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The oncoprotein, gankyrin, is up-regulated in middle ear cholesteatoma
Kim, Ki Hyun,Lim, Hye Jin,Kim, Yeon Ju,Kim, Seung Won,Kim, Young Sun,Tian, Chunjie,Park, Keehyun,Park, Tae Jun,Choung, Yun-Hoon Scandinavian University Press 2014 Acta oto-laryngologica Vol.134 No.3
<P><I>Conclusion:</I> Gankyrin seems to be a better biomarker for cholesteatoma compared with Ki-67. <I>Objective:</I> Gankyrin is an oncoprotein, and occurs in cancers but not in benign diseases. The goal of this study was to compare expression of gankyrin, p53, and a proliferation marker (Ki-67) in cholesteatoma and retroauricular skin (RAS), and to evaluate their significance as clinical parameters. <I>Methods:</I> The levels of expression of gankyrin, Ki-67, and p53 in 10 cholesteatoma and 10 paired samples of normal RAS were evaluated by immunohistochemical staining and Western blot. The results were compared with clinical profiles to investigate a correlation. <I>Results:</I> The expression of gankyrin, Ki-67, and p53 proteins was observed in both basal and suprabasal layers of cholesteatoma. The intensity of gankyrin expression was ‘positive’ in two cases (20%) and ‘strongly positive’ in eight cases (80%); p53 expression in the suprabasal layer was ‘positive’ in 70% of cases; and the Ki-67 staining was ‘focal’ in 80% of cases. In RAS, these proteins were expressed dominantly in the basal layer. Western blot analysis showed that the gankyrin band was more intense in cholesteatoma than in RAS for three of four cases (<I>p</I> < 0.05). However, there was no significant difference in the expression of gankyrin, Ki-67, and p53 according to clinical variables.</P>
한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고
양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.
이야기도식을 활용한 읽기훈련이 ADHD아동의 읽기 이해 및 읽기 태도에 미치는 영향
노승림,신현기 檀國大學校 特殊敎育硏究所 2007 特殊敎育要求 兒童硏究 Vol.18 No.-
ADHD아동은 정상지능의 범위에 있음에도 불구하고 읽기에 어려움을 나타내는 경우가 많다. 따라서 본 연구는 ADHD아동에 대한 효과적인 읽기 지도 방법을 알아보기 위하여 이야기 도식을 통한 읽기 훈련이 ADHD아동의 읽기 이해 및 읽기 태도에 미치는 영향을 알아보았다. 본 연구의 대상은 초등학교 3학년 ADHD아동으로 KISE-BAAT 읽기 검사결과 학년 규준 1년 이상의 지체를 나타내는 아동 3명으로 하였으며, 연구방법은 기초선, 중재, 중재를 마친 후 2주일 뒤 유지 단계로 나누어 중다간헐기초선설계(multiple-probe baseline design)로 이루어졌다. 본 연구의 결과는 첫째 이야기 도식을 통한 읽기 훈련이 ADHD아동의 읽기 이해에 긍정적인 영향을 주었다. 둘째 이야기 도식을 통한 읽기 훈련이 ADHD아동의 읽기 향상에 도움을 주었다. 따라서 연구 결과를 종합하여 볼 때 이야기 도식을 통한 읽기 훈련이 ADHD아동의 읽기 이해를 향상시킬 수 있는 교수 방법이 될 수 있으며, 태도에 있어서의 긍정적인 변화도 모색할 수 있을 것이다. Although Children with ADHD have normal intelligence, they often exhibit problems in reading. Therefore, the purpose of this study was examine the effect of story mapping-training on reading comprehension and reading attitude of children with ADHD to make a investigation into effective reading teaching method. The studying prblems suggested in this study are as follows. First, Does story mapping-training improve reading comprehension of children with ADHD? Second, Does story mapping-training effect on reading attitude of children with ADHD? The subject of this study were 3 of third-grade student with ADHD who have l-year delay in reading ability base on the result of the KISE-BAAT and this study was designed as multiple-prove baseline design which was divided into baseline, intervention, maintenance. The results were as follows. First, story-mapping training was effective in improving the reading comprehension of student with ADHD. Second, story-mapping training was effective in improving the reading attitude of student with ADHD. Based on the results mentioned above, it could be concluded that the story-mapping training is a effective method of improving the reading comprehension and reading attitude for children with ADHD.
