Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitals

Son, Jun Seong,Song, Jae-Hoon,Ko, Kwan Soo,Yeom, Joon Sup,Ki, Hyun Kyun,Kim, Shin-Woo,Chang, Hyun-Ha,Ryu, Seong Yeol,Kim, Yeon-Sook,Jung, Sook-In,Shin, Sang Yop,Oh, Hee Bok,Lee, Yeong Seon,Chung, Doo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. <I>Escherichia coli</I> was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, <I>Staphylococcus aureus</I> (15.2%), coagulase-negative <I>Staphylococcus</I> (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.</P>

전방 불안정성 견관절에서 이두박근의 근전도 활동성

김승호,하권익,김현숙,김선우,박종혁,김영민 대한견.주관절학회 2000 大韓肩.주關節學會誌 Vol.3 No.2

CT-26 선암을 접종한 마우스에서 Iodine-131-Iodomisonidazole 의 생체분포 및 종양저산소증의 영상화

Yang, David J,Kim, E Edmund,김혜원,김창근,윤권하,김현정,정선관,노병석,Lee, Hyun-Chul 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3

urpose: Misonidazole is a radiosensitizer that binds in hypoxic cells. The purpose of this study was to find out the feasibility of I-131-Iodomisonidazole (IMISO) for imaging of tumor hypoxia. Materials and Methods: Tosyl precursor was dissolved in acetonitrile and I-131-NaI was added to synthesize IMISO. Balb/c mice inoculated with CT-26 adenocarcinoma were injected with IMISO. Mice were sacrificed at 1,2,4,24 hr and % of injected dose per gram of tissue (%ID/g) was determined. For scintigraphy and MRI, mouse bearing CT-26 adenocarcinoma was administered with IMISO and imaging was performed 4 hr after. Then, mouse body was fixed and microtomized slice was placed on radiographic film for autoradiography. Results: %ID/g of tumor was 1.64 (1h), 0.98 (2h), 0.85 (4h) and 0.20 (24h), respectively. At 24h, %ID/g of tumor was higher than that of all other tissues except thyroid. Tumor to muscle ratio increased with time and tumor to blood ratio also increased with time and reached 1.53 at 24 hr. On autoradiogram, tumor was well visualized as an increased activity in central hypoxic area of the tumor which corresponds to the area of high signal intensity on T2-weighted MR image. On scintigraphy, tumor uptake was visualized. Conclusion: This results suggest that IMISO may have a potential for tumor hypoxia imaging in mouse model. However, further study is needed to improve it's localization in tumor tissue and to achieve acceptable images of tumor hypoxia.

煎湯方法의 變化에 의한 五積散 물추출액이 Hydrocortisone acetate로 유발한 瘀血病態에 미치는 효과

서부일,김미려,박지하,지선영,Seo, Bu-Il,Kim, Mi-Ryeo,Park, Ji-Ha,Ji, Seon-Yeong 대한한방안이비인후피부과학회 2001 한방안이비인후피부과학회지 Vol.14 No.1

This study was performed to compare the effect of Ojeoksan which have extracted by varied extractor(press extractor : PE, pressless extractor : PLE, short acting extractor : SE) on model of blood stasis in rats, Except for the normal group, hydrocortisone acetate(HA;25mg/kg in ethanol. IM) to induce experimental blood stasis model for 1 weeks and each extract of Ojeaksan was administrated after 1hr following HA injection for 1week. We measured the hematocrit, the platelet count, the prothrombin time, levels of fibrinogen in rats' blood, The sample Ⅰ(Ojeoksan extracted by PE) group showed significant decrease of hematocrit. prothrombin time and significant increase of the platelet count, levels of fibrinogen in comparison with those of the control group, The sample Ⅱ(Ojeaksan) extracted by PLE) group showed significant decrease of hematocrit and significant increase of levels of fibrinogen in comparison with those of the control group. Administration of the sample Ⅲ(Ojeaksan extracted by SE) group showed significant decrease of hematocrit and significant increase of the platelet count, levels of fibrinogen in comparison with those of the control group.

