin in Sprague-Dawley rats. The serum-biochemical value which is used as an indicator for major liver damages, activities of asparatate aminotransferase(AST) and alanine aminotransferase(ALT) after injection of PLC increased by 2-fold and 3-fold, respectively. Immunohistochemical staining for P450 1A1/2, 2B1/2, 2E1, 3A1 and 4A2/3 was performed in liver at various times after injection of PLC or alpha toxin. In all experimental groups, immunoreactivities of P450 2E1, 2B1/2, 1A1/2 and 4A2/3 were weak and the immunoreactivities of P450 2C11 were not detectable until 6hrs. Among them,P4503A1 showed strong immunoreactivity on pericentral area at 2hrs after PLC administration. Following a time course of 1∼24 hrs, HNE, a product of lipid peroxidation, was noted positive immunoreactivity on the peripheral area after PLC injection. In immunoblot analyses, the expressions of P450 2E1, 2B1/2, 1A1/2 and 4A2/3 slightly decreased while P450 2C11 significantly decreased until 6hrs. In contrast, HNE was significantly induced at 3.5hrs and increased expression of HNE persisted until 6hrs. In conclusion, the increased expression of HNE, a well known toxic product of the membrane lipid, indicated that PLC showed drug metabolizing enzyme via suicidal inhibitory effects and functions. So, these data support a membrane damaging effect of enzymatic impairment in pathological conditions of the lipid peroxidation.