飼料作物의 生育에 關한 調査 Ⅱ : 晉州地方을 中心으로 for Chinju Area
文勝式,金基元,鄭鉉承 진주산업대학교 1971 論文集 Vol.8 No.-
Sowing 6 Kinds of leguminous grasses 8 Kinds of forage grasses 6a ward of mixture grasses 20 kinds in total, I had bbserved them for 8 month (Marchs. 1970~ october 30 1970) and acquired the results as follow; 1. The growth of forage crops and mixture was well in good soil with plenty rainfall in moderate atmospherical condition. 2. The summer drought is sure in ladino clover alfalfa, birds foot trefoil, Perennial ryegrass, Timothy and Brome grass, The mixture ward is comparatively little. 3. The respective fresh yield of orchard grass, Red clover O+OL+B+R were 5,500㎏, 5,100㎏, 4,325㎏.
partial pulpotomy를 이용한 미성숙 영구치의 치수 치료: 증례 보고
장기택,노승철,한세현,김정욱,김용수 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4
치수치료의 주요한 목적은 구강조직의 본래의 건강을 유지하는 것이며, 치수치료 시 가장 중요하고 어려운 점은 치수조직의 건강상태 또는 염증의 정도를 결정함으로써 최선의 치료방법을 결정하는 것이다. 미성숙 영구치는 풍부한 혈류 공급으로 다양한 손상에 성공적으로 반응하게끔 치수의 능력을 향상시킴으로써 많은 치수치료 술식을 위한 좋은 조건을 가지고 있다. 기저재(base) 또는 이장재(liner), 간접 치수복조술, 직접 치수복조술, 그리고 치경부 치수절단술을 포함한 여러 종류의 보존적인 치수치료가 미성숙 영구치를 위해 추천되어 왔다. 근래에는 외상으로 인하여 치수노출된 영구절치를 치료하는데 있어 주로 제시된 부분 치수절단술(partial pulpotomy)이 우식으로 인해 치수노출된 영구대구치를 치료하는 또다른 술식으로 제안되고 있다. 부분 치수절단술 후 치아가 다음의 criteria를 만족시킬 때 치유가 되었다고 결론지었다. 1. 임상적 무증상 2. dentin bridge 형성의 방사선학적 증거 3. 방사선상에 치수내 또는 치근단 병소가 없다는 증거 4. 지속적인 치근 발육과 미성숙 치아의 치근첨 형성 5. 성숙된 치아에서 정상적인 상아질의 축적 6. 전기치수검사에서 양성 반응 이에 저자는 미성숙 영구치에서 우식 또는 외상으로 인한 치수노출시 부분 치수절단술을 행하여 양호한 결과를 얻었기에 이를 보고하는 바이다. The primary objective of pulp treatment is to maintain the integrity and health of the oral tissues. The most important and difficult aspect of pulp therapy is determining the health of the pulp, or its stage of inflammation, so that a decision can be made regarding the best form of treatment. Immature permanent teeth are good candidates for many pulp healing procedures, due to their rich blood supply, which is believed to enhance the pulp's ability to react successfully to various insults. Healing was considered to have taken place when the tooth fulfilled the following criteria: 1. Abscence of clinical symtoms 2. Radiographic evidence of dentin bridge formation 3. No intrapulpal or periapical pathosis was evident radiographically 4. Continued root development and closure of the apex in immature teeth 5. Normal dentin apposition in mature teeth 6. Positive response to electrical pulp test This presents a report of cases in which immature permanent teeth, pulp-exposed by caries or trauma, was treated successfully by partial pulpotomy
윤승조,류현기 충주대 산업과학기술연구소 1999 産業科學論文集 Vol.7 No.2
The structure which was introduced in this case study of the safe degree was the structure of Chungju Mun Wha Hall located in downtown in Chungju City, Chungbuk. In this case that our country had been developed the rapidly economic development since the 1970's, the several problems of the maintain and management of the existing structure had been started finding on the starting point of the breakdown of Sampung Department and Seongsu Bridge in building a large construction business like the apartment construction of 2 million houses in new town; Illsan, Bundang, Pyongchon, Sanbon, express electric railway and new airport construction, etc, for solving the housing problem including Seoul Olympic Games. In this situation, the evaluation of a concrete crack and its durability, the forecasting of concrete life, the caution in time of selecting the repair method of construction, and the importance of technology development were emphasized again. As a structure which had been built ten years ago, because there have been some cracks in sub-material parts, this thesis researched a crack and the modified state like the several present, the iron frame and the concrete reinforcing degree, the existance or nonexistance of the deficient of the iron framed trust, etc. On the basis of this result, after this thesis investigated the state degree of the structure, it presented the proper repair and the reinforcement of this structure.