인간의 행위를 고려한 공동주택 단위공간의 디자인평가를 위한 공간데이터모델 개발에 관한 연구

김하나,강미선,이상현 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

This research intends to implement an evaluator as well as a building unit data model Through this system, It will be possible to represent a building unit in such a semantically rich manner and also to evaluate a building unit design against the given design criteria To do this, 1) a design checklist was created, 2) it was structured according to its original intentions, 3) the set of structured checklist was transformed into the computable format, 4) the classes representing the elements inn a building unit were developed, 5) finally the building unit data model was developed, 6) in addition, an evaluator module which works on the building unit data model was implemented

아동의 눈-사지 협응과 물체조작 기술의 관계

김선진,한동욱,박승하,김용호 한국스포츠심리학회 2003 한국스포츠심리학회지 Vol.14 No.2

본 연구의 목적은 아동의 눈-사지 협응 능력과 물체조작 기술의 차이를 알아보고, 두 변인군의 관계를 구명하는 데 있다. 피험자는 남?여 5-10세의 아동 186명을 대상으로 하였다. 눈-사지 협응 능력은 예측 타이밍 능력, 추적 능력, 전신 반응 능력을 측정하여 분석하였으며, 물체조작 기술은 TGMD(Test of Gross Motor Development)에서 제시한 받기, 던지기, 치기, 차기, 튀기기 기술을 평가하였다. 먼저 눈-사지 협응 능력과 물체조작 기술의 연령과 성별에 따른 특성을 알아보기 위해 이원 변량분석을 실시한 결과, 5세의 아동 집단은 전반적으로 수행능력이 6세, 7세, 8세, 9세, 10세의 아동에 비하여 수행능력이 떨어졌으며, 10세의 아동은 다른 연령 집단에 비하여 우수한 수행능력을 나타냈다. 이러한 결과는 5-6세, 9-10세의 연령 시기가 눈-사지 협응 능력과 물체조작 기술이 변화되는 시기임을 나타내주고 있으며 이는 연령에 따른 특징을 보여주는 것이다. 다만 눈-사지 협응 능력과 다르게 물체조작 기술에 있어서는 성별에 따른 수행 능력이 9세와 10세의 연령 집단에 있어서 상반된 특징이 나타났다. 즉 남자 아이들의 경우, 9세의 연령 집단과 비교하여 10세의 연령 집단은 물체조작 기술의 수행 능력이 급격하게 증가한 반면에 여자 아이들은 수행 능력이 떨어지는 특징을 보였다. 또한 눈-사지 협응과 물체 조작 기술간의 관계를 알아보기 위해 정준 상관분석을 실시한 결과, 두 과제간 상관계수 .599로 통계적으로 유의한 상관관계를 보였다. 이러한 결과를 바탕으로 눈-사지 협응 능력과 물체조작 기술의 관계를 설명해 주는 각 변인들의 상대적 기여도를 살펴보면, 눈-사지 협응 능력에서 손과 발을 사용한 예측 타이밍 능력이 추적 및 전신 반응 능력보다 높은 기여도를 보였다. 또한 물체조작 기술에 있어서는 받기와 튀기기 능력이 눈-사지 협응 능력과 물체조작 기술의 상관관계를 설명하는데 많은 기여를 하는 것으로 나타났다. The purpose of this study was to investigate the difference of eye-limb coordination and the object-control skills with age and sex, and examine the relationship between two-variable groups. For this experiment, 186 children with the age of 5 to 10(99 boys and 87 girls) participated in the study. The eye-limb coordination ability(anticipation timing ability, pursuit ability and reaction ability) and the object-control skill(catching skill, throwing skill, striking skill, kicking skill, bouncing skill) suggested in TGMD(Test of Gross Motor Development)were tested. The two-way ANOVA was used to present the characteristics of the eye-limb coordination ability and the object-control skills according to age and sex. As a result, children with the age of 5 demonstrated the lowest performance while children with the age of 10 showed high performance significantly among age groups. The children with the age of 5 to 6 and 9 to 10 were found to be two critical periods of change with age. However, unlike the eye-limb coordination ability, there was a distinctive feature in the object-control skills of the age 9 and 10 over sex. 10 year-old boys showed a radical progress, but the 10 year-old girls showed a decline on the object-control skills compared with the 9 year-old. A canonical correlation analysis was used to examie the relationship between the eye-limb coordination and the object-control skills for the early childhood. The relationship revealed significantly showing canonical correlation with coefficient .599. Overall, the results indicated the eye-limb coordination ability such as anticipation timing ability with hand and foot showed higher role than pursuit and reaction ability. In addition, the object control skills such as catching and bouncing ability contributed importantly in explaining the relationship between the eye-limb coordination ability and the object control skill.

