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신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)
This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.
Seung Hoon Yoo,Byung Jun Min,Kum Bae Kim,Sungho Cho,Eun Ho Kim,Jeong Hoon Park,Won-Gyun Jung,Geun Beom Kim,Seung Young Ko,Hyun Soo Shin,Sei Kyung Chang,Ho Jin Jeong,Dong Ho Shin,Kwan Ho Cho 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.12
The aim of the present study was to find the optimum dynamic conformal arc (DCA)-based radiosurgery conditions for treatment of patients with intracranial tumors. DCA plans were generated on a commercial treatment-planning system (BrainSCAN v.5.31) for various beam-number and gantry-angle combinations by using computed tomography (CT) scans to delineate the planning target volume (PTV) and the organs at risk (OARs). To evaluate planning quality related to the various planning conditions, we analyzed the dose quality factors (DQFs) for 22 patients as a function of the number and the total angle of arcs related to the target volume, which were determined on the basis of patient-specific features. When the total angle of arcs was less than 250, the DQF values were under 0.98 (worst group). When the total angle of arcs was more than 350 degrees, the DQF values were maximized, and the highest DQF values (best group, DQF > 0.995) occurred in the range between 50 and 120/cm3 for the total angle/target volume condition. In this optimal range of angle/volume, the asymmetric distribution of the arcs resulted in decreased DQF values. For a relatively large target volume (more than 10 cm3), the DQF values were lower than these for a relatively small target volume (less than 10 cm3). Re-planning results showed that the planning quality could be improved using optimized planning conditions. We expect that this study will provide a basis for the evaluation of various DCA conditions prior to actual planning and treatment.
Anti-inflammatory activity of Camellia japonica oil
( Seung Beom Kim ),( Eun Sun Jung ),( Seung Woo Shin ),( Moo Han Kim ),( Young Soo Kim ),( Jong Sung Lee ),( Deok Hoon Park ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.3
Camellia japonica oil (CJ oil) has been used traditionally in East Asia to nourish and soothe the skin as well as help restore the elasticity of skin. CJ oil has also been used on all types of bleeding instances. However, little is known about its anti-inflammatory effects. Therefore, the anti-inflammatory effects of CJ oil and its mechanisms of action were investigated. CJ oil inhibited LPS-induced production of NO, PGE2, and TNF-α in RAW264.7 cells. In addition, expression of COX-2 and iNOS genes was reduced. To evaluate the mechanism of the anti-inflammatory activity of CJ oil, LPS-induced activation of AP-1 and NF-κB promoters was found to be significantly reduced by CJ oil. LPS-induced phosphorylation of IκBα, ERK, p38, and JNK was also attenuated. Our results indicate that CJ oil exerts anti-inflammatory effects by downregulating the expression of iNOS and COX-2 genes through inhibition of NF-κB and AP-1 signaling. [BMB reports 2012; 45(3): 177-182]
( Beom Kyung Kim ),( Do Young Kim ),( Hye Jin Choi ),( Seung-hoon Beom ),( Hye Won Lee ),( Seung Up Kim ),( Jun Yong Park ),( Sang Hoon Ahn ),( Jinsil Seong ),( Kwang-hyub Han ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Patients with advanced hepatocellular carcinoma (HCC) have a particularly poor prognosis of the median overall survival of less than 12 months. Even though sorafenib has been approved for treating advanced stage HCC, the unsatisfactory objective response rate still remain unresolved. In the current study, we aimed to evaluate the efficacy and safety of localized concurrent chemoradiotherapy (CCRT) followed by sequential sorafenib treatment for advanced hepatocellular carcinoma. Methods: This study is an ongoing, phase II trial. Patients with advanced HCC not amenable for curative treatments were eligible. In the course of radiotherapy for 5 weeks, hepatic arterial infusion of 5-fluorouracil (500mg/day) via implanted port was applied during the first 5 days and the last 5 days of radiotherapy. Four weeks after localized CCRT, sorafenib (400mg bid) was maintained. The pri mary endpoint was overall survival. Results: A total of 47 patients were enrolled. After the completion of localized CCRT, the objective response rate was 31.9%. During the overall treatment course, the objective response rate was 46.8% respectively. Overall, 7 patients (14.9%) underwent curative resection or transplantation after down-staging. The median overall survival was 18.4 months and the progression-free survival was 6.8 months. Adverse events were predictable and manageable with conservative care. Conclusions: Localized CCRT followed by sequential sorafenib treatment in patients with advanced HCC showed significant activity and good tolerability. Furthermore, such a treatment modality, when compared to the use of sorafenib alone, might provide the additional therapeutic benefit through initial tumor reduction, allowing curative treatment after down-staging in 14.9% of patients, Further randomized trial should be required to make the more robust evidence.