제2형 당뇨병 동물모델인 OLETF 쥐에서 장기간 라미프릴 투여가 내당능 및 췌도 베타세포에 미치는 효과
고승현,윤건호,김명미,안유배,송기호,유순집,손현식,차봉연,이광우,손호영,강성구 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6
연구배경:최근 소개된 HOPE(Heart Outcomes Prevention Evaluation)study의 결과에 의하면, 심혈관질환이나 이에 대한 위험인자가 1가지 이상인 9,541명을 대상으로 안지오텐신 전환효소 억제제의 일종인 라미프릴을 투여하여 사망율과 뇌졸증, 심부전, 당뇨병 합병증이 개선되었을 뿐 아니라 다른 항고혈압제에 비해 새롭게 당뇨병으로 진단되는 환자가 줄었음을 보고한바 있다. 이에 저자들은 라미프릴(ramipril)을 제2형 당뇨병 동물모델에 장기간 투여함으로써 당뇨병을 예방하거나 고혈당 상태 또는 인슐린 감수성을 개선시킬수 있는지를 알아보고자 하였다. 방법:생후 24주된 체중 400∼450g의 OLETF와 LETO 쥐를 대상으로 6개월간 라미프릴 경구투여 하였고 혈압, 24시간 단백뇨 및 인슐린 내성검사를 시행하였다. 6개월 이후로는 8주간 투여군과 대조군의 체중을 비슷하게 맞추어 내당능 상태를 평가하였고 이후 다시 8주간 고농도 포도당을 투여하였다. 경구당부하검사를 시행한 후 희생시켜 조직표본을 만들어 guinea pig antihuman insulin 항체로 염색후 DAB로 발색하여 point count 법으로 베타세포를 정량하였고, 면역염색으로 췌도의 변화와 섬유화의 정도를 관찰하였다. 결과:라미프릴을 6개월간 투여하였을 때 OLETF 쥐에서 1)체중 증가가 적었으며 2)경구 당부하검사시 포도당하 면적은 의미있게 감소하였고 3)인슐린 내성검사상 Kitt가 증가되는 경향을 보였으며 4)수축기, 이완기 혈압과 24시간 단백뇨양이 의미있게 감소하였고 5)체중을 맞추면 내당능 상태가 비슷해졌다가 고농도 포도당 주입시 다시 포도당하 면적이 대조군에서 더 증가되었다. 라미프릴 투여군에서 췌도변형 및 파괴와 탈과립, 췌도내 섬유화가 감소하였다. 결론:본 실험에서는 인슐린 비의존성 당뇨병 동물 모델인 OLETF 쥐에서 당뇨병 발생 이전 단계부터 장기간 라미프릴을 투여할 경우 체중증가가 적었고, 투여군과 대조군의 체중을 맞추었을 때는 내당능상태의 차이가 없아가 고혈당 투여시 다시 투여군과 대조군에서 의미있는 차이를 보였다. 라미프릴 투여가 베타세포의 기능면에서 이로운 효과를 보일 것으로 생각되었다. 따라서 비만한 환자에서 안지오텐신 전환효소 억제제의 장기투여는 단백뇨 감소, 혈압강하 효과 이외에 체중증가의 억제 및 당뇨병 발생을 억제할 가능성을 시사한다. Background : In a Heart Outcomes Prevention Evaluation HOPE study, ramipril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, significantly reduced the death rates the number of myocardial infarctions, strokes, heart failure as well as the risk of complications related to diabetes and of diabetes itself. However, it is known that ACE inhibitors improve glucose tolerance or insulin sensitivity or reduce the incidence of diabetes. Methods : 24 week-old OLETF (Otsuka Long Evans Tokushima Fatty) rats weighing 400 ~ 450 g were used in this study. 4 groups of rats were examined in parallel for 40 weeks. The OLETF rats were randomized for treatment with an aqueous solution of ramipril (5 mg/Kg) daily [OL (RMP), n=10)] and with saline [OL (CON), n=10)]. The LETO rats were also randomized in the same was as the OLETF rats (LT(RMP), n=10, LT (CON), n=10). The blood glucose level, body weight, systolic and diastolic blood pressure was assessed every month. At 3 and 6 months, the 24hrs urinary protein concentration was measured, and as insulin tolerance test and oral glucose tolerance test were conducted in all experimental groups. After 6 months, the body·weight was matched for 2 months in each corresponding group. Subsequently, a 15% sucrose loading was done for 2 months. After the glucose tolerance test, the pancreas was excised and immuno histochemical staining was conducted for insulin to quantify the beta cell mass by a point-counting method. In addition, the islet morphology was evaluated in the pancreas. Results : Ramipril treatment for a period of 6 months improved the 2hr blood glucose level, the area under the glucose curve in the oral glucose tolerance test, insulin sensitivity in addition to lowering significantly systolic and diastolic blood pressure and 24hrs urinary protein level significantly in OLETF rats. Of note, a lower weight gain was observed in both the ramipril-treated animals at 6 months. After weight matching, the AUC g and 2hr blood glucose level values were similar between the corresponding groups, but a 15% sucrose loading worsened the AUC g value. Histologically, the islets were less disorganized and the extent of fibrosis was lower in the ramipril-treated OLETF rats in the trichrome stain. Conclusion : Long-term treatment of ramipril, a long acting angiotensin-converting enzyme inhibitor may be useful for suppressing weight gain and proteinuria in addition to having a protective effect on the islet to harmful stimuli such as hyperglycemia (J Kor Diabetes Asso 25:469~482, 2001).