폴리에스테르계 메디아를 이용한 염색폐수처리에 관한 연구

김선덕,이선하,김재현 大邱大學校附設 基礎科學硏究所 1997 基礎科學硏究 Vol.14 No.1

Dyeing wastewater, BOD 1,742mg/ 2 , CODMr, 517mg/ 2 was treated polyester-media process, BOD removal efficiency was 55% in 30% of packing ratio. In case of activated sludge process BOD removal efficiencies were 82%, 87% and 90% in the hydraulic retention time of 17hr, 24hr and 35hr, respectively, in case of polyester-media process were 96%, 97.5% and 98.3%, respectively. In case of activated sludge process COD,,,, removal efficiencies were 25.7%, 49.2% and 51.8% in the hydraulic retention time of 17hr, 24hr and 35hr, respectively, in case of polyester-media process were 62.5%, 72.9% and 77.1%, respectively. T-N removal efficiencies in case of hydraulic retention time of 35hr were 80% and 87.9% in activated sludge process and polyester-media process, respectively. Color removal efficiencies in case of hydraulic retention time of 35hr were 44.9% and 68.8% in activated sludge process and polyester-media process, respectively.

골다공증성 대퇴골 골절의 위험인자 평가

정선관,박성훈,김혜원,이영환,윤권하,최시성,노병석,원종진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

최근 8년간 K지방대학병원 응급실로 내원한 치과 응급환자에 관한 임상적 연구

유재하,김종배,김태우,문선재,권혁찬,김승범 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

The delivery of the proper care to the emergency dental patients is more important in the aspdect of community dental service. To attain such a purpose requires the sacred duty to the training of oral and maxillofacial surgeons. This is a retrospective study on the characteristics of dental injuries and diseases in emergency patients. Ths study was based on a series of 2,649 patients treated as dental emergency patients at K country hospital of medical college, from Jan. 1, 1993, to Dec. 31, 2000. The obtained results were as follows. The trauma(71.6%) was the most frequent cause in dental emergency patients, odontogenic infection and oral hemorrhage were next in order of frequency. The primary interdental wiring and transpalatal wiring were frequent proper methods with rubber drainage for prevention of hemorrhage and infection in the primary care of jaw fracture. The peak incidence(45.0%) about the infection group was occurred in the pulpitis of advanced dental caries, and common treatments were the medication of antibiotics & anagesics and I&D. In the dentoalveolar hemorrhage group, a major cause was postoperative hemorrhage(57.9%) and hemostasis was obtained by pressure dressing, suture and drainage of infected wound. About TMJ disorder group, the peak incidence was showed in the post-traumatic myofascial pain dysfunction syndrome and its primary care was medications(anagesics & sedatives). In the other groups, various irritable specific pains were complained, such as trigeminal neuralgia-form pain, acute stomatitis, chemical burn, terminal stage neuritis of head & nech cancer and their primary care methods were various individually. For the rapid and correct care of the emergency dental disease above, well-trained education should be presented in the intern and resident curriculum of oral & maxillofacial surgery.

제강 집진 dust에 포함된 중금속제거에 관한 연구

이선하,김재현,박영서 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

This study was conducted continuous-type process to remove heavy metals for dust generated from steel manufacture-collection process. According to increasing ratio of the dust and extraction solvent, heavy metal-extraction of dust was increased slowly, and extracted heavy metals(Cr, Cd etc.) were under the water quality standard of effluent, except for Pb metal.