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정원우,이윤종,기우항,김영호,양승영,강용희,안병호,임성규,윤일희,김중욱,윤성효,강동진 경북대학교 과학교육연구소 1997 科學敎育硏究誌 Vol.21 No.-
The purpose of this study is to investigate the status of the experimental and practical education in high school earth. The present status and reasonable management of the experimental and practical education in high school earth science have been grasped from the questionaires. To do this, eighty eight earth science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of earth science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.
현행 중학교 과학 실험·실습교육에 대한 교사들의 견해와 개선방안
이윤종,기우항,김영호,정원우,양승영,강용희,안병호,임성규,윤일희,김중욱,강동진 경북대학교 과학교육연구소 1996 科學敎育硏究誌 Vol.20 No.-
The status of facilities, management of the experiment, practices, and Science education teaching method in middle school have been investigated. The present status and reasonable management of middle school science education have been grasped from the questionaires. The results are as follows : The reasonable management for expeiments and practices of science education were scanty in the middle school around the urban and rural schools owing to the shortage of facilities and equipments, crowded class, excessive classes, work for teachers, excessive contents of present textbook and insufficience of administrative support etc. The current teaching method of middle school science has emphasized knowledge. This fact does not satisfy the objective of learning due to lack of teaching method. Desirable directions for the improvement of present status of middle school science education were proposed in this paper.
강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-
과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.
늑막삼출환자에서 늑막액 Cholesterol 농도와 늑막액 / 혈청 Cholesterol 비의 진단적 의의
김성숙(Seong Suk Kim),신경철(Kyeong Cheol Shin),최희진(Hee Jin Choi),류헌모(Hon Mo Ryu),서정일(Jeong Ill Suh),임종식(Jong Sik Lim),이재성(Jae Seong Lee),정진홍(Jin Hong Chung),이관호(Kwan Ho Lee),이현우(Hyun Woo Lee) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Objectives: To validate the use of pleural cholesterol and the pleural cholesterol/serum cholesterol ratio (P-/S-CHOL) for differentiating between transudates and exudates in pleural effusion of diverse etiology and to compare the diagnostic efficacy of these parameters with those of Light criteria. Methods: Between September 1991 and June 1992, 118 patients with pleural effusion were studied. We measured pleural protein/serum protein ratio, pleural LDH, pleural LDH/serum LDH ratio, pleural cholesterol and pleural cholesterol/serum cholesterol ratio. Mean values of the parameters in transudates group and exudates group were compared, and the misclassification rate and the diagnostic efficacy for each parameters were calculated. Results: 1) The pleural cholesterol (P-CHOL) values were 21.88±8.86rng/dl for transudates, 86.38±30.09mg/dl for tuberculous exudates, 76.96±18.63 mg/dl for neoplastic exudates, and 85±24.69mg/dl for the parapneumonic effusion group (p<0.001 in tuberculous and neoplastic exudates, p<0.05 in parapneumonic effusion group). And the pleural cholesterol/serum cholesterol ratio (P-/S-CHOL) were 0.17±0.07 for transudates, 0.64±0.16 for tuberculous exudates, 0.52±0.16 for neoplastic exudates, and 0.68±0.17 for the parapneumonic effusion group (p<0.001). 2) Misclassification rates for each parameters in seperating the exudate group from the transudate group were as follows; pleural protein/serum protein ratio (P-/S-PROT) 1 69%, P-/S CHOL 2.54%, P-CHOL 3.38%, pleural LDH (P-LDH) 4.23%, pleura LDH/serum LDH ratio (P-/S-LDH) 4.23%. 3) With a cut-off value of 50mg/dl, P-CHOL had a sensitivity of 96% and a specificity of 10096 for diagnosis of exudates, and with a cut-off value of 0.3, P-/S-CHOL had a sensitivity of 98% and a specificity of 94%. 4) Diagnostic efficiencies for each parameters in seperating the exudate group from transudate group were as follow; P-/S-PROT 98%, P-/S-CHOL 97%, P-CHOL 96%, P-LDH 95%, and P-/S-LDH 95%. 5) In the exudate group, pleural cholesterol was significantly correlated with serum cholesterol (r=0.5S84, p<0.001) and the pleural LDL/Cholesterol ratio was significantly correlated with the serum LDL/Cholesterol ratio (r=0.4408, p<0.001). Conclusion: we think that measurements of P-CHOL and P-/S-CHOL is of great value for distinguishing between pleural exudates and transudates, and high P-CHOL and P-/S-CHOL values appear to be related to increased permeability of pleural capillaries. Therefore, we suggest that determination of these parameters should be included in routine laboratory analysis of pleural effusions.