항행 및 항법 : A-SMGCS 구현을 위한 위험요소 식별에 대한 연구
홍승범 ( Seung Beom Hong ),최승훈 ( Seung Hoon Choi ),최연철 ( Youn Chul Choi ) 한국항행학회 2015 韓國航行學會論文誌 Vol.19 No.1
최근 국내에서 A-SMGCS (advance surface movement ground control systems) 레벨 Ⅳ 단계를 구현하기 위한 연구가 활발히 진행중에 있다. 전체 A-SMGCS 시스템의 안전을 확보하기 위하여 안전성 평가가 필요하며, 유로컨트롤에서는 A-SMGCS의 안전성 평가를 위하여 기능별 위험요소 평가, 예비시스템 안전성 평가, 그리고 시스템 안전성 평가를 수행하도록 권고하고 있다. 본 논문에서는 기능별 위험요소 평가 방법을 통하여 전체 A-SGMCS의 위험요소를 식별한다. 따라서 A-SMGCS레벨 Ⅳ 시스템에 대하여 29가지 위험 요소를 식별하고 각 위험요소의 심각도를 평가하는 자료로 활용할 것이다. Recently, it is actively under study for the implementation of advance surface movement ground control systems (A-SMGCS) level Ⅳ in Korea. To ensure the safety of the A-SMGCS system needs the safety assessment, and Eurocontrol is encouraged to perform the functional hazard assessment, preliminary system safety assessment, and system safety assessment to the safety assessment of A-SMGCS. In this paper, we identify the hazard of A-SMGCS through a functional hazard assessment. Therefore, we will identify 29 types of hazard for the A-SMGCS level Ⅳ and serve as important data to evaluate the severity of each hazard.
Sim, Sung Hoon,Beom, Seung‐,Hoon,Ahn, Yong‐,Oon,Keam, Bhumsuk,Kim, Tae Min,Lee, Se‐,Hoon,Kim, Dong‐,Wan,Heo, Dae Seog Wiley-Blackwells 2016 Thoracic cancer Vol.7 No.2
<P><B>Abstract</B></P><P><B>Background</B></P><P>The neutrophil‐lymphocyte ratio (NLR) is a marker of poor prognosis in lung cancer patients. However, previous data have been based on an heterogeneous population of lung cancer patients and various treatments. In this study, we evaluate the prognostic value of NLR in an homogeneous population of epidermal growth factor receptor (EGFR)‐mutant non‐small cell lung cancer (NSCLC) patients.</P><P><B>Methods</B></P><P>We restrospectively evaluated the data of 250 NSCLC patients with EGFR mutations. All data are based on first‐line treatment.</P><P><B>Results</B></P><P>All tumors harbored in‐frame deletions in exon 19 or an L858R point mutation. Eighty‐five patients were treated with tyrosine kinase inhibitors (TKIs), while 165 received cytotoxic chemotherapy as first‐line treatment. Multivariate survival analysis revealed that the NLR was a significant prognostic factor for first‐line progression‐free survival (PFS) in the chemotherapy group (hazard ratio [HR] 1.882, 95% confidence interval [CI] 1.319–2.686, <I>P</I> = 0.001), but was not significant in the TKI group (HR 1.239, 95% CI 0.693–2.215, <I>P</I> = 0.469). The response rate (RR) to first‐line treatment was 76.5% in the TKI group and 29.5% in the chemotherapy group; however, the RR, according to the NLR (≤3 vs. > 3), was the same for both groups.</P><P><B>Conclusions</B></P><P>The NLR was a significant prognostic factor in the chemotherapy group, but it did not affect either RR or PFS in EGFR‐mutant NSCLC patients treated with TKIs.</P>
Wine drinking and epithelial ovarian cancer risk: a meta-analysis.
Kim, Hee Seung,Kim, Jae Weon,Shouten, Leo J,Larsson, Susanna C,Chung, Hyun Hoon,Kim, Yong Beom,Ju, Woong,Park, Noh Hyun,Song, Yong Sang,Kim, Seung Cheol,Kang, Soon-Beom Korean society of gynecologic oncology and colposc 2010 Journal of Gynecologic Oncology Vol.21 No.2
<P>Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies.</P>
( Seung Up Kim ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang-hyub Han ),( Yong- Beom Park ),( Sang-won Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Co-morbidities as well as conventional risk factors influence the prognosis of rheumatoid arthritis (RA) patients. We investigated whether liver fibrotic burden is associated with all-cause mortality in RA patients. Methods: A total of 2,812 patients with newly diagnosed RA between October 2000 and September 2016 were retrospectively selected. Liver fibrosis was assessed using Fibrosis-4 (FIB-4) index [age (years)x AST level (IU/L)/ platelet count (109/L)/ √ALT (IU/L)]. Results: The mean age of the study population was 51.5 years (482 men and 2,330 women). The mean erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and FIB-4 was 43.5 mm/hr, 9.0 mg/L, and 1.0, respectively. Methotrexate was used in 2,524 (89.9%) patients and biological or targeted synthetic disease modifying ant-rheumatic drug (DMARD) was used in 310 (11.0%) patients. During the follow-up period (mean 93.7 months), 89 (3.2%) patients were dead. Patients with mortality had significantly higher age (mean 64.4 vs. 51.1 years), proportion of male gender (31.5 vs. 16.7%), hypertension (40.4 vs. 18.5%), and diabetes (25.9 vs. 7.7%), ESR (mean 57.1 vs. 43.0 mm/hr), CRP (mean 16.9 vs. 8.7 mg/L), and FIB-4 (mean 1.5 vs. 1.0) (all P<0.05). On multivariate analysis, higher FIB-4 was independently associated with a higher risk of all-cause mortality (hazard ratio=1.130, P=0.004), together with male gender, hypertension, diabetes, ESR, and intensity of glucocorticoid exposure, whereas the use of methotrexate was independently protective (all P<0.05). Conclusions: Beside of conventional risk factors, fibrotic burden assessed using FIB-4 might be useful for risk stratification of newly diagnosed RA patients.
