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( Dam Kim ),( Soo-kyung Cho ),( Seoung Wan Nam ),( Hyuk Hee Kwon ),( Sun-young Jung ),( Chan Hong Jeon ),( Seul Gi Im ),( Dalho Kim ),( Eun Jin Jang ),( Yoon-kyoung Sung ) 대한류마티스학회 2017 대한류마티스학회지 Vol.24 No.5
Objective. To estimate the cardiovascular (CV) and gastrointestinal (GI) risks of etoricoxib in the treatment of osteoarthritis (OA) compared to a placebo and other non-steroidal anti-inflammatory drugs (NSAIDs). Methods. A systematic review of randomized, controlled trials (RCTs) of etoricoxib were performed. Bayesian network meta-analysis was used over a duration of 12 weeks. The incidence of CV and GI events for a duration ≥26 weeks were also tabulated and presented using descriptive statistics. Results. From this search, 10 studies were identified. Of these, 6 and 5 RCTs that measured the CV and GI events at 12 weeks were included in meta-analysis. They showed that etoricoxib did not increase the CV events compared to the placebo or NSAIDs during the 12 week period (odds ratio [OR]=0.59 compared to celecoxib, OR=0.89 with ibuprofen, OR=0.70 with placebo, and OR=2.16 with naproxen). The risk of GI events was comparable to that of most comparators, with the exception of naproxen, which had a significantly lower risk of GI events (OR=0.18) during the 12 week period. For a duration ≥26 weeks, the incidence of CV and GI events with etoricoxib increased with increasing duration. Conclusion. Etoricoxib is an alternative short-term treatment option for OA, showing comparable CV and GI complications to other NSAIDs. Nevertheless, further studies will be needed to elucidate the long-term safety of etoricoxib in the treatment of OA. (J Rheum Dis 2017;24:293-302)
Quality of Communication Life in Prelingually Deafened Adults with Cochlear Implant
Seul-Gi Lee(이슬기),Sang-Im Jung(정상임),Pyung-Kon Tark(탁평곤),Soo-Bok Lee(이수복),Youngmee Lee(이영미) 한국언어청각임상학회 2018 Communication Sciences and Disorders Vol.23 No.2
배경 및 목적: 청각장애인들은 부족한 의사소통 능력으로 인해 인간관계에서 끊임없이 좌절을 경험하고, 사회 적응에 여러 제약을 받아 건청인과 비교하여 상대적으로 낮은 삶의 질을 보인다. 본 연구는 인공와우이식을 받은 선천성 농 성인과 건청 성인 간의 의사소통 관련 삶의 질(quality of communication life, QCL)을 비교하여 QCL의 하위요인별(의사소통 효능감, 자아 존중 및 역할, 일상생활 참여, 의사소통 태도) 차이를 파악하고, 그들의 의사소통 능력(단음절 단어검사의 음소점수, 이음절 단어검사의 음소점수, 문장검사 단어점수, 조음정확도, 수용어휘 점수) 중 QCL을 예측할 수 있는 변인을 알아보고자 하였다. 방법: 만 19-39세의 인공와우이식 선천성 농 성인 18명과 생활연령을 일치시킨 건청 성인 18명을 대상으로 QCL에 대한 설문을 진행하였고, 인공와우이식 선천성 농 성인의 의사소통 능력을 평가하였다. QCL의 하위요인에 따라 집단 간의 유의한 차이가 있는지를 살펴보기 위해 t-검정을 실시하였고, 의사소통 능력과 인공와우이식 선천성 농 성인의 QCL 간의 관계를 살펴보기 위해 피어슨 상관분석을 실시하였다. 또한 인공와우이식 선천성 농 성인의 QCL에 대한 예측 변인을 알아보고자 다중회귀분석을 실시하였다. 결과: 인공와우이식 선천성 농 성인의 QCL은 건청 성인에 비해 유의하게 낮았고, QCL의 하위요인별 분석에서는 ‘의사소통 효능감’, ‘일상생활 참여’, ‘의사소통 태도’에서 인공와우이식 선천성 농 성인의 점수가 유의하게 낮게 나타났다. 또한, 의사소통 능력 중 듣기능력(단음절, 이음절, 문장)과 조음정확도가 QCL과의 상관을 보였으며, 그 중 이음절 듣기능력이 QCL에 대한 30% 정도의 예측력을 보였다. 논의 및 결론: 인공와우이식을 받은 청각장애인은 성인이 되어서도 듣기능력과 말산출 능력 향상을 위한 중재를 꾸준히 받는 것이 QCL을 향상시키고, 궁극적으로 전반적인 삶의 질을 증진시킬 수 있음을 시사한다. 또한 언어장애전문가는 QCL 측정을 통해 더 효율적인 개별 중재 프로그램을 제공할 수 있는 근거 자료를 확보할 수 있다. Objectives: The present study was designed to compare the quality of communication life (QCL) between prelingually deafened adults with cochlear implants (ACI) and adults with normal-hearing (ANH), seeking to determine the relationship between QCL and communication abilities of ACI while investigating the predictors of QCL. Methods: The QCL scale of 18 ACI and 18 age-matched ANH was measured. Communication abilities of ACI, such as listening, receptive vocabulary and articulation were also evaluated. A t-test was conducted to examine the differences between the groups according to sub-factors of QCL. Pearson correlation analysis was performed to examine the relationship between the communication ability and QCL of ACI. Finally, multiple regression analysis was performed to evaluate predictor factors of QCL for ACI. Results: ACI scored significantly lower than ANH on the QCL scale. They also showed significantly lower scores among the sub-factors of QCL: communication efficacy, daily life participation, and communication attitude. Among the communication abilities, listening ability (monosyllabic word, bisyllabic word, sentence) and articulation accuracy were correlated with QCL. Also, bisyllabic word listening ability was significantly correlated with QCL, predicting 30.2% of QCL. Conclusion: The results of this study suggest the need to improve QCL of ACI by participating in aural rehabilitation programs and that improving listening ability will have a positive influence on the overall quality of life of adults with cochlear implant.
Treatment patterns of knee osteoarthritis patients in Korea
( Ha-rim Park ),( Soo-kyung Cho ),( Seul Gi Im ),( Sun-young Jung ),( Dalho Kim ),( Eun Jin Jang ),( Yoon-kyoung Sung ) 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.5
Background/Aims: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea. Methods: Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in combination with a procedure for a knee X-ray. Patterns of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CSs), analgesics, and symptomatic slow acting drugs for OA (SYSADOA) were analyzed. Prevalence and characteristics of knee OA patients who received a CS intra-articular injection (IAI) were also evaluated. Results: We identified 2,016,516 knee OA patients whose age (mean ± standard deviation) was 63.2 ± 10.8 years. The number of patients with at least one use of NSAIDs, analgesics, CS, and SYSADOA were 82.5%, 32.2%, 8.6%, and 43.4%, respectively. The use of herbal SYSADOAs was 29.7%. For regular users (medication possession ratios ≥ 50%), the use of NSAIDs was substantially decreased (48.8%), while the use of SYSADOA (37.3%) and CS (6.7%) were not significantly changed. The number of CS IAI users among knee OA patients was 0.18%; they were slightly older (64.4 ± 10.9 vs. 63.2 ± 10.8, p < 0.01) and more skewed towards females (75.7% vs. 71.5%, p < 0.01) than patients who had not received CS IAI. Conclusions: In Korea, the use of SYSADOA or CS in knee OA patients was relatively high. Further studies on the effectiveness and the safety of these treatment options for knee OA are needed.