Antiplatelet activity and clinical outcomes on CYP3A4-metabolized statin in PCI
( Sung Woo Kwon ),( Jong-beom Shin ),( Jae-hyung Park ),( Sehwan Oh ),( Mi-hwa Park ),( Sang-ho Jeong ),( Sung-hee Shin ),( Seong-ill Woo ),( Sang-don Park ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Purpose: Statins primarily metabolized by cytochrome P450 3A4 (CYP3A4) reportedly reduce clopidogrel metabolism to active metabolite. Recent studies suggest that CYP 3A4-metabolized statins attenuate the anti-aggregatory effect of clopidogrel. We sought to assess the antiplatelet activity of a CYP 3A4 metabolized statin and its association with clinical outcomes duringdual antiplatelet therapy following percutaneous coronary intervention (PCI). Methods: Among 3,755 patients enrolled the HOST-ASSURE trial, 1,187 patients with both baseline and 1-month platelet reactivity unit (PRU) values assessed by VerifyNow P2Y12 assay were assigned to the CYP 3A4-metabolized statin group (n=725) or non-CYP 3A4-metabolized statin group (n=462) according to type of statins used. The co-primary outcome were the differences between baseline and 1-month follow-up of PRU value and the composite of cardiovascular death, recurrent MI, including stent thrombosis, any revascularization and cerebrovascular accident (CVA) during the follow-up period. We compared the outcomes between groups both in the propensity adjusted and matched cohorts. Results: Mean difference of PRU values was not significant in the CYP 3A4-metabolized statin group (mean difference: -4±84, p=0.367) and was significant in the non-CYP 3A4-metabolized statin group (mean difference: -12±69, p=0.006) both in the propensity scoreadjusted and matched cohorts. Patients with high PRU value at baseline, irrespective of the type of used statins, were associated with a significant reduction in mean difference of PRU values both in the propensity score adjusted (mean difference: -53.35, p<0.001) and matched cohort (mean difference: -41.57, p<0.001). The composite of clinical events did not differ between groups both in the propensity score adjusted (hazard ratio [HR] 0.962, 95% confidence interval [CI] 0.621-1.489, p=0.861) and matched (HR 0.902, 95% CI 0.554-1.468, p=0.678) cohorts. Conclusions: This study showed that a CYP 3A4-metabolized statin slightly reduces antiplatelet activity of clopidogrel during dual antiplatelet therapy but did not increase clinical events in patients following PCI.
실증시험용 배전급 초전도 한류기의 특성 평가 및 운전 시험
임성우(Seong-Woo Yim),박충렬(Chung-Ryul Park),유승덕(Seung-Duck Yu),김혜림(Hye-Rim Kim),현옥배(Ok-Bae Hyun),박권배(Kwon-Bae Park),심정욱(Jungwook Sim),이경호(Kyoung-Ho Lee),오일성(Ill-Sung Oh) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
Superconducting fault current limiter (SFCL) is an power device of a novel concept. While SFCLs generate no ohmic loss during the operation carrying normal currents, they can limit fault currents very fast making large impedance by their quench characteristics. In 2006, KEPCO has developed a distribution class hybrid type SFCL by a collaborative research project with LS industrial systems. The SFCL has merits in practical and economical points of view. In the SFCL, the superconductor just plays a role of a fault detector and the current limiting is completed by the other current limiting element made of normal metals throu호 the line commutation. As a result, the required amounts of superconductors can be reduced considerably. Consequently, the hybrid SFCL can be fabricated with small size and cost, maintaining perfect current limiting performance. Currently, KEPCO is carrying out a research project at Gochang power test center for the purpose of the verification test of the 22.9 ㎸/ 630 A class SFCL for the practical application in real grid. Through the project, a long term operational test and fault current test will be done. In this paper, the back ground of development and installation of the SFCL will be explained and the operation plan of the SFCL for the verification test is also introduced.