( Beom Kyung Kim ),( Seung Up Kim ),( Hyon Suk Kim ),( Jun Yong Park ),( Sang Hoon Ahn ),( Chae Yoon Chon ),( In Rae Cho ),( Dong Hoo Joh ),( Young Nyun Park ),( Kwang Hyub Han ),( Do Young Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background/Aims: Diagnostic values of FibroTest (FT) for hepatic fibrosis have rarely been assessed in Asian chronic hepatitis B (CHB) patients. We aimed to validate its diagnostic performances in comparison with liver stiffness (LS). Methods: From 2008 to 2010, 194 CHB patients who underwent liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis stage was assessed according to the Batts and Ludwig system. Results: To predict significant fibrosis (F≥2), advanced fibrosis (F≥3), and cirrhosis (F=4), areas under receiver operating characteristic curves (AUROCs) of FT were 0.903, 0.907, and 0.866, comparable to those of LS (0.873, 0.897, and 0.910, respectively). Optimized cutoffs of FT to maximize sum of sensitivity and specificity were 0.32, 0.52, and 0.68 for F≥2, F≥3, and F=4, while those of LS were 8.8, 10.2, and 14.1 kPa, respectively. According to FT and LS cutoffs, 123 (63.4%) and 124 (63.9%) patients were correctly classified consistent with histological fibrosis (F1, F2, F3, and F4), respectively. Overall concordance between each fibrosis stage estimated by FT and LS was observed in 111 patients, where 88 were correctly classified with histological results. A combination formula adding LS to FT (LS+FT) showed similar AUROC levels (0.885, 0.905, and 0.915), while another multiplying LS by FT (LS×FT) showed the best AUROCs (0.941, 0.931, and 0.929 for F≥2, F≥3, and F4, respectively). Conclusions: FT provides good fibrosis prediction, with comparable outcomes to LS in Asian CHB patients. FT substantially reduces need for liver biopsy, especially when used in combination with LS.
( Beom Kyung Kim ),( Seung Up Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Jin Sil Seong ),( Do Youn Lee ),( Kwang Hyub Han ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aims: The most informative staging system regarding survival outcomes for treatment-naive hepatocellular carcinoma (HCC) remains debated. We evaluated prognostic values of Barcelona Clinic Liver Cancer (BCLC) stage compared to other staging systems, and identified discrepancies between treatment options chosen in Korean clinical practice and BCLC guidelines. Methods: Between 2003 and 2008, 1,717 prospectively enrolled patients with treatment-naive HCC were analyzed. Prognostic ability of each staging system was assessed using timedependent receiver-operating characteristic (ROC) curves. Results: The most common etiology was hepatitis B virus (1,238, 72.1%); 167 (9.8%) patients were classified as BCLC stage 0, 526 (30.6%) as A, 333 (19.4%) as B, 608 (35.4%) as C, and 83 (4.8%) as D. Median overall survival was 22.5 months, and 1-, 2-, 3-, 4-, and 5-year survival rates were 62.6, 48.3, 39.9, 34.7, and 29.3%, respectively. Of 6 staging systems, BCLC had the highest area under ROC (AUROC; 0.821) for overall survival, followed by Japan Integrated Scoring (JIS, 0.809), Tokyo score (0.771), Cancer of the Liver Italian Program (CLIP, 0.746), Chinese University Prognostic Index (CUPI, 0.701), and Groupe d’Etude du Treatment du Carcinome H´epatocellulaire (GRETCH, 0.685) system. In both subgroups stratified according to treatment strategy (curative vs. palliative), BCLC also showed the best AUROCs (curative, 0.708/palliative, 0.807) for overall survival. Regarding discrepancies between treatment options chosen in our cohort and BCLC guidelines, more than half with very early/early-stage HCC underwent transarterial chemoembolization, rather than resection or local ablative therapy; most of those with advanced-stage HCC received intra-arterial chemotherapy-based treatments rather than sorafenib. Conclusion: BCLC was the best long-term prognostic model for treatment-naive HCC in a large-scale Korean cohort. However, treatment modalities did not exactly match BCLCparadigm.