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( Young Su Joo ),( Chan Ho Kim ),( Youn Kyung Kee ),( Chang Yun Yoon ),( Eun Young Lee ),( In Mee Han ),( Seung Gyu Han ),( Jung Tak Park ),( Seung Hyek Han ),( Tae Hyun Yoo ),( Shin Wook Kang ),( Hyu 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Mean platelet volume (MPV) is suggested as an index of infi ammation and disease activity in addition to refi ecting the effi cacy of anti-infi ammatory treatment in chronic infi ammatory disorder patients. However, the prognostic value of MPV on mortality remains unclear in patients with severe sepsis. Methods: We prospectively enrolled 345 patients admitted to the emergency department (ED) who received standardized resuscitation for severe sepsis and/or septic shock between Nov. 2007 and Dec. 2011. The change in MPV between hospital admission and 72 hours after treatment (ΔMPV72h-adm) was evaluated as a prognostic factor for 28- day mortality. Linear mixed model and Cox proportional hazards analysis were used. Results: The mean age of the enrolled patients was 64.2±15.7 years, 169 (49.0%) of them were males. Thirty-fi ve (10.1%) patients died within 28 days after ED admission. During the fi rst 72 hrs of ED admission, MPV signifi cantly increased in both non-survivors (P = 0.001) and survivors (P < 0.001) compared to baseline. ΔMPV72h-adm was signifi cantly higher, indicating an increase in MPV during the fi rst 72 hours, in non-survivors compared to survivors (P = 0.003). However, the change in the number of platelets over the fi rst 72 hours did not differ signifi cantly between the two groups (P = 0.360). Multivariate analysis revealed that ΔMPV72h-adm was an independent predictor of 28-day mortality, even after adjusting for age, sex, body mass index, Sequential Organ Failure Assessment score, renal replacement therapy, platelet count, C-reactive protein level, albumin level, and lactate level (hazard ratio, 1.44; 95% confi dence interval, 1.01-2.06; P = 0.044). Conclusions: An increase in MPV during the fi rst 72 hours of hospitalization could be an independent risk factor for adverse clinical outcomes in severe sepsis.
Kim, Dokyoon,Kwon, Hyek Jin,Shin, Kwangsoo,Kim, Jaehyup,Yoo, Roh-Eul,Choi, Seung Hong,Soh, Min,Kang, Taegyu,Han, Sang Ihn,Hyeon, Taeghwan American Chemical Society 2017 ACS NANO Vol.11 No.8
<P>Colloidal assemblies of nanoparticles possess both the intrinsic and collective properties of their constituent nanoparticles, which are useful in applications where ordinary nanoparticles are not well suited. Here, we report an immunoassay technique based on colloidal nanoparticle assemblies made of iron oxide nanoparticles (magnetic substrate) and manganese-doped zinc sulfide (ZnS:Mn) nano particles (photoluminescent substrate), both of which are functionalized with antibodies to capture target proteins in a sandwich assay format. After magnetic isolation of the iron oxide nanoparticle assemblies and their bound ZnS:Mn nanoparticle assemblies (MZSNAs), photoluminescence of the remaining MZSNAs is measured for the protein quantification, eliminating the need for washing steps and signal amplification. Using human C-reactive protein as a model biomarker, we achieve a detection limit of as low as 0.7 pg/mL, which is more than 1 order of magnitude lower than that of enzyme-linked immunosorbent assay (9.1 pg/mL) performed using the same pair of antibodies, while using only one-tenth of the antibodies. We also confirm the potential for multiplex detection by using two different types of photoluminescent colloidal nanoparticle assemblies simultaneously